Dab tsi yogCov Properties Ntawm Chenodeoxycholic Acid Thiab Ursodeoxycholic Acid?
Qauv:
Ob lub molecules yog C24 bile acids nrog ob pawg hydroxyl (ib 3 -hydroxyl ntau rau ntau cov kua tsib acids, thiab 7-hydroxyl). Kev taw qhia (lossis ) ntawm 7-hydroxyl txawv lawv: CDCA yog 3, 7 -dihydroxy-5 -cholan-24-oic acid (7 -OH), thiab UDCA hmoov yog 7 -epimer (3 , 7 -dihydroxy-5 -cholan-24-oic acid). Qhov no epimerization ntawm C-7 hloov crystal packing, solubility cwj pwm thiab lom lom.
Hydrophobicity / hydrophilicity:
CDCA yog ntau hydrophobic (tsawg dej-phooj ywg) dua UDCA. Ursodeoxycholic Acid hmoov yog cov hydrophilic thiab suav hais tias yog "hydrophilic" bile acid piv nrog CDCA thiab lwm cov kua tsib hydrophobic acids (xws li deoxycholic acid thiab lithocholic acid). Qhov sib txawv no piav qhia txog ntau yam ntawm lawv qhov sib txawv ntawm cov cellular toxicity thiab muaj peev xwm tiv thaiv: hydrophobic bile acids yog cov tshuaj ntxuav tes -zoo li thiab tuaj yeem ua rau cov cell membranes thiab organelles; hydrophilic bile acids tsawg dua puas tsuaj thiab tuaj yeem tiv thaiv cov hlwb los ntawm kev hloov ntau cov kua tsib hydrophobic los ntawm cov kua tsib- cov kua qaub.
Lub cev qhov tshwm sim:
Kev hloov pauv ntawm - mus rau -hydroxyl hloov pauv cov molecule peb - qhov ntev ntawm qhov chaw thiab yog li khi rau cov proteins thiab cov receptors, nrog rau kev xav ua micelles, cuam tshuam nrog daim nyias nyias, thiab hloov kho los ntawm cov kab mob plab. Crystal-cov ntaub ntawv tshawb fawb thiab cov ntaub ntawv sib piv ntawm lub cev chemistry sau qhov sib txawv no.
Yuav Ua Li Cas Chenodeoxycholic Acid Thiab Ursodeoxycholic AcidRecycle Bile Acids?
Ntuj tshwm sim:
Hauv tib neeg, cov kua tsib cov kua qaub ua ke hauv lub siab los ntawm cov roj cholesterol yog cholic acid thiab chenodeoxycholic acid (CDCA). Ursodeoxycholic acid mechanism yog tam sim no nyob rau hauv me me nyob rau hauv tib neeg, tab sis muaj ntau nyob rau hauv ib co lwm yam tsiaj (xws li, dais). Lub plab microbiota tuaj yeem cuam tshuam thiab dehydroxylate bile acids. Cov kab mob 7 -dehydroxylation thiab epimerization txoj hauv kev tuaj yeem hloov CDCA rau hauv lwm yam khoom thiab tuaj yeem koom nrog kev hloov pauv ntawm CDCA thiab UDCA cov hmoov ntau nyob ntawm cov enzymes microbial tam sim no.
Conjugation thiab recirculation:
Ob leeg CDCA thiab UDCA yog conjugated nyob rau hauv daim siab (glycine los yog taurine conjugates) ua ntej tso rau hauv cov kua tsib, tso rau hauv cov hnyuv uas cov kab mob ua rau lawv, thiab yog heev reabsorbed nyob rau hauv lub terminal ileum. Qhov sib txawv ntawm cov kab mob hauv plab ua rau lawv ua rau muaj qhov sib txawv hauv pas dej ua ke thiab cov teebmeem hauv qab ntawm cov lipid metabolism.
Dab tsiYogQhov txawvt SivNtawm Chenodeoxycholic Acid Thiab Ursodeoxycholic Acid?
Hauv qab no yog cov ntaub ntawv kho mob tseem ceeb thiab CDCA thiab UDCA piv li cas.
Cov roj (cholesterol) siab
Ob leeg muaj peev xwm yaj me me, radiolucent cholesterol gallstones los ntawm kev txo cov roj cholesterol nyob rau hauv cov kua tsib thiab maj mam shrinking pob zeb. Keeb kwm, ob qho tib si chenodeoxycholic acid (chenodiol) thiab ursodeoxycholic acid (urso / ursodiol) tau siv rau kev tshem tawm cov roj cholesterol tsis zoo.
Cov txiaj ntsig sib piv thiab cov kev mob tshwm sim:
Cov kev tshawb fawb soj ntsuam los ntawm 1970s-1980s tau pom tias UDCA feem ntau yaj cov pob zeb sai dua thiab muaj kev cuam tshuam tsawg dua li CDCA; CDCA zoo li yuav ua tau zoo dua ntawm cov koob tshuaj ntau dua rau cov pob zeb me tab sis ua rau muaj kev phom sij ntau dua hauv plab hnyuv thiab cov kab mob hauv lub cev (xws li, raws plab, kuaj lub siab tsis zoo hauv qee kis). Sij hawm dhau mus, Ursodeoxycholic Acid bulk hmoov tau nyiam rau kev tshem tawm cov pob zeb vim nws qhov kev nyab xeeb dua thiab sib piv ntev ntev - siv tau.
