NMN (nicotinamide mononucleotide) uas yog ib qho tseem ceeb ntawm NAD + ua ntej hauv kev tiv thaiv kev laus thiab cov kab mob neurodegenerative tau txais kev saib xyuas ntau hauv kev tshawb fawb thiab kev kho mob. NAD + yog ib qho tseem ceeb coenzyme hauv hlwb. Nws koom nrog ntau yam txheej txheem physiological xws li cellular zog metabolism, kho DNA, thiab kev tiv thaiv kab mob. Guanjie Biotech tau tsom mus rauNMN bulk hmoov rau ntau tshaj 20 xyoo. Niaj hnub no peb tham txog nws txoj haujlwm ntawm kev tiv thaiv mob stroke. Nrog rau kev tshawb fawb ntxiv, lub peev xwm ntawm NMN hauv kev txo qis kev pheej hmoo ntawm kev paub tsis meej nyob rau hauv cov nqe lus ntawm mob stroke yog maj mam tshwm sim.
•Blood-brain barrier thiab NMN
Blood-brain barrier (BBB) yog ib qho kev tiv thaiv ntawm lub hlwb thiab cov ntshav. Nws yog ib qho tseem ceeb rau kev tswj kom ruaj ntseg ntawm lub hlwb microenvironment. Raws li peb muaj hnub nyoog, kev ncaj ncees ntawm BBB raug cuam tshuam, ua rau kev paub tsis meej thiab cov kab mob neurodegenerative. Txoj kev tshawb fawb los ntawm Peking University pab pawg taw qhia tiasnicotinamide mononucleotide yog tsim los ntawm cov tshuajhmoovmuaj kev kho cov teebmeem ntawm kev laus-induced ntshav-hlwb barrier puas tsuaj los ntawm CX43-PARP1-NAD+ txoj kev taw qhia.
•Kev Tshawb Fawb Thaum Ntxov ntawm NMN Kev sim
Txhawm rau nkag siab txog lub luag haujlwm ntawm NAD + hauv ntshav-hlwb teeb meem, cov kws tshawb fawb tau ua qhov kev sim. Lawv muaj nas tsis muaj protein ntau hu ua SIRT3. Cov protein no yuav pab tswj NAD + qib hauv lub cev. Nws tau pom tias cov ntshav-hlwb barrier ntawm cov nas uas tsis muaj SIRT3 tau raug puas tsuaj loj, txawm tias lawv tau txais kev txhawb nqa hauv chav kuaj (nrog LPS, ib yam khoom uas ua rau kis kab mob) lossis tsis. Cov ntshav-hlwb barrier yog lub hlwb tiv thaiv txheej, thiab yog hais tias nws puas lawm, lub paj hlwb yog teeb meem.
•Kev tshawb nrhiav nruab nrab ntawm NMN kev sim
Txhawm rau tshawb nrhiav ntxiv txog lub luag haujlwm ntawm NAD + hauv cov txheej txheem kev laus, lawv tau ntxiv ib pab pawg nas nrog nicotinamide mononucleotide hmoov thiab pom cov teebmeem txog li 12 lub hlis. Cov txiaj ntsig tau pom tias NMN supplementation pab txhim kho kev noj qab haus huv ntawm cov ntshav-hlwb thaiv hauv ob qho tib si nas thiab nas uas muaj CX43 noob tsis raug. Txawm tias nyob rau hauv cov xwm txheej uas ua rau mob hnyav, kev cuam tshuam ntawm cov ntshav-hlwb hlwb tau rov qab los ntawm 5 hnub ntawmNMN bulk hmoovkev kho mob ua ntej.
