Guanjie Biotech tau tsom mus raubulk glutathione hmoovrau ntau tshaj 20 xyoo. Peb glutathione tej hmoov yog dawb muaju los yog crystalline hmoov. Qhov kev ntsuam xyuas yog ntau dua lossis sib npaug li 99.0%. Nws yog pob tshab, uas tuaj yeem soluble hauv dej. Nws saj qaub, astringent, nrog lub saj tshiab zoo ib yam li MS. Niaj hnub no peb tham txog cov teebmeem antioxidants ntawm bulk glutathione.
Thaum tib neeg xav txog glutathione, huab tais ntawm antioxidants, lawv ib txwm xav txog nws txoj kev koom tes zoo hauv kev tiv thaiv kev laus thiab kev zoo nkauj. Tab sis qhov tseeb, raws li super antioxidant, glutathione kuj paub txog nws cov txiaj ntsig hauv daim siab noj qab haus huv, kev tiv thaiv kab mob, nrog rau cov ntshav qab zib sib npaug thiab mob plawv. Tam sim no, nrog kev tshawb pom thiab siv Lactobacillus fermentum ME-3, ib hom kab mob uas tso cai rau lub cev tsim nws tus kheej.bulk glutathione hmoovnyob rau theem siab, nws yuav pab lub cev tsim cov kab mob probiotic-antioxidant uas yuav txhawb lub cev los ntawm sab hauv.
Super Antioxidant Glutathione
Glutathione (GSH) yog ib qho tripeptide uas muaj -amide bond thiab sulfhydryl pawg. Nws muaj glutamic acid, cysteine thiab glycine. Thiab nws muaj nyob hauv yuav luag txhua lub cell hauv lub cev. Nws tsis tsuas yog pab tswj lub cev tiv thaiv kab mob ua haujlwm, tab sis kuj muaj cov tshuaj tua kab mob antioxidant thiab kev sib koom ua ke detoxification cuam tshuam [1]. Yog li ntawd, glutathione feem ntau yog siv rau hauv thaj chaw xws li kev zoo nkauj thiab kev tiv thaiv lub siab. Qhov tseeb, feem ntau cov neeg uas muaj cov kab mob plawv thiab cerebrovascular kev noj qab haus huv thiab cov ntshav qabzib txawv txawv kuj tau nrog cov kev puas tsuaj oxidative tseem ceeb hauv lawv lub cev, thiab lawv lub peev xwm antioxidant tau poob qis heev. Nws tau raug pom tias exogenous supplementation ntawm glutathione pab ua kom cov ntshav qab zib antioxidant muaj peev xwm ua kom muaj zog tiv thaiv atherosclerosis thiab ntshav qab zib txawv txav. Yog li, glutathione yog qhov tseem ceeb sib npaug rau kev tswj hwm vascular thiab glycemic noj qab haus huv. Txawm li cas los xij, hauv kev xyaum, glutathione's inherent "kab" ntawm kev raug oxidation tau cuam tshuam nws txoj haujlwm zoo.
Glutathione muaj nyob rau hauv ob qho tib si txo (G-SH) thiab oxidised (GSSG) daim ntawv. Daim ntawv txo qis muab electrons, neutralises dawb radicals thiab ua oxidised glutathione kom txog thaum nws tau txais electrons dua thiab rov qab mus rau daim ntawv txo. Thiab nws yog qhov txo glutathione uas yeej tawm tsam dawb radicals. Nyob rau hauv ib txwm physiological tej yam kev mob txo glutathione occupies feem ntau. Txawm li cas los xij, thaum cov hlwb raug rau ntau cov dawb radicals (xws li cov xeev inflammatory), ntau qhov txo qis.bulk glutathione hmoovyog siv thiab oxidized glutathione yog tsim. Yog li, qhov yuav tsum tau ua ua ntej kom ntseeg tau qhov kev ua haujlwm ntawm glutathione hauv lub cev yog los tswj cov qib ntawm glutathione hauv lub cev.
Lactobacillus fermentum ME -3 thiab glutathione
Xyoo 1995, ib pab neeg uas coj los ntawm Estonian tus kws tshawb fawb Prof. Marika Mikelsaar cais cov kab mob probiotic, Limosilactobacillus fermentum ME-3 (tom qab no hu ua 'Lactobacillus fermentum ME-3'), los ntawm tib neeg txoj hnyuv. (tom qab no hu ua 'Lactobacillus fermentum ME-3'). Cov kab no yog qhov tshwj xeeb uas nws tsis tsuas yog tsim cov super antioxidant glutathione, tab sis kuj tswj cov qib siab ntawm nws hauv lub cev los ntawm nws cov hlab ntsha, uas tiv thaiv nws los ntawm kev tawg sai heev los ntawm lub plab zom mov.
