Urolithin A Vs NMN

Urolithin UAthiabNtshiab nicotinamide mononucleotide NMNyog ob lub siab -cov khoom xyaw loj hlob hauv lub neej ntev thiab kev ua lag luam ntxiv. Yog li dab tsi yog qhov txawv ntawm Urolithin A thiab NMN? Qhov twg zoo dua?

Why Urolithin ATseem ceebRau Cov Neeg Yuav Khoom?

Urolithin A UA yog ib qho me me molecule tsim nyob rau hauv lub plab los ntawm kev noj haus ellagitannins (pom nyob rau hauv pomegranate, walnuts, berries) los ntawm tej microbiota. Nyob rau hauv xyoo tas los no, UA tau ntxim nyiam vim nws zoo nkaus li txhawb mitophagy - cov txheej txheem ntawm tes uas tshem tawm cov mitochondria puas thiab pab tswj cov mitochondrial zoo. Rau cov formulators, UA yog positioned raws li ib tug mitochondrial kev noj qab haus huv / nqaij -kev ua tau zoo / kev laus- txhawb cov khoom xyaw, thiab nws yog siv nyob rau hauv cov khoom noj khoom haus thiab nce nyob rau hauv daim ntawv teev cov khoom xyaw.

Why NMNTseem ceebRau Cov Neeg Yuav Khoom?

NMN yog tus thawj coj ncaj qha rau NAD⁺, lub hauv paus cofactor rau cellular metabolism, DNA kho enzymes thiab sirtuins. NMN tau ua lag luam raws li "NAD + booster" thiab tau siv dav hauv cov qauv kev noj qab haus huv, lub zog thiab kev noj qab haus huv metabolic. Ntshiab nicotinamide mononucleotide NMN xav tau yog tsav los ntawm cov neeg siv khoom siv dav dav ntawm NAD + biology thiab ntau yam luam tawm tib neeg kev nyab xeeb / PK thiab kev tshawb fawb txog kev ua tau zoo.

Urolithin A UA yog ib qho nqaim dua, txheej txheem - cov khoom muaj tshwj xeeb (mitophagy → nqaij / mitochondrial thov). NMN yog cov khoom siv hauv platform nrog cov txheej txheem kev noj qab haus huv uas muaj peev xwm txuas nrog NAD⁺ biology.

Peb pib li cas

 

 

NMN ua li cas?

NMN bulk hmoov tuaj yeem tsim cov khoom siv hluavtaws lossis los ntawm biofermentation. Scaling yog ua tiav nrog tsim tshuaj synthesis lossis fermentation kab. Kev txhawj xeeb tseem ceeb ntawm kev tsim khoom: raw khoom purity, tswj NAD⁺-txog impurities, ruaj khov (NMN yog hygroscopic), thiab cov txheej txheem analytic zoo ib yam (HPLC/LC-MS). Vim tias ntau NMN hmoov yog muag ntawm nplai, ntau tus neeg muag khoom lag luam muaj nyob thiab tus nqi sib tw yog qhov tseem ceeb. Cov ntawv pov thawj (GMP, ISO) thiab kev pabcuam kev soj ntsuam ywj pheej (daim ntawv pov thawj ntawm kev tshuaj xyuas, cov ntaub ntawv ruaj ntseg) yog kev yuav khoom tseem ceeb rau cov hom.

 

 

 

Ua li casUrolithin A tsim?

Urolithin A UA feem ntau yog tsim los ntawm chemical synthesis lossis los ntawm cov txheej txheem fermentation / postbiotic; Nws tsis ntseeg tau los ntawm cov nroj tsuag ncaj qha rho tawm (nws yog cov metabolite tsim tawm hauv vivo los ntawm microbiota). Kev tsim khoom tsom mus rau kev tsim cov molecule uas tau hais tseg nrog siab purity thiab zoo ib yam stereochemistry, thiab ntawm kev tshem tawm los ntawm - khoom. Vim tias Urolithin A UA yog kev lag luam tshiab, tsawg dua cov khoom tsim nyog Urolithin A cov chaw muag khoom muaj nyob thiab cov khoom ntim tsawg dua, uas tuaj yeem txhawb nqa cov nqi siab dua. Kev ruaj ntseg, micronization rau solubility, thiab formulation compatibility (capsules, hmoov, dej qab zib) yuav tsum tau validated.

