Ntuj phosphaterylserine ntshiabYog cov phosphogyceride phospholipid, yog qhov tseem ceeb thiab qhov tseem ceeb ntawm cov roj ntsha cov tshuaj. Nws tsis yog ib qho kev coj ua vaj tsev. Nws tshwj xeeb lub cev thiab kev faib cov khoom noj asymmetric nyob rau hauv cell membrane nws tseem ceeb ua haujlwm (agoptosis (programmed cell tuag), thiab kev saib xyuas ntawm neuronal kev ncaj ncees. Lo lus nug "Qhov twg phosphatidylserine pom?" tuaj yeem teb tau ntawm ntau theem: los ntawm macroscopic (kev noj haus cov khoom siv) mus rau lub microscopic (cellular thiab subcainular intocization).
Noj Zaub PhosphatidylserineSpeb uaNnyob rau hauv
Tib neeg lub cev tuaj yeem suav nrog phosphaterine Endogenously los ntawm lub hauv paus {{kev hloov pauv nrog phosphatidylcholine thiab phosphatidylylashanline. Txawm li cas los xij, qhov xwm txheej no yuav tsis muaj qhov txaus, tshwj xeeb nrog kev laus lossis kev noj haus kom muaj kev noj haus tseem ceeb rau kev ua kom zoo tshaj rau qib. Cov ntaub ntawv pov thawj rau ntuj phosphaterline ntshiab hauv cov khoom noj tau los ntawm kev ntsuas cov tshuaj chromatography (HPLC) txuas ntxiv rau cov khoom siv chromatography)
Tsiaj -} Cov khoom siv tau
Keeb kwm, kev noj zaub mov nplua nuj tshaj plaws ntawm phosphaterylserine qhov twg ntawm cov tsiaj keeb kwm, tshwj xeeb yog khoom nruab nrog nqaij thiab lub hlwb.
• Bovine lub hlwb:
Rau kaum xyoo, bovine lub hlwb lub hlwb cortex yog qhov tseem ceeb ntawm lub ntsej muag zoo nkauj rau kev tshawb fawb thiab tshuaj noj thaum ntxov. Kev tshawb nrhiav kev tshawb nrhiav tau ua ntu zus nws kom muaj qhov siab tshaj plaws ntawm ntuj phosphaterline ntawm cov zaub mov ntuj. Cov ntaub ntawv pov thawj los ntawm cov txheej txheem huv si qhia tias PS tuaj yeem tsim mus txog 15% ntawm tag nrho cov phospholipids hauv lub hlwb bovine. Txawm li cas los xij, vim muaj kev txhawj xeeb tshaj transmissible spongiform encephalopathies (piv txwv li, kev siv based tau muaj feem cuam tshuam nrog kev nyab xeeb ntawm kev nyab xeeb ntawm kev nyab xeeb ntawm kev nyab xeeb ntawm kev nyab xeeb ntawm kev nyab xeeb ntawm kev nyab xeeb ntawm kev nyab xeeb ntawm kev nyab xeeb ntawm kev nyab xeeb.
• Qaib lub plawv thiab lwm yam zaub noj nqaij:
Nqaij qaib thiab ntses thiab ntses thiab cov chaw tseem ceeb. Piv txwv li, lub plawv nqaij qaib tau txheeb xyuas raws li muaj feem ntau ntawm PS. Ib txoj kev tshawb fawb tshuaj pleev ntau cov nqaij los ntawm - Cov khoom pom pom tias feem pua sab hauv, thiab feem ntau dua ntawm cov uas yog cov nqaij leeg leeg.
• ntses:
Qee cov ntses, tshwj xeeb yog mackerel, onlantic herring, thiab tuna, yog cov txiaj ntsig zoo ntawm ntuj phosphaterline ntshiab. Phospholipid muaj pes tsawg leeg ntawm ntses roe (qe) kuj yog qhov tseem ceeb. Cov ntaub ntawv pov thawj ntawm daim ntaub thaiv li Lipidomic, uas qhia tau tias feem pua fatty ntses suav nrog cov peev txheej muaj txiaj ntsig ntawm cov nqaij nruab cev.