Piv txwv li, tsis muaj glutathione redox lub voj voog, tus kab mob nws tus kheej yuav tsis tuaj yeem tiv thaiv glutathione tiv thaiv cov pa oxygen reactive. Txawm li cas los xij, ib daim ntawv luam tawm xyoo 2010 tau pom tias Lactobacillus fermentum mucilaginousum ME -3 muaj ob qho tib si glutathione peroxidase thiab glutathione reductase. Yog li, txo glutathione (GSH) tuaj yeem hloov mus rau oxidised glutathione (GSSG) los ntawm glutathione peroxidase, uas tuaj yeem hloov mus rau GSH los ntawmbulk glutathione hmoovreductase, implying tias Lactobacillus mucilaginosus ME -3 muaj ib tug ua tiav glutathione "tso tawm thiab rov ua dua" system, uas tso cai rau nws mus synthesize, uptake thiab redox-hloov glutathione rau hauv GSSG. Qhov no txhais tau hais tias Lactobacillus fermentum ME -3 muaj ua tiav "tsim thiab rov ua dua" system ntawm glutathione, uas tuaj yeem ua ke, noj thiab hloov mus rau GSH los ntawm redox enzymes, yog li ua kom cov nyhuv antioxidant ntawm GSH [2].
ME-3 tsim kom muaj cov kab mob probiotic-antioxidant los ntawm glutathione
Saum toj no, peb tau piav qhia yuav ua li cas Lactobacillus fermentum ME -3 ua tiav nws cov nyhuv antioxidant los ntawmbulk glutathione hmoovnyob rau theem mechanics. Tom ntej no, cia peb saib cov pov thawj tshawb fawb uas Lactobacillus fermentum ME-3 tsim kom muaj cov kab mob probiotic-antioxidant los ntawm glutathione.
Hauv kev sim ob qhov muag tsis pom kev randomized placebo-tswj, cov kws tshawb fawb tau soj ntsuam TAA (Tag nrho Antioxidant Activity) thiab TAS (Tag nrho Antioxidant Status) hauv cov ntshav los ntawm cov txheej txheem molecular kom nkag siab txog qhov muaj peev xwm antioxidant ntawm Lactobacillus fermentum ME-3, thiab Los ntawm kev hloov pauv ntawm tag nrho cov tshuaj tiv thaiv antioxidant, cov kws tshawb fawb tau xaus lus tias Lactobacillus fermentum ME-3 pab txhawb kom lub cev tiv thaiv oxidative kev nyuaj siab [3].
Ib txoj kev tshawb nrhiav kev tswj hwm suav nrog 164 tus neeg laus noj qab haus huv nrog cov ntshav lipoprotein cholesterol tsawg (LDL-C) thiab / lossis ntshav triglycerides (TG) ntawm qib noj qab haus huv / kab mob. Txoj kev tshawb no siv cov ntsiab lus ntawm European Cov Lus Qhia rau Cardiology rau kev suav nrog cov kev kawm. Cov txiaj ntsig tau pom tias tom qab 8 lub lis piam ntawm kev noj kefir nrog lossis tsis muaj ME -3, tsuas yog ME -3 pab pawg tau pom qhov txo qis hauv cov ntshav lipoprotein cholesterol tsawg (LDL-C), oxidised low-density. lipoprotein (ox-LDL), thiab ntshav triglyceride (TG) qib 5%, 6%, thiab 17%, feem. Tsis tas li ntawd, cov ntsiab lus hauv ME-3 pab pawg tau pom qhov txo qis hauv HDL / LDL piv, thaum qhov ntsuas no tsis txo qis tab sis nce hauv cov ntsiab lus hauv pawg placebo [4].
Hauv lwm qhov randomised, ob-dig muag, kev sim tshuaj placebo nrog rau 100 yam kev noj qab haus huv, cov kws tshawb fawb pom tias Lactobacillus fermentum mucilaginousum ME-3 tau muaj txiaj ntsig zoo rau postprandial oxidative stress (OxS), postprandial triglycerides (TG) thiab lipoproteins. ]. Nws yog qhov kev xav tias ME-3 ua tiav kev ua kom zoo ntawm lipid muaj pes tsawg leeg thiab kev tswj hwm ntawm lipid oxidation qib los ntawm kev txhim kho qib ntawm oxidative kev nyuaj siab hauv lub cev.
