Niacin , nicotinamide (NAM) thiab nicotinamide ribose (NR) yog ntau hom vitamin B3. Txhua homvitamin B3muaj cov txiaj ntsig tshwj xeeb. Cov no suav nrog txo cov roj cholesterol thiab ua kom tawv nqaij laus. Cov kev tshawb fawb tau qhia tiasNR hmoovthiabNMN hmoovr muaj cov teebmeem zoo sib xws. Qhov zoo sib xws thiab qhov sib txawv ntawm NMN bulk hmoov (nicotinamide mononucleotide hmoov) thiab vitamin B3 hmoov tsis meej pem. Hauv ntej, NMN tsis yog vitamin B3. Peb hom ntawm vitamin B3 yog niacin (NA), nicotinamide (NAM), thiab nicotinamide riboside (NR). Txawm li cas los xij, tag nrho peb hom vitamin B3, nrog rau NMN, tau hloov mus rau NAD +.
Qhov tseem ceeb ntawm kev tswj hwm qib txaus ntawm NAD + yog ib feem ntawm xyoo 1937, thaum nws pom tias pellagra, tus kab mob tuag taus, yog tshwm sim los ntawm vitamin B3 tsis txaus. Yog li ntawd, niacin, ib tug hluavtaws version ntawm NA, tau tsim. Niaj hnub no, niacin yog ib lub ntsiab lus siv los hais txog cov vitamins B3, NA, NAM, thiab qee zaum NR. Txawm li cas los xij, ntxiv rau kev txhawb nqa NAD +, cov ntsiab lus no tshwm sim los pab txhawb rau cov txheej txheem lom neeg sib txawv hauv lub cev, muab cov txiaj ntsig tshwj xeeb.
Cov txiaj ntsig tshwj xeeb ntawm vitamin B3 thiab NMN:
• Niacin/Nicotinic Acid
Niacin yog tej zaum paub zoo tshaj plaws ntawm cov vitamin B3. Nws tau siv rau ntau xyoo los kho thiab tiv thaiv pellagra, ib qho mob uas tshwm sim los ntawm dermatitis, raws plab thiab dementia. Niacin tau lees paub dav dav rau nws lub peev xwm los txhim kho cov roj cholesterol. Nws ua kom cov lipoprotein ntau ntom ntom (HDL) cov roj (cholesterol) thiab txo qis lipoprotein (LDL) cov roj cholesterol thiab triglycerides. Los ntawm kev txhim kho qib roj cholesterol, niacin tuaj yeem pab txo qis kev pheej hmoo ntawm cov kab mob plawv.
• Niacinamide/Nicotinamide
NMN hmoov tseem hu ua nicotinamide mononucleotide hmoov. Nws yog lwm hom vitamin B3. Tsis zoo li niacin, NAM tsis muaj tib yam lipid-hloov cov teebmeem thiab tsis ua rau 'niacin flushing', ib qho kev mob tshwm sim ntawm NA tus cwj pwm los ntawm redness thiab warmth ntawm daim tawv nqaij NAM yog cov khoom siv nrov hauv cov khoom siv tawv nqaij vim nws cov tshuaj tiv thaiv. cov khoom, nws muaj peev xwm los txhim kho daim tawv nqaij barrier muaj nuj nqi, txo hyperpigmentation, thiab txo cov tsos ntawm zoo kab thiab wrinkles. wrinkles. Nws kuj tau kawm txog nws lub peev xwm los txhim kho kev sib koom ua ke thiab txo cov tsos mob ntawm osteoarthritis.
• NR thiab NMN
NR thiab NMN tau pom tom qab NA thiab NAM. Kev nce qib NAD + nrog NR thiab NMN tau txuas rau kev txhim kho mitochondrial muaj nuj nqi, nce lub zog ntau lawm, thiab txhim kho cellular kho mechanisms - txhua yam tseem ceeb hauv kev noj qab haus huv cellular aging. Tsis tas li ntawd, kev tshawb fawb qhia tias kev nce qib NAD + nrog NR hmoov lossis NMN hmoov ntxiv tuaj yeem pab tua cov kab mob uas muaj hnub nyoog, txhim kho cov leeg nqaij, txhim kho kev txawj ntse, thiab txuas ntxiv lub neej.
Thaum ob qho tib si NMN thiab NR muaj txiaj ntsig zoo hauv kev nce qib NAD +, lawv txoj hauv kev biochemical thiab cov txiaj ntsig zoo sib txawv. NMN tau hloov pauv ncaj qha mus rau NAD + hauv cov hlwb thiab tau pom tias muaj peev xwm txhim kho lub cev muaj zog thiab kev noj qab haus huv metabolic hauv kev tshawb fawb soj ntsuam. nR hloov mus rau NMN ua ntej nws hloov mus rau NAD + thiab tau tshawb xyuas txog nws cov teebmeem ntawm neuroprotection, kev noj qab haus huv ntawm lub plawv thiab kev tswj hwm metabolic.
Nws Ua Haujlwm Li Cas?
NAD + loj precursors tryptophan, B3 (NR nicotinic acid), nicotinamide riboside (NR), thiab nicotinamide mononucleotide (NMN). Cov txheej txheem metabolic tseem ceeb yog txoj hauv kev 'scratch synthesis pathway' thiab 'remedial salvage pathway'.
