Cov lus teb luv luv thiab teb tsis meej yog tsis muaj. Sulelaphane hmoov ntauthiab3,3-Diindolylmethane Hmoovtsis yog tib qho sib txuas. Thaum lawv yog ob qho tib si me me me me me ntawm cov zaub ntsuab, xws li zaub ntsuab, cov qauv ntawm kev ua, thiab cov teebmeem kev ua haujlwm hauv tib neeg lub cev. Confusion ntawm ob feem ntau tshwm sim vim tias lawv tau ua yeeb yam rau lawv cov txiaj ntsig kev noj qab haus huv, tshwj xeeb hauv lawv cov kev pab cuam mob cancer, cov tshuaj hormone, thiab kev tshem tawm cov tshuaj hiam xwm. Txawm li cas los xij, kev nkag siab txog lawv qhov sib txawv yog qhov tseem ceeb rau kev txaus siab rau lawv lub luag haujlwm tshwj xeeb hauv kev noj haus thiab kho.
Kev sib txawv ntawm cov tshuaj thiab keeb kwm
Sulforaphhane
• Chav Kawm Txuj Ci Tshuaj:
Sulforaphane yog ib qho ayothiocyanate (ITC). Nws cov mis mis yog c₆h₁₁nos₂.
• Prefursor:
Sulelaphane Hmoov Bulc tsis muaj ua ntej ua ntej - tsim hauv zaub cob pob. Hloov chaw, nws tau muab los ntawm nws cov inert, ruaj khov precursor, glucoraphanin, hom glucosinolate.
• Tsim cov txheej txheem:
Qhov hloov dua tshiab ntawm glucorapanin kom nquag Sulforaphane tau qhib thaum cov nroj tsuag raug puas (piv txwv li, zom, txhoov, lossis sib xyaw). Cov txheej txheem no yog enzymatically mediated los ntawm enzyme hu ua myrosinase, uas tau khaws cia hauv cov khoom sib cais hauv cov nroj tsuag cell. Thaum cov nroj tsuag raug puas, myrosinase los rau hauv kev sib cuag nrog glucorapanin thiab hydrolyzes nws, yielding sulforaphane.
• Ntsiab lus Ntsiab Lus Tseem Ceeb:
Cov txheej txheem no tseem tuaj yeem yog catalyzed los ntawm myrosinase enzymes tam sim no nyob rau hauv lub plab microbiome ntawm tib neeg, tab sis tsis muaj peev xwm tsawg. Yog li ntawd, maj mam steaming broccoli (uas khaws cia cog myrosinase) yog qhov ua tau zoo rau sulelaphane hmoov ntau ntau dua li npau npau (uas rhuav tshem nws).
Dim
• Chav Kawm Txuj Ci Tshuaj:
Diindolylmethane bul hmoov yog ib qho tseem ceeb.
• Prefursor:
Saim yog muab tau los ntawm ib qho txawv glucosinolate hu ua Guucobrassicin.
• Tsim cov txheej txheem:
Kev hloov dua siab tshiab yog ntau lo lus. Thaum glucobrassicin yog hydrolyzed los ntawm myrosinase, nws ua ntej ua cov compound tsis muaj npe hu ua Indole-3-Carbinol (I3C). I3C yog cov khoom siv hydroxygygygsis. Diindolylmethane bul hmoov tsis tsim nyob rau hauv cov nroj tsuag. Hloov chaw, I3C raug tso tawm thaum peb siv zaub ntsuab ntoo. Thaum I3C ntsib cov acidic ib puag ncig ntawm lub plab, nws undergoes ib qho tshuaj tiv thaiv hws, txuas ob molecules ntawm I3C los ua ib qho molecule ntawm qhov chaw ruaj khov.
Cov ntsiab lus ntawm Keeb Kwm:
Sulernane los ntawm glucoraphanin ntawm cov enzyme myrosinase. Sim los ntawm glucobrassicin, uas thawj ua I3C ntawm myrosinase, thiab tom qab ntawd i3C condenses rau hauv plab acid. Qhov no siv tau sib txawv hauv keeb kwm thiab cov qauv tshuaj pleev lawv txoj kev sib txawv nkaus thiab kev cuam tshuam hauv lub cev.
