NMN bulk hmoov thiabNMNH hmoov hmoov tau attracted ntau xim nyob rau hauv lub teb ntawm anti-aging kev tshawb fawb. Txawm hais tias NMN paub zoo dua, NMNH tau maj mam nthuav tawm nws cov kev tiv thaiv kev laus thiab kev tswj hwm ntawm tes ntawm tes muaj peev xwm nrog kev tshawb fawb tob zuj zus. Hauv daim ntawv no, peb yuav tham txog cov txheej txheem ntawm kev ua haujlwm ntawm NMNH thiab nws cov peev txheej hauv kev tiv thaiv kev laus.
NMNH vs NMN
1. NMN yog dab tsi?
NMN ua raws li ib qho ntawm cov qauv ua ntej ntawm NAD +. Nws tuaj yeem hloov mus rau NAD + los ntawm ntau cov tshuaj tiv thaiv enzymatic tom qab nkag mus rau hauv lub cev, thiab tom qab ntawd koom nrog ntau yam haujlwm ntawm lub cev. Xws li lub zog metabolism, kho DNA thiab tswj kev ua haujlwm ntawm tes.NAD + ua raws li cov khoom siv hluav taws xob thaum lub sij hawm ua pa ntawm tes, uas yog qhov tseem ceeb rau kev tswj cov cellular muaj nuj nqi thiab ua rau kev laus qeeb. Txawm li cas los xij, raws li peb muaj hnub nyoog, qib ntawm NAD + maj mam txo qis, uas cuam tshuam rau cov cell metabolism thiab muaj peev xwm antioxidant. Yog li ntawd,NMN bulk hmoovsupplementation tau dhau los ua lub peev xwm txhais tau tias txhawm rau txhim kho NAD + qib thiab qeeb kev laus.
2. NMNH yog dab tsi?
NMNH yog daim ntawv txo qis ntawm NMN. Raws li tus thawj coj ncaj qha ntawm NAD +, nws tau hloov pauv sai rau NAD + los ntawm txoj hauv kev tshwj xeeb hauv metabolic, ua rau cov hlwb kom nce qib NAD + hauv lub sijhawm luv luv. Muab piv rau NMN, NMNH muaj qhov luv luv thiab muaj txiaj ntsig zoo metabolic txoj hauv kev thiab tuaj yeem ua kom nce qib ntawm NADH nyob rau hauv lub cell, muab kev txo hwj chim ntxiv rau ntawm tes. Yog li ntawd, NMNH hmoov zoo dua NMN ob qho tib si hauv vivo thiab hauv vitro raws li NAD + txhawb nqa cov nyhuv.
NMNH - Anti-agingMuaj nuj nqi
Cov txiaj ntsig ntawm kev tshawb fawb luam tawm nyob rau hauv cov ntawv xov xwm thoob ntiaj teb renowned ACS qhia tau hais tias NMNH bulk hmoov yog ib qho zoo NAD + enhancer. Nws nce cellular NAD + qib hauv vitro thiab hauv vivo, thiab tuaj yeem txhawb nqa NAD + thiab inhibit glycolysis, TCA voj voog thiab kev loj hlob ntawm tes. Nws nthuav tawm tias NMNH muaj txiaj ntsig zoo hauv kev tswj hwm cellular metabolism thiab tiv thaiv kev laus.
Daim duab 1. NMNH zoo txhawb NAD + thiab inhibits glycolysis, TCA voj voog thiab kev loj hlob ntawm tes
● NMNH nce cellular NAD+ qib
Cov kws tshawb fawb tau kho cov hlwb nrog 100 μM NMNH thiab pom tias NAD + qib nce 5-fold. Piv txwv li, 100 μMNMN bulk hmoovtsuas yog me ntsis nce NAD + qib. Tsis tas li ntawd, hauv kev tshuaj xyuas seb qhov koob tshuaj ntau ntawm NMNH ua rau hepatotoxicity, qhov kev sim tau pom tias cov koob tshuaj ntau ntawm NMNH tsis yog hepatotoxic. Tsis tas li ntawd, cov kws tshawb fawb pom tau tias kev kho NMNH tau nce cov kab mob siab NAD + cov ntsiab lus ntawm cov nas nyob rau hauv koob tshuaj. 1000 mg/kg NMNH kev kho mob tau nce lub siab NAD + cov ntsiab lus ntawm cov nas los ntawm ntau dua 10-fold. Cov txiaj ntsig no qhia tias NMNH yog qhov muaj zog NAD + ua kom zoo dua piv rau NMN.
