Puas yog Nicotinamide Mononucleotide Powder Ua Haujlwm?

Hauv xyoo tas los no, kev tshawb fawb txog NMN hmoov (nicotinamide mononucleotide hmoov) tau kub heev hauv kev tiv thaiv kev laus. Ib tug xov tooj ntawm cov ntaub ntawv kawm tau raug luam tawm nyob rau hauv cov ntaub ntawv pov thawj kev kawm ntawv uas sawv cev los ntawm Cell, Xwm thiab Science, thiab lub anti-aging muaj nuj nqi ntawm NMN tau nrhiav tsis tu ncua. Thiab kev tshawb fawb ntau ntxiv tau ua tiav. Yog li dab tsi muaj kev tshawb fawb tau tshawb pom txog NMN cov teebmeem?

NAD + (nicotinamide adenine dinucleotide) yog ib qho tsim nyog rau kev muaj sia nyob. Nws muaj nyob rau hauv tag nrho cov hlwb thiab muaj lub luag hauj lwm nyob rau hauv ntau lab ntawm physiological kev tshwm sim thoob plaws hauv lub cev. Raws li cov metabolic tivthaiv thiab co-molecule nyob rau hauv kev tswj ntawm lwm yam physiologically active proteins. Nws lub luag haujlwm tseem ceeb yog muab lub zog rau cov hlwb, nce kev tiv thaiv, thiab kho cov ntaub so ntswg sai thiab rov tsim dua tshiab, ua rau lub cev khaws cov kev noj qab haus huv thiab tiv thaiv kev laus.

Hauv xyoo 2013, ib pab neeg tshawb fawb los ntawm Prof. David Sinclair ntawm Harvard Medical School tau qhia tias NAD+ qib tau nce hauv 22-cov nas hnub nyoog ib hlis tom qab ib lub lim tiam ntawm qhov ncauj NMN bulk hmoov kho. Cov cim qhia txog biochemical tseem ceeb ntsig txog mitochondrial homeostasis thiab cov leeg nqaij ua haujlwm tau rov qab los rau lub xeev sib npaug rau cov menyuam yaus 6-hli cov nas. Cov txiaj ntsig kev tshawb fawb tau luam tawm hauv phau ntawv xov xwm Cell.

Sirtuins yog ib hom NAD+-dependent deacetylase protein. Nws suav nrog Sirtuins 1 txog 7. Ze li ntawm 20 xyoo ntawm kev tshawb fawb tau pom tias Sirtuins ua haujlwm tseem ceeb hauv kev coj ua txhua yam ntawm tes.Sirtuins cuam tshuam cov txheej txheem physiological xws li mob, kev loj hlob ntawm tes, circadian rhythms, lub zog metabolism, neuronal muaj nuj nqi, thiab kev nyuaj siab ntev.
Xyoo 2019, Prof. Kane AE li al, Department of Genetics, Harvard Medical School, tau tshawb pom tias NMN yog ib qho tseem ceeb ua ntej rau NAD + ntau lawm hauv kab mob. Ntau qhov txiaj ntsig zoo (piv txwv li, cov metabolism zoo dua, kev tiv thaiv kab mob plawv, thiab lwm yam) uas nws ua haujlwm tom qab nce qib hauv lub cev NAD + yog kho los ntawm Sirtuin activation.

Hauv 2019, Dr. de Picciotto NE, Department of Integrative Physiology, University of Colorado Boulder, thiab al. tshawb pom tias kev txhaj tshuaj intraperitoneal ntawm NMN txhim kho arterial Sirtuin1 kev ua haujlwm thiab kho lub hnub nyoog ntsig txog vascular dysfunction thiab oxidative stress nyob rau hauv nas. Ntxiv nrog rau kev ua kom Sirtuin1, ntxiv txoj hauv kev tuaj yeem siv los txo qis oxidative kev nyuaj siab thiab txhim kho vascular muaj nuj nqi hauv cov tsiaj laus. Piv txwv li,nicotinamide mononucleotide hmoovtuaj yeem cuam tshuam cov haujlwm ntawm Sirtuin3 hauv mitochondria, txo qis oxidative kev nyuaj siab thiab txhim kho lub cev muaj zog.

