Ursodeoxychocic acid Udcatau tawm los ua lub pob zeb kho mob kho mob hauv cov kws kho tsiaj Hepatology. Ameslikas pom nyob rau hauv dais bile (lub npe "UPOPS" yog tau los ntawm Latin rau "dais"), nws yog tam sim no tsim tawm synthetical siv, ua kom muaj kev sib xws thiab kev coj ua. Hauv cov dev, UDCA feem ntau siv los tswj cov spectrum ntawm cov kab mob siab ntev. Nws kho tus nqi lus dag tsis nyob hauv ib qho kev txiav txim, tab sis nyob rau hauv ib tug multifaceted mechanism uas lub hom phiaj kev mob siab ntawm Hepatobiliary tsis sib haum xeeb. Kab lus no yuav muab cov ncauj lus kom ntxaws ntawm dab tsi UDCA ua rau cov dev, txhawb los ntawm cov pov thawj scientific.
Dab tsi yog txoj haujlwm ntawm UDCA?
Cov tshuaj kho tau ntawmUrsodeoxychocic acid Udcayog ntaus nqi rau kev sib xyaw ua ke ntawm cov tshuab sib tshuam.
Choleret nyhuv
UDCA stimulates lub zais ntawm bile los ntawm hepatocytes rau hauv biliary Canaliauli. Qhov kev hnoos qeev no feem ntau ua tiav los ntawm kev ua kom cov neeg thauj khoom tshwj xeeb hauv lub cell membrane, xws li cov kua zaub ntsev export (BSSP). Los ntawm nce bile flow, UDCA pab kom yaug tawm cov kua txob lom Qhov no "rinsing" kev ua haujlwm pab kom tiv thaiv cholestasis (tus stagnation ntawm bile), uas yog ib qho kev cuam tshuam ntawm cov kab mob siab uas tuaj yeem ua rau kev puas tsuaj ntxiv.
Tiv Thaiv Hepatocytes
Nov yog ib qho ntawm UDCA qhov tseem ceeb tshaj plaws. Nws sib xyaw ua ke rau hauv Hepatocyte lub cell membrane, ruaj khov nws cov qauv thiab ua rau nws tiv thaiv ntau dua rau cov kev cuam tshuam bile acids. Los ntawm kev ua li ntawd, nws txo cov membbrane permeability thiab tiv thaiv lub cell los ntawm kev ua kom huv.Ursodeoxychocic acid Udcatau pom tias muaj kev cuam tshuam mitochondrial txoj kev ntawm apoptosis, lub keych ua ke ntawm kev tuag ntawm tes tuag hauv daim siab raug mob.
Anti -} inflammatory
Yuav luag mob lub siab sim yog yuav luag ib txwm muaj mob. UDCA modulates the immune response by reducing the expression of major histocompatibility complex (MHC) class I and II molecules on hepatocytes and cholangiocytes (bile duct cells). Qhov kev txiav txim siab no ua rau cov hlwb no tsis pom rau lub cev tiv thaiv kab mob, yog li muaj autenuualating autoimmune- kev tawm tsam kev tawm tsam. Tsis tas li ntawd, UDCA interhits qhov ntau lawm -} pa cytokines uas tsav cov txheej txheem mob.
Antifibricoticical Muaj Peev Xwm
Nrog rau lub siab mob, daim siab ua haujlwm los ntawm kev tso cov ntaub so ntswg fibrous, ua rau fibrosis thiab thaum kawg rau kev mob siab. Thaum Udca tsis yog thawj cov tshuaj tiv thaiv kev ua yeeb yam, nws cytoprotective thiab anti- {incammatory kev loj hlob tuaj yeem ua rau tus neeg tsav tsheb ntxov los ntawm kev raug mob thawj zaug- hepatocyte kev raug mob. Qee cov pov thawj qhia tias nws kuj tseem tuaj yeem tiv thaiv cov kab mob hepatic stellate, tus thawj lub xov tooj ntawm lub luag haujlwm rau kev ua collagen thiab lwm yam kev ua haujlwm.
Li casPuas yog UDCA cuam tshuambile?
