Cycloastragenol hmoovyog lub ntuj sib xyaw ua los ntawm Astragalus membranaceus nrog ntau yam kev ua si, xws li tiv thaiv kev ua si, antioxidant, thiab immunomodatory siab. Nws tuav ib qho chaw tseem ceeb hauv suav tshuaj ib txwm muaj thiab tau dav thiab siv nyob rau hauv cov teb ntawm cov khoom noj qab haus huv thiab cov kws tshuaj. Lub solubility ntawm cyclotragenol yog qhov tseem ceeb hauv nws cov kev ua haujlwm thiab cov hluav taws xob. To taub nws cov yam ntxwv solubility yog qhov tseem ceeb rau nws tus menyuam zoo thiab kev nqus.
Kab lus no yuav tshawb txog solubility ntawm cyclotragenol hmoov nyob rau hauv qhov tob, suav nrog nws cov kev coj ua sib cais hauv dej, cov kuab tshuaj, thiab lwm yam xov xwm. Nws tseem yuav sib tham txog qhov cuam tshuam rau solubility thiab ua li cas solubility cuam tshuam nws cov kev ua tau zoo. Cov hauv qab no yog cov ncauj lus kom ntxaws ntxaws ntawm solubility ntawm cyclotragenol.
Lub cev muaj lub cev ntawm Cyclotragenol
Cycloastragenol yog flavonoid compound nrog molecular mis c41h68o14 thiab qhov hnyav molecular ntawm 784.97. Nws ua pov thawj muaj zog antioxidant, anti-inflampatory, thiab immunomodatory teebmeem. Vim nws cov qauv nyuaj, Cyclotragenol hmoov muaj cov dej solubility tsawg. Feem ntau, cov tebchaw ntawm qhov xwm no muaj solubility uas tsis muaj dej hauv dej, uas yuav txwv lawv cov txiaj ntsig ntawm cov xyoob ntoo thiab kev kuaj mob.
Solubility hauv dej
Cyclotragenol 98 hmoov muaj cov solubility uas tsis muaj dej hauv dej, uas yog ib txwm muaj ntawm feem ntau flavonoids. Kev txom nyem dej solubility yog ib qho tseem ceeb cuam tshuam rau nws cov bioavailability. Feem ntau, cov solubility ntawm cyclotragenol nyob rau hauv dej ranges los ntawm {}}. 5 mg, nrog rau tus nqi tshwj xeeb los ntawm cov txiaj ntsig xws li pH, thiab lwm yam kev daws teeb meem ntawm kev daws.
Vim nws cov dej dej qis, kev thov ntawm cyclotragenol hmoov nyob rau hauv lub teb teb teb ntsib qee txoj kev cov nyom. Piv txwv li, hauv cov qauv tshuaj ntawm qhov ncauj, cov solubility qis yuav ua rau txo qis tus nqi, yog li ploj zuj zus nws txoj kev ua tau zoo.
Solubility hauv Organic kuab tshuaj
Nyob rau hauv sib piv rau dej, cyclotragenol cov khoom pov thawj siab dua selubility hauv cov kuab tshuaj muaj kuab. Nws cov solubility nyob rau hauv cov kuab tshuaj zoo li ethanol, methanol, thiab Duethyl sulfoxide (DMOPS) yog qhov zoo dua li hauv dej. Qhov no yog vim tias cyclotragenol molecule muaj cov qauv hydrophobic zoo, ua rau nws ntau soluble hauv hydrophobic cov kuab tshuaj.
Piv txwv li, nws solubility hauv ethanol feem ntau yog qhov siab, tshaj li 10 mL / ml, thiab hauv DMSO, nws yog qhov siab dua, ib puag ncig 50 mg / ml. Yog li ntawd, cov solubility ntawm cyclotragenol hmoov nyob rau hauv cov organic cov kuab tshuaj muab cov kev npaj ntau ntxiv rau kev npaj cov tshuaj, tshwj xeeb yog rau cov yeeb yaj kiab thiab tsis muaj qhov ncauj.