Ntxiv rau qhov cuam tshuam rau kev ua haujlwm ntawm Sirtuins, qib ntawm NAD + hauv lub cev kuj yog ib qho tseem ceeb substrate rau DNA kho enzymes PARPs (polyadenosine diphosphate ribose polymerase) ua haujlwm.

Xyoo 2017, ib pab neeg tshawb fawb coj los ntawm Prof. David Sinclair ntawm Harvard Medical School tau tshawb pom lub tshuab uas NAD + kho DNA puas. Raws li NAD + qib poob qis nrog lub hnub nyoog, DNA kho enzyme PARP1 tau nce zuj zus los ntawm DBC1 (mob qog noj ntshav tshem tawm 1) los tsim PARP1-DBC1 complex. Cov complex no tiv thaiv PARP1 los ntawm kev kho DNA puas, thiab nce NAD + ntau ntau cuam tshuam nrog PARP1-DBC1 txoj kev tsim, yog li rov kho PARP1 txoj haujlwm kho DNA. Txo DNA kev puas tsuaj tau pom nyob rau hauv hluav taws xob uas muaj hnub nyoog nas tom qab ib lub lim tiam ntawm qhov ncauj kev tswj hwm ntawm nicotinamide mononucleotide hmoov. Cov txiaj ntsig kev tshawb fawb tau luam tawm hauv phau ntawv Journal Science.

Metabolism, yog ib qho kev sau ntawm cov tshuaj lom neeg muaj sia nyob hauv lub cev. Nws yog lub ntsiab lus dav dav rau cov tshuaj tiv thaiv uas txhawb nqa lub neej hauv lub cev. Cov tshuaj tiv thaiv no ua rau cov kab mob loj hlob thiab rov tsim dua tshiab, tswj lawv cov qauv, thiab teb rau lawv ib puag ncig. Metabolism yog cov txheej txheem uas cov kab mob txuas ntxiv pauv cov teeb meem thiab lub zog, thiab thaum kev sib pauv ntawm cov teeb meem thiab lub zog tas lawm, lub cev lub neej yuav xaus.

Hauv 2019, kev tshawb fawb los ntawm Prof. Nina Klimova li al. nyob rau hauv University of Maryland Tsev Kawm Ntawv Tshuaj Kho Mob tau pom tias kev txhaj tshuaj intraperitoneal ntawm NMN ua rau muaj kev nce ntxiv hauv mitochondrial NAD + qib hauv hippocampus ntawm lub hlwb ntawm cov nas kuaj, thiab nce qib ntawm ATP, lub zog molecule, hauv cov ntaub so ntswg hauv hlwb, uas ua rau lub cev muaj zog bioenergetic metabolism. Tsis tas li ntawd, NMN tuaj yeem txhim kho kev ua haujlwm ntawm cov enzymes antioxidant hauv mitochondria, txo qis kev tsim cov pa oxygen reactive.

Thaum Lub Kaum Ob Hlis 2019, ib txoj kev tshawb fawb luam tawm hauv Phau Tsom Faj Txog Kev Nyuaj Siab tau pom tias NMN tuaj yeem txhim kho kev nyuaj siab cortisol hauv cov nas. Hauv qhov kev sim no, nicotinamide mononucleotide hmoov txhim kho lub zog metabolism thiab mitochondrial muaj nuj nqi thiab kho tus cwj pwm tsis zoo hauv cov nas kev nyuaj siab.

Xyoo 2020, kev tshawb fawb los ntawm Dr. Xiaoxian Jie los ntawm Zhejiang University of Technology thiab lwm tus pom tias tom qab kev tswj hwm qhov ncauj ntawm NMN rau cov nas muaj kev nyuaj siab, nws txhim kho mitochondrial zog metabolism hauv hippocampus thiab daim siab hlwb ntawm lub hlwb ntawm cov nas los ntawm kev nce qib ntawm NAD + thiab ua kom Sirtuin 3, yog li txo cov tsos mob ntawm kev nyuaj siab.