Ursodeoxychocic acid UdcaStimulates lub zais cia ntawm bicarbonate - nplua nuj bile ntws. Qhov no "Bicarbonate Kaus lub kaus" Tiv thaiv cov kua tsib dog dig, muab lwm txheej ntawm cov kab mob cuam tshuam rau cov kab mob uas cuam tshuam rau cov kab mob biliary.
Dab tsi Ursodeoxychholic acid ua rau dev?
Lub theoretical tshuab ntawm UDCA yog sib sau, tab sis nws tus nqi tau lees paub los ntawm cov pov thawj kev kuaj mob thiab siv thoob plaws hauv canine hepatonic.
Kev muaj kab mob siab phem
Kev mob siab ntev yog ib qho tseem ceeb tshaj plaws rau UDCA hauv cov dev. Nws yog qhov mob nce qib uas tuaj yeem ua rau fibrosis thiab mob siab ua tsis tiav. Thaum lub sijhawm thawj zaug kev kho mob feem ntau koom nrog immunosuppressives zoo li corticosteroids yog tias tiv thaiv {2} Kev siv tshuaj tiv thaiv acid Udca yog qhov tseem ceeb uas tseem ceeb txuas kev kho.
Kev tshawb nrhiav hauv lub hauv paus los ntawm Center et al. (1999) tshawb xyuas qhov cuam tshuam ntawm UDCA hauv cov dev uas muaj kab mob siab ib txwm muaj. Txoj kev tshawb nrhiav pom tias UDCA Administres tau cuam tshuam nrog kev txhim kho tseem ceeb hauv daim siab enzyme qib (tshwj xeeb alt thiab alp) thiab txo cov ntshav plab cov kua txiv accoment. Kev soj ntsuam keeb kwm kev soj ntsuam kuj tau pom zoo kom txo qis hauv kev mob hepatic thiab necrosis. Txoj kev tshawb no tau xaus tias Udca yog "muaj txiaj ntsig kho tus neeg sawv cev rau cov dev uas muaj kab mob siab."
Nyob rau hauv tus kab mob siab ntev, Udca's anti {{{ Nws tiv thaiv hepatocytes los ntawm kev puas tsuaj los ntawm kev puas tsuaj thaum lub pib ua haujlwm yog tswj, ua rau cov txiaj ntsig zoo dua thiab cov kab mob muaj peev xwm qeeb.
Mob raum mob siab
Tej yam mob uas cuam tshuam los yog cuam tshuam rau cov kua tsib (chollypication), lossis cov pa roj hmab rau hauv cov nplais, los yog biliary sludge, bilgatic bileing thaiv kev, kev ua rau cholestasis. Tus thaub qab ntawm Bile cov kua txiv qaub ua rau muaj kev puas tsuaj loj.
Cov tshuaj cholu hlau ntawm ursodeoxychocolic acid Udca yog zoo - cov ntaub ntawv hauv tib neeg thiab cov kws tshaj lij. Los ntawm kev txhim kho qhov khiav ntawm tsawg toxic bile, UDCA pab kom decompress cov kab mob raug mob thiab txo cov tshuaj tua kab mob los ntawm kev ruam, muaj cov roj ntsha toxic bile acids. Thaum phais kev cuam tshuam feem ntau yuav tsum muaj rau kev siv thaiv kev ua tiav, Udca yog qhov tseem ceeb rau kev tswj kev ua mob ua rau kev kho mob los tswj kev kho mob bile du.
UDCA yog cov tshuaj xaiv rau kev tswj hwm intraepatic cholestasis. Nws pab kom "yaug" lub kaw lus, txo txoj kev pheej hmoo ntawm sludge tsim thiab tiv thaiv cov bile sing hlwb thaum lub sijhawm ntws tawm.
Tooj liab - koom nrog Hepatopathy
Qee tus dev breeds, xws li Bedlington Terriers, West Highland Dawb terriers, thiab Dobman pinschars, yog predethposed rau kev ntaus caj ces uas ua rau lub siab loj heev hauv lub siab. No cia tooj liab catchalyzes kev tsim cov dawb radicals, ua rau oxidative kev ntxhov siab, kab mob siab, thiab tus kab mob siab.