 

Qhov twg zoo dua: Urolithin A lossis NMN?

NMN - NAD⁺ Precursor

NMN yog ib tug ncaj precursor ntawm Nicotinamide Adenine Dinucleotide (NAD⁺), ib coenzyme tseem ceeb rau lub zog metabolism, kho DNA, cell signaling, thiab sirtuin activation. NAD⁺ qib poob qis nrog lub hnub nyoog, ua rau txo qis cellular muaj nuj nqi thiab kev laus phenotypes. Los ntawm kev nce qib NAD⁺, NMN lub hom phiaj los kho lub zog ntawm tes thiab txhawb nqa cov txheej txheem homeostatic.

Mechanistically:

Ntshiab nicotinamide mononucleotide NMN nkag mus rau hauv cov hlwb thiab hloov mus rau NAD⁺, txhawb nqa mitochondrial enzymes thiab txhawb nqa cellular zog.

NAD⁺ txhawb nqa ntau txoj hauv kev mus ntev, suav nrog sirtuins thiab kho DNA. Mitopure

Urolithin A - Mitophagy Enhancer

Urolithin A UA ua haujlwm txawv. Es tsis txhob nce NAD⁺, nws txhim kho mitophagy, cov txheej txheem ntawm tes uas txheeb xyuas thiab tshem tawm cov mitochondria puas thiab rov ua dua lawv mus rau cov neeg noj qab haus huv. Qhov no tuaj yeem txhim kho mitochondrial zoo thiab ua haujlwm ntawm nws tus kheej ntawm NAD⁺ qib.

Cov txheej txheem tseem ceeb muaj xws li:

Ua kom cov mitophagy txoj hauv kev uas tshem tawm cov dysfunctional mitochondria.

Txhim kho mitochondrial zoo tswj, uas tuaj yeem txhim kho kev ua siab ntev thiab txo cov kev ntxhov siab ntawm tes.

Yog li, ntshiab nicotinamide mononucleotide NMN thiab Urolithin A UA hais txog qhov sib txawv ntawm mitochondrial thiab cellular aging; ib tug fuels metabolism (NMN), thiab lwm yam cleans thiab refreshes mitochondria (UA).

Kev noj qab haus huv sib txawv ntawm Urolithin A thiab NMN

Kev nyab xeeb thiab kev mob tshwm sim

Ob leeg Urolithin A UA thiab Nicotinamide Mononucleotide (NMN) tau dav siv nyob rau hauv lub neej ntev thiab kev noj qab haus huv ntawm tes lag luam thiab tau raug soj ntsuam hauv tib neeg kev tshawb fawb soj ntsuam. Zuag qhia tag nrho, ob qho tib si cov khoom xyaw suav hais tias yog qhov zoo- zam tau thaum siv los ntawm kev kawm tshuaj ntxiv. Txawm li cas los xij, lawv cov ntaub ntawv kev nyab xeeb thiab cov kev mob tshwm sim tuaj yeem txawv me ntsis vim lawv txoj haujlwm lom neeg sib txawv.

Urolithin A (UA)

Urolithin A yog lub plab microbiome-derived metabolite (tseem ua hluavtaws rau cov tshuaj ntxiv) uas txhawb nqa kev noj qab haus huv ntawm mitochondrial los ntawm mitophagy. Tib neeg kev sim tshuaj tau pom tias UA tshuaj ntxiv muaj kev nyab xeeb thiab zam tau zoo, txawm tias siv txhua hnub ntau lub hlis.

