LuteolinHmoovntawm Guanjie Biotech sawv tawm hauv kev ua lag luam vim nws cov kev siv thev naus laus zis hauv kev tswj cov hmoov tshauv, qhov tseem ceeb cuam tshuam los ntawm lub cev lub cev ntawm luteolin. Kev lig kev cai, kev ua lag luam tau pom cov hmoov luteolin nrog cov hmoov tshauv nyob ib ncig ntawm 10%. Cov hmoov tshauv siab tuaj yeem qhia tau tias txo qis purity thiab kev ua tau zoo ntawm flavonoid. Peb tau pioneered thev naus laus zis los txo cov hmoov tshauv hauv lawv cov hmoov luteolin. Peb txo cov hmoov tshauv los ntawm qhov raug 10% mus rau qis dua 2%.
Luteolin yog ib txwm tshwm sim flavonoid. Nws lub npe tshuaj yog 3', 4', 5, 7-tetrahydroxyflavone. Nws tau dav faib nyob rau hauv lub nceeg vaj cog. Piv txwv li, nws muaj nyob rau hauv acacia, txiv laum huab xeeb plhaub, honeysuckle, qus chrysanthemum thiab broccoli.Luteolinhmoovtuaj yeem muab rho tawm los ntawm honeysuckle. Cov qauv tshuaj chemical yog qhia hauv daim duab 1.
Luteolin muaj peev xwm nkag mus rau hauv daim tawv nqaij. Nws tuaj yeem ncav cuag tob rau hauv txheej tawv nqaij. Cov teebmeem yog raws li nram no: antioxidant, ncua kev laus, tiv thaiv inflammatory, whitening, antibacterial, inhibition thiab tshem tawm ntawm daim tawv nqaij discoloration. Txawm li cas los xij, nws raug kev txom nyem los ntawm qhov teeb meem tseem ceeb ntawm kev solubility tsis zoo, uas ua rau muaj kev txwv ntawmLuteolin uahmoovdaim ntawv thov hauv tshuaj pleev ib ce. Nws solubility thiab siv tau tuaj yeem txhim kho los ntawm cov khoom tawg, cyclodextrin inclusion complexes, phospholipid complexes, nanoemulsions, polymer micelles thiab lwm yam txheej txheem formulation. Nyob rau hauv lem, nws yuav ua hauj lwm zoo. Daim duab 2 teev cov kev tshawb fawb txog kev ua tau zoo ntawm lignans ntsig txog tshuaj pleev ib ce.
Kev nce qib hauv Formulation Research
01 Khoom dispersion
Solid dispersion (SD) yog ib qho khoom tawg uas tau txais los ntawm kev sib txuas cov khoom siv refractory nrog cov neeg nqa khoom hnyav heev los ntawm fusion (fusion), txoj kev hnyav los yog molten hnyav. Qhov no ua rau cov tshuaj tso tawm thiab ua rau kom muaj kev sib cais ntawm cov tshuaj insoluble. Solubility ntawmluteolin uahmoovnyob rau hauv luteolin khoom dispersion (Lut-SD) thiab luteolin phospholipid complex solid dispersion (Lut-PC-SD) npaj los ntawm Xiangtao Deng li al. tau nce los ntawm (61.09±0.09) µg/mL rau 6-7 npaug ntawm qhov qub. Kev sib piv ntawm solubility yog qhia hauv daim duab 3.
02 Cyclodextrin inclusion complexes
Cyclodextrin yog cyclic oligosaccharide. Nws muaj lipophilic puab kab noj hniav thiab ib tug hydrophilic txheej txheej, thiab muaj peev xwm cuam tshuam nrog ntau yam ntawm cov qhua molecules los tsim cov non-covalent inclusion complexes. Nws yog tsuas yog siv los txhim kho cov dej solubility, physicochemical stability thiab bioavailability ntawm cov tshuaj. Xudong Wang et al. npaj sustained-release antimicrobial nanofibers (PVA-Lut-IC-NF) los ntawm kev sib xyawluteolin uahmoovinclusion complex (Lut-IC) rau hauv poly (vinyl cawv) (PVA) los ntawm electrostatic spinning.PVA-Lut-IC-NF muaj dej solubility zoo thiab thermal stability. Thiab nws muaj cov nyhuv inhibitory tseem ceeb ntawm Staphylococcus aureus, Candida albicans thiab Escherichia coli.
