Bulk NMNHyog ib txoj kev tshiab raubulk NMN. FDA "tso tseg" NMN. NMN bulk hmoov yog tam sim no muaj nyob rau ntawm Amazon thiab lwm qhov chaw muag khoom. Puas yuav NMNH hmoov hloov NMN hmoov? Puas muaj kev nyab xeeb? Puas yuav raug txwv zoo li NMN?
Nicotinamide mononucleotide (NMN) yog derivative ntawm vitamin B3 (niacin). Nws kuj yog ib qho ntawm ob peb lub precursors rau nicotinamide adenine dinucleotide (NAD +), ib qho tseem ceeb compound rau cellular txheej txheem hauv lub cev. Raws li cov neeg muaj hnub nyoog, NAD + qib yuav poob qis heev. Cov kws tshawb fawb ntseeg tias qhov no tuaj yeem ua rau muaj hnub nyoog txog kev noj qab haus huv.
Cov kev tshawb fawb tau pom tias NMN bulk hmoov tshuaj tuaj yeem nce NAD + qib. Qhov no tuaj yeem pab txo qis kev mob ntawm lub hnub nyoog, txhawb kev mob plawv, thiab txhim kho lub hlwb ua haujlwm. Txawm hais tias muaj peev xwm los tiv thaiv kev laus, US Food and Drug Administration (FDA) tsis ntev los no txwv tsis pub muag NMN ua ib qho ntxiv. Qhov kev txwv no tuaj tom qab lub koomhaum tau tso cai rau cov tuam txhab muag nws. Qhov no ua rau muaj kev npau taws ntawm cov neeg tawm tswv yim txog kev noj qab haus huv thiab kev lag luam ntxiv kev noj haus.
Txawm li cas los xij, lwm qhov sib xyaw tam sim no tau tshwm sim - dihydro nicotinamide mononucleotide (NMNH). Nws raug muag raws li lwm txoj hauv kev rau NMN ntawm Amazon thiab lwm qhov chaw muag khoom. Qhov no yog kev txav los ntawm cov tuam txhab ntxiv. Nws tuaj yeem tsim teeb meem kev cai lij choj tib yam li NMN.
Txawm li cas los xij xav tau kev tshawb fawb ntxiv los txiav txim siab nws txoj kev nyab xeeb. Txawm li cas los xij cov kws tshaj lij hais tias ntau NMNH yuav zoo dua rau NMN raws li NAD+- txhim kho qhov sib xyaw.
NMNH yog dab tsi thiab nws puas zoo dua NMN?
NMNH yog ib qho molecule unnatural. Nws muaj peev xwm hloov NMN rau NMNH hauv ntau txoj kev dag. Nws txoj kev nyab xeeb thiab kev ruaj ntseg hauv tib neeg lub cev tsis tau kawm lossis ua pov thawj.
Dr Robert Verkerk, Founder thiab Executive Scientific Director ntawm Alliance for Natural Health, hais tias NMNH yog ib daim ntawv txo NMN. Nws ua haujlwm zoo ib yam li NMN. Qhov no yog vim lawv yog ob qho tib si NAD + precursors, tab sis zoo li muaj qee qhov sib txawv ntawm txoj hauv kev enzymatic koom nrog.
"Qee qhov kev tshawb fawb soj ntsuam tsis ntev los no qhia tias Bulk NMNH hmoov yuav ua tau zoo dua li cov hmoov NMN ntau hauv kev nce qib NAD + hauv lub cev," Dr Verkerk tau hais. [1]
Dr Andrew Shao, tus lwm thawj coj loj ntawm kev tswj hwm thoob ntiaj teb thiab kev tshawb fawb ntawm ChromaDex, tau hais tias NMNH yuav muaj 5-10 npaug zog dua NMN hauv cov tsiaj.
Thaum kev tshawb fawb muaj tsawg, kev tshawb fawb 2021 pom tias NMNH yog qhov zoo dua NAD + ua kom zoo dua li NMN hauv kev tshawb fawb thiab kev tshawb fawb txog kab mob.
Cov txiaj ntsig los ntawm kev tshawb fawb luam tawm xyoo 2021 kuj tau qhia tias NMNH nce qib NAD + sai dua thiab ntau dua li NMN lossis nicotinamide ribose (NR). Nov yog lwm NAD + ua ntej. Cov kws tshawb fawb pom tias cov nas uas muab cov khoom sib xyaw no kuaj pom qhov nce nrawm thiab txhawb nqa ntawm NAD + hauv lawv cov ntshav.
Puas yog NMNH muaj kev nyab xeeb?
Dr Shao hais tias kev nyab xeeb ntawm qhov ncauj ntau NMNH hmoov tsis meej. Qhov no yog vim tsis muaj kev tshawb fawb txog nws txoj kev nyab xeeb hauv tsiaj lossis tib neeg. Cov kev tshawb fawb tshuaj xyuas nws cov txiaj ntsig NAD-txhim kho tau ua los ntawm kev txhaj tshuaj NMNH. Yog li ntawd, kev nyab xeeb, kev ua tau zoo, thiab kev ruaj ntseg ntawm nws qhov ncauj daim ntawv tsis meej.
Dr Verkerk hais tias "Kev tshawb fawb ntawm cov molecule no tseem nyob rau theem pib." "Txawm hais tias tsis muaj cov cim kev nyab xeeb tseem tau tshwm sim, nws yog qhov tsim nyog los xav txog qhov ntawd. Vim qhov zoo sib xws ntawm cov molecules, qhov kev nyab xeeb profile ntawm NMNH bulk hmoov yuav zoo ib yam li NMN."
