Pure Inulin hmoov yog siv dav siv cov khoom noj muaj fiber ntau thiab tau lees paub tias yog prebiotic los ntawm International Scientific Association for Probiotics thiab Prebiotics (ISAPP) nrog rau oligogalactose thiab oligofructose. Inulin raws li kev noj haus fiber ntau muaj kev ua haujlwm ntawm kev txhawb nqa kev loj hlob ntawm bifidobacteria thiab txhim kho txoj hnyuv. Ua tsaug rau inulin lub peev xwm los txhim kho cov khoom noj khoom haus zoo nkauj thiab cov khoom siv rheological, inulin-based prebiotics tau siv dav hauv cov khoom ci, khoom noj txom ncauj, khoom noj siv mis, khoom noj khoom haus thiab cov khoom noj me nyuam mos.
Raws li cov ntaub ntawv txheeb xyuas txog thaum Lub Ob Hlis 2021, muaj ntau dua 350 qhov kev sim tshuaj ntsuam xyuas tau ua los ntawm inulin, suav nrog kev sim rau cov neeg tshwj xeeb xws li cov menyuam mos thiab cov poj niam cev xeeb tub. Yog li ntawd, inulin tau raug lees paub tias yog khoom noj khoom haus thoob ntiaj teb thiab nyab xeeb. Txawm li cas los xij, thaum Lub Kaum Ib Hlis 2022 Xwm tau luam tawm ib tsab xov xwm ntawm inulin-induced type 2 inflammatory teb kho los ntawm cov hnyuv ntawm cov koob tshuaj ntau, coj kev sib cav txog kev nyab xeeb thiab kev ua tau zoo ntawm inulin rau hauv qhov teeb meem. Kab lus no tshuaj xyuas cov txiaj ntsig kev noj qab haus huv ntawm inulin thiab tseem tham txog yuav ua li cas nws thiaj li siv tau zoo thiab muaj kev nyab xeeb.
● Cov txiaj ntsig kev noj qab haus huv ntawm inulin
Prebiotics yog cov khoom noj uas feem ntau tsis zom thiab nqus los ntawm tib neeg lub cev tab sis tuaj yeem xaiv tau los ntawm tib neeg cov kab mob kom txhim kho cov muaj pes tsawg leeg thiab / lossis kev ua haujlwm ntawm cov kab mob hauv plab hnyuv, yog li muaj txiaj ntsig zoo rau tib neeg kev noj qab haus huv. Ua raws li ISAPP txhais ntawm prebiotics, Hughes li al. ua qhov kev tshuaj ntsuam meta-kev soj ntsuam ntawm kev sim tshuaj inulin hauv cov neeg laus thiab luam tawm cov txiaj ntsig hauv Advances in Nutrition, 2022.
Thoob plaws tag nrho 78 qhov kev sim tshuaj, qhov tsawg kawg nkaus ntshiab Inulin hmoov kom tsawg yog 2.5 g ib hnub twg thiab qhov siab tshaj plaws yog 30 g ib hnub twg, nrog rau feem coob (65) ntawm cov kev tshawb fawb muaj inulin noj tsawg dua 15 g ib hnub twg. Cov txiaj ntsig ntawm kev tshuaj ntsuam meta pom tau tias qhov ncauj noj ntawm inulin-based prebiotics tuaj yeem txhawb kev loj hlob ntawm cov txiaj ntsig zoo xws li Bifidobacterium, Lactobacillus thiab Clostridium flexneri hauv tib neeg txoj hnyuv, ua kom satiety, txo cov hnyuv mucosal permeability thiab txo cov cem quav (Daim duab 2. ). Nyob rau tib lub sijhawm, kev noj cov tshuaj inulin kuj tseem txhim kho cov neeg mob insulin rhiab heev, txo cov ntshav triglycerides, thiab ua kom cov calcium thiab magnesium ions nqus tau. Tshwj xeeb, nws yuav tsum tau muab sau tseg tias nyob rau hauv tag nrho 78 qhov kev sim tshuaj, qhov kev mob tshwm sim tseem ceeb ntawm qhov ncauj inulin kom tsawg yog plab flatulence, thiab tsis muaj lwm yam tsis zoo rau kev noj qab haus huv. Ntxiv mus, lub molecular saw ntev ntawm inulin cuam tshuam rau kev siv nws. Kev sib xyaw ntawm cov saw ntev thiab luv luv tau pom tias muaj txiaj ntsig zoo rau kev noj qab haus huv, thiab qhov ntau ntawm qhov ncauj inulin (oligofructose) yuav ua rau flatulence.