Cov hlab ntsha yog "cov hlab ntsha ntawm cov ntshav ntws" thiab yog cov ntaub so ntswg uas tsis tuaj yeem nqa oxygen thiab cov as-ham, ua cov pa roj carbon dioxide thiab metabolites, thiab tswj lub cev kub thiab lwm yam haujlwm tseem ceeb. Thaum peb muaj hnub nyoog, cov hlab ntsha poob lawv cov suppleness thiab ua nyuaj, tuab, thiab nqaim, ua rau "atherosclerosis.

Hauv xyoo 2018, ib pab neeg tshawb fawb coj los ntawm Prof. David Sinclair ntawm Harvard Medical School pom tias thaum 18-cov nas muaj hnub nyoog ib hlis tau noj cov tshuaj nicotinamide mononucleotide hmoov rau 2 lub hlis, cov naj npawb thiab qhov ntom ntawm cov hlab ntsha tau rov qab los rau qib. ntawm cov nas hluas, thiab cov leeg nqaij perfusion thiab yaj cov pa oxygen tau nce thaum so, thiab kev tawm dag zog ntawm cov nas qub tau txhim kho los ntawm 58% -80%, thiab qib ntawm lactic acid hauv cov ntshav tom qab kev tawm dag zog tau txo qis. Cov kev tshawb fawb tau luam tawm hauv phau ntawv xov xwm Cell. Xyoo 2016, Dr. de Picciotto NE, Department of Integrative Physiology, University of Colorado at Boulder, et al. pom tias kev tswj hwm qhov ncauj ntawm NMN rov qab kho endothelium-dependent diastolic dysfunction (EDD) thiab nitric oxide NO-mediated EDD hauv cov hlab ntsha carotid ntawm cov nas laus, txo qis aortic pulse-walking velocity (aPWV), txo nitrotyrosine, thim rov qab collagen I, thiab ntxiv collagen I. Cov txiaj ntsig tau luam tawm hauv phau ntawv xov xwm Cell. Nws txo qhov aortic pulse conduction rate (aPWV), txo cov nitrotyrosine, thim rov qab collagen I, nce elastin thiab rov ua haujlwm vascular SIRT1, yog li tswj cov elasticity ntawm cov hlab ntsha thiab tswj cov hlab ntsha noj qab haus huv.

Qhov hnyav tuaj yeem cuam tshuam tus neeg mob. Qhov hnyav tsis tsuas yog cuam tshuam rau lub neej thiab kev noj qab haus huv, tab sis kuj ua rau lwm yam kab mob. Kev tswj qhov hnyav yog hais txog kev tswj hwm qhov sib npaug ntawm lub cev lub zog thiab cov khoom siv metabolism los ntawm kev noj zaub mov zoo thiab kev tawm dag zog. Ob qho tag nrho cov rog thiab rog rog yog qhov ua rau muaj kev pheej hmoo ntawm cov kab mob ntev.

Nyob rau hauv 2017, ib pab neeg coj los ntawm Prof. Margaret J. Morris ntawm University of New South Wales Lub Tsev Kawm Ntawv Tshuaj tau ua ntau txoj kev tshawb fawb txog kev cuam tshuam ntawm NMN kev tswj hwm qhov hnyav, thiab pom tias hauv cov nas rog rog, ob qho tib si NMN thiab kev tawm dag zog txo kev rog. thiab coj mus rau kev txhim kho qabzib kam rau ua thiab kev ua haujlwm mitochondrial. Txawm li cas los xij, nicotinamide mononucleotide hmoov tau tshwm sim kom muaj kev cuam tshuam rau lub siab rog catabolism (Hadh) thiab anabolism (Fasn) dua li kev tawm dag zog, tej zaum vim tias NMN txhaj nce NAD + qib hauv lub cev uas ua rau cov protein ntau Sirtuins, uas ua rau cov rog rog catabolism thiab anabolism.

Kev noj qab haus huv ntawm lub plawv yog ib qho teeb meem ntawm txoj sia thiab kev tuag rau tib neeg lub cev, thiab nws yog ib qho tseem ceeb los tswj lub plawv ua haujlwm.