Cov kab mob cholestatic daim siab
- UDCA (ursodiol)
Ursodeoxycholic Acid yog tus tsim thawj zaug - kab kev kho mob rau thawj tus kab mob biliary cholangitis (PBC). Ntev-Lub sij hawm UDCA txhim kho biochemical cholestatic cov cim (alkaline phosphatase, bilirubin) thiab cuam tshuam nrog kev txhim kho kev hloov pauv-dawb ciaj sia thaum pib ntxov; Nws kuj tseem siv rau hauv lwm qhov chaw cholestatic (xaiv thawj cov neeg mob sclerosing cholangitis, intrahepatic cholestasis ntawm cev xeeb tub, cholestasis los ntawm parenteral khoom noj khoom haus) nrog cov pov thawj sib txawv. UDCA's choleretic thiab cytoprotective teebmeem ua rau nws yog qhov tseem ceeb rau cov teeb meem no.
- CDCA hauv cholestasis:
Vim hais tias CDCA yog cov hydrophobic thiab tuaj yeem ua rau hepatotoxic ntau dua, nws tsis yog siv los ua kev kho mob rau cov kab mob siab cholestatic thiab tsis yog tus qauv rau PBC. CDCA's FXR kev ua ub no yuav muaj txiaj ntsig zoo hauv qee qhov xwm txheej metabolic, tab sis Ursodeoxycholic Acid UDCA tseem yog cov kws kho mob tsim kho rau cov kab mob cholestatic.
Inborn yuam kev ntawm cov kua tsib-acid synthesis thiab cov enzyme deficiencies
- CDCA kev kho rau qee yam kua tsib -acid synthesis defects:
Ib qho tseem ceeb ntawm kev siv CDCA ua tus neeg sawv cev kho mob yog nyob rau hauv cov kab mob hauv lub cev tsis zoo ntawm cov kua tsib -acid synthesis (piv txwv li, qee qhov - enzyme deficiencies) thiab hauv cerebrotendinous xanthomatosis (CTX). Hauv CTX lossis qee qhov kev sib txuam tsis xws luag, CDCA cov thawj coj muab cov lus tawm tswv yim inhibition ntawm cov kua tsib txawv txav -acid synthesis pathways thiab tuaj yeem txo cov tshuaj lom neeg nruab nrab; Kev hloov CDCA tuaj yeem kho qhov tsis txaus metabolic. Yog li CDCA muaj lub luag haujlwm hauv cov kab mob genetic bile-acid disorders uas Ursodeoxycholic Acid UDCA tsis ua tiav zoo.
Lipid metabolism, cuam tshuam cov metabolism, thiab cuam tshuam rau lub plawv
- FXR- cov teebmeem lipid nyob nrog CDCA:
CDCA qhov kev ua kom muaj zog FXR tuaj yeem txo cov kua tsib -acid synthesis thiab hloov lipoprotein tuav. Kev ua kom FXR tuaj yeem txo qis hepatic de novo bile-acid synthesis thiab cuam tshuam rau LDL/PCSK9 txoj hauv kev; Cov teebmeem metabolic no tau raug tshawb fawb kho (thiab hluavtaws FXR agonists tau tsim). Yog li CDCA muaj zog thiab ncaj qha cuam tshuam rau cov kua tsib -acid-sensitive metabolic circuits dua li UDCA ua.
- UDCA thiab lipids:
Ursodeoxycholic acid mechanism ntawm kev txiav txim ntawm cov kab mob lipid profile yog qhov tsis muaj zog thiab tsis muaj peev xwm xav tau vim tias nws cov yeeb yam tseem ceeb hauv zos (cov kua tsib muaj pes tsawg leeg, kev tiv thaiv hepatocyte) ntau dua li qhov muaj peev xwm hloov pauv hloov pauv los ntawm FXR.
Dab tsi yog Kev Nyab XeebNtawm Chenodeoxycholic Acid Thiab Ursodeoxycholic Acid?
CDCA:
Vim tias CDCA muaj ntau dua hydrophobic thiab muaj zog FXR agonist, nws tuaj yeem ua rau muaj kev phiv ntau dua xws li raws plab, nce siab enzymes, thiab -tsis tshua muaj - phem hepatotoxicity hauv qee cov ntsiab lus cholestatic. Raws li keeb kwm, cov txiaj ntsig siab dua ntawm cov kab mob plab hnyuv tau txwv nws qhov ntev - lub sij hawm kam rau ua rau UDCA hauv gallstone- cov txheej txheem sib cais. CDCA yog siv ua tib zoo thiab hauv cov kab mob metabolic tshwj xeeb uas nws cov txiaj ntsig zoo dua qhov kev pheej hmoo.