Inulin-based fructan prebiotics tau siv ntau hauv cov qauv me nyuam mos rau peb lub xyoo dhau los thaum tau nce mus rau cov neeg laus. Ntau qhov kev soj ntsuam randomized ob qhov muag tsis pom kev sim (RCTs) tau pom tias qhov sib ntxiv ntawm 4-8 g/L ntawm inulin thiab/los yog oligofructose rau cov menyuam mos mos txog li ib xyoos muaj txiaj ntsig zoo hauv kev nce bifidobacteria thiab lactobacilli hauv tus menyuam mos cov hnyuv. , txo cov quav pH, ua kom cov quav mos, thiab txo cov sij hawm quaj. Txog niaj hnub no, ntau dua 130 cov kev tshawb fawb soj ntsuam tau luam tawm ntawm kev siv cov inulin ua prebiotic rau cov me nyuam mos, cov menyuam yaus thiab cov poj niam cev xeeb tub, lees paub qhov kev nyab xeeb thiab kev ua tau zoo ntawm inulin-based prebiotics rau kev siv hauv cov neeg tshwj xeeb xws li cov me nyuam mos.
● Muaj peev xwm tsis zoo rau kev noj qab haus huv ntawm kev noj tshuaj ntau ntawm cov hmoov Inulin ntshiab
Peb tsab xov xwm tshawb fawb luam tawm xyoo 2018 thiab 2022 los ntawm cov kws tshawb fawb los ntawm ntau lub koom haum Asmeskas tshawb fawb hauv Cell, Xwm, Cell Host & Microbes, raws li, qhia txog kev sib raug zoo ntawm kev noj inulin thiab hom 2 inflammatory teb nrog rau daim siab carcinogenesis. Nws tau pom tias kev noj tshuaj ntau ntawm inulin-based soluble dietary fiber hauv nas ua rau muaj kev hloov pauv hauv plab hnyuv thiab nce cov kua tsib ntsev hydrolase (BSH) kev ua ntawm Bacteroides ovatus, uas cuam tshuam rau cov kua tsib acid metabolism ntawm tus tswv, tsim Cov kua tsib ntau dhau (Cholic acid, AC), uas ua rau muaj kev nce hauv eosinophils los ntawm kev tswj hwm ntawm FXR receptors thiab thaum kawg ua rau hom 2 inflammatory teb. ua rau hom 2 inflammatory teb.
Txawm li cas los xij, nyob rau hauv 2018 Cell thiab 2022 Nature cov khoom, ob qho tib si siv cov qauv nas raws li kev kawm, kev noj cov tshuaj inulin mus txog 7.5 feem pua thiab 26 feem pua ntawm cov khoom noj, raws li, qhia tias qhov hnyav dhau ntawm kev noj zaub mov prebiotic feem kuj tuaj yeem xaiv los cuam tshuam rau cov muaj pes tsawg leeg. ntawm plab microbes, ua rau hloov pauv cov qib metabolite thiab ntxiv cuam tshuam rau tus tswv lub cev thiab kev ua haujlwm ntawm immunomodulatory. Kev tshaj tawm ntawm Cell thiab Nature cov khoom tau tsa ntau qhov kev txhawj xeeb thiab kev tsis sib haum xeeb txog kev nyab xeeb ntawm kev siv inulin hauv tsev thiab txawv teb chaws. Txawm hais tias cov kua tsib acids (CA) tau xaiv hauv txoj kev tshawb no kuj yog ib qho tseem ceeb ntawm tib neeg cov kua tsib acids, cov kua tsib acid muaj pes tsawg leeg thiab cov metabolism hauv cov nas muaj qhov sib txawv ntawm tib neeg, thiab cov txiaj ntsig ntawm kev tshawb fawb nas tsis tuaj yeem sib npaug nrog tib neeg kev tshawb fawb.
Dab tsi tiag tiag nyiam ntau ntawm kev mloog yog tib neeg kev sim tshuaj ntsuam xyuas luam tawm hauv Cell Host & Microbes los ntawm Lancaster li al. Hauv txoj kev tshawb no, 18 tus neeg tau txais peb koob tshuaj inulin lossis soluble arabinoxylan hauv cov qauv sib txawv, qis (10g), nruab nrab (20g) thiab siab (30g) koob rau peb lub lis piam. Txawm li cas los xij, cov qib plasma ntawm cov metabolites tsis cuam tshuam rau cov pab pawg qis thiab nruab nrab (Daim duab 3), qhia tias kev noj tshuaj ntau ntawm inulin ua rau muaj kev cuam tshuam loj rau tib neeg. Yog li ntawd, piv nrog cov kev tshawb pom zoo ntawm ntau pua qhov kev tshawb fawb soj ntsuam ntawm inulin, txawm hais tias tsuas muaj ib qho kev sim tib neeg thiab ob txoj kev tshawb fawb nas, qhov kev pheej hmoo cuam tshuam nrog kev noj ntau dhau ntawm inulin yog qhov tseeb.
Kev noj cov hmoov ntshiab inulin yuav tsum tsis txhob ntau dhau, thiab yuav tsum tau nce qeeb. Nws raug nquahu kom tsis txhob noj ntau dhau thaum xub thawj, tsawg dua 10g ib hnub, thiab qee qhov qhia tsawg dua 5g ib hnub rau thawj ib lossis ob lub lis piam. Yog tias koj xav tau inulin, thov hu rau peb:info@gybiotech.com
