NR Powder

NR Powder Supplier:

Guanjie yog nicotinamide ribosideNR Powdertus neeg muag khoom, thiab peb NR yog cov hmoov dawb nrog cov ntsiab lus siab dua 98%. Nicotinamide riboside (CAS 1341-23-7) tsis ruaj khov ntawm chav tsev kub, yog li cov khoom lag luam muaj npe hu ua nicotinamide riboside yog nicotinamide riboside chloride (CAS 23111-00-4). Yog tias muaj kev tso cai, nws yog qhov zoo tshaj los khaws nws saum toj no xoom degrees. Peb muaj cov chaw tsim khoom ywj pheej thiab cov kab ntau lawm, suav nrog nicotinamide riboside Hoobkas. Thiab peb cov nicotinamide riboside chloride hmoov yog qhov zoo thiab lub Hoobkas nqi. Peb tuaj yeem muab koj daim ntawv tshaj tawm thib peb thiab lwm daim ntawv pov thawj. Yog tias koj txaus siab rau peb cov khoom, thov koj xav tiv tauj peb:info@gybiotech.com

 

Khoom Taw Qhia:
Nicotinamide riboside (NR) Powder yog ib qho derivative ntawm vitamin B3 thiab tus thawj ntawm nicotinamide adenine dinucleotide (NAD +, tseem hu ua coenzyme I). Nws tshwm sim nyob rau hauv ntau metabolic tshua ntawm hlwb thiab koom nyob rau hauv lub decomposition ntawm cov proteins, carbohydrates, thiab lwm yam. Cov tshuaj thiab cov rog, yog li lub neej kev ua ub no ntawm tib neeg lub cev yog inseparable ntawm no coenzyme. Raws li cov hlwb muaj hnub nyoog lossis muaj mob, lawv cov lej yuav txo qis, thiab tib neeg yuav tsum tau ntxiv nicotinamide riboside kom nce cov ntsiab lus ntawm cov coenzyme (NAD +), yog li txhim kho qhov tseem ceeb ntawm cov hlwb thiab txhim kho ntau yam kev ua haujlwm ntawm tib neeg lub cev.

 

Vim li cas thiaj xaiv Guanjie?

● Peb yog ib tus kws tshaj lij NR bulk hmoov khoom muag, uas muaj txog 20 xyoo kev paub hauv kab no.
● CovNR Powderua los ntawm peb lub tuam txhab muaj kev ywj pheej tshawb fawb thiab kev loj hlob chaw, nyob rau hauv uas, muaj txog 10 tus kws tshaj lij.
●Qhov zoo ntawm peb cov Nicotinamide Riboside Bulk Powder yog ruaj khov thiab tuaj yeem khaws cia hauv chav sov rau lub sijhawm ntev.
●Tus nqi ntawm peb Nicotinamide Riboside Chloride Powder muaj kev sib tw nrog cov khoom zoo, txais tos nug.
● Peb lub Hoobkas tuaj yeem npaj cov khoom tseem ceeb txhua xyoo kom tsis txhob muaj kev ncua.
 

Certificate of Analysis

Kuaj	Txoj kev	Analyte	Specification	Kev tshwm sim
Txheeb xyuas	NMR	Nicotinamide Riboside Cloroid	Conforms rau cov qauv	Conforms rau cov qauv
Purity	HPLC/UV (wt%)	Nicotinamide Riboside Cloroid	98%	98.90%
Moisture	Karl Fischer	Dej	0.5%	0.30%
Residual Solvents	GC/FID Headspace	Ethyl acetate hmoov	5000 ppm * 5000 ppm * 5000 ppm * 5000 ppm * 410 ppm * 3000 ppm * 5000 ppm *	< 20 ppm < 21 ppm 9 00ppm 1200 ppm < 40 ppm 500 ppm NP
		Methyl acetate
		Acetic acid Acetone Cov tshuaj acetonitrile
		Methanol
		MTBE
Hnyav Hlau	ICP-MS	coj Arsenic Cadmium Mecury	0.5 ppm * 1 ppm * 1 ppm * 1 ppm *	< 0.030 ppm < 0.020 ppm < 0.030 ppm < 0.030 ppm
Microbial	USP<2021> USP<2021> USP<2022>	Tag nrho Plate suav Poov thiab Pwm E. coli	1000 CFU/g 100 CFU/g Tsis muaj / 10g	< 7 CFU/g < 6 CFU/g Tsis muaj / 10g
Qhov tshwm sim	NA	Xim, Daim Ntawv	Dawb rau lub teeb xim av hmoov	lub teeb xim av hmoov
Kev ceev ceev			0 5- 0.6 g/ml	0.51 g/ml
Kev cia khoom	Cia txias tshaj xoom degree C.. Tab sis, chav tsev kub thaum lub sij hawm xa khoom.

 

 

Flow Chart:

 

Txoj kev tsom xam:

● Zoo:Dawb rau lub teeb xim avNR Powder.