Tshaj tawm cov kev mob tshwm sim feem ntau me me thiab tsis tshua muaj, thiab tej zaum yuav muaj xws li:

• Mob plab me me (xws li tsam plab lossis mob plab)

• Qee zaus xeev siab, feem ntau yog ntau dua

Qhov tseem ceeb, cov kev tshawb fawb tsis tau pom muaj qhov cuam tshuam loj rau lub siab enzymes, lub raum ua haujlwm, lossis cov cim inflammatory. Vim tias Urolithin A UA ua haujlwm los ntawm kev txhim kho mitochondrial zoo dua li stimulating metabolism, nws tsis feem ntau ua rau overstimulation lossis pw tsaug zog. UA yog suav tias tsim nyog rau kev siv sijhawm ntev - nyob rau hauv cov neeg laus noj qab haus huv thaum siv nyob rau hauv ntau npaum li cas pom zoo.

NMN (Nicotinamide Mononucleotide)

NMN yog tus thawj coj ncaj qha rau NAD⁺ thiab ua lub luag haujlwm hauv lub zog metabolism thiab kho cellular. Tib neeg txoj kev tshawb fawb qhia tias NMN feem ntau muaj kev nyab xeeb thiab ua tau zoo nce qib NAD⁺.

Cov kev phiv tshwm sim, feem ntau me me, yuav muaj xws li:

• digestive tsis xis nyob

• Mob taub hau

• yaug me me los yog sov

• Kev pw tsaug zog ib ntus nyob rau hauv cov neeg rhiab heev yog tias noj lig hnub

Thaum noj ntau dua, ntshiab nicotinamide mononucleotide NMN tuaj yeem ua rau muaj kev ua haujlwm metabolic, uas piav qhia vim li cas qee cov neeg siv qhia txog kev mob me me. Ntev - cov ntaub ntawv kev nyab xeeb lub sij hawm tseem tab tom tsim, tab sis tam sim no tib neeg kev sim tsis tau txheeb xyuas qhov cuam tshuam loj heev.

Kev soj ntsuam kev nyab xeeb tag nrho

Ob leeg Urolithin A UA thiab NMN qhia txog kev nyab xeeb zoo hauv tib neeg kev tshawb fawb.

Cov kev mob tshwm sim feem ntau yog mob me thiab koob tshuaj - nyob ntawm.

Tsis muaj cov khoom xyaw pom zoo rau cov poj niam cev xeeb tub lossis pub niam mis yam tsis muaj lus qhia kho mob.

Hauv kev xyaum, kev noj kom zoo, cov khoom lag luam siab huv, thiab cov qauv tsim khoom zoo yog qhov tseem ceeb hauv kev ua kom muaj kev nyab xeeb rau ob qho tib si Urolithin A thiab NMN.

Kev tswj hwm thiab kev thov ib puag ncig

Qhov no yog qhov tseem ceeb rau kev lag luam lus thiab kev nyab xeeb.

• NMN:

Txoj cai raws li txoj cai txawv ntawm kev ua lag luam. Kev nce cov ntaub ntawv kev nyab xeeb ntawm tib neeg thiab ntau cov ntaub ntawv tau tsim txoj hauv kev rau cov ntshiab nicotinamide mononucleotide NMN kom muag raws li kev noj haus ntxiv hauv khw loj; Txawm li cas los xij, cov cai hauv zos txawv thiab qee lub tebchaws yuav tsum tau txais kev pom zoo noj zaub mov tshiab lossis cov ntaub ntawv kev nyab xeeb ntxiv. Ib txwm txheeb xyuas ib cheeb tsam.