03 Phospholipid complexes
Phospholipid complex yog ib qho kev sib sau ua ke ntawm liposome zoo li cov hlwv uas tsim hauv dej los ntawm kev sib cuam tshuam ntawm phospholipids thiab cov khoom xyaw nquag los ntawm kev sib txuas tsis yog covalent (them hloov pauv, hydrogen bonding, van der Waals rog, thiab lwm yam). Nws tsub kom lub stability ntawm lub active thiab prolongs lub sij hawm ntawm kev ua. Cov kev tshawb fawb cuam tshuam tau pom tias phospholipid complexes muaj lignans. Lub solubility hauv dej yog li 2.5 npaug ntawm cov ntshiabluteolin uahmoov.
04 Nanoemulsion
Nanoemulsion yog ua los ntawm ob qho dej tsis zoo. Nrog kev pab los ntawm tsim nyog surfactant thiab co-surfactant muaj pes tsawg leeg ntawm particle loj ntawm 1 ~ 100 nm homogeneous dispersion system. Nws muaj qhov zoo ntawm kev nce lub solubility ntawm cov khoom nquag thiab txhim kho bioavailability, thiab lwm yam. Shin li al. npaj luteolin nanoemulsions uas muaj poly (ethylene oxide)-thaiv poly (ε-caprolactone) thiab lecithin polymerized ntawm O / W interface. Nws pom tau tias muaj kev ruaj ntseg zoo heev thaum lub sij hawm rov qab khov-thaw cycles thiab khaws cia ntev. Thiab minoxidil tau siv los ua kev tswj hwm zoo los siv rau ntawm daim tawv nqaij depilated ntawm nas, thiab cov txiaj ntsig tau pom zoo li cov plaub hau loj hlob tom qab 17 hnub. Txawm li cas los xij, cov plaub hau ntawm qhov chaw ntawm daim tawv nqaij kho nrogluteolin uahmoovnanoemulsion tau zoo ib yam thiab mos.
05 Polymeric micelles
Polymer micelles yog amphiphilic block copolymers uas nws tus kheej sib sau ua ke hauv dej rau hauv kev txiav txim siab nrog cov qauv / plhaub. Lub hydrophobic chains ntawm block copolymer tsim lub hauv paus ntawm micelle. Lawv yog siv los encapsulate hydrophobic tshuaj. Cov saw hlau hydrophilic tsim nws lub plhaub sab nrauv thiab tuav lub spatial stability ntawm micelle. Nws tau qhia tiasluteolin uahmoovtau sib sau ua ke rau hauv methoxy polyethylene glycol polycaprolactone (mPEG5K-PCL10K) micelles. Nws tsis tsuas yog muaj kev ruaj ntseg thiab encapsulation tus nqi, tab sis cov dej solubility ntawm luteolin kuj zoo heev.
Luteolin hmoov ntawm Guanjie Biotech, nrog nws cov hmoov tshauv cov ntsiab lus tsawg, muab kev xaiv zoo tshaj rau cov kws tshawb fawb thiab kev lag luam tab tom nrhiav kev zoo luteolin. Yog tias koj xav tau, txais tos hu rau peb:info@gybiotech.com.
Cov ntaub ntawv:
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[3] Pasarkar N, Waghmare S, Kamble H. Khoom tawg: kev tshuaj xyuas ［J］. Iconic Research thiab Engineering Journals, 2022, 5(7): 6
[4] Deng Xingtao, Hao Navy, Chen Xiaofeng, et al. Kev npaj, tus cwj pwm thiab hauv vivo pharmacokinetic tus cwj pwm ntawm ob qho khoom tawg ntawm luteolin hauv nas[J]. Suav tshuaj ntsuab,2018,49(24):5787-5793.
[5] Shin K, Choi H, Song SK, et al. Nanoemulsion tsheb ua cov nqa khoom rau follicular xa ntawm luteolin ［J］. ACS Biomaterials Science & Engineering, 2018, 4(5): 1723-1729.
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