Txoj kev ab initio, raws li lub npe qhia, yog ib qho 8- cov txheej txheem pib nrog tryptophan thiab xaus nrog cov synthesis ntawm NAD +. Qhov no tseem hu ua kynurenine txoj kev. Txoj kev no yog lub luag haujlwm rau kev tsim cov NAD + thiab serotonin melatonin. Kev tsim khoom ntawm NAD + yog siv sijhawm thiab tsis muaj txiaj ntsig. NAD + qib qis ua rau lub cev tsim NAD + ua ntej, txo qis kev tsim cov serotonin thiab melatonin.
Txoj kev kho kom rov zoo yog qhov kev txhawb nqa ncaj qha ntawm NAD + precursors xws li nicotinic acid (NA), nicotinamide mononucleotide (NMN) thiab nicotinamide riboside (NR). Txoj kev khaws cia yog, raws li lub npe qhia, txoj hauv kev metabolic uas tsim cov tshuaj tshiab los ntawm cov metabolites uas twb muaj lawm.
● Niacin yog ib qho kev nyab xeeb thiab muaj txiaj ntsig NAD + ua ntej
Niacin, ib daim ntawv ntawm vitamin B3, yog ib qho tseem ceeb precursor rau synthesis ntawm NAD +. Niacin hloov mus rau nicotinic acid adenine dinucleotide (NaMN), uas yog tom qab ntawd los ntawm cov txheej txheem ntawm 3-cov tshuaj tiv thaiv biochemical, txoj hauv kev Preiss-Handler, uas kuj yog txoj hauv kev khaws cia.
Kev tshawb fawb soj ntsuam ntawm niacin ua tus thawj coj rau NAD + tau luam tawm nyob rau lub Rau Hli 2020 Cell subissue rau cov neeg mob uas muaj kev txhim kho mitochondrial myopathy, noj cov tshuaj niacin li ntawm 250mg ib hnub NMN hmoov mus rau qhov siab tshaj plaws ntawm 750-1000mg ib hnub rau nce. mus rau 10 lub hlis. Cov txiaj ntsig tau pom tias txhua yam kev kawm (cov neeg mob ntxiv rau kev tswj hwm tib neeg noj qab haus huv) tau nce qib ntshav NAD + mus txog 8-fold. Cov leeg nqaij muaj zog thiab mitochondrial biosynthesis tau nce siab hauv txhua yam.
Tsib tus neeg mob ib tug ntawm lawv, ib tug txiv neej, qhia txog kev txhim kho ntawm cov tsos mob gout. Ob qhov kev tswj hwm (tseem noj B3) tsis txuas ntxiv txoj kev tshawb fawb tom qab ob lub hlis vim yog mob plab hnyuv; cov neeg koom nrog rau niacin zoo.
Cov niacin siv nyob rau hauv qhov kev sim yog ib tug ncua-tso daim ntawv ntawm niacin, tsis yog ib tug nquag siv nutraceutical. Nws yog ib daim ntawv muab tshuaj. Nws tso cai rau kev tso tawm cov tshuaj mus rau hauv lub cev ntev dua. . es tsis yog kev tso tawm ib zaug.
● Tam sim no, vitamin B3 muaj kev nyab xeeb tuaj yeem ua rau metabolised zoo rau NAD +, kev sim siv tshuaj ntau.
Vitamin B3 yog ib lub ntsiab lus dav. Nws yog siv los piav txog cov dej-soluble vitamins hauv tsev neeg B vitamin. Cov no suav nrog NA, NMN hmoov, thiab NR hmoov. Txawm hais tias NMN molecule yog tsim los ntawm NR molecules, nws tsis suav hais tias yog ib daim ntawv ntawm vitamin B3. Txawm li cas los xij, txhua qhov sib xyaw no muaj cov txiaj ntsig tshwj xeeb: NA yog qhov paub zoo tshaj plaws rau nws lub luag haujlwm hauv kev tswj cov roj cholesterol thiab kev noj qab haus huv ntawm lub plawv, NAM yog khoom plig rau nws cov txiaj ntsig kev noj qab haus huv ntawm daim tawv nqaij thiab lub peev xwm kho cellular, thiab NR thiab NMN tau paub ntau ntxiv rau lawv lub peev xwm los nce NAD + qib, nrog rau kev tiv thaiv kev laus thiab cov txiaj ntsig kev noj qab haus huv metabolic.
Thov tsis txhob yig tiv tauj peb ntawminfo@gybiotech.comYog tias koj xav yuav NMN hmoov, NR hmoov lossis B3 hmoov. Peb pab pawg tau mob siab rau daws txhua qhov kev thov.
Siv:
Canto C. (2022). NAD + Precursors: Cov Lus Nug Ntxiv. Metabolites, 12(7), 630.https://doi.org/10.3390/metabo12070630
Jacobson, MK, & Jacobson, EL (2018). Vitamin B3 nyob rau hauv kev noj qab haus huv thiab kab mob: Mus rau lub xyoo pua thib ob ntawm Discovery. Methods in molecular biology (Clifton, NJ), 1813, 3–8.https://doi.org/10.1007/978-1-4939-8588-3_1
Trammell, SA, Schmidt, MS, Weidemann, BJ, Redpath, P., Jaksch, F., Dellinger, RW, Li, Z., Abel, ED, Migaud, ME, & Brenner, C. (2016). Nicotinamide riboside yog qhov tshwj xeeb thiab qhov ncauj bioavailable nyob rau hauv nas thiab tib neeg. Nature Communications, 7(1), 1-14.https://doi.org/10.1038/ncomms12948
Xu, P., & Sauve, AA (2010). Vitamin B3, nicotinamide adenine dinucleotides thiab kev laus. Mechanisms of Aging and Development, 131(4), 287-298.https://doi.org/10.1016/j.mad.2010.03.006
