Zero, Pomegranate tsis muaj ncaj qhaurolithin AUA. Hauv kev ua lag luam los tiv thaiv- kev laus ntxiv kev lag luam, cov ntshiab Urolithin A tau dhau los ua lub hom phiaj tseem ceeb hauv cov teb ntawm mitophagy thiab noj qab haus huv laus. Txawm li cas los xij, cov neeg siv khoom kawg thiab txawm tias qee qhov kev lag luam tshiab feem ntau muaj kev xav tsis zoo: tias kev noj cov pomegranates ncaj qha muab cov txiaj ntsig ntawm lub cev Urolithin A. Raws li cov kev tshawb fawb tshawb fawb uas twb muaj lawm, tsab xov xwm no nruj me ntsis qhia, los ntawm peb qhov ntev -bioavailability, plab microbiota dependence, thiab cov ntaub ntawv kho mob ncaj qha 5} tsis muaj cov ntaub ntawv pov thawj. Hloov chaw, Urolithin A yog cov khoom lag luam ntawm cov metabolism ntawm ellagic acid precursors hauv pomegranates los ntawm cov plab hnyuv microbes.
Muaj pes tsawg urolithin A hauv pomegranate?
Zero. Pomegranate txiv hmab txiv ntoo, kua txiv hmab txiv ntoo, thiab cov extracts tsis muaj dawb urolithin A. Urolithin A tsis yog ib tug natural Secondary metabolite ntawm cov nroj tsuag, tab sis yog ib tug thib ob metabolite uas ua los ntawm cov metabolism ntawm ellagic acid los ntawm txoj hnyuv microorganisms nyob rau hauv cov tsiaj (nrog rau tib neeg).
Nyob rau hauv cov ntsiab lus ntawm chemistry thiab biochemistry, nws yog ib qho tseem ceeb kom paub qhov txawv ntawm cov ntsiab lus ntawm "precursor substances" thiab "end products."
Cov tshuaj muaj pes tsawg leeg ntawm pomegranates yog heev complex. Lawv yog nplua nuj nyob rau hauv ellagitannins thiab dawb ellagic acid. Ellagatin yog ib chav kawm ntawm siab -molecular- hnyav polyphenolic compounds, feem ntau pom nyob rau hauv pomegranates nyob rau hauv cov ntaub ntawv xws li pungentin. Txawm hais tias cov tshuaj no yog qhov tseeb precursors rau Urolithin A, lawv tsis muaj cov tshuaj lom neeg ntawm cov ntshiab Urolithin A lawv tus kheej.
Freshly harvested pomegranate txiv hmab txiv ntoo, pomegranate kua txiv, los yog pomegranate extract tsis muaj dawb Urolithin A. Urolithin A tsis yog ib tug nroj tsuag theem nrab metabolite tab sis yog ib tug metabolite. Nws tsim nyob ntawm lub nplhaib- qhib thiab dehydroxylation cov tshuaj tiv thaiv ntawm ellagic acid los ntawm lub plab microbiota ntawm cov tsiaj txhu (xws li tib neeg).
Qhov kev sib txawv no yog qhov tseem ceeb rau cov neeg siv khoom B2B. Yog tias cov khoom lag luam tau lees tias muaj "pomegranate extract" thiab hais txog kev ua tau zoo ntawm ntuj Urolithin A, qhov no yog qhov tsis raug tshawb fawb. Qhov tiag tiag active molecule, Urolithin A, tsuas yog muaj nyob rau hauv vivo metabolic dab los yog nyob rau hauv cov ntaub ntawv ntshiab synthesized nyob rau hauv vitro.
Ib tug neeg nyob ntawm Gut Microbiota
Txawm hais tias cov neeg siv khoom noj pomegranate ntau npaum li cas, seb lawv lub cev puas tuaj yeem tsim cov ntshiab Urolithin A txaus nyob ntawm qhov muaj peev xwm metabolic ntawm lawv lub plab microbiota. Cov txheej txheem no yog heev uncontrolled.
Urolithin Metabolic Hom
Raws li kev tshawb fawb pej xeem luam tawm hauv cov ntawv xov xwm xws li * Khoom Noj & Kev Ua Haujlwm *, cov tib neeg raug faib ua ntau hom urolithin metabolic:
• Metaboloid A (UM{0}}A): Feem ntau tsim cov tshuaj Urolithin A.
• Metaboloid B (UM-B):
Feem ntau tsim Urolithin B (isomer) thiab ib qho me me ntawm Urolithin A.
• Metaboloid O (UM-0):
Tsis muaj peev xwm tsim tau Urolithin A. Txawm tias muaj cov koob tshuaj ntau ntawm pomegranate extract, cov khoom xyaw nquag ntawm Urolithin A tsis tuaj yeem kuaj pom hauv cov ntshav ntawm pab pawg no.