● Tus nqi PH hauv dej:( NR : 500mg , Pure water 5ml. ) Dissolved NR hauv dej ntshiab, ua kom nws cov concentrations hauv 100mg/ml, kuaj los ntawm pH meter. Tom qab 3 feeb coj cov txiaj ntsig.

Kev lees paub:PH nqi : 2.0~4.0.

 

● HPLC Purity

Kem: Xtimate C18 (4.6 × 250 nm, 5 μm)

Txawb theem A: 20mmol/L NaH2PO4 buffer solution (2.4g NaH2PO4 yaj hauv dej, siv 6 mol/L sodium hydroxide tov los kho pH rau 3.5, dilute mus rau 1000ml, thiab lim nrog 0.22 μm microporous membrane (aqueous membrane)).

Mobile theem B: methanol (chromatographic qib) Elution gradient

Sijhawm (Min)	Txawb theem A (%)	Mobile theem B (%)
0	99
4	99	1
5	95	5
10	85	15
12	80	20
12.1	99	1
16	99	1

 

Tus nqi ntws: 1.0ml / min ; Kem kub: 25 degree; Ntsuas wavelength: 260nm; Txhaj ntim: 20ul

 

Cov qauv kuaj ({{0}}.35mg/ml): Coj cov qauv kuaj tawm mus rau chav tsev (kub ntawm 25 degree C, 40%-60% av) thiab tau txais 0.35mg cov qauv kuaj thaum nws qhov kub thiab txias tuaj li qub .ces ntxiv cov dej ntshiab los ua cov tshuaj uas muaj 0.35mg ib 1ml .

Cov ntaub ntawv siv ({{0}}.35mg/ml): Nqa NR tawm mus rau hauv chav tsev (kub ntawm 25 degree C, 40%-60% humidity) thiab tau 0.35 mg cov qauv kuaj thaum nws qhov kub thiab txias tuaj, tom qab ntawd ntxiv cov dej ntshiab los ua cov tshuaj uas muaj 0.35mg ib 1ml.

 

Precisely noj 20ul ntawm cov tshuaj ntsuam xyuas saum toj no thiab cov kev siv tshuaj rau hauv cov kua chromatograph, thiab sau cov chromatogram. Lub sijhawm khaws cia ntawm lub ntsiab ncov ntawm qhov kev tshuaj ntsuam xyuas yog ua raws li lub sijhawm khaws cia ntawm lub ntsiab ncov ntawm kev siv tshuaj.

Acceptance criterion: Purity >98%

 

● Cov ntsiab lus dej

Cov dej huv: 10 ~ 30mg, cov kuab tshuaj yog methanol (AR) thiab formamide (AR) hauv lub raj mis titration hnyav. Sib tov nyob rau hauv ib qho ratio ntawm 2: 1 thiab co zoo. Cov khoom lag luam muaj Karl Fischer cov tshuaj ntsuam xyuas ncaj qha nrog lub ntsuas dej noo, thiab qhov ntsuas tau ua tiav peb zaug. RSD ntawm peb qhov txiaj ntsig yuav tsum tsis pub tshaj 3%. Yog tias nws siab dua 3%, qhov ntsuas tau ua dua ib zaug, thiab cov ntaub ntawv yuam kev raug muab pov tseg, thiab RSD rov suav dua kom txog thaum RSD ntawm 3 ntawm cov txiaj ntsig tau tsawg dua 3%.

Kev lees txais: Cov ntsiab lus dejTsawg dua los yog sib npaug 2% .

 

HPLC ntiv tes:

 

Puas yog Nicotinamide Riboside Hmoov Zoo?

US Food and Drug Administration tau tso cai nicotinamide riboside "New Food Ingredient (NDI)" raws li txoj cai.NR Powderkuj tau txais "Kev Pom Zoo Raws Li Kev Nyab Xeeb (GRAS)" raws li txoj cai, thiab tuaj yeem muab ntxiv rau ntau yam zaub mov thiab dej haus ntawm cov qib tau teev tseg. Hauv ntau cov kev tshawb fawb hauv vivo thiab hauv vitro toxicity, kev sim nruj tau pom tias nicotinamide riboside muaj kev nyab xeeb thaum noj ntawm qhov pom zoo koob tshuaj ntawm 3 mg ib kilogram ntawm lub cev hnyav ib hnub, lossis 180 mg ib hnub rau cov neeg laus. Tsis tas li ntawd, hauv ob qhov kev sim tshuaj, nws tau tshawb pom tias nws muaj kev nyab xeeb los noj 1000 mg ntawm nicotinamide riboside hmoov ib zaug ib hnub rau 6 hnub sib law liag.

 

Muaj nuj nqi:

● Ncua kev laus:
Nicotinamide riboside tuaj yeem rov ua haujlwm ntawm cov hlwb laus thiab rov ua kom lub cev tsis muaj zog ntawm tib neeg lub cev, thiaj li ua tiav lub hom phiaj ntawm kev ncua kev laus.

 

● Txhim kho cov hlab plawv:
NR hmoovtuaj yeem txhim kho kev ua haujlwm ntawm cardiomyocytes thiab vascular hlwb, thiab tseem txo cov ntshav lipid hauv cov hlab plawv. Yog li ntawd, nws tuaj yeem txhim kho cov hlab plawv.