UrsodeoxYColic Acid Udca yog ib feem ntawm kev tswj hwm kev tswj hwm rau kev tswj hwm hepiecathy, nrog delation {4} {{5} {} tooj liab noj. Kev kawm los ntawm Hoffmann (2009) ntawm kev kho mob canine tooj liab-}}}}}}}}}}}}}}}} Cov nqi hluav taws xob tseem ceeb ntawm UDCA. Nws cov tshuaj antioxidant thaj chaw ncaj qha rau kev puas tsuaj oxidative los ntawm tooj liab. Tsis tas li ntawd, nws cov tshuaj chev choleretic ua rau lub ntsej muag ntawm tooj liab ntawm cov bile, uas yog lub cev txoj kev rau kev tshem tawm cov tooj liab ntau dhau ntau.
UDCA provides a dual benefit in this condition: it protects liver cells from copper-induced damage and facilitates the removal of copper from the liver.
Lub Plawv Zob Hlab Mucocele
Lub taub cev yog ib qho mob hnyav yog qhov mob uas yog qhov tsis txaus ntseeg, cov tshuaj tsw qab, cov kua txob peritonitis, thiab kev tuag. While surgery is the definitive treatment for symptomatic or high-risk mucoceles, UDCA has a role in medical management for incidental, non-obstructive mucoceles or as a postoperative supplement.
Kev siv ntawm urtsodoxychocolic acid Udca rau mucoceles yog ntau dua anecdotal thiab raws li pathhotysiological cov ntsiab cai ntau dua li loj- teev tswj kev sim siab. Qhov kev tshawb xav yog tias los ntawm kev txhawb nqa gallbladder thiab zais pa ntawm ib tug tsawg dua viscous, ntau dua watile bile, ntau dua cov dej ntws thiab kev sib hwm uas ua rau muaj kev sib txuam. Kev kawm los ntawm kev ua noj li al. (2016) ntawm Kev Tswj Xyuas Kev Kho Mob ntawm Gallbladder Mucoceles suav nrog UDCA, feem ntau ua kev sib xyaw ua ke nrog lwm cov tshuaj, txawm hais tias qhov chaw no yuav tsum muaj kev tshawb nrhiav ntau dua.
A: Kev tswj hwm lub computer (cnc) Cov txheej txheem tuaj yeem siv los tswj cov tshuab ntau ntawm cov tshuab ua ke, los ntawm girnders thiab lathes rau cov micts thiab CNC routers.
Yog UDCA muaj kev nyab xeeb rau cov dev?
UDCA feem ntau yog tswj hwm qhov ncauj lus ntawm kev txhaj tshuaj ntau npaum li ntawm 10-15 mg / kg ib zaug lossis ob zaug ib hnub. Nws yog qhov zoo tshaj plaws muab nrog cov khoom noj kom txhim kho nws cov kev nqus thiab los txhawb cov flatobbladder khoob, uas synergizes nrog nws cov nyhuv choleretic.
● Kev nyab xeeb thiab kev mob:
UDCA feem ntau suav tias muaj kev nyab xeeb rau dev. Cov kev mob tshwm sim muaj tsawg thiab feem ntau feem ntau, muaj peev xwm suav nrog ntuav, raws plab, lossis tsis muaj zog. Cov no feem ntau hloov chaw thiab tuaj yeem raug txo los ntawm kev tswj hwm cov tshuaj noj nrog ib pluas noj.
● Cov kev tsis tseem ceeb thiab kev txiav txim siab:
Ursodeoxychocic acid Udca yuav tsum tsis txhob siv nyob rau hauv cov neeg mob ua tiav extraeepatic bile slection thaiv. Txij li UDCA stimulates bile ntau lawm, tswj hwm nws thaum bile dev yog qhov kev cuam tshuam loj tuaj yeem ua rau tawg ntawm lub qog lossis cov kua txiv. Yog li no, tus kws kho tsiaj yuav tsum lees paub qhov kev ua tiav ntawm cov txheej txheem biliary ua ntej pib kho kev kho.