Cov ntaub ntawv Empirical ntawm Conversion Efficiency
Cov ntaub ntawv tshawb fawb tsiaj pom tau hais tias txawm hais tias gavage kev tswj hwm ntawm cov kua txiv pomegranate tuaj yeem nce cov ntsiab lus ntawm Urolithin A ntau hauv cov hnyuv ntawm cov nas, cov txheej txheem no yog nyob ntawm qhov tshwj xeeb microbiota ib puag ncig ntawm tus tsiaj qauv. Hauv kev tshawb fawb tib neeg, qhov kev hloov pauv no hloov pauv tau zoo heev. Ib feem tseem ceeb ntawm cov pej xeem yog "cov neeg teb qis" lossis "tsis yog- cov neeg teb."
Kev cuam tshuam kev lag luam: Yog tias cov tshuaj tiv thaiv kev laus - cov tshuaj tiv thaiv kev laus vam khom rau cov neeg siv khoom "tsim" ntshiab Urolithin A los ntawm kev noj pomegranates, cov khoom lag luam yuav raug txwv hnyav los ntawm kev sib txawv ntawm tus kheej. Rau B2B los tiv thaiv- cov khoom lag luam laus uas ua raws li cov qauv thiab cov pov thawj-raws li cov tshuaj, qhov "black box" qauv no tso siab rau lub plab microbiota tsis tuaj yeem muab cov neeg siv khoom ruaj khov.
Yuav Ua Li Cas Ntxiv Urolithin A?
Txhawm rau hais txog qhov sib txawv ntawm tus kheej tau hais los saum no thiab ua tiav los tiv thaiv- kev laus los ntawm kev siv tshuaj kho mob tau txais txiaj ntsig, cov zej zog kev tshawb fawb thiab kev lag luam tau hloov mus ncaj qha ntxiv ntawm cov ntshiab Urolithin A. Cov tswv yim no tau raug lees paub hauv ntau qhov kev sim tshuaj tib neeg.
Mechanism ntawm Action
Lub luag haujlwm tseem ceeb ntawm kev ua ntawm ntuj Urolithin A yog kev ua kom mitophagy. Nrog lub hnub nyoog, cov hlwb muaj peev xwm tshem tawm cov kev puas tsuaj mitochondria poob, ua rau lub zog metabolism tsis zoo. Urolithin A txhim kho cov leeg nqaij thiab kev noj qab haus huv ntawm tes los ntawm kev kho cov txheej txheem autophagy.
Kev Pabcuam Cov Ntaub Ntawv
Ib qho randomized, ob npaug - dig muag, placebo- tswj tib neeg sim luam tawm hauv *Nature Metabolism* qhia cov hauv qab no:
• Kev nyab xeeb:
Kev noj tshuaj txhua hnub nrog 250 mg rau 1000 mg ntawm Urolithin ntshiab A pom tau tias muaj kev nyab xeeb zoo hauv cov neeg laus, tsis muaj qhov tshwm sim tsis zoo.
• Kev ua tau zoo:
Natural Urolithin A supplementation ho nce mitochondrial biosynthesis thiab fatty acid oxidation theem nyob rau hauv cov leeg hlwb ntawm cov kev kawm.
• Kev Tshawb Fawb Sib Piv:
Pomegranate-dependent: Kev tswj tsis tau ntau npaum li cas, muaj kev pheej hmoo siab ntawm tsis yog- cov lus teb, qeeb pib ua haujlwm (nyob ntawm plab microbiota colonization).
• Direct Urolithin A supplementation:
Precise npaum li cas, 100% bioavailability (piv txwv li purity), kwv yees cov teebmeem.
Tsis tas li ntawd, Urolithin A bulk hmoov tau pom tias inhibit osteoclast kev ua haujlwm los ntawm kev sib kho ntawm p38 / MAPK txoj hauv kev, uas muaj peev xwm siv tau hauv kev kho pob txha. Cov kev tshawb fawb thev naus laus zis no yog tag nrho raws li kev cuam tshuam ncaj qha nrog siab -purity Urolithin A molecules, es tsis yog crude pomegranate extract.
Yuav Ua Li Cas Xaiv Urolithin A?
Rau B2B cov neeg siv khoom hauv kev lag luam los tiv thaiv -aging ntxiv kev lag luam, cov kev ntsuas hauv qab no yuav tsum tau txiav txim siab thaum xaiv cov khoom siv raw khoom:
• Source thiab Purity:
Vim tias tsis muaj cov qoob loo uas muaj txiaj ntsig zoo rau kev rho tawm ncaj qha ntawm cov ntshiab Urolithin A hauv cov xwm txheej, cov khoom lag luam muaj Urolithin A yog tsim los ntawm cov txheej txheem tshuaj lossis biosynthetic (xws li cov kab mob tshwj xeeb fermentation). Guanjie Biotech siv cov thev naus laus zis thev naus laus zis thev naus laus zis los xyuas kom meej tias cov khoom kawg yog siab -purity Urolithin A hmoov, tsis yog cov khoom sib xyaw uas muaj cov tshuaj tiv thaiv ellagic acid. Peb pom zoo kom cov neeg siv khoom thov HPLC lossis LC-MS cov ntawv ceeb toom los ntawm cov chaw muag khoom kom paub meej tias cov khoom tsis hloov pauv ellagic acid.