Cov txiaj ntsig thiab cov ntawv thov
Sulforaphhane
Kev tshawb fawb txog sulforaphane hmoov loj yog loj heev thiab tsom mus rau nws cytoprotive thiab neuromodatory cov khoom.
• Kev tiv thaiv mob cancer thiab kev kho kom haum:
Piv txwv li kev tshawb fawb: Lub seminal 1992 kawm nyob rau hauv cov txheej txheem ntawm National Academy pawg ntawm Paus 'enzs
Tib neeg kev sim siab: kev tshawb fawb tau qhia tias kev noj cov kab mob sulforexin}}}}} puas muaj mob qog ntshav thiab tawv nqaij muaj kev pheej hmoo.
Lub zog ua haujlwm: nws cov chev saib xyuas yog qhov tsis txaus ntseeg rau NRF2-sib detoxification, ua rau lub cev ua kom nruab siab thiab ua kom lub cev muaj peev xwm muaj peev xwm ntau dua.
• Neuroprotection thiab lub hlwb kev noj qab haus huv:
Tsis muaj tus cwj pwm tsis txaus ntseeg (asd)) Qhov cuam tshuam ploj zuj zus tom qab kho tau nres. Cov txheej txheem yog xav los koom nrog kev txhim kho ntawm kev ntxhov siab oxidative kev ntxhov siab thiab mitochondrial kawg hauv ASD.
Neurodegenerative kev tshawb fawb: Cov kev tshawb fawb preflinical qhia tau tias los ntawm kev txo cov kab mob oxid2), ntawm cov kab mob NRF2) Nws kuj tseem tuaj yeem pab txhim kho lub hlwb lub hlwb tus antioxidant, glutathione.
• Kev Noj Qab Haus Huv Kev Noj Qab Haus Huv:
Kev tshawb fawb qhia tias sulforaphane hmoov ntau tuaj yeem txhim kho cov ntshav siab thiab txo qis cov ntshav siab thiab txo qis cov ntshav siab. Nws kuj tseem tuaj yeem tiv thaiv rau Opotthelial ua haujlwm, yog cov cim thaum ntxov ntawm atherosclerosis.
• Kev Txhawb Nqa thiab Detoxification Txhawb:
Kev tshawb nrhiav tib neeg xwm yeem qhia tau tias sulelaphane kev ua kom muaj ntau yam ntawm NRF2-txhawb nqa lub cev muaj peev xwm lis cov co toxins ib puag ncig thiab kev ntxhov siab oxidative.
Dim: Tus Hormone Indalancer
Kev tshawb nrhiav ntawm Diindolylmethane loj hmoov hmoov hnyav rau cov neeg mob los ntawm cov metrogen metabolism.
• Lawm {- Cov qog nqaij hlav:
Tus mob cancer mis: muaj ntau nyob hauv kev tshawb fawb vitro thiab tsiaj tsim qhia tias kev tshaj tawm tuaj yeem ua rau muaj kev loj hlob ntawm cov qog nqaij hlav cancer mis. Nws lub peev xwm los txhawb qhov tsim ntawm "zoo"-hydroxyestRone metabolite yog lub keych key. Qee qhov kev tshawb fawb tib neeg kev saib xyuas txuas ntxiv rau cov zaub muaj kev pheej hmoo mob cancer mis, txawm tias kev txhawb nqa mob cancer mis, tab sis kev txhawb nqa ncaj qha yog txuas ntxiv.
Cervical Cancer: Kev tshawb nrhiav hauv tsev kawm ntawv uas pom tias kev txhawb nqa sai (2 mg / kg ib hnub) tau ua haujlwm zoo rau cov neeg mob ncauj tsev neeg tsis zoo (cnc), ib qho mob uas muaj pes tsawg.
Prostate cancer: Kev tshawb fawb qhia tau hais tias qhov kev nthuav dav ntawm cov muaj peev xwm ntawm cov mob prostate ntawm prostate cancer hlwb thiab induce apoptosis. Nws tau raug tshuaj xyuas rau nws cov peev xwm kom qeeb zuj zus ntawm tus kab mob.
