Gamma Aminobutyric Acid Hmoov

Taw qhia:

Gamma aminobutyric acid hmoov(GABA), ib txwm tshwm sim tsis yog -protein amino acid, yog ib qho tseem ceeb heev inhibitory neurotransmitter nyob rau hauv cov tsiaj hauv nruab nrab paj hlwb. Gamma-aminobutyric acid (GABA) yog tsim los ntawm L-glutamate nyob rau hauv catalysis ntawm glutamate decarboxylase. Hauv nruab nrab lub paj hlwb, thaum GABAergic neurons tso GABA, nws khi rau cov receptors sib xws ntawm cov synapses ntawm cov neurons uas nyob ib sab, tiv thaiv cov neuron los ntawm kev tsim muaj peev xwm thiab yog li tiv thaiv cov neuron los ntawm kev tso nws cov neurotransmitters. neurotransmitters nyob rau hauv nws, yog li ntawd nws tsis tuaj yeem cuam tshuam rau lwm cov paj hlwb uas tuaj yeem tiv nrog nws.

Muaj tsawg kawg peb hom ntawm -aminobutyric acid receptors: ionotropic channel GABA-A, GABA-C receptors, thiab metabotropic GABA-B receptors. Ntawm lawv, GABA-A thiab GABA-C yog ligand-gated chloride ion channels. Thaum GABA khi rau lawv, cov receptors qhib thiab tso cai rau cov tshuaj chloride ions ntws mus rau hauv cov neuron, ua rau cov cell membrane super-saturated, yog li txo qhov muaj peev xwm ua tau zoo; GABA-B yog cov metabotropic receptors uas, thaum qhib, ua rau qhib cov poov tshuaj ion channels uas tso cai rau cov poov tshuaj ions zoo kom ntws tawm ntawm cov neuron, rov supercharging cov neuron thiab inhibiting paj hlwb ua haujlwm.

 

 

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COA

Khoom npe	Gamma{0}}aminobutyric acid hmoov	Hnub tsim khoom	Lub Ob Hlis . 08, 2022
Batch Number	TIAB SA 220208	Hnub Soj Ntsuam	Lub Ob Hlis . 13, 2022
Ntau	500 kgs	Daim ntawv pov thawj hnub	Lub Ob Hlis . 07, 2025
Kev tsom xam	Specification	Cov txiaj ntsig
Assay	> 98%	99.8%
Kev tswj lub cev & tshuaj
Kev txheeb xyuas	Qhov zoo	Ua raws
Qhov tshwm sim	Daj los yog dawb, crystalline hmoov	Ua raws
tsw	Yam ntxwv	Ua raws
Saj	Yam ntxwv	Ua raws
Poob rau ziab	<0.5%	0.3%
Residual Solvents	Eur. Pharm.	Ua raws
Hnyav Hlau	<10PPM	0.40 ppm ua
Pb	<2.0ppm	Ua raws
Raws li	<2.0ppm	Ua raws
Hg	<0.5ppm	Ua raws
Cd	<0.5ppm	Ua raws
Tshuaj tua kab	Tsis zoo	Tsis zoo
Microbiological
Tag Nrho Phaj suav	<1000CFU/gm	Ua raws
Yeast & Pwm	<100CFU/gm	Ua raws
Salmonella	Tsis zoo	Tsis zoo
E. Coli.	Tsis zoo	Tsis zoo
Xaus
Cia	Khaws rau hauv qhov chaw txias & qhuav, Khaws kom deb ntawm lub teeb muaj zog thiab cua sov.
Txee lub neej	18 Lub Hlis thaum khaws cia zoo

 

Txoj Kev Xeem:

A.1 Txoj Cai

Gamma aminobutyric acid hmoov yog quantitatively derivatized nrog o-phthalaldehyde los tsim isoindole derivatives nrog muaj zog fluorescence thiab UV nqus. Qhov sib txawv ntawm cov amino acid derivatives nkag mus rau hauv chromatographic kem tib lub sij hawm, vim qhov sib txawv ntawm kev sib cais, adsorption, permeation los yog ion pauv ntawm cov theem ntawm lub xov tooj ntawm tes thiab cov theem nyob ruaj ruaj, tau rov faib dua ntawm ob theem ntawm chromatographic kem nrog rau theem mobile. Vim yog qhov sib txawv txav nrawm ntawm txhua qhov sib xyaw hauv chromatographic kem, tom qab dhau los ntawm qee qhov ntev ntawm chromatographic kem, lawv tau sib cais los ntawm ib leeg, ntws tawm ntawm chromatographic kem nyob rau hauv ib ntus, nkag mus rau lub teeb liab ntes, thiab tso saib txhua yam ntawm lub kaw lus lossis cov ntaub ntawv tshawb nrhiav thiab ua cov cuab yeej. Tus nqi siab tshaj plaws ntawm cov spectrum tau ntsuas los ntawm cov txheej txheem sab nraud raws li lub sijhawm khaws cia.