• UA:

Muab faib feem ntau raws li cov khoom xyaw tshiab lossis ib qho postbiotic, nyob ntawm txoj cai. Cov ntawv thov yuav tsum tsom mus rau kev noj qab haus huv, kev txhawb nqa cov leeg, lossis lub zog ntawm tes es tsis yog cov ntaub ntawv hais txog kab mob. Vim tias Urolithin A UA yog qhov tshiab dua, kev tswj xyuas txoj hauv kev (cov khoom noj tshiab, cov ntawv ceeb toom cov khoom noj tshiab) yog qhov tseem ceeb rau kev ua lag luam thaum ntxov.

Yuav Ua Li Cas Ntxiv Urolithin A thiab NMN rau Formulation?

 

• Cov kev xaiv tsim nyog.

Ob qho khoom xyaw feem ntau yog muag li hmoov thiab tshuaj ntsiav; NMN yog hygroscopic thiab tuaj yeem xav tau desiccation thiab oxygen -barrier ntim; UA kev ruaj ntseg nyob ntawm cov qauv matrix thiab yuav tsum tau lees paub nrog cov txee- kev tshawb fawb txog lub neej. Liposomal lossis sublingual technologies yog qee zaum tshawb nrhiav rau NAD + precursors tab sis xav tau kev siv tau ntxiv. Xyuas kom meej tias microbial, hnyav hlau, thiab cov ntaub ntawv kuaj tus kheej raug sau tseg.

• Kev sib koom ua ke thiab kev sib koom ua ke.

Kev sib xyaw Urolithin A UA thiab NMN hauv ib qho khoom lag luam tuaj yeem txaus nyiam vim tias lawv lub hom phiaj ua tiav ntawm kev saib xyuas ntawm tes (mitochondrial zoo vs NAD + metabolism). Txawm li cas los xij, kev sib koom ua ke yuav tsum muaj cov ntaub ntawv kev nyab xeeb ntawm kev sib xyaw ua ke, kev tshawb fawb ruaj khov, thiab ua tib zoo mloog cov lus lag luam. Cov khoom lag luam ib txwm pib nrog ib qho - cov khoom SKUs, tom qab ntawd qhia ua ke SKUs tom qab kev lees paub hauv khw.

• Noj

Siv cov koob tshuaj uas haum rau tib neeg kev sim ntau yam: ntau cov tshuaj dawb huv nicotinamide mononucleotide NMN sim siv 300-900 mg / hnub; Urolithin A UA kev sim feem ntau siv kaum mus rau ob peb puas mg / hnub, nyob ntawm kev tsim qauv - daim ntawv lo qhia tseeb yuav tsum tsom iav luam tawm muaj kev nyab xeeb, muaj txiaj ntsig zoo thiab cov lus qhia hauv zos. Ib txwm sau cov ntaub ntawv tshawb fawb hauv cov ntaub ntawv technical rau kev ua raws cai.

Guanjie Biotech yog positioned los txhawb ob lub tswv yim raws li bulk urolithin A thiab NMN hmoov tsum. Peb muab cov khoom zoo, tus nqi sib tw, thiab cov ntawv pov thawj (HALAL, HACCP, ISO, KOSHER) los pab txhim kho cov khoom lag luam sai thiab kev lag luam.

Yuav Ua Li Cas Xaiv Cov Khoom Noj Zoo Rau Koj?

Xaiv txoj cai Urolithin A UA thiab ntshiab nicotinamide mononucleotide NMN cov tshuaj yog nyob ntawm koj lub hom phiaj kev noj qab haus huv, hnub nyoog, kev ua neej, thiab cov khoom zoo. Vim tias ob qho khoom xyaw no ua haujlwm los ntawm ntau txoj hauv kev lom neeg, qhov kev txiav txim siab tsawg dua qhov uas yog "zoo dua" thiab ntau dua txog qhov uas tsim nyog rau koj cov kev xav tau. Cov lus qhia hauv qab no piav qhia yuav ua li cas xaiv qhov zoo thiab nyab xeeb.