•Tom qab Kev Tshawb Fawb ntawm NMN Kev sim
Thaum kawg, cov kws tshawb fawb kuj tau tshuaj xyuas cov teebmeem ntawm NMN ntawm kev mob stroke. Lawv qhov kev cuam tshuam NMN, muab 5 hnub ua ntej qhov nruab nrab cerebral artery occlusion, txo qis cerebral infarct ntim piv rau kev tswj. Cov ntaub ntawv no qhia tau hais tias kev ua tau zoo ntawmnicotinamide mononucleotide yog tsim los ntawm cov tshuajhmoovKev noj zaub mov ntxiv hauv kev tawm tsam vascular degeneration thiab ntshav-hlwb barrier dysfunction hauv kev laus thiab o. Nws qhib txoj hauv kev tshiab rau kev tiv thaiv thiab kho kev puas hlwb tom qab mob stroke.
Txoj kev tshawb no tsis tsuas yog muab lub hauv paus tshiab rau kev sivNMN bulk hmoovhauv kev tiv thaiv neuroprotection, tab sis kuj muaj cov tswv yim tshiab los daws cov teeb meem kev noj qab haus huv los ntawm kev muaj hnub nyoog thoob ntiaj teb.NMN yuav dhau los ua ib qho tseem ceeb rau kev txhim kho kev paub txog kev noj qab haus huv thiab lub neej zoo ntawm cov neeg laus. Txawm li cas los xij, nws tsim nyog sau cia tias cov kev tshawb fawb tom ntej yuav tsum tau tshawb nrhiav qhov ua tau zoo ntawm NMN hauv cov kab mob sib txawv, nrog rau nws txoj kev nyab xeeb mus ntev thiab ua tau zoo.
NMN thiab post-stroke cognitive impairment
Stroke, tseem hu ua mob stroke, yog tshwm sim los ntawm ischaemia lossis hemorrhage nyob rau hauv cov ntaub so ntswg ntawm lub paj hlwb vim yog txhaws lossis tawg ntawm cov hlab ntsha hauv lub hlwb. Qhov no tsis tsuas yog ua rau mob neurological puas tsuaj.NMN bulk hmoovtseem tuaj yeem ua rau muaj kev puas siab puas ntsws mus ntev. Qhov no suav nrog kev nco tsis zoo, kev tsis txaus ntseeg, kev ua haujlwm tsis zoo, thiab lwm yam. NMN, ib qho tseem ceeb ntawm NAD + precursor, tau pom tias ua lub luag haujlwm tseem ceeb hauv kev tswj cov cellular zog metabolism thiab txhawb cov paj hlwb kev noj qab haus huv.
Mechanism of action of NMN
Nrog lub hnub nyoog, qib ntawm NAD + hauv lub cev maj mam poob qis, uas tau xav tias yog ib qho ntawm qhov ua rau muaj hnub nyoog txog kev paub txog kev poob qis.NMN pab kho thiab tswj lub cev muaj zog los ntawm kev hloov mus rau NAD +, yog li muaj peev xwm ameliorating kev txawj ntse tom qab mob stroke. .
Cov ntaub ntawv pov thawj los ntawm kev tshawb fawb preclinical
Tsiaj cov qauv kev tshawb fawb tau pom tias NMN supplementation nce NAD + ntau ntau hauv lub hlwb, txhim kho cov metabolic lub xeev ntawm cov paj hlwb, thiab txhawb cov paj hlwb thiab kho. Hauv cov qauv mob stroke, NMN kev kho mob tau pom tias yuav txo tau lub hlwb puas tsuaj thiab txhim kho kev puas hlwb. Tsis tas li ntawd, NMN tau pom cov tshuaj tiv thaiv kab mob antioxidant thiab tiv thaiv kab mob, uas yuav pab tiv thaiv cov paj hlwb los ntawm kev puas tsuaj tom qab mob stroke.
Kev cia siab rau kev tshawb fawb soj ntsuam
Txawm hais tias muaj kev txhawb nqa cov txiaj ntsig ntawm kev tshawb fawb preclinical, ntau cov kev tshawb fawb soj ntsuam yuav tsum tau ua kom paub tseeb txog kev siv cov tshuaj.NMN bulk hmoovnyob rau hauv kev kho mob ntawm post-stroke cognitive impairment nyob rau hauv tib neeg. Cov kev sim tshuaj tsis tu ncua tau raug ua los ntsuas kev nyab xeeb, kev ua tau zoo, thiab kev pom zoo ntawm NMN. Cov txiaj ntsig ntawm cov kev tshawb fawb no yuav muab lub hauv paus tseem ceeb rau kev siv NMN raws li kev kho mob rau kev puas siab puas ntsws post-stroke.
