Cov zaub mov muaj siab nyob hauv urolithin li cas?

Ntshiab urolithin ib qho hmoovtau nyiam ntau anti -} kev txhawj xeeb. Nyob rau hauv lub siab tsis tau ntawm kev noj qab haus huv thiab kev ncua sijhawm, lub zej zog science txuas ntxiv hloov nws lub ntsej muag ntawm tib neeg cov metabolism thiab cov micronutrients uas cuam tshuam nws. Tsis zoo li cov vitamins lossis cov zaub mov noj ncaj qha los ntawm cov zaub mov, ntshiab yog cov hmoov tsis pom nyob hauv cov khoom noj. Nws zaj dab neeg yog ib qho qauv zoo tshaj plaws ntawm lub zwjmomiosis ntawm peb cov zaub mov noj, peb plab lug microbiome, thiab peb cov tshuab cellular. Kab lus no muab cov urolithin ua kom tiav.

Vim li cas urolithin tsis nyob hauvMov?

Lub tswvyim tseem ceeb tshaj plaws kom nkag siab yog tias urolithin ib qho chaw ua si tsis ncaj ncees nyob hauv cov zaub mov. Hloov chaw, nws yog qhov kawg ua kom dawb huv cov khoom ntawm cov txheej txheem biochemical uas pib nrog kev noj ntawm cov metabolic muaj peev xwm ntawm peb cov kab mob plab.

Lub biochemical txoj kev

Cov lus mus rauhuvUrolithin ahmoovPib nrog chav kawm ntawm polyphenols hu ua Elellagitannins. Thaum peb haus cov zaub mov nplua nuj nyob rau hauv ellagitannins, lawv mus rau lub plab thiab txoj hnyuv me, uas tsis cuam tshuam los ntawm tib neeg lub plab zom mov. Thaum ncav txoj hnyuv, lawv ntsib cov kab mob loj heev ntawm cov plab microbiota.

• Hydrolysis:

Cov kab mob tshwj xeeb cov kab mob, tshwj xeeb tshaj yog cov uas yog Gorda Gordonibacter, muaj tus enzyme ellagitannase. Qhov no enzyme hydrolyzes (so sib nrug) qhov loj, complex ellagitannin molecule, tso nws tus tub ntxhais kawm acid.

• Decarboxylation thiab dehydroxylation:

Ellagic acid nws tus kheej yog ces raug rau cov metabolism ntxiv. Los ntawm cov kauj ruam ntawm kev sib tw ua haujlwm (tshem tawm cov pawg muaj acid embed

• Cov khoom kawg: urolithin a:

Qhov kawg thiab feem ntau cov metabolailable metabolite hauv cov koob no yog urolithin ntshiab. Nws yog nqus los ntawm cov hnyuv rau hauv cov hlab ntshav, qhov twg nws muab nws cov teeb meem ntawm cov kabmob thiab cov ntaub so ntswg.

Tus txheej txheem no tsis tuaj yeem lav rau txhua tus neeg. Lub peev xwm los ua urolithin ntshiab, qhov ceev ntawm kev tsim khoom, thiab qhov kawg siab sib txawv ua tiav thiab vam khom cov ntshav tau ua tiav: qhov sib xyaw ntawm lawv cov plab microbiome.

Lub plab microbiome sib txawv

Cov tib neeg tuaj yeem faib rau hauv peb qhov kev sib tw metabolic phenotypes raws li lawv cov kab mob plab muaj peev xwm tsim urolithins:

• Ntaus A:

Cov neeg tsim khoom (cov neeg tsim khoom siab): Pab pawg no muaj cov kab mob tsim nyog los hloov cov urolithin A. Lawv tau muaj cov hmoov zoo tshaj plaws ntawm urolithin hmoov.

Hom B:

Cov chaw tsim khoom nruab nrab: Cov pab pawg no tuaj yeem tsim urolithin ib qho tab sis maj mam, feem ntau ua tau zoo, feem ntau yog qhov ua tsis tau zoo, feem ntau, C, thiab D), uas tsis muaj dua cov paj ntaub.

• Ntaus C:

Tsis -} cov neeg tsim khoom (qis lossis tsis muaj cov neeg tsim khoom): Cov pab pawg no tsis muaj qhov tsis txaus ntseeg ntawm ib qho urolithins. Lub ellagitannins thiab ellagic acid dhau los ntawm lawv lub system nrog kev hloov dua siab tshiab.

Yam cuam tshuam rau ib tus phenotype suav nrog lub hnub nyoog, kev noj haus, kev noj qab haus huv, kev siv tshuaj tua kab mob, thiab noob caj noob ces. Qhov kev hloov siab no yog qhov kev sib tw tseem ceeb hauv kev noj qab haus huv ib leeg rau urolithin cov hmoov zoo, uas yog vim li cas kev txaus siab tau txais kev txaus siab.

Cov zaub mov twg muaj siab nyob hauv urolithin a(Ellagitannins)?