• Cov khoom noj siv mis:
Mis nyuj thiab cheese muaj ntuj phaosterylserine ntshiab, feem ntau nyob rau hauv cov mis nyuj muaj rog globule membrane (mfgm). MFGM yog ib tug qauv ua qauv nyuaj heev nplua nuj nyob hauv Phospholipids, thiab PS yog ib qho xwm yeem, thim rov qab, tivthaiv. Kev tshawb fawb tias ntau meej txog cov khoom noj mis nyuj tau pom tias PS feem ntau account tau pom rau 2-6% ntawm tag nrho cov phospholipids hauv MFGM.
Tsob nroj -} Cov khoom siv tau
• Soyean Lecithin:
Qhov no yog cov nroj tsuag tseem ceeb tshaj plaws- nyob ntawm qhov chaw thiab cov khoom siv ntawm thawj cov khoom siv tshiab rau cov khoom siv niaj hnub no. SoyBeans lawv tus kheej muaj tag nrho cov ntaub ntawv phospholip. Thaum phosphatidylcholine yog qhov muaj ntau tshaj plaws, PS yog tam sim no nyob rau hauv me me. Cov lag luam ntau lawm ntawm sy - derived PS muaj ntau yam kev sib cav sib ceg ntawm kev ua kom zoo nkauj phospholipase (zoo li phosphologipase (zoo li phospholterine d hauv tus txheej txheem hu ua transphosphatidylation. Cov ntaub ntawv pov thawj los ntawm kev tsim cov patents thiab kev tswj kom zoo tam sim ntawd qhov siab- purity ps (feem ntau tshaj 50%) tuaj yeem ntseeg tau tawm los ntawm soy.
• Cov taum dawb thiab lwm yam legumes:
Ntawm tag nrho cov zaub mov, taum dawb (thiab rau ib qho tsawg dua, lwm yam li lentils thiab chickpeas) tau pom tias muaj siab dua PS cov ntsiab lus. Txawm li cas los xij, tus nqi tsis tshua muaj. Txhawm rau kom tau txais cov tshuaj uas tseem ceeb uas cuam tshuam (piv txwv li, 100-300 mg), ib qho yuav tsum tau haus cov khoom muaj tsawg ntawm cov zaub mov no.
• Mov thiab sunflower Lecithin:
Cov no yog tshwm sim ua lwm cov khoom cog ntoo, tshwj xeeb rau cov tib neeg uas muaj ua xua. Cov ntsiab lus phospholipid ntawm Rice cov nplej uas yog cov noob paj noob hlis suav nrog phosphatidylserine, txawm hais tias qhov tag nrho cov txiaj ntsig yog feem ntau qis dua los ntawm cov kua muag. Cov ntaub ntawv pov thawj rau lawv siv yog loj hlob raws li cov tuam ntxhab nrhiav kev sib tw muab kev sib tw sib txuas thiab kev ua lag luam tsis pub muaj kev ua xua. Guanjie Biotech yog ib qho loj phosphaterine cov khoom lag luam uas feem ntau yog los ntawm kev ua yeeb yam los ntawm kev ua yeeb yam ntawm kev coj dawb huv thiab kev ua xua {5} nco tau ntau lawm.
Thawj cov pov thawj rau cov phosphatidylylserine ntshiab hauv cov zaub mov yog chromatographic. Piv txwv li, yog seminal ntawv los ntawm DJs li al. (2000) Siv HPLC los tshuaj xyuas cov phospholipid sib xyaw ntau yam, muab cov ntaub ntawv ntau tshaj, ua raws li los ntawm lwm cov tsiaj thiab cov ntses, thiab tom qab ntawd cog cov khoom siv zoo li kua taum. Cov ntaub ntawv tshawb nrhiav no ua rau cov tswv yim rau kev noj zaub mov thiab cov tswv yim ntawm cov tswv yim ntawm kev lag luam nutraceutical.
A: Kev tswj hwm lub computer (cnc) Cov txheej txheem tuaj yeem siv los tswj cov tshuab ntau ntawm cov tshuab ua ke, los ntawm girnders thiab lathes rau cov micts thiab CNC routers.
Phosphatidylserine Hauv tib neeg lub cev
Kev faib tawm PS nyob rau hauv lub cev tsis yog khaub ncaws. Nws qhov chaw nyob tau tshwj xeeb thiab ua haujlwm tseem ceeb, nrog cov pov thawj tshaj plaws los ntawm Biology Cell, Biochemistry, thiab cov kev ua haujlwm ua haujlwm.