Yam cuam tshuam rau solubility
Lub solubility ntawm cyclotragenol yog cuam tshuam los ntawm ntau yam, suav nrog cov kev daws teeb meem, pH nqi, ntsuas kub.
Cov Khoom Siv Hnyav
Cov polarity ntawm cov kev daws teeb meem tseem cuam tshuam rau cyclotragenol's solubility. Vim tias Cyclotragenol hmoov muaj ntau pab pawg polar, nws yaj tau ntau dua hauv cov roj av polar (ethanol) thiab tsawg dua n-hexane thiab benzene).
PH nqi
Tus lej ntawm cov kev daws teeb meem tseem cuam tshuam rau Cyclotragenol's solubility. Cov piam thaj moiety nyob rau hauv nws glycoside qauv yuav yauv mus hauv cov hydrolysis lossis kev sib cais nyob rau hauv hom PH sib txawv.
Hauv ib puag ncig acidic, cycloastragenol feem ntau ua rau muaj kev cuam tshuam ntau dua nrog hydrogen ions hauv kev daws. Hloov siab, hauv qhov chaw alkaline, cov hydrolysis ntawm cov chaw glycoseside tej zaum yuav ua rau qhov tsis zoo ntawm Cyclotragenol hmoov, txo nws solubility.
Qho so
Qhov kub yog lwm qhov tseem ceeb cuam tshuam rau solubility. Feem ntau, raws li kub nce ntxiv, yog li doubility. Qhov no yog vim hais tias ntau zaus kub nce molecular suab, txhawb kev sib cuam tshuam ntawm Cyclotragenol thiab cov kuab tshuaj molecules.
Siv cov ntawv cog tseg
Txhawm rau txhim kho cov solubility ntawm cyclotragenol, cov lus cog tseg xws li surfactants thiab cosvents yog feem ntau ua haujlwm. Cov tshuaj no tuaj yeem txhim kho solubility los ntawm kev hloov cov khoom ntawm kev daws teeb meem.
• Sodfactants, xws li sodium dodecyl sulecyl sulecyl sulecyl sulecyl sulecyl sulecate (SDS), tuaj yeem encapsulate cyclotragenol hmoov los ntawm kev ua cov solubility hauv dej.
• Cov tshuaj pleev ib ce, xws li polyethylene glycol (peg) thiab dimethyl sulfoxide (DMOPS), pab yaj xwm txheej ntawm polarity lossis txo qis kev lom zem.
Kev Kuaj Solubility
Ob peb txoj kev siv los sim ua solubility ntawm cyclotragenol:
Saturation solubility hom:
Nov yog ib txoj kev sib xws los txiav txim solubility. Ib qho nyiaj ntawm Cyclotragenol hmoov ntxiv rau cov paub ntim ntawm cov kuab tshuaj thiab do kom txog thaum tsis muaj ntau ntxiv los ua cov tshuaj khov. Qhov hnyav yog tshem tawm los ntawm kev lim lossis evaporation, thiab qhov loj ntawm yaj Cyclotragenol yog txiav txim siab los laij solubility.
HPLC:
Kev ua tau zoo ua kua chromatography (HPLC) yog siv los ua kom muaj nuj nqis cyclotragenol ntau hauv cov kuab tshuaj. Tus qauv nkhaus ua rau kom raug kev ntsuas yog ntawm Cyclotragenol hauv cov qauv, los ntawm qhov solubility tuaj yeem ua tau.
UV-VAJ SPECTROSCOPY:
Txij li cycloastragenol absombs lub teeb, nws solubility tuaj yeem raug ntsuas los ntawm kev ntsuas yoj, los ntawm qhov kev kub siab thiab solubility yog inferred.
Daim ntawv thov hauv tshuaj thiab cov khoom noj qab haus huv
Cov yam ntxwv solubility ntawm cyclotragenol hmoov cuam tshuam loj heev kev txhim kho cov tshuaj kho mob thiab cov khoom siv kho mob, tshwj xeeb ntawm qhov kev npaj ntawm qhov ncauj thiab txhaj tshuaj. Qes solubility tuaj yeem txo nws cov bioavailability thiab efficacy.