Kev nyab xeeb thiab cov lus qhia yav tom ntej
NMN, raws li cov khoom siv endogenous, muaj kev ruaj ntseg profile. Txawm li cas los xij, kev nyab xeeb thiab cov kev mob tshwm sim ntawm kev noj qab haus huv NMN mus sij hawm ntev tseem yuav tsum tau soj ntsuam los ntawm cov kev tshawb fawb soj ntsuam loj. Cov kev tshawb fawb yav tom ntej yuav tsom mus rau kev txiav txim siab txog kev ua tau zoo ntawm NMN hauv cov neeg mob uas muaj ntau hom mob stroke thiab yuav ua li cas nws tuaj yeem ua ke nrog lwm cov kev kho mob rov qab los kom ua tiav cov txiaj ntsig kho tau zoo.
Cov ntaub ntawv hais txog NMN kom txo qis kev twv txiaj ntawm kev puas siab puas ntsws hauv kev mob stroke. Nov yog qee qhov kev tshawb nrhiav thiab cov ntaub ntawv tseem ceeb:
Kev tshuaj xyuas los ntawm Peking College qhia tias NMN tuaj yeem pab kho lub hnub nyoog cuam tshuam txog kev mob ntshav siab. Qhov no yuav txiav txim siab cuam tshuam rau kev tiv thaiv kev puas hlwb tom qab mob stroke. Kev tshuaj xyuas pom tiasNMN bulk hmoovcuam tshuam rau maturing incited ntshav-lub siab hindrance raug mob los ntawm CX43-PARP1-NAD+ txoj kev chij.
Lwm qhov kev tshuaj xyuas tau tshuaj xyuas qhov cuam tshuam ntawm NMN ntawm kev mob stroke thiab pom tias NMN intercession tau muab 5 hnub ua ntej qhov chaw nruab nrab ntawm lub paj hlwb uas cuam tshuam qhov cuam tshuam qhov tseem ceeb txo qis cerebral infarct ntim qhov sib piv nrog cov txiaj ntsig ntawm pawg.
Ib yam li ntawd, muaj cov ntawv ceeb toom hais txog tias NMN txo qis kev mob stroke-pib lub siab mob thiab ua rau muaj kev cuam tshuam ntawm cov ntshav-cerebrum ciam teb, uas yuav txiav txim siab cuam tshuam rau kev cuam tshuam tom qab mob stroke.
NMN ua ib qho kev kho mob. Qhov no muab cov tswv yim tshiab rau kev rov qab los ntawm kev paub tsis meej tom qab mob stroke. Nrog kev tshawb nrhiav tob,NMN bulk hmoovtuaj yeem yog ib qho cuab yeej zoo los txhim kho lub neej zoo ntawm cov neeg mob stroke.
Guanjie tsim cov khoom zoo NMN hmoov. Guanjie siv cov txheej txheem khov qhuav thiab lub tshuab nqus tsev qhuav los tsim cov khoom siv purity siab dua lossis sib npaug li 99% NMN. Yog tias koj txaus siab, thov koj xav tiv tauj peb:info@gybiotech.com. Wb tham txog NMN bulk.
Cov ntaub ntawv:
[1] Shan W, Zhu Y, Ji L, Pan B, Yu Y, Li W, Zhao X, He Q, Liu X, Huang Y, Liao S, Zhou B, Chui D, Chen YE, Sun Z, Dong E. , Wang Y, Zheng L. NAD+ cawm cov laus-induced ntshav-hlwb barrier puas tsuaj ntawm CX43-PARP1 axis. Neuron. 2023 Nov 15;111(22):{10}}.e7.