Xyoo 2014, Dr. Yamamoto T et al. los ntawm New Jersey Tsev Kawm Ntawv Kho Mob tau pom tias kev txhaj tshuaj intraperitoneal NMN hauv cov nas tau nce qib NAD + hauv plawv thiab tiv thaiv qhov txo qis ntawm NAD + thaum lub sij hawm ischemia, thiab NMN tiv thaiv lub plawv los ntawm ischemia / reperfusion raug mob. Xyoo 2017, Cov nas tau ua tiav tiv thaiv kev raug mob ischemia / reperfusion raug mob los ntawm kev txhaj tshuaj intraperitoneal luv luv ntawm NMN, raws li qhia los ntawm Dr. Rongli Zhang li al. los ntawm Case Western Reserve University School of Medicine. 2017 tau pom qhov kev tiv thaiv zoo ntawm nas lub siab tshaj qhov ua rau lub plawv tsis ua haujlwm los ntawm kev txhaj tshuaj intraperitoneal luv luv ntawm NMN, raws li kev tshawb fawb los ntawm Dr. Rongli Zhang li al. ntawm Case Western Reserve University School of Medicine. Qhov no yog vim NMN lub peev xwm los tiv thaiv mitochondria's ultrastructure, qis dua cov pa oxygen reactive, thiab nres lub plawv tuag.

Thaum ntxov vascular thiab neurodegenerative cognitive impairment tuaj yeem tshwm sim los ntawm tus kab mob neurovascular. Vascular dementia thiab Alzheimer's disease tau cuam tshuam nrog cov kev pheej hmoo xws li ntshav qab zib, ntshav siab nyob nruab nrab, rog rog, lub cev tsis muaj zog, thiab haus luam yeeb. Nws yog ib qho tseem ceeb los khaws cov haujlwm ntawm cov hlab ntsha neurovascular txhawm rau tiv thaiv cov kab mob neurodegenerative.

Lub Tsev Kawm Ntawv Qib Siab Oklahoma Health Sciences Center Dr. Tarantini S. et al. tshawb pom xyoo 2019 tias kev txhaj tshuaj intraperitoneal ntawm NMN tau tiv thaiv cov nas laus lub paj hlwb microvasculature. Tsis tas li ntawd, nicotinamide mononucleotide hmoov txo cov endothelial oxidative kev nyuaj siab nyob rau hauv lub paj hlwb microvasculature, txhim kho endothelial muaj nuj nqi thiab khaws cia neurovascular coupling (NVC) cov lus teb nyob rau hauv cov laus nas lub cortex, muaj peev xwm ua rau txhim kho cortical muaj nuj nqi. Xyoo 2020, Dr. Tamas Kiss thiab cov npoj yaig ntawm University of Oklahoma Health Sciences Center tau tshawb pom tias kev txhaj tshuaj intraperitoneal ntawm nicotinamide mononucleotide hmoov rov qab los ntawm cellular NAD + qib hauv cov nas senescent, yog li txhim kho kev paub, nce ntshav hauv hlwb, thiab txo qis kev ua haujlwm ntawm lub paj hlwb.

Insulin Resistance (IR) yog ib qho mob uas ib txwm siv ntawm cov tshuaj insulin xa tawm tsawg dua ntawm cov kab mob lom; Nws txhais tau tias yog txo qis hauv qhov kev nkag siab ntawm lub hom phiaj ntawm kev ua haujlwm ntawm insulin mus rau qhov kev ua ntawm insulin. Cov qib ntawm cov tshuaj insulin kuj tau piav qhia los ntawm insulin rhiab heev.Qhov qis dua ntawm cov tshuaj insulin, qhov kev ua haujlwm ntawm cov tshuaj insulin tsawg dua thiab tsawg dua nws lov cov suab thaj. Hom 2 mob ntshav qab zib yog tshwm sim los ntawm cov tshuaj insulin tsawg rau ib yam; qis insulin rhiab heev rau lwm tus.