Daim duab 2.NMNH yog lub zog NAD + txhawb nqa hauv vitro thiab hauv vivo
● NMNH nce Cellular NADH qib
Cov kws tshawb nrhiav pom tias qib NADH hauv qee lub hlwb kho nrog NMNH yog 2.5 npaug ntau dua li cov hlwb tsis kho thiab NMN nkaus xwb. Hauv cov hlwb ntxiv, cov kws tshawb fawb kuj pom tias kev kho NMNH ntawm ib koob ntawm 340 mg / kg nce NADH concentrations hauv daim siab ntawm nas peb npaug. Hauv qhov sib piv, tib koob tshuaj NMN kev kho mob tau nce nws tsuas yog 1.7-fold. Tsis tas li ntawd, 1000 mg / kg NMNH kev kho mob nce siab NADH qib hauv cov nas ze li 10-fold.
Daim duab 3. 2.5-fold ntau dua NMNH-kho hlwb piv rau NMN
● NMNH inhibits glycolysis thiab TCA voj voog
Nyob rau tib lub sijhawm, cov kws tshawb fawb tau pom tias NMNH bulk hmoov txo cov qib ntawm glycolytic intermediates nrog rau cov ntawm TCA lub voj voog. Qhov no suav nrog cov neeg nruab nrab hauv txoj kev glycolytic. Cov txiaj ntsig no qhia tau tias qhov sib xyaw ntawm NADH tsim los ntawm NMNH inhibits cellular glycolysis thiab TCA lub voj voog. Hauv qhov sib piv, NMN kev kho mob ntawm glycolysis thiab TCA lub voj voog ua rau tsuas yog txo qis hauv cov khoom hauv glycolysis, uas yuav luag tsis muaj kev txo qis hauv TCA-cycling cells. Cov txiaj ntsig no qhia tias NMNH muaj qhov cuam tshuam loj heev ntawm glycolysis thiab TCA lub voj voog. Hauv qhov sib piv, NMN kuj muaj qhov cuam tshuam rau glycolysis, tab sis rau qhov tsawg dua.
Daim duab 3.NMNH inhibits glycolysis thiab TCA voj voog
● NMNH inhibits cell loj hlob
Cov kws tshawb fawb pom tias kev kho NMNH inhibited cell loj hlob ntawm qhov siab tshaj 250 μM, uas, 289 protein qhia qib nce. Thaum qhov kev qhia theem ntawm lwm 171 proteins poob. Txoj kev tshawb no tseem pom tau tias NMNH txo cov theem ntawm cov neeg tswj xyuas tseem ceeb ntawm lub voj voog ntawm tes los ntawm 2-fold thiab hloov cov noob hloov pauv. Hauv kev txheeb xyuas lub voj voog ntawm 1 mM NMNH bulk hmoov lossis bulk NMN kho rau 12 teev, cov kws tshawb fawb pom tias NMNH ua rau lub voj voog ntawm tes raug ntes. Hauv qhov sib piv, NMN tsis cuam tshuam rau lub voj voog ntawm tes.
Daim duab 4.NMNH inhibits cell loj hlob hauv vitro
Hauv cov ntsiab lus, NMNH zoo dua rau NMN raws li NAD + txhim kho hauv txoj kev tshawb no. nws ua tau zoo hauv kev tiv thaiv kev laus. Nws ua tau zoo nce cellular NAD + thiab NADH qib, inhibited glycolysis thiab TCA lub voj voog, thiab hloov pauv lub voj voog tseem ceeb ntawm tes tswj thiab cov noob hloov pauv. Cov kev tshawb pom no muab cov pov thawj muaj zog rau kev siv NMNH hauv kev tiv thaiv kev laus thiab kev tswj hwm ntawm tes, ua kom pom nws lub peev xwm zoo.