UDCA:
Puas yog ursodeoxycholic acid muaj kev nyab xeeb? Feem ntau zoo zam. Cov kev mob tshwm sim feem ntau yog mob plab hnyuv me (piv txwv li, raws plab, tsam plab) hauv cov neeg mob tsawg. Vim tias Ursodeoxycholic Acid tshem tawm ntau cov kua tsib hydrophobic acids, nws feem ntau txo cov cytotoxicity ntau dua li nws. Hauv kab mob cholestatic ntev - lub sij hawm kev nyab xeeb tau raug sau tseg. Tsis tshua muaj, ursodeoxycholic acid (UDCA) tuaj yeem ua rau cov txiaj ntsig tsis zoo hauv qee qhov xwm txheej (kev tshawb pom keeb kwm ceeb toom hauv qee qhov kev sim), yog li kev soj ntsuam cov ntsiab lus tseem ceeb.
Dab tsiPuas yog Kev Noj Qab Haus Huv Ntawm Chenodeoxycholic Acid Thiab Ursodeoxycholic Acid?
Kev tswj hwm:
Ob leeg tau muab qhov ncauj thiab nqus, sib txuas hauv daim siab, zais cia hauv cov kua tsib, thiab feem ntau reabsorbed (enterohepatic ncig). Conjugation (nrog glycine los yog taurine) cuam tshuam cov dej solubility thiab biliary secretion.
Hom koob tshuaj:
Ursodeoxycholic Acid koob tshuaj rau PBC feem ntau yog nyob ib ncig ntawm 13-15 mg / kg / hnub hauv cov koob tshuaj sib faib (cov txheej txheem kho mob). Rau kev puas tsuaj rau lub gallstone, cov koob tshuaj me me (piv txwv li, 8-10 mg / kg / hnub) tau siv keeb kwm.
CDCA (chenodiol) koob tshuaj thaum siv rau kab mob gallstone keeb kwm cuam tshuam nrog ntau yam (piv txwv li, 10–15 mg / kg / hnub) tab sis yuav ua rau muaj kev cuam tshuam ntau dua ntawm cov kev tswj hwm siab dua. Kev noj tshuaj npaum li cas nyob ntawm qhov qhia tau thiab tus neeg mob yam xwm txheej; Cov kev taw qhia tshwj xeeb yog xav tau rau CDCA siv rau cov kab mob metabolic tsawg. (Faj seeb: ib txwm ua raws li cov lus qhia hauv zos thiab cov kws kho mob tshwj xeeb.)
Xaus:
Hauv cov ntsiab lus, chenodeoxycholic acid thiab ursodeoxycholic acid, txawm tias yog epimers txawv tsuas yog nyob rau hauv kev taw qhia ntawm ib pawg hydroxyl, yog molecular doppelgangers nrog kev tawm tsam natures. CDCA, thawj tib neeg cov kua tsib acid, yog hydrophobic, membrane- cuam tshuam, thiab cytotoxic. Nws lub luag haujlwm kho mob yog txwv rau qhov tshwj xeeb metabolic tsis xws luag ntawm Cerebrotendinous Xanthomatosis, qhov twg nws ua haujlwm los kho cov lus qhia tseem ceeb hauv metabolic. Hauv qhov sib piv, ntshiab UDCA, hydrophilic thiab cytoprotective molecule, tau tshwm sim los ua ntau yam thiab muaj kev nyab xeeb hepatoprotective agent. Nws muaj peev xwm detoxify cov kua tsib kua qaub pas dej ua ke, txhawb nqa bicarbonate - cov kua tsib nplua nuj, thiab tiv thaiv cov hlwb los ntawm apoptosis underpins nws txoj kev vam meej hauv kev kho cov kab mob cholestatic daim siab, los ntawm PBC mus rau ICP. CDCA thiab Ursodeoxycholic Acid cuam tshuam rau molecular stereochemistry ntawm kev ua haujlwm lom neeg. Nws underscores lub hauv paus ntsiab lus nyob rau hauv pharmacology: ib tug me me yam ntxwv kev hloov yuav ua tau qhov sib txawv ntawm ib tug toxin thiab kev kho mob.
Kev thov thoob ntiaj teb rau siab -purity ursodeoxycholic acid UDCA rau kev siv tshuaj tau ntsib los ntawm cov tuam txhab tshwj xeeb, thiab Guanjie Biotech yog cov chaw tsim khoom loj ursodeoxycholic acid ua lub luag haujlwm tseem ceeb hauv cov khoom siv no, kom ntseeg tau tias cov tshuaj tseem ceeb no mus txog cov neeg mob thoob ntiaj teb. Raws li ib qho ntawm cov kws tshaj lij ursodeoxycholic acid manufacturers, peb tuaj yeem muab siab - zoo ursodeoxycholic acid. Yog tias koj xav tau peb cov ursodeoxycholic acid hmoov, txais tos nug nrog peb ntawminfo@gybiotech.com.
Cov ntaub ntawv
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