Txij li thaum urolithin ntshiab yog cov metabolial me me, lo lus "yog hais txog cov zaub mov nplua nuj, feem ntau yog cov duab qhia ua ntej, feem ntau ellagitannins. Cov kev noj haus muaj zog tshaj plaws yog:

Pomegranates (punica granatum):
Pomegranates yog sib cav tshaj plaws thiab ib qho ntawm cov kev noj haus nplua nuj tshaj plaws ntawm ellagitannins, tshwj xeeb rau tub hauv. Punksagins muaj qhov tshwj xeeb rau pomegranates thiab yog cov ntawm cov loj tshaj plaws ntawm Ellagitannin Molecules pom nyob rau hauv qhov. Lawv muaj cov muaj txiaj ntsig zoo nyob rau hauv cov khoom tsis muaj txiaj ntsig thiab tsis muaj cov kua dawb rau hauv cov txiv hmab txiv ntoo uas tau muab los ntawm nias cov txiv ntoo, suav nrog rind. Qhov no yog vim li cas 100% kua txiv pomegranate yog feem ntau muaj ntau mloog cov khoom ntawm Ellagitannins tshaj li kev noj cov arils ib leeg.
 

Berries:
Ob peb berries yog qhov chaw zoo, nrog kev hloov pauv hauv cov hom tshwj xeeb thiab ntau ntawm ellagitannins.

• Txiv pos nphuab:

Muaj cov kua qaub ntawm cov kua qaub ob qho tib si hauv nws daim foos dawb thiab khi hauv ellagitannins.

• Raspberries & blackberries:

Tshwj xeeb yog liab raspberries thiab blackberries yog heev nyob rau hauv Ellagitannins li Sangeriin H-6 thiab Lambertianin C.

• Cloundberries thiab muscat grapes:

Tsawg dua -}}}} paub tab sis tsuas yog siv ntau yam.

Ceev:

• Walnuts:

Ntawm cov neeg nplua nuj tshaj plaws. Cov tawv nqaij cov tawv nqaij ntawm Walnut yog tshwj xeeb tshaj yog nyob rau hauv Ellagitannins, qhia txog qhov tseem ceeb ntawm kev siv tsis tau kev txwv, nyoos, lossis maj mam toasted walnuts.

• Pecans thiab txiv ntseej:

Kuj tseem muaj cov txiaj ntsig tshwj xeeb, txawm tias feem ntau tsawg dua walnuts.

Lwm qhov chaw:

• Cov txiv hmab txiv ntoo tauj: tej yam txiv hmab txiv ntoo muaj xyoob ntoo zoo li guava thiab Lychee muaj cov theem nrab ntawm Ellagitannins.

• Oak -} aged dej haus:

Lub ellagitannins hauv cov ntoo ntoo qhib tuaj yeem ua kom cov kua khaws cia hauv cov ntoo qhib. Qhov no yog vim li cas ib co khib nyiab thiab wines muaj ellagitannins, tab sis cov cawv txiv hmab txiv ntoo thiab lwm yam yuav ua rau lawv muaj kev noj qab haus huv zoo tagnrho muaj hmoov.

Cov lus: Ntsiab ntawm cov thawj kev noj zaub mov ntawm Ellagitannins

Kev Pabcuam Noj Qab Haus Huv

Cov kev tshawb fawb dav dav thiab cov neeg kuaj mob loj hlob tau kev sim siab ntawm cov huab tais ntshiab ntawm urolithin ib hmoov hla dhau ntawm ntau yam kev noj qab haus huv.

Cov leeg noj qab haus huv thiab Sarcopenia:
Sarcopenia, hnub nyoog {-}}}}}} ecrident tsis muaj txiaj ntsig rau mitochonderts nyob rau hauv cov leeg hlwb. Ntau tus tib neeg kev tshawb fawb tau pom tias urolithin ntshiab ntxiv (piv txwv li, 500-1000 mg txhua hnub) hauv cov laus:

• txhim kho cov leeg nqaij mus thiab lub zog:

Tseem ceeb nce cov leeg hlav rau kev qaug zog hauv kev tawm dag zog.

• txhim kho mitochondrial noob qhia:

Upregulates cov noob muaj feem cuam tshuam rau mitochondrial kev noj qab haus huv hauv tib neeg cov leeg nqaij.

• Ua kom muaj lub zog nruab ntawm lub zog ntawm lub zog

Qhov no yog cov pov thawj tshaj plaws -} backed daim ntawv thov rau UA, kev pab ncaj qha, ntsuas tau hauv kev sib txuas ntawm kev laus.

Lub Hlwb Kev Noj Qab Haus Huv thiab Nuroprroction:
Lub hlwb yog lub zog - pa mitochondria tseem ceeb rau nws txoj haujlwm. Ntshiab urolithin hmoov muaj peev xwm hla cov ntshav -} barb hauv tsiaj qauv qhia cov qauv rau:

• Alzheimer tus kab mob:

Txo amyloid - beta thiab sau petaology {1} {}}} los ntawm kev txhim kho mitochondrial muaj nuj nqi hauv neurons.

• Parkinson tus kab mob:

Kev tiv thaiv dopaminergic neurons los ntawm kev ua si.

• Kev ua haujlwm dav dav:

Txhim kho lub cim xeeb thiab kev kawm los ntawm kev txhawb nqa hluav taws xob xav tau ntawm lub hlwb.