Xyoo 2016, kev tshawb fawb los ntawm Dr. Kelly L. Stromsdorfer li al. ntawm Washington University Tsev Kawm Ntawv Tshuaj Kho Mob tau pom tias qhov txo qis ntawm NAD + hauv cov ntaub so ntswg adipose ntawm cov nas rog rog thiab cov hnub nyoog laus tau cuam tshuam nrog ntau cov kab mob insulin tsis kam. Los ntawm kev tswj hwm NMN rau cov tsiaj muab cov dej haus nrog ib qho enzyme inactivation uas ua rau insulin tsis kam, insulin tsis kam rov qab thiab cov ntshav plasma dawb fatty acid concentration tau qis dua. Hauv cov nas uas muaj hom 2 mob ntshav qab zib mellitus, kev txhaj tshuaj intraperitoneal ntawm NMN nce qib NAD +, uas ua rau txhim kho cov ntshav qabzib siab, kev faib cov lipids, thiab mob siab rau insulin (Dr. Yoshino J li al., Department of Developmental Biology, University of Washington School of Medicine. , 2012). Tsis tas li ntawd, nws txhim kho lub siab rhiab heev ntawm daim siab rau insulin thiab rov qab qhia cov noob txuas nrog lub circadian atherosclerosis, inflammatory teb, thiab oxidative kev nyuaj siab.

Kev tshawb fawb mus sij hawm ntev ntawm cov nas nrog qhov ncauj nicotinamide mononucleotide hmoov tau ua nyob rau xyoo 2016 los ntawm pab pawg tshawb fawb los ntawm Prof. Shinichiro Imai ntawm Washington University School of Medicine. NMN tswj hwm qhov ncauj rau ib xyoos tiv thaiv ntau yam ntawm lub cev tsis muaj zog cuam tshuam nrog kev laus, suav nrog kev laus ntawm qhov hnyav nce, nce metabolism hauv lub cev, txhim kho lub cev muaj zog, txhim kho insulin rhiab heev thiab plasma rog indexes, txhim kho qhov muag pom kev, txhim kho kev tiv thaiv kab mob, thiab tiv thaiv pob txha. kev poob qis. Cov kev tshawb pom no tau ua tom qab sib piv cov nas uas tau txais NMN ntawm qhov ncauj rau ib xyoos nrog cov uas tsis tau txais NMN rau kev laus ib txwm muaj. Tsis tas li ntawd, nicotinamide mononucleotide hmoov tsis muaj tshuaj lom lossis tsis zoo.Robert Huizenga, MD ntawm Harvard University thiab Cedars-Sinai Medical Center tshaj tawm rau lub Plaub Hlis 20, 2020, tias tus neeg mob muaj hnub nyoog 55- xyoo uas muaj mob hnyav (ua pa nyuaj, kub 39.4 degree) neocoronary mob caj dab zoo tuaj tom qab tau txais qhov ncauj NMN cocktail rau 12 teev. Kev suav cov lymphocyte kiag li tau nce los ntawm 85%, thiab tom qab 10 hnub, kev kuaj kab mob rov qab tsis zoo.

Kev poob qis hauv oocyte zoo yog qhov txwv ntawm poj niam fertility. Qhov kev poob qis hauv oocyte zoo no tshwm sim nrog kev poob sai hauv NAD + qib nrog hnub nyoog.

Ib qho kev tshawb fawb luam tawm nyob rau lub Ob Hlis 2020 tsab ntawm Cell Report pom tias siv lub precursor ntawm NAD +, NMN, txhim kho oocyte zoo nyob rau hauv cov laus nas, ua rau muaj zog fertility.Cov zoo ntawm nicotinamide mononucleotide hmoov kuj txuas mus rau lub tsim embryo, countering qhov tsis zoo. cov teebmeem ntawm niam hnub nyoog rau kev loj hlob ntawm embryo. Cov kev tshawb pom no qhia tau hais tias kev kho kom rov qab NAD + qib pab txhim kho kev yug me nyuam hauv cov poj niam tsiaj.

Guanjie tsim cov khoom zoo NMN hmoov. Guanjie siv cov txheej txheem khov qhuav thiab lub tshuab nqus tsev qhuav los tsim cov purity NMN ntau dua lossis sib npaug li 99%. Yog tias koj txaus siab, thov koj xav tiv tauj peb:info@gybiotech.com. Wb tham txog NMN bulk.