Tib neeg daim tawv nqaij nws tus kheej muaj ntau ntawm ceramides. Ua ke nrog cov roj cholesterol thiab cov roj fatty acids dawb, ceramides tsim cov txheej txheem lamellar uas ua rau qhov chaw nruab nrab ntawm keratinocytes. Nws suav txog li 40 txog 55 feem pua.Ceramide hmoov ntau Nyob rau hauv lub basal cell txheej thiab dermis yog tsuas yog faib nyob rau hauv lub nuclear membrane, sab hauv thiab sab nrauv mitochondrial membranes, thiab thiaj li nyob. Ceramides nyob rau hauv lub Upper epidermal txheej yog tsuas yog faib nyob rau hauv lamellar vesicles, interstitial chaw ntawm keratinocytes, thiab lwm yam.
Ceramide hmoov ntauyog tsim los ntawm sphingosine analogues thiab ntev-chain fatty acids khi los ntawm amide bonds. Nws yog synthesized thiab secreted los ntawm lamellar vesicles. Qhov no kho cov tawv nqaij puas ua haujlwm los ntawm kev ua kom cov tawv nqaij hydration thiab txo cov dej transepidermal.
Ceramides zoo li peptides. Qhov no yog chav kawm loj heev nrog 16 subtypes txheeb xyuas hauv kev tshawb fawb tam sim no. Cov fatty acids sib txawv nrog cov saw ntev sib txawv ua rau cov subtypes sib txawv ntawm ceramides. Lawv pom nyob rau hauv sib txawv proportions nyob rau hauv lub stratum corneum ntawm daim tawv nqaij.
Ntawm lawv, cov saw ntev ntev tuaj yeem raug cais raws li neurosphingosine (S), dihydrosphingosine (DS), phytosphingosine (P) thiab 6-OH sphingosine (H). Fatty acids tuaj yeem faib ua cov tsis-hydroxy fatty acids (N), -OH fatty acids (A), ω-OH fatty acids (EO), thiab esterified ω-OH fatty acids (EOH). Kev sib xyaw ua ke ntawm ob yog cov ceramide NP, NH, AH, NDS, AS, AP, EOP, NS thiab lwm yam ceramide isoforms.
Dab tsi yogCeramide NP?
Ceramide NP yog ib qho tseem ceeb ceramide subclass nyob rau hauv daim tawv nqaij stratum corneum. Nws muaj phytosphingosine thiab non-hydroxy fatty acids. Nws muaj qhov feem pua siab tshaj plaws hauv tib neeg stratum corneum piv rau lwm yam ceramide subtypes. Qhov no suav nrog 22.1 feem pua.
Ceramide NP tsis yog ib yam khoom, tab sis cov ntsiab lus dav dav rau pawg loj ntawm ceramides nrog cov qauv zoo sib xws. Ob leeg ceramide 3 thiab ceramide 3B muaj nyob rau hauv pawg no ntawm ceramide NP. Cov fatty acid feem ntawm ceramide 3 yog stearic acid. Ceramide 3B yog oleic acid, uas yog tsim los ntawm amide bonding nrog phytosphingosine (P), feem.
Lub luag haujlwm ntawm ceramide NP hauv daim tawv nqaij yog dab tsi?
• Moisturizing thiab xauv hauv dej:
Ceramide NP nkag mus rau ntawm daim tawv nqaij sai. Nws khi cov dej molecules hauv stratum corneum thiab tsim cov qauv mesh kom kaw hauv dej. Qhov no tsis tsuas yog ntxiv dag zog rau qhov adhesion ntawm cov hlwb ntawm stratum corneum tab sis kuj txhim kho cov tawv nqaij qhuav thiab txo qis flaking.Ceramide hmoov ntautxhawb kev nthuav qhia ntawm filamentous polyprotein (FLG), lub hauv paus tseem ceeb ntawm lub ntuj moisturizing yam NMF. Raws li cov moisturizer zoo heev, Ceramide NP yog 16 npaug zoo dua li hyaluronic acid. Nws yog yooj yim absorbed los ntawm daim tawv nqaij. Nws kuj txhawb kev nkag mus ntawm lwm cov as-ham thiab muaj cov nyhuv moisturizing txog li 80% ntawm cov laus cov tawv nqaij qhuav.
• Txhim kho daim tawv nqaij barrier muaj nuj nqi:
Ceramide NP thiab cell deg proteins daim ntawv cog lus cov hlwb los ntawm kev sib txuas ntawm ester los tsim cov lipid-cell-protein suav nrog. Nws tsis tsuas yog tswj kev ncaj ncees ntawm sebaceous daim nyias nyias, tab sis kuj ntxiv dag zog rau keratinocyte txheej. Qhov no txhim kho epidermal cell cohesion thiab ua tiav thickening ntawm stratum corneum.
• Soothing thiab anti-allergic:
Ceramide NP txuas cov lipid matrix rau cov hlwb keratinized, txo qhov nkag ntawm cov khoom tsis zoo rau hauv daim tawv nqaij los ntawm qhov pores thiab hws qog. Qhov no muaj anti-allergic nyhuv. Ceramide NP inhibits qhov pib ntawm apoptosis hauv cov lus teb inflammatory thiab txo qhov kev puas tsuaj rau cov ntaub so ntswg los ntawm cov lus teb inflammatory. Rau cov tawv nqaij rhiab heev, ntxiv nrog Ceramide NP pab kho liab thiab tsis txhob rhiab heev.