• Tswj cov tshuaj estrogen:
Diindolylmethane Thile Hmoov yog dav siv ua ib qho tsos mob ntawm estrocystic mis kab mob, thiab lub npe {}} cov tsos mob. Txhawb kev noj qab haus huv cov metabolism nws tuaj yeem pab sib npaug ntawm cov tshuaj estrogen estrod {2} {{progesterone piv. Anecdotal cov lus qhia thiab qee qhov kev soj ntsuam cov tshuaj ntsuam xyuas txhawb nws txoj kev siv rau kev txo lub mis lub cev, hloov pauv ntawm lub siab, thiab bloating.
• Lwm cov ntawv thov:
Pob txuv: Vim nws cov cawv ntawm Androgen receptor kev ua si thiab anti {{{
Kev tswj qhov hnyav: Qee cov ntaub ntawv pov thawj qhia tau tias los ntawm kev txhim kho cov metabolism estrogen, tshwj xeeb tshaj yog cov rog thiab cov ncej puab uas rhiab rau estrogen.
Qhov sib txawv
|
Yam zoo |
Sulforaphhane |
Dim (3,3 '- diindolylmethane) |
|
Tshuaj Yeeb Kawm Txuj Ci |
Isothiocyanate |
Tseem ceeb |
|
Coj ncaj qha ua ntej |
Kua nplaum |
Indole-3-Carbinol (I3C) |
|
Tsim khoom |
Via enzyme (myrosinase) |
Ntawm cov kua qaub acid ntawm I3C hauv lub plab |
|
Thawj mechanism |
Muaj pes tsawg lub zog NRF2 |
Modulator ntawm estrogen metabolism |
|
Npaj Txhawb |
Cellular Detoxification, Antioxidant Defense, Neuroprotection, thiab General Chilling |
Cov tshuaj tshuav li cas, estrogen - bex} Cov ntshav tiv thaiv mob cancer, thiab cov tsos mob estrogen ntawm dominance |
|
Tau qhov chaw hauv kev noj haus |
Siab tshaj plaws hauv cov zaub cob pob zaub, tom qab ntawd cov zaub ntsuab paub tab |
Siab tshaj hauv cov zaub zoo li zaub qhwv, kale, Brussels sprouts (raws li I3C) |
Kev xyuas xim
Ob qho tib si sib txuas yog feem ntau suav tias muaj kev nyab xeeb thaum noj los ntawm kev noj haus cov khoom. Hauv daim ntawv qhia ntxiv:
Sulforaphane:
Koob tshuaj ntau yuav ua rau mob plab zom mov me me. Raws li nws tau Upregulates retoxification pathways, nws tuaj yeem hloov siab hloov cov metabolism ntawm qee yam tshuaj. Nws yog qhov tseem ceeb los xaiv cov tshuaj uas tau lees tias ua kom muaj kev tiv thaiv sulforaphanin), muaj ntau sulosaphale), raws li ntau sulosaphale), raws li ntau suloraphane hmoov ntau yam khoom ntawm kev ua lag luam tsis ruaj khov.
Dim:
Nws yog cov roj - soluble thiab yuav tsum tau noj nrog zaub mov. Cov koob tshuaj ntau yuav ua rau mob taub hau, roj av, lossis tsaus nti ntawm cov zis (ib qho cuam tshuam zoo). Vim nws cov nyhuv ncaj qha rau cov tshuaj hormones hormones (piv txwv li ntawm kev tswj hwm ntawm tus kws kho mob (},}}, sensitive sensitive conditions)) yuav tsum tau sab laj nrog kws kho mob ua ntej siv cov tshuaj lom neeg ua ntej siv Diindolylmethanethanethane.
Thaum nrhiav siab - Zoo, txhim khu kev qha suloraphane cov khoom xyaw, lub qaub ntawm cov khoom siv raw yog qhov tseem ceeb. Paramount. Guanjie Biotech yog tus neeg xa khoom raug lees paub hauv qhov chaw no, tshwj xeeb hauv kev muab cov khoom siab zoo- broccoli noob extract cov khoom xyaw. Lawv tsom rau cov extraction siab thiab ruaj khov ua kom ntseeg tau tias yog cov khoom lag luam sullochane thoob ntiaj teb los tsim cov pov thawj- raws cov qauv.