Teeb meem kev cai lij choj nrog NMNH
Thaum lub tuam txhab xav ua lag luam cov khoom xyaw tshiab ntxiv, nws yuav tsum yeem xa daim ntawv thov Kev Noj Qab Haus Huv Tshiab (NDI) rau FDA.
Txawm hais tias FDA pib lees txais NMN raws li kev noj haus ntxiv, tom qab ntawd nws tau thim nws qhov kev txiav txim siab. Lawv qhov tseem ceeb suav tias muag NMN tsis raug cai. FDA tau hais tias NMN tau tso cai rau kev tshawb xyuas raws li cov tshuaj tshiab. Yog li nws tsis tuaj yeem muag hauv Asmeskas lag luam.
NMN bulk hmoov thiab lwm yam teeb meem kev txawj tej zaum yuav muaj feem xyuam rau NMNH. uas tam sim no tau muag hauv online thiab hauv khw.
"Txawm hais tias FDA qhov kev txiav txim siab tsuas yog siv rau NMN, NMNH yog tshuaj sib txawv ntawm NMN. Qhov no ua rau nws muaj cov khoom noj tshiab uas yuav tsum tau ceeb toom rau FDA," Shao piav qhia. "Raws li niaj hnub no, tsis muaj NDI ceeb toom tau xa mus rau FDA rau NMNH. qhov no txhais tau tias NMNH ntawm kev ua lag luam yog technically tsis raug cai."
Dr Verkerk pom zoo tias FDA yuav xav txog NMNH cov khoom noj tshiab. Nws cia siab tias cov tuam txhab lag luam lag luam ntau NMNH hmoov yuav ua raws li cov cai ntawm NDI daim ntawv thov kom raug txiav txim siab raug cai. "Cov tuam txhab ntxiv kuj tseem siv cov txheej txheem Kev Pom Zoo Raws Li Kev Nyab Xeeb (GRAS) los nqa cov khoom tshiab los ua lag luam."
Puas yuav NMNH raug txwv zoo li NMN?
Dr Verkerk tau hais tias dab tsi tshwm sim rau NMN tuaj yeem tshwm sim rau NMNH yog tias lub tuam txhab muag tshuaj tau thov Daim Ntawv Thov Kev Tshawb Fawb Tshiab Tshuaj (IND) ua ntej NMNH tau muag khoom ntxiv.
"Dab tsi ntxhov siab txog qhov kev cai lij choj no yog tias INDs tsis pub leej twg paub, yog li cov tuam txhab tshuaj muaj peev xwm tuav tau lawv tau ntau xyoo. Thiab cov kev lag luam ntxiv paves lub khw rau cov khoom xyaw. Tom qab ntawd cov tuam txhab muag tshuaj tuaj nrog lawv cov INDs. Lawv tsav tawm kev sib tw ntxiv, ua tau zoo. tsim kom muaj monopoly. " Dr Verkerk hais tias.
Shao ntseeg tias nws tsis zoo li FDA yuav txwv NMNH nyob rau theem no.
"Txawm li cas los xij, vim tias tsis muaj cov kev tshawb fawb luam tawm los sim kev nyab xeeb lossis kev ua tau zoo ntawm qhov ncauj ntau NMNH hmoov. Tsis muaj lub tuam txhab xa Daim Ntawv Thov Kev Tshawb Fawb Tshiab Tshuaj (NDI) rau FDA, NMNH tseem nyob rau theem tshawb fawb. Nws tseem muaj. Txoj kev mus ntev yog txoj kev mus ntev," Shao hais.
FDA tsis "pom zoo" cov khoom noj khoom haus - suav nrog cov tshuaj xws li NMNH hmoov - txog thaum cov khoom muag muag. Hloov chaw, nws saib xyuas cov tshuaj los ntawm kev tshuaj xyuas cov chaw tsim khoom thiab saib cov ntawv ceeb toom ntawm cov xwm txheej tsis zoo cuam tshuam nrog cov khoom tom qab nws muag rau cov neeg siv khoom.
Yog li ntawd, kom txog thaum cov kws tshawb fawb paub ntau ntxiv txog kev nyab xeeb thiab kev ua tau zoo ntawm NMNH, cov neeg siv khoom yuav tsum xav txog kev siv ceev faj thaum yuav cov tshuaj hauv online lossis hauv khw muag khoom.
Cov ntaub ntawv
Zapata-Pérez, R., Tammaro, A., Schomakers, BV, Scantlebery, AML, Denis, S., Elfrink, HL, Giroud-Gerbetant, J., Cantó, C., López-Leonardo, C., McIntyre, RL, van Weeghel, M., Sánchez-Ferrer, Á., & Houtkooper, RH (2021). Txo nicotinamide mononucleotide yog ib qho tshiab thiab muaj zog nad + precursor nyob rau hauv mammalian hlwb thiab nas. FASEB Journal, 35(4), 1-17. ib e21456. https://doi.org/10.1096/fj.202001826R
Nqe lus.
Kab lus no sawv cev qhov kev xav ntawm ib tus neeg. Guanjie Biotech tau mob siab rau kev tsim cov khoom zoo NMN bulk hmoov thiab bulk NMNH hmoov. Peb muaj peb lub Hoobkas thiab lav qhov zoo ntawm peb cov khoom. Rau kev nug txog peb cov NMNH ntau thiab ntau NMN hmoov lossis cov lus nug, thov hu rau peb ntawminfo@gybiotech.com. Wb tham txog NMN thiab NMNH ua ke.