Thiab ib txoj kev tshawb fawb 2019 ntawm cov neeg laus thiab cov laus tau pom tias noj qhov ncauj NR rau rau lub lis piam txo qis systolic ntshav siab thiab vascular txhav. Ob leeg ntshav siab thiab cov hlab ntsha tawv yog cov cim tseem ceeb ntawm cov kab mob plawv, yog li txoj kev tshawb no qhia tau hais tias kev noj tshuaj nicotinamide riboside tuaj yeem txo qhov kev pheej hmoo ntawm kev mob thiab kev tuag.

 

● Txhim kho lub hlwb noj qab haus huv:
NRC hmoov tuaj yeem txhim kho qhov tseem ceeb ntawm cov hlwb hlwb thiab lwm cov paj hlwb, thiab txhim kho kev ua haujlwm ntawm tag nrho cov paj hlwb. Yog li, nws tuaj yeem txhim kho lub hlwb kev noj qab haus huv thiab muaj txiaj ntsig zoo rau Alzheimer's disease.

 

● Txhim kho cov roj metabolism:
Nicotinamide riboside hmoov ntau tuaj yeem txo lub cev nqus cov lipids hauv cov zaub mov, nce kev noj cov rog hauv cov rog, thiab ua tiav lub hom phiaj ntawm kev poob phaus.

 

● Cosmetic nyhuv:
NR Powdertuaj yeem txhim kho kev ua haujlwm ntawm cov hlwb epidermal, nrog rau kev ua haujlwm ntawm lwm cov hlwb hauv lub cev, thiab tuaj yeem ua rau cov tawv nqaij hluas.

 

● Txhawb Kev Paub Txog Kev Noj Qab Haus Huv

Raws li ib tug precursor rau NAD +, nicotinamide riboside tiv thaiv hlwb hlwb los ntawm oxidative kev nyuaj siab uas yuav ua rau muaj hnub nyoog txog cov kab mob hlwb.

Kev tshawb fawb luam tawm nyob rau hauv Neurobiology Aging qhia tias NAD + boosts zus tau tej cov PGC -1-, ib tug protein uas txhim kho mitochondrial muaj nuj nqi thiab txo cov kev pheej hmoo ntawm kev txawj ntse.
Cov kws tshawb fawb ntawm National Institute on Aging hauv Maryland tau tshawb pom tias hauv cov nas, NAD + deficiency ua rau neuroinflamation, DNA puas, thiab neuronal degeneration hauv Alzheimer's kab mob. Kev tshawb fawb ntxiv yog xav tau kom nkag siab tag nrho yuav ua li cas nce NAD + qib nrog NR supplementation txhim kho kev paub txog kev noj qab haus huv, tab sis txoj kev tshawb fawb tam sim no zoo li cog lus.

Txo txoj kev pheej hmoo ntawm kab mob plawv

 

Cov Lus Qhia Ntxiv thiab Kev Siv Tshuaj
Cov tshuaj Nicotinamide riboside muaj nyob hauv NR tab, NR capsule, thiabNR hmoovdaim ntawv. Qhov kev pom zoo ntau npaum li cas rau nicotinamide riboside yog noj 250-500 mg ib hnub. Qhov loj me me nyob ntawm lub hom, tab sis kev pom zoo siv feem ntau yog ib mus rau ob lub tshuaj ntsiav ib hnub.

NR cov tshuaj pab qee zaum tau tshaj tawm lossis sau tias "tsis muaj dej ntws". Qhov no yog vim nicotinamide riboside tsis zoo li yuav ua rau dej ntws tawm, uas tuaj yeem ua rau muaj kev cuam tshuam ntawm niacin hu ua niacin flushing. Siv NR cov tshuaj ntxiv yog txoj hauv kev zoo tshaj plaws los nce qib NAD +. Txawm li cas los xij, me me ntawm cov vitamin kuj muaj nyob hauv cov mis nyuj thiab cov poov xab.

 

Peb lub Hoobkas:

Muaj ob lub chaw tsim khoom hauv Baoji nroog thiab Shangluo City, Guanjie cov chaw ua haujlwm npog thaj tsam ntawm 7000㎡, suav nrog GMP tus qauv rhiav ntawm 2000㎡.

 

Cov khoom tsim nyog

NRC hmoov yog tsim nyob rau hauv ib qho chaw ua haujlwm huv si thiab txhua kauj ruam yog ua los ntawm cov kws tshaj lij. Ob qhov txheej txheem ntawm kev tsim khoom thiab nws tus kheej ua tau raws li txhua tus qauv thoob ntiaj teb. Thiab yog tias koj xav tau peb tsab ntawv ceeb toom, peb tuaj yeem muab rau koj.

Daim ntawv pov thawj

 

Ntim & Xa khoom

Cim npe nrov: nr hmoov, Tuam Tshoj nrum hmoov manufacturers, lwm tus neeg, Hoobkas