Muaj ntau zuj zus ntawm cov kev tshawb fawb preclinical uas qhia txog cov teebmeem ntawm antioxidant probiotic ME-3 nyob rau hauv ntau yam kev qhia txog kev noj qab haus huv. Ib txoj kev tshawb fawb pom tias ME-3 txhim kho glycosylation thiab dysglycemia hauv hom II mob ntshav qab zib nas [6]. Lwm qhov kev tshawb fawb soj ntsuam pom tau hais tias kev noj ntawm ME -3 txo qis cov theem ntawm cov kab mob inflammatory thiab nce qib ntawm cov tshuaj tiv thaiv kab mob hauv daim siab ntawm cov qauv nas [7].
Ntxiv rau qhov no, cov teebmeem ntawm qhov ncauj glutathione rau tib neeg kev noj qab haus huv tau raug tshaj tawm hauv kev tshawb fawb ntau ntxiv. Ib txoj kev tshawb fawb soj ntsuam tau pom tias qhov ncauj glutathione tau txais 3 lub lis piam sib law liag tau muaj txiaj ntsig zoo thiab muaj txiaj ntsig zoo rau insulin rhiab heev [8]. Cov teebmeem ntawmbulk glutathione hmoovkev noj ntawm daim tawv nqaij kuj tau lees paub los ntawm ntau qhov kev tshawb fawb soj ntsuam [9,10]. Txawm tias tus kws tshawb fawb Kauslim tau pom tias kev noj cov glutathione muaj txiaj ntsig zoo rau kev txhim kho kev ua kis las ntawm triathletes nrog rau kev txhim kho cov kev ntsuas ntsig txog kev tawm dag zog rov qab [11].
Nws pom tau tias probiotic ME -3, uas muaj peev xwm rov tsim dua glutathione rau tib neeg lub cev, yuav ua rau muaj txiaj ntsig zoo dua thiab cov kev daws teeb meem tshiab rau kev lag luam khoom noj qab haus huv hauv ntau cov lus qhia kev noj qab haus huv yav tom ntej.
Txhawm rau ua kom tiav, los ntawm glutathione, Lactobacillus fermentum ME -3 pab lub cev tsim kom muaj 'probiotic-antioxidant system'. Ua tsaug rau qhov no muaj zog antioxidant system, cov kabmob thiab cov ntaub so ntswg xws li ntshav lipids, ntshav qabzib, tawv nqaij, siab, thiab lwm yam tau txais cov lus pom zoo ntawm lawv cov antioxidant ib puag ncig muaj peev xwm, yog li ua rau koj tsis tau muaj dua 'rejuvenation' kev paub. Tshwj xeeb tshaj yog nrog kev sib sib zog nqus ntawm kev tshawb fawb txog probiotics, kev siv cov probiotics los txhim kho cov teeb meem kev noj qab haus huv tshwj xeeb tau dhau los ua lub ntsiab lus kub. Txawm li cas los xij, thaum nws los txog rau qhov tseebbulk glutathione hmoovtxoj kev loj hlob, muaj ob peb hom nrog ib tug meej mechanism thiab cov kev tshawb fawb soj ntsuam ntawm lawv cov antioxidant zog.
Guanjie Biotech tau tsom mus raubulk L-glutathione hmoovtau ntau xyoo. Siab zoobulk hmoov glutathionethiab tus nqi qis, txais tos nug peb:info@gybiotech.com.
Cov ntaub ntawv:
[1] Cong Fengsong. Cov khawv koob ntawm me me molecule active peptide. Shanghai Jiao Tong University Xovxwm. 2015. 18
[2] ПРИКЛАДНАЯ БИОХИМИЯ И МИКРОБИОЛОГИЯ, 2010, том 46, № 5, с. 527-531
[3] Nutrition Journal 2005, 4:22
[4] Mikelsaar et al. BMC Nutrition (2015) 1:27
[5] Cent. Eur. J. Biol. - 6(1) - 2011 - 32-40
[6] Guilbaud A, et al. Mol Nutr Food Res. Peb Hlis 2020; 64(6):e1901018
[7] Truusalu K, et al. APMIS. 2010 Nov; 118(11):864-72
[8] Søndergård SD, et al. Appl Physiol Nutr Metab. 2021 Sep; 46(9):1133-1142
[9] Sitohang BS, et al. Dermatology Research and Practice Volume 2020, Tshooj ID 8547960, 6 nplooj
[10] Wahab S, et al. Int J Dermatol. 2021 Aug; 60(8):1013-1018
[11] Lee EJ, et al. Nutrients 2023, 15, 3324-3340