• Slows kev laus:
Los ntawm kev ua kom cov dej tuav lub peev xwm ntawm cov laus laus,ceramide hmoov ntaupab txo wrinkles. Nws tsis tsuas yog txhim kho daim tawv nqaij elasticity, tab sis kuj inhibits kev qhia ntawm matrix metalloproteinase MMP, tshem tawm cov dawb radicals, thiab txhawb nqa fibroblast proliferation. Qhov no tuaj yeem ua tiav cov txiaj ntsig ntawm kev qeeb ntawm daim tawv nqaij laus.
• Ceramide NP muaj ntau yam zoo dua lwm yam khoom xyaw. Raws li lub kaus tsis pom rau ntawm daim tawv nqaij, ceramide NP muaj qhov chaw tseem ceeb hauv kev kho tawv nqaij thiab kho tawv nqaij.
Daim tawv nqaij Barrier thiab Ceramide NP
Cov tawv nqaij yog lub cev loj tshaj plaws ntawm tib neeg lub cev. Nws ua lub luag haujlwm tseem ceeb hauv kev tswj hwm homeostasis ntawm lub cev hauv ib puag ncig thiab tiv thaiv kev puas tsuaj los ntawm cov teeb meem sab nraud. Kev ua haujlwm ntawm daim tawv nqaij hauv qhov nqaim feem ntau yog hais txog cov epidermis. Tshwj xeeb tshaj yog lub cev los yog mechanical barrier qauv ntawm stratum corneum.
Lub ntsiab feature ntawm daim tawv nqaij barrier yog stratum corneum lipids uas muaj ceramides, fatty acids thiab cov roj cholesterol. Lub stratum corneum muaj qee qhov sib npaug ntawm ceramides, fatty acids thiab roj cholesterol. Lub stratum corneum nthuav tawm cov txheej txheem sib txuam, yog li ua kom muaj kev ncaj ncees ntawm daim tawv nqaij. Nyob rau hauv sib piv, ib qho txawv txav los yog cuam tshuam ntawm stratum corneum lipids yuav ua rau muaj kev cuam tshuam ntawm daim tawv nqaij thiab lub cev tsis zoo.
Cov kev tshawb fawb tau pom tias biosynthesis ntawm ceramide NPceramide hmoov ntau yog down-regulated los yog degraded nyob rau hauv cov kab mob ntawm daim tawv nqaij. Xws li psoriasis lossis atopic dermatitis. Kev hloov pauv ntawm tus nqi lossis qhov zoo ntawm ceramide yuav cuam tshuam ncaj qha rau kev ua haujlwm ntawm daim tawv nqaij barrier.
Dab tsi ua rau txo qis hauv qib ceramide NP?
Ceramide NP yog ib qho ntawm cov khoom tseem ceeb uas cuam tshuam txog kev ua haujlwm ntawm daim tawv nqaij. Thaum muaj qhov txo qis ntawm cov tshuaj ceramide NP, cov tawv nqaij ua haujlwm tsis muaj zog. Thaum cov epidermis puas lawm, cov txheej txheem ntawm kev rov qab los ntawm daim tawv nqaij barrier muaj nuj nqi yog pib sai thiab cov synthesis ntawm ceramide NP yog nce. Rau cov tawv nqaij puas, los ntawm kev siv tshuaj pleev xim ntawm ceramide NP. Ntxiv cov ceramides txo mus rau stratum corneum los kho cov tawv nqaij barrier muaj kev nyab xeeb thiab zoo.
Cov kws tshawb fawb tau sim cov teebmeem ntawm emollients uas muaj ceramide NP ntawm daim tawv nqaij barrier qauv thiab ua haujlwm rau cov laus laus uas muaj tawv nqaij qhuav. Hauv cov neeg muaj hnub nyoog tshaj 60 xyoo nrog cov tawv nqaij qhuav (n=21), cov teebmeem ntawm 28 hnub ntawm kev kho mob nrog cov tshuaj ntsuam emollient (TE) ntawm daim tawv nqaij pH (a), hydration (b), redness (c) , dej poob (d), thiab SC kev ncaj ncees (e) tau muab piv rau cov tswj tsis tau kho (NTC).
Cov nyhuv moisturizing ntawm qhov kev sim emollients ntawm daim tawv nqaij yog qhov muaj zog dua thiab kav ntev dua piv rau cov tswj emollients. Cov nyhuv no tau cuam tshuam nrog kev nce siab ntawm carboxylic acid pawg hauv stratum corneum. Tsis tas li ntawd, kev kho mob nrog kev sim emollient ua rau muaj qhov txo qis hauv cov kev ua si zoo li curd trypsin thiab txo qis hauv trypsin zoo li kev ua si. Qhov kuaj emollient tiv thaiv cov qauv thiab kev ua haujlwm ntawm daim tawv nqaij barrier. Hauv kev xaus, qhov kev sim emollient hais txog cov yam ntxwv ntawm cov tawv nqaij qhuav thiab laus.
Guanjie Biotech tau tsom mus rau cov khoom siv rawceramide hmoov ntau. Los ntawm cov ntaub ntawv mus rau cov khoom, peb ua raws li tus qauv siab. Zoo siab thiab tus nqi sib tw, txais tos nug peb:info@gybiotech.com.