• Muaj siab nyob rau hauv lub hlwb:
Lub paj hlwb muaj lub cev cov qib siab tshaj plaws, muaj li 10-15% ntawm nws cov phospholipids tag nrho. Nws yog qhov tseem ceeb rau kev tswj hwm neuronal membrane fluidity, txhawb cov neurotransmitter tso tawm, thiab ua haujlwm yooj yim thiab kev kawm.
• Asymmetric ntshav membma Faib:
Hauv kev noj qab haus huv hlwb, ntuj phosphatidylserine ntshiab tsis tau muab faib rau tusyees. Nws yog nquag tswj nyob rau sab hauv (cytosolic) daim ntawv qhia txog ntshav memma los ntawm cov enzymes hu ua flippases. Cov asymmetry no yog qhov tseem ceeb ntawm kev muaj mob condility.
• Cov txheej txheem sab nraud raws li lub teeb liab tseem ceeb:
Cov tswj kev txav ntawm PS mus rau sab nraud daim paib yog teeb liab tseem ceeb heev. Qhov no tshwm sim thaum lub sijhawm:
Apoptosis: Kos npe Phemocytic cells mus rau ENGULF cov cying dying.
Ntshav Clotting: Muab ib qho saum npoo rau coagulation yam hauv platelets.
• Muaj nyob rau lwm cov ntaub so ntswg:
PS pom thoob plaws lub cev, nrog cov leeg loj hauv cov leeg pob txha (txhawb hluav taws xob metabolism) thiab cov kab mob tiv thaiv kab mob (kho cov phiajcim ntawm tes). Nws tseem yog ib qho kev tiv thaiv loj ntawm intracellular ib daim nyias nyias, xws li cov ntawm mitochondria thiab endosomes.
Kev Lag Luam thiab Ntxiv Khoom
Muab cov kev cov nyom ntawm kev tau txais cov koob tshuaj kho mob ntawm cov tsiaj phosphaterycserine ntshiab (100}} Khib / hnub) los ntawm tag nrho cov khoom noj, kev ua lag luam ntxiv tau ua tiav. Cov ntaub ntawv pov thawj rau kev ua tau zoo ntawm cov tshuaj no tau muab los ntawm kev sim tshuaj, uas nyob rau ntawm kev ntseeg siab ntawm lub siab- zoo ps.
Evolution ntawm cov khoom:
Ua ntej -}} cortex): cov kev sim siab thaum ntxov thiab 90s tau txais txiaj ntsig zoo hauv cov neeg laus hauv lub hlwb los ntawm Bovine Bris. Cov ntaub ntawv pov thawj rau nws txoj kev ua tau zoo yog muaj zog, tab sis kev txhawj xeeb kev nyab xeeb coj mus ua haujlwm.
• Thib ob -} - raws):
Kev tshawb fawb tom ntej tau tsom mus rau kev tsim kom muaj kev sib txig sib luag ntawm - derated tsiaj phosphaterline ntshiab. Lub cev tseem ceeb ntawm cov pov thawj los ntawm cov kev sim tshuaj ntsuam uas tau muab piv rau lossis siv sia- ps. Piv txwv li, kev ntsuam xyuas xyoo 2001 los ntawm Kidd xaus tias soy - ps cov kev kawm txog kev nco qab uas yog muab piv rau kev tshawb fawb thaum ntxov. Qhov no yuav tsum muaj cov kua yias - ps kom zoo - tus cwj pwm thiab ntawm siab purity.
• Thib Peb {{-} tiam (lwm yam nroj tsuag thiab marine chaw):
Kev Tshawb Fawb Txog Kev Tshawb Fawb PS los ntawm Sunflowers thiab lwm yam kom muaj feem rau kev xav tau kev noj haus tshwj xeeb.
Lub luag haujlwm ntawm bulk supLub thoob:
Lub sib xws thiab zoo ntawm lub ntuj phosphaterycserine ntshiab siv hauv kev sim tshuaj thiab cov khoom lag luam yog qhov tseem ceeb tshaj plaws. Nov yog cov tuam txhab uas ua tshwj xeeb hauv qhov loj- teev cov phospholipids yog qhov tseem ceeb. Ntxig Guanjie Biotech yog ib qho loj phosphaterycserine uas ua haujlwm nyob rau hauv qhov chaw no. Cov ntaub ntawv pov thawj rau qhov zoo ntawm lawv cov khoom yuav pom nyob hauv:
• Cov ntaub ntawv pov hwm ntawm kev tsom xam (COA):
Cov ntaub ntawv no, muab los ntawm lub ntuj phosphaterycserine ntshiab, nthuav dav lub purity ntawm ps (piv txwv li muaj kev sib txig sib luag zoo li cov hlau hnyav xws li cov hlau hnyav thiab cov kuab tshuaj thiab cov microbial.