Pib Nrog Koj Lub Hom Phiaj Noj Qab Haus Huv

• Xaiv NMN yog tias koj lub hom phiaj tseem ceeb yog lub zog tag nrho thiab muaj zog txhua hnub.
NMN txhawb nqa NAD⁺ ntau lawm, uas ua lub luag haujlwm tseem ceeb hauv cellular zog, metabolism, thiab kho DNA. Nws feem ntau raug xaiv los ntawm cov neeg uas xav tau kev tiv thaiv kev laus - txhawb nqa kev laus, txhim kho lub zog, lossis kev sib npaug ntawm cov metabolism.

• Xaiv Urolithin A UA yog tias koj lub hom phiaj yog cov leeg nqaij thiab kev noj qab haus huv mitochondrial.
UA txhawb nqa mitophagy, cov txheej txheem uas tshem tawm mitochondria puas. Nws feem ntau xaiv los ntawm cov neeg laus, cov neeg siv lub cev, lossis ib tus neeg muaj kev txhawj xeeb txog cov leeg nqaij thiab hnub nyoog - cuam tshuam txog kev poob qis.

• Xav txog kev sib txuas UA thiab NMN yog tias koj xav tau kev txhawb nqa ntawm tes.
Ntshiab nicotinamide mononucleotide NMN pab tsim lub zog, thaum Urolithin A UA pab txhim kho qhov zoo ntawm mitochondria uas siv lub zog ntawd. Txoj kev sib txuas ntxiv no tau nrov zuj zus hauv kev ua neej nyob ntev - tsom rau cov kev pab cuam ntxiv.

Xav txog hnub nyoog thiab kev ua neej

• Nyob rau hauv 40:

Ntau tus neeg ib txwm tswj hwm qib NAD⁺ siab dua. UA tej zaum yuav muaj txiaj ntsig yog tias cov leeg rov qab los yog kev ua siab ntev yog qhov tseem ceeb, thaum cov ntshiab nicotinamide mononucleotide NMN tuaj yeem xaiv tau.

• 40–60:

Ob leeg NAD⁺ poob thiab mitochondrial dysfunction pib tshwm. NMN rau kev txhawb zog thiab UA rau cov leeg mob tuaj yeem pab tau.

• Tshaj 60:

Urolithin A UA tuaj yeem muab cov txiaj ntsig zoo dua rau cov leeg mob, thaum NMN tuaj yeem pab txhawb nqa tag nrho cov cellular metabolism.

Cov tib neeg nquag thiab cov neeg ncaws pob feem ntau nyiam UA, thaum cov neeg uas muaj kev ua neej nyob tsis muaj zog tuaj yeem pom tias muaj txiaj ntsig ntau dua los ntawm NMN.

Ntsuas cov khoom zoo

Thaum xaiv Urolithin A UA lossis ntshiab nicotinamide mononucleotide NMN tshuaj, nco ntsoov xyuas:

• Purity thiab ntau npaum li cas pob tshab (paub meej cov ntsiab lus nquag)

• Thib peb-kev xeem los yog daim ntawv pov thawj ntawm kev tshuaj xyuas

• Cov ntawv pov thawj zoo xws li ISO, HACCP, HALAL, lossis KOSHER

• Tsim keeb kwm thiab traceability

• Tsis txhob siv cov khoom uas tsis tsim nyog los yog cov khoom tsis meej.

Dosing thiab Timing

Ntshiab nicotinamide mononucleotide NMN feem ntau yog noj thaum sawv ntxov los ua kom muaj zog metabolism.

UA tuaj yeem noj nrog lossis tsis muaj zaub mov, feem ntau ib hnub ib zaug.

Pib nrog cov koob tshuaj qis dua los ntsuas qhov kam rau ua.

Kev xav txog kev nyab xeeb

Yog tias koj cev xeeb tub, pub niam mis, lossis tswj tus mob, nrog tus kws kho mob tham ua ntej siv.