Tag
Sulelaphane thiab dim, thaum yug los ntawm tib tsev neeg cov zaub, nws muaj cov molecular molecular nrog tshwj xeeb thiab tsis muaj lub luag haujlwm nyob rau hauv tib neeg lub cev. Sulforaphane tau txais kev nkag siab zoo tshaj raws li qhov dav - spectrum cellular activator uas bolrassic lub cev tiv thaiv oxidative, thiab ib puag ncig cov co toxins. Diindolylmethane Bulless Hmoov yog tus qauv tshwj xeeb uas feem ntau nplua oveabolism, ua rau nws muaj feem cuam tshuam rau cov tshuaj hormones zoo rau cov kev mob.
Qhov kev xaiv ntawm lawv tsis yog teeb meem ntawm uas yog "zoo dua," tab sis es tsim nyog rau lub hom phiaj kev noj qab haus huv tshwj xeeb. Rau overarching antioxidant thiab neuroprotrotawm kev txhawb nqa, sulforaphane yog cov khoom seem. Rau cov ntawv thov tsom rau kev siv tshuaj, siab- Zoo tshuaj los ntawm cov neeg xa npe tuaj yeem muab cov npe, muaj koob tshuaj. Guania Biotech lub ntuj suloraphana hmoov loj thiab cov hmoov khoom hmoov, txais tos los nug nrog peb ntawminfo@gybiotech.com.
Ntawv Sawv cev
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[2] Kensler, Tw, thiab Al. (2005). Qhov cuam tshuam ntawm glucosinolate - rab brocoli sprods thiab sidlatoxin {{{{{{{{{{{{{{{{{{{ Cancer Ecidlemiology, biomarksers & kev tiv thaiv, 14 (11 pt 1), 2605-2613.
[3] Singh, K., li al. (2014). Sulelaphane kev kho mob ntawm kev tsis paub txog kev tsis sib haum xeeb (ASD). Kev hais plaub ntawm National Academy ntawm Kev Tshawb Fawb, 111 (43), 15550-15555.
[4] Tarozzi, A., li al. (2013). Sulforaphane raws li lub peev xwm tiv thaiv phytochemical tawm tsam cov kab mob nurodegenerative. Oxidative tshuaj thiab cellular lub sijhawm ntev, 2013, 415078.
[5] Bjeldanes, LF, li al. (1991). Cov kev paub txog hydrocarivenessly- Cov}} pupbinol hauv vitro thiab hauv vivo-} {,8-tetrachlorodibenzo-p-dioxin. Kev hais plaub ntawm National Academy ntawm Kev Tshawb Fawb, 88 (21), 9543-9547.
[6] Dalessandri, KM, li al. (2004). Kev Kawm Txog Kev Tshawb Fawb: Kev Ua Haujlwm ntawm 3,3 '- diindolylmethanes ntawm eterminal metabloet hauv overnary {{}}} panclim ntawm tus mob cancer mis thaum ntxov. Khoom Noj Khoom Haus thiab Mob Cancer, 50 (2), 161-167.
[7] Sepkovic, DW, li al. (2001). Cov nyhuv ntawm Diindolylmethane ntawm cov metrogen metabolism hauv cov poj niam. Phau ntawv sau txog poj niam kev noj qab haus huv & poj niam txiv neej {{}}} saib tshuaj, 10 (7), 615-620.
[8] Chen, D., li al. (2001). Oxidative Demetylation ntawm 3,3 '- diechrome p} A1} {{10} {{10} {{10} {overput assay. Biochemical Pharmology, 62 (8), 1061-1068.
[9] Weng, JR, li al. (2008). Isti - angiogenic kev ua si ntawm 3,3 {}}}} diindolility ntawm vasindolility ntawm kev qhia txog kev mob qog nqaij hlav. Kev tshawb fawb cancer, 68 (19), 7892-7900.