• Cov Qauv Raug Raug:
Kev ua raws li cov qauv zoo li ISO, CGMP (tam sim no kev tsim kho cov ntaub ntawv zoo) muab pov thawj ntawm cov txheej txheem tswj tau ntau lawm. Lub Enzymatic hloov dua tshiab los ntawm soy lecithin yog cov txheej txheem ntse uas yuav tsum muaj kev txawj ntse.
• Cov ntaub ntawv kev ruaj khov thiab cov ntaub ntawv:
Cov ntaub ntawv ua pov thawj tias lub ntuj phosphaterline ntshiab yog ruaj khov nyob rau hauv nws daim ntawv form thiab yog bioavailable thaum encapsulated rau hauv cov khoom kawg.
Lub neej ntawm kev ntseeg tau ntau phos phosphaterine yog qhov yuav tsum tau ua ua ntej rau cov ntaub ntawv pov thawj hauv chaw kho mob uas txhawb nqa PS kev ntxiv. Yog tsis muaj ib qho xwm txheej, siab- Cov khoom siv raw, kev sim tshuaj yuav tsis muaj txiaj ntsig, thiab cov neeg siv khoom yuav tsis muaj txiaj ntsig.
Tag
Hauv cov ntsiab lus, ntuj phosphaterylserine ntshiab yog pom nyob rau hauv lub fasciningly tshwj xeeb thiab ua haujlwm tau txiav txim siab thoob plaws ntau teev ntawm biology. Kev noj haus muaj zog, nws yog lub hlwb thiab lub plawv tau muab los ntawm guanjie biotech muab cov khoom lag luam guaranterley rau kev lag luam nutraceutical. Hauv tib neeg lub cev, nws yog ntau tshaj nyob rau hauv lub hlwb thiab cov paj hlwb, tab sis nws qhov chaw ua haujlwm tau txhais los ntawm nws txoj kev faib tawm asymmetric faib hauv lub ntshav membrane. Yog li ntawd, teb "Qhov twg phosphatidylserine pom?" Yuav tsum muaj ntau {{- Faceted Cov Khoom Noj, encompining kev lag luam, txhua yam uas tau txais kev txhawb nqa los ntawm lub cev muaj zog thiab hloov zuj zus ntawm lub cev scientific. Yog tias koj xav tau ntuj phosphaterylserine ntshiab, zoo siab txais tos nug Guanjie Biotech ntawminfo@gybiotech.com.
Ntawv Sawv cev
[1] Kidd, PM (2001). Phosphatidylserine: membrane asfi assient rau kev nco. Kev soj ntsuam thiab kev soj ntsuam kev sivchicistic. Lwm yam tshuaj xyuas tshuaj xyuas, 6 (2), 142-152.
[2] Kim, Hy, Huang, BX, & Spector, AA (2014). Phosphatidylserine nyob rau hauv lub hlwb: metabolism thiab muaj nuj nqi. Kev kawm hauv Lipid kev tshawb fawb, 56, 1-18.
[3] Vance, JE, & Tasseva, G. (2013). Tsim thiab muaj nuj nqi ntawm phosphatidylserine thiab phosphatidylyletyllethanbon hauv cov tsiaj mammalian hlwb. Biochimica thiab biophysica Acta (BBA) {{{{{{{{{{{{}} molecular thiab biology ntawm lipids, 1831 (543-554.
[4] SF li al. (2000). Kev tsom xam ntau ntawm phosphaterine, phosphatidic acid thiab phosphatidylchology hauv high {6} Kev ua kua chratography nrog evaporative lub teeb pom kev zoo. Phau ntawv Journal ntawm cov chromatography a, 876 (1-2), 233-236.
[5] Jorissen, Bl, Li Al. (2002). Tus cawv ntawm syn - doldived phosphaterycserine ntawm kev nkag siab hauv lub hnub nyoog {}} inidientiam anagnitment tsis zoo. Khoom noj zaub mov neuroscience, 5 (5), 337-343.
[6] OP Den KAM, JA (1979). Lipid Asymmetry hauv cov ntaub nyias nyias. Kev tshuaj xyuas txhua xyoo ntawm biochemistry, 48 (1), 47-71.