Qhov zoo tshaj ntawm ursodeoxychholic acid tej hmoov hmoov zoo siv yog qhov tseem ceeb rau kev ua tau zoo thiab kev nyab xeeb. Cov neeg xa khoom, xws li Guanjie Biotech, ib qho loj ursodeoxychholic acid cov khoom siv uas ua kom pom tseeb thiab huv si, uas yog qhov tseem ceeb rau kev hais ua kom zoo rau hauv cov neeg kho vajtse. Yog tias koj yog tus neeg xa khoom ntxiv, txais tos nug nrog peb ntawminfo@gybiotech.com.
Tag
Ursodeoxychocic acid Udcatau ruaj khov tsim nws tus kheej ua qhov tseem ceeb, ntau -} tsom hepatoprotureive tus neeg sawv cev hauv cov kws kho tsiaj. Nws cov txiaj ntsig rau cov dev nrog kab mob siab tsis yog raws li ib qho txuj ci tseem ceeb. Tseem, nyob rau ib qho zoo - elucidated symphidated, nws tiv thaiv cov dej pheeb suab los ntawm kev tuag, thiab kev sib txuas ntawm kev ntxhov siab oxidations. Cov ntaub ntawv pov thawj los ntawm kev tshawb fawb soj ntsuam thiab ntau caum xyoo kev siv tsiaj ua haujlwm txhawb nws txoj kev siv tus kab mob siab, coppes cov kab mob, thiab lwm yam kev mob hepatobiliary.
Guanjie Biotech yog ib qho loj ursodeoxychholic acid tsum, uas yog qhov tseem ceeb rau kev ntseeg tau kom tau txais kev pab kom tau txais kev pab tau thiab ua tau zoo UDCA rau lawv cov neeg mob canine. Txais tos rau nug nrog peb ntawm info@gybiotech.com.
Ntawv Sawv cev
[1] Chaw, SA, Warner, KL, & ERB, HN (1999). Daim siab ua kom lub siab glutathione ntau dua hauv cov dev thiab miv nrog ntom tshwm sim rau daim siab. American Journal of Veterinary Kev Tshawb Fawb, 60 (5), 672-677. (Qhov kev kawm no, thaum tsom ntsoov rau Glutathione, yog ib feem ntawm lub cev ntawm kev ua haujlwm los ntawm ib pab pawg neeg nyob hauv kws kho tsiaj Hepatology uas muaj kev soj ntsuam ntau yam UdCA).
[2] Chaw, SA (2005). Cov metabolic, antioxidant, nutraceietical, probioticutical, thiab tshuaj ntsuab kev kho cuam tshuam nrog kev tswj hwm ntawm cov hepatobiliary tsis sib haum. Cov chaw kho kws kho tsiaj ntawm North America: Kev xyaum me me, 35 (1), 81-104.
[3] Hoffmann, G. (2009). Tooj liab -} cuam tshuam rau cov kev sim siab. Cov chaw kho kws kho tsiaj ntawm North America: Kev xyaum me me, 39 (3), 489-511.
[4] Ua noj, AK, Wright, ZM, & Swbodolski, JS (2016). Kev ntsuam xyuas kev nyab xeeb ntawm kev nyab xeeb thiab kev ua tau zoo ntawm ursodeoxychocic acid thiab taurine nyob rau hauv kev kho mob ntawm GallCele hauv dev. Phau ntawv Journal ntawm Asmeskas Asmeskas Tus Tsev Kho Mob Menyuam Mos, 52 (2), 77-84.
[5] Pazzi, P., PUVIAN, AC, & OTTOLURGENGI, C. (2004). Lub luag haujlwm ntawm ursodeoxychocolic acid nyob rau hauv kev tswj hwm ntawm kev mob hlwb. Cov chaw kuaj mob tam sim no, 1 (1), 41-46.
[6] Rodrigues, CM, & Hla, CJ (2001). Kev kho mob ntawm urtsodeoxychholic acid ua ib qho anti - agoptotic tus neeg sawv cev. Cov kws tshaj lij ntawm cov kws tshaj lij ntawm kev soj ntsuam cov tshuaj, 10 (7), 1243-1253.