Anti -}}}} aging thiab thiav:
Los ntawm phiaj los ntawm qhov tseem ceeb ntawm kev sib cav ntawm kev laus {{0} mitochondrial dysfunction {}}HuvUrolithin ahmoovTau pom pro pro - kev cuam tshuam nrog C. Elegans) thiab Kev Noj Qab Haus Huv, Kev Noj Qab Haus Huv (lub sijhawm ntawd muaj sia nyob hauv kev noj qab haus huv).

Cov me nyuam kev noj qab haus huv:
Kev tshawb fawb qhia tau ua ntej ua tau txhim kho cov ntsuas metabolic:

• Txo cov tshuaj o: nws modulates golmarmation pathways xws li nf - κ.

• Txhim kho cov insulin rhiab siab: los ntawm kev txhim kho mitochondrial muaj nuj nqi nyob rau hauv cov nqaij metabolic zoo li daim siab thiab cov leeg nqaij.

• Kev tswj qhov hnyav: Kev tshawb nrhiav tsiaj qhia nws tuaj yeem txo cov zaub mov noj kom muaj kev noj haus {0} epatic steatity thiab mob siab tawv).

Sib koom ua ke:
Cov ntaub ntawv pov thawj tawm tau hais tiasHuvUrolithin ahmoovTej zaum yuav pab tiv thaiv pob txha pob txha pob qij txha thiab kev ntxhov siab ntawm cellular (pob txha cell)

Tag

HuvUrolithin ahmoovsawv cev rau kev hloov pauv paradigm hauv kev hloov ua noj ua haus science, tsiv tawm ntawm "koj yog dab tsi koj noj" rau "koj yog dab tsi koj noj." Thaum cov zaub mov zoo li pom pom kev, thiab cov txiv ntoo yog qhov kev noj haus tseem ceeb ntawm cov txheej txheem ua ntej yog ib tus kheej cov txheej txheem ntawm cov me nyuam yaus microbiome. Nws lub peev xwm ua rau muaj peev xwm rejuvenate cellular mitochondria nws lub peev xwm los tawm tsam lub hnub nyoog- kev poob hauv cov leeg, lub hlwb, thiab metabolic noj qab haus huv. Rau cov neeg xav tau lees paub thiab muaj txiaj ntsig zoo ib yam, txhawb nqa ncaj qha nrog cov urolithin siabhuvUrolithin ahmoovCov neeg muag khoom los ntawm cov txheej txheem biotechnological, muaj kev cog lus thiab kev tshawb fawb}}}} backed cov kab mob cellular kev noj qab haus huv thiab ntev.

Guanjie Biotech yog qhov siab - Zoo urolithin cov hmoov los ntawm cov tshuaj. Zoo Siab Txais Tos Kev Kho Mob Ntxiv rau cov tuam ntxhab rau sab laj peb ntawm info@gybiotech.com.

Tuaj txog::

[1] André, P., li al. (2022). "Urolithin A thiab B: Tus tsis txawj, enigmatic, thiab thaum kawg txheeb xyuas mitochondenating rejuvalating rejcholites los ntawm pomegranate thiab txiv ntseej." Cov tswv yim tam sim no hauv kev kho mob hauv chaw kuaj mob thiab kev saib xyuas metabolic, 25 (4), 247-253.

[2] D'Amico, D., li al. (2021). "Kev cuam tshuam ntawm lub ntuj sib sau urolithin ib qho rau kev noj qab haus huv, kab mob, thiab laus." Tiam sis hauv cov tshuaj molecular, 27 (7), 687-699.

[3] Liu, S., li al. (2021). "Cov kab mob me me thiab kev hloov pauv ntawm Ellagitannins rau urolithin A: Tus tshiab mechanism kev cai rau cov txiaj ntsig kev noj qab haus huv ntawm pomegranate." Khoom noj & muaj nuj nqi, 12 (20), 10006-10022.

[4] Ryu, D., li al. (2016). "Urolithin yog ntxias mitophagy thiab ntev lifespan hauv C. Elegans thiab nce leeg nqaij hauv nas." Xwm tshuaj, 22 (8 (8), 879-888.

[5] Singh, A., li al. (2019). "Urolithin ib qho kev ua kom muaj zog, kev siv dag zog, thiab kev kho mob biomarkers ntawm kev sim siab hauv nruab nrab- laus." Ntawv Qhia Txog Cell, 3 (5), 100633.

[6] Tomás - barberán, fa, li al. (2017). "Ellagic acid metabolism los ntawm tib neeg lub plab mog xws li peb cov urolithypes hauv kev cuam tshuam kev cuam tshuam, kev ywj pheej ntawm cov zaub mov, hnub nyoog, thiab kev noj qab haus huv." Phau ntawv Journation ntawm cov neeg ua liaj ua teb thiab 65 (32), 6894-6902.

[7] Zhao, W., li al. (2023). "Urolithin A: Kev cog lus rau cov metabolite rau kev txhawb nqa osteoarthritis los ntawm modulating mitochondrist thiab oxidative kev ntxhov siab." Biochemical Pharmology, 215, 115723.