Qhov zoo ntawm NMNH vs NMN
1. NAD + thiab NADH boosting efficiency
Los ntawm cov ntaub ntawv tshawb fawb, NMNH muaj txiaj ntsig zoo hauv kev txhawb nqa NAD + thiab NADH. Nyob rau tib lub concentration, NMNH tuaj yeem nce qib ntawm NAD + thiab NADH sai sai hauv cov hlwb thiab tsiaj txhu. Hauv qhov sib piv, qhov cuam tshuam ntawm NMN yog me me. Qhov no qhia tias NMNH muaj ntau dua bioavailability thiab kev ua haujlwm zoo hauv kev ua haujlwm ua NAD + ua ntej. Nws yog qhov zoo dua rau kev tiv thaiv kev laus daim ntawv thov scenarios uas yuav tsum tau ceev NAD + ntxiv.
2. Kev tswj cov txheej txheem metabolic
NMNH tuaj yeem txo cov cellular metabolic lub nra los ntawm inhibiting glycolysis thiab TCA voj voog. Qhov no tshwj xeeb tshaj yog muaj txiaj ntsig zoo rau cov laus thiab cov hlwb uas tsis muaj zog metabolism. Hauv qhov sib piv, bulk NMN hmoov tsis tshua muaj txiaj ntsig hauv kev tswj cov txheej txheem metabolic. Qhov sib txawv no tuaj yeem ua rau NMNH ua tau zoo dua hauv kev cuam tshuam ntawm cov kab mob metabolic thiab cov xwm txheej ntawm kev laus.
3 Kev nyab xeeb thiab cytotoxicity
Cov koob tshuaj ntau ntawm NMNH tsis pom muaj qhov ua rau hepatotoxicity tseem ceeb hauv kev sim. Qhov no qhia txog kev nyab xeeb profile zoo li kev ntxiv. Hauv qhov sib piv, txawm tiasNMN bulk hmoovmuaj kev phiv tsawg dua. Cov teebmeem thiab kev nyab xeeb ntawm cov koob tshuaj ntau yuav tsum tau tshawb xyuas ntxiv. Yog li ntawd, NMNH yuav ua tau zoo dua nyob rau hauv high-dose anti-aging kev kho mob, muab ntau npaum thiab ntev-ntev anti-aging teebmeem.
4. Cell voj voog thiab kev loj hlob txoj cai
NMNH tuaj yeem cuam tshuam kev loj hlob ntawm tes los ntawm kev hloov cov protein qhia thiab theem ntawm cov txheej txheem tseem ceeb ntawm tes, uas yog ib qho tseem ceeb hauv kev tiv thaiv kev laus thiab kev tiv thaiv kab mob. Piv txwv li, NMN muaj peev xwm tsis muaj zog los tswj lub voj voog ntawm tes thiab kev loj hlob, thiab tej zaum yuav tsis muaj peev xwm ua tau zoo ib yam li NMNH hauv kev siv mus ntev. Yog li ntawd, NMNH qhia tau hais tias muaj peev xwm ntau dua hauv kev ua kom qeeb ntawm kev laus thiab txo cov cell proliferation ntau dhau.
Guanjie Biotech NMNH raw khoom
Guanjie Biotech's NMNH bulk hmoov tsis tsuas yog paub thoob ntiaj teb kev tsim khoom loj raws li cov txheej txheem enzyme ua haujlwm tab sis kuj muaj qhov purity ntau dua 98%. Qhov tseem ceeb tshaj, Guanjie Biotech's NMNH kuj muaj nyob rau hauv ob hom: dawb acid thiab sodium ntsev. Qhov kev ua tau zoo no ua rau daim ntawv thov ntawm NMNH hloov tau yooj yim dua thiab ua tau raws li cov kev xav tau ntawm ntau qhov chaw thiab kev lag luam. Txawm hais tias koj xav tau NMNH hauv daim ntawv dawb acid lossis sodium ntsev, Bontec Biotech tuaj yeem muab cov khoom lag luam zoo thiab coj tau kev paub zoo dua rau cov neeg siv khoom. Yog tias koj xav tau peb cov NMNH lossis NMN bulk hmoov, txais tos nug peb:info@gybiotech.com.
Siv:
[1] Liu Y, Luo C, Li T, Zhang W, Zong Z, Liu X, Deng H. Txo Nicotinamide Mononucleotide (NMNH) Muaj peev xwm txhim kho NAD thiab txo qis glycolysis, TCA Cycle, thiab cell loj hlob. J Proteome Res. 2021 Lub Tsib Hlis 7; 20(5): 2596-2606.