Ua kom tiav qhov ncauj npaj
Txog kev npaj qhov ncauj, xws li tsiav tshuaj thiab cov ntsiav tshuaj, txhim kho Cyclotragenol's solubility yog qhov tseem ceeb. Cov kev qhia ua ke suav nrog kev siv solubility enhancers (piv txwv li, surfactants), micronization), micronization), micronization), thiab cov khoom tawg. Cov hau kev no tuaj yeem txhim kho ob qho solubility thiab bioavailability.
Kua npaj
Hauv cov kua ua kua (piv txwv li, kua dej thiab txhaj tshuaj), lub solubility ntawm cyclotragenol hmoov ncaj qha rau nws cov kev siv tshuaj. Los ntawm kev ua kom zoo dua cov kuab tshuaj thiab siv cov nqi zog, solubility tuaj yeem txhim kho kom ruaj khov, ua kom muaj kev txhim kho ruaj khov thiab ua haujlwm ntawm kev npaj.
Nano Cov Khoom Siv Siv Tshuaj Tshuab
Cov kev txhim kho tsis ntev los no hauv Nano Cov Khoom Siv Ntim Tshuaj tau ua pov thawj tau zoo hauv kev txhim kho cov tshuaj solubility. Los ntawm kev hloov pauv cyclotragenol hmoov rau hauv nanoparticles, nws solubility thiab bioavailability tuaj yeem ua kom zoo dua. Cov thev naus laus zis tsis tsuas yog AIDS hauv kev tso tawm Cyclotragenol txoj kev ua tau zoo tab sis kuj txo qhov kev pheej hmoo ntawm cov kev pheej hmoo ntawm kev phiv.
Cyclotragenol hmoov yog lub ntuj sib xyaw nrog kev ua haujlwm muaj roj ntsha. Txawm li cas los xij, nws cov solubility qis txwv nws cov ntawv thov tshuaj. Los ntawm kev xaiv cov kuab tshuaj uas tsim nyog, kho p, thiab ntiav Nanotechnology, nws solubility, ua tau zoo dua qub, yog li txhim kho nws cov hauj lwm zoo. Ua ntej tshawb nrhiav lub hom phiaj los tshawb nrhiav cov hau kev ntxiv los txhim kho Cyclotragenol's solubility, txhawb nqa nws cov kev coj ua thiab cov khoom siv kho mob.
Guanjie Biotech yog cyclotragenol hmoov khoom. Yog tias koj xav tau peb cov khoom, thov hu rau peb ntawm info@gybiotech.comCov. Peb cov khoom dhau Halal, Kosher, ISO9001, thiab lwm tus.
Tuaj txog::
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[2] Zhang, W., li al. (2012). Cyclotragenol: ib qho muaj zog telomerase activator nrog kev tiv thaiv laus. Kev tshawb nrhiav rejuvenation, 15 (4): 362-368.
[2] Zhou, L., li al. (2015). Ib lub cyclodextrin-raws li kev suav ua ke los txhim kho rau solubility thiab ruaj khov ntawm cyclotragenol. Cov ntaub ntawv thoob ntiaj teb ntawm cov kws tshuaj xov xwm, 494 (1): 312-320.
[4] Li, M., li al. (2019). Kev npaj thiab tshuaj ntsuam ntawm Cyclotragenol nanocrystals los txhim kho qhov ncauj ntawm qhov ncauj. Kev txhim kho yeeb tshuaj thiab muaj chaw muag tshuaj, 45 (2): 197-204.
[5] Chen, J., li al. (2020). Amorphous muaj zog dispersion ntawm Cyclotragenol: Tsim qauv tsim thiab bioavailability kawm.european phau ntawv xov xwm ntawm cov kws tshuaj thiab biophartutics, 146: 57-65.