Xaiv cov ntshiab NMN hmoov ntau rau kev txhawb nqa lub zog ntawm tes, ntshiab Urolithin A UA rau lub hom phiaj mitochondrial thiab cov leeg nqaij noj qab haus huv, thiab xav siv ob qho tib si ua ke yog tias koj xav tau kev ua kom tiav ntev dua - tsom rau cov tswv yim ntxiv.

Xaus:

Tsis yog Urolithin A lossis ntshiab nicotinamide mononucleotide NMN yog qhov "zoo dua" hauv txhua lub ntsiab lus. Lawv cov txiaj ntsig yog nyob ntawm cov hom phiaj lom neeg tshwj xeeb thiab cov txiaj ntsig:

• NMN yog qhov zoo dua rau kev dav NAD⁺-nyob ntawm lub zog ntawm tes thiab kev txhawb nqa metabolism.

• Urolithin A UA muab cov phiaj xwm kev txhim kho mitochondrial los ntawm mitophagy.

Rau ntau daim ntawv thov, tshwj xeeb tshaj yog nyob rau lub neej ntev thiab kev noj qab haus huv ntawm tes-cov qauv tsim, kev sib txuas ob qho tib si yuav ua tau zoo tshaj plaws vim lawv ua los ntawm cov txheej txheem sib txawv.

Guanjie Biotech yog ib qho loj Urolithin A thiab NMN hmoov khoom muag. Siab -zoo nrog tus nqi sib tw. Peb cov khoom dhau HALAL, HACCP, ISO, KOSHER thiab lwm yam. Peb muab CoA, cov ntaub ntawv ruaj khov, thiab kev txhawb nqa kev pab cuam los pab cov hom lag luam thiab cov tuam txhab cog lus luv luv - rau - kev ua lag luam. Txais tos kom nug nrog peb ntawm info@gybiotech.com.

Cov ntaub ntawv

[1] Ryu, D., et al. (2016). Urolithin A induces mitophagy thiab prolongs lifespan nyob rau hauv C. elegans thiab tsub kom cov leeg muaj nuj nqi nyob rau hauv nas. Nature Medicine, 22(8), 879–888.

[2] Andreux, PA, et al. (2019). Lub mitophagy activator urolithin A muaj kev nyab xeeb thiab ua rau muaj kev kos npe molecular ntawm kev txhim kho mitochondrial thiab cellular noj qab haus huv hauv tib neeg. Nature Metabolism, 1(6), 595–603.

[3] Li, Y., et al. (2022). Urolithin A supplementation pab txhim kho cov leeg endurance thiab mitochondrial noj qab haus huv nyob rau hauv cov neeg laus: Ib tug randomized tswj mus sib hais. Cell Reports Medicine, 3(3), 100633.

[4] Mills, KF, et al. (2016). Ntev -kev tswj hwm lub sij hawm ntawm nicotinamide mononucleotide txo qis hnub nyoog- cuam tshuam txog kev poob qis hauv cov nas. Cell Metabolism, 24(6), 795–806.

[5] Rajman, L., Chwalek, K., & Sinclair, DA (2018). Kev kho muaj peev xwm ntawm NAD⁺- txhawb nqa molecules: Cov pov thawj hauv vivo. Cell Metabolism, 27(3), 529–547.

[6] Elhassan, YS, et al. (2019). Nicotinamide riboside txhawb cov neeg laus cov pob txha pob txha NAD⁺ metabolome thiab induces transcriptomic thiab anti- kos npe inflammatory. Cell Reports, 28(7), 1717–1728.e6.

[7] European Food Safety Authority (EFSA). Kev taw qhia txog kev siv zaub mov tshiab thiab kev ntsuas kev nyab xeeb ntawm cov khoom xyaw tshiab.

[8] Smith, JJ, et al. (2020). Kev tsim khoom thiab kev xav txog kev ruaj ntseg rau NAD⁺ precursors hauv kev noj zaub mov. Phau ntawv Journal of Dietary Supplements, 17(5), 567–582.