• Bioavailability:
Kev tsim cov khoom tiav yuav tsum xav txog cov khoom siv physicochemical ntawm ntuj Urolithin A. Thaum nws twb muaj qhov nqus tau zoo, rau cov neeg siv B2B, peb muab cov ntaub ntawv micronized los yog siv lead ua tshwj xeeb kom haum rau ntau hom tshuaj (capsules, ntsiav tshuaj, lossis hmoov strips).
• Kev Ua Raws Cai:
Txoj cai tswj hwm ntawm cov ntshiab Urolithin A sib txawv nyob rau hauv ntau txoj cai. Piv txwv li, nws tau raug lees paub tias yog cov khoom noj khoom haus tshiab hauv qee thaj tsam. Thaum muab cov khoom siv raw, cov khoom lag luam yuav tsum xaiv cov khoom lag luam Urolithin A nrog cov ntaub ntawv ua tiav (xws li COA, MSDS, Halal / Kosher ntawv pov thawj).
Xaus:
Pomegranates tsis muaj ntau Urolithin A. Qhov kev txiav txim siab no yog qhov zoo - tsim los ntawm phytochemistry.
Pomegranates muab "cov khoom siv raw" ellagic acid, tab sis seb tib neeg lub cev puas tuaj yeem hloov mus rau hauv "cov khoom tiav" Urolithin A nyob ntawm qhov tsis tuaj yeem tswj lub plab microbiota metabolism. Kev tiv thaiv - cov npe laus uas nrhiav cov qauv kev tshawb fawb nruj heev yuav tsum tsis txhob cia siab rau "cov nyhuv dub" ntawm cov neeg siv khoom lub plab microbiota. Directly natural Urolithin A supplementing nrog standardized, siab -purity Urolithin A hmoov yog tib txoj kev suab suab los xyuas kom meej cov khoom mitophagy ua tau zoo thiab ua kom cov nqaij noj qab haus huv thiab tiv thaiv - laus lub hom phiaj.
Guanjie Biotech yog Urolithin Ib tus neeg muag khoom tshwj xeeb hauv R & D thiab tsim cov bulk Urolithin A hmoov, tau cog lus tias yuav tshem tawm qhov tsis paub tseeb ntawm kev ua tau zoo los ntawm kev sib txawv ntawm tus kheej metabolic. Peb cov neeg muas zaub nyob hauv ntau tshaj 100 lub teb chaws thoob ntiaj teb, thiab peb muab Urolithin A raw cov ntaub ntawv los ntawm R&D mus rau loj - teev ntau lawm. Peb pom zoo kom cov neeg tsim khoom lag luam hla dhau "pomegranate" cov kauj ruam nruab nrab thiab ncaj qha siv siab -purity Urolithin A raws li cov khoom siv tseem ceeb los xyuas kom meej tias kev ua tau zoo ntawm txhua pawg ntawm Urolithin A cov khoom ua tau raws li cov qauv kev xav tau ntawm kev tshawb fawb soj ntsuam.
Yog xav paub ntxiv, thov emailinfo@gybiotech.comthov cov qauv, kev specifications, los yog los tham txog customized formulations.
Cov ntaub ntawv
[1] Singh A, D'Amico D, Andreux PA, et al. Direct supplementation nrog Urolithin A overcomes cov kev txwv ntawm kev noj zaub mov raug thiab plab microbiome variability nyob rau hauv cov neeg laus noj qab haus huv kom ua tau raws li theem nyob rau hauv cov pej xeem. Eur J Clin Nutr. 2022;76(2):297-308.
[2] Cortés-Martín A, Iglesias-Aguirre CE, Marín A, et al. Urolithin A ntau lawm ua rau cov teebmeem ntawm pomegranate rau lub plab microbial metabolism ntawm cov kua tsib acids thiab cov roj cholesterol hauv cov neeg mob hnyav dyslipidaemic thiab rog. Food Funct. 2024;15(5):2422-2432.
[3] Li J., Li J., Li J., et al. Kev noj haus- muab tau los ntawm urolithin A yog tsim los ntawm dehydroxylase encoded los ntawm tib neeg lub plab Enterococci hom. Nat Commun. 2025; 16:999.
[4] Singh R, Chandrashekhar S, Kumar R, et al. Txhim kho lub plab barrier kev ncaj ncees los ntawm microbial metabolite los ntawm txoj kev Nrf2. Nat Commun. 2019; 10:89.
[5] Liu S, D'Amico D, Shankland E, et al. Cov nyhuv ntawm Urolithin Ib qho ntxiv rau cov leeg mob thiab kev noj qab haus huv Mitochondrial hauv cov neeg laus: Kev sim tshuaj ntsuam xyuas Randomized. JAMA Netw Qhib. 2022;5(1):e2144279.
[6] Patel K, Shah Y, Soni J, et al. Mitigating Pro-Inflammatory SASP thiab DAMP Nrog Urolithin A: Novel Senomorphic Strategy. bioRxiv. 2025; (Preprint). PIB: 10.1101/2025.01.15.632145.