A. 2 Cov cuab yeej

A.2.1 Siab-kev ua haujlwm ua kua chromatograph nruab nrog UV lossis evaporative lub teeb diffraction ntes thiab cov ntaub ntawv ua haujlwm

A.2.2 Kem: C18

A. 2. 3 Kev ntsuas ntsuas qhov ntsuas: qhov ntsuas siab 0.1 mg

A. 2.4 Ultrasonic yaj

A . 2.5 Microporous lim

A. 2.6 Lub raj mis Volumetric: 100 mL

A. 2. 7 Syringe Lim (0.22 μm)

A.3 Reagents:

Tshwj tsis yog tias tau teev tseg, tag nrho cov reagents siv nyob rau hauv kev tshuaj ntsuam yog ntawm analytical qib.

A.3.1 Methanol: Chromatographic Qib

A.3.2 acetonitrile: qib chromatographic

A.3.3 Orthophthalaldehyde (OPA)

A. 3.4 Triethylamine

A.3.5 Crystalline Sodium Acetate

A.3.6 Trichloroacetic acid

A.3.7 Glacial acetic acid

A.3.8 Tetrahydrofuran

A.3.9 Gamma-aminobutyric acid tus qauv: purity tsis tsawg dua 99.0%

A.3.10 Boric acid

A.3.11 Sodium hydroxide

A.4 Cov kauj ruam tsom xam

A.4.1 Kev npaj cov txheej txheem daws teeb meem

Ua kom raug hnyav 0.05g ntawm gamma-aminobutyric acid tus qauv (qhov tseeb rau 0.0001 g), yaj nws nrog dej thiab dilute mus rau 100 mL, lim nrog 0.22 μm membrane, thiab sau cov lim raws li cov qauv kev daws teeb meem.

A.4.2 Kev npaj cov qauv kev daws teeb meem

Ua kom raug hnyav 0.05 g ~ 0.25 g ntawm cov qauv pulverized (qhov tseeb rau 0.0001 g), yaj nws nrog dej thiab dilute mus rau 100 mL, tom qab ultrasonic dissolving, lim nws nrog 0.22 μm lim membrane, thiab sau cov lim raws li cov qauv kev daws teeb meem.

A.4.3 Kev npaj ntawm 0.4 mol / L boric acid tsis

Ua kom raug hnyav 2.47 g ntawm boric acid (ua kom raug rau 0.000 1 g), ntxiv txog 80 mL dej, kho pH rau 10.2 nrog sodium hydroxide, thiab dilute rau 100 mL nrog dej.

A.4.4 Kev npaj ntawm derivatizing reagents

Qhov hnyav 0.1 g ntawm o-phthalaldehyde (OPA), yaj nws hauv 1 mL ntawm acetonitrile, ntxiv 130 μL ntawm mercaptoethanol, thiab ua rau 10 mL nrog 0.4 mol / L boric acid tsis

A.4.5 Pre-Kumn derivatization

Precisely ntsuas qhov ntim ntawm cov qauv kev daws teeb meem thiab 5.0 μL ntawm derivatization reagent, sib tov thiab hnov ​​​​mob li ntawm 2 feeb ua ntej txhaj tshuaj.

A.4.6 Chromatographic tsom xam tej yam kev mob

A.4.6.1 Mobile Phase

Theem A: Nyhav 8.0 g ntawm crystalline sodium acetate, yaj hauv dej thiab ua kom txog li 1 000 mL; tom qab ntawd ntxiv 220 μL ntawm triethylamine, do thiab ntxiv 5% acetic acid dropwise los kho cov pH rau 7.20+0.02; Thaum kawg ntxiv 5 mL ntawm tetrahydrobark N, sib tov thiab lim, tso tseg

Theem B: Nyhav 8.0 g ntawm crystalline sodium acetate, yaj nws hauv dej thiab dilute rau 1 000 mL; tom qab ntawd ntxiv 2% acetic acid dropwise los kho cov pH rau 7.20 ± 0.02; ces nias sodium acetate tov: acetonitrile: methanol=1: 2: 2 (ntim piv) lim tom qab sib tov thiab tso tseg

Cov txheej txheem gradient elution muaj nyob rau hauv Table A.1

Sijhawm / min	A/%	B/%	Ceev / (ml / min)
0	92	8	1.0
20	60	40	1.0
24	0	100	1.5
24.5	0	100	1.5
26.5	100	0	1.0
28	92	8	1.0

A.4.6.2 Kem kub: 40 degree

A.4.6.3 Flow tus nqi: 1.0 mL / min

A.4.6.4 Ntsuas wavelength: 338 nm

A.4.7 Standard nkhaus

Ua kom raug kos 2 μL, 4 μL, 5 μL, 10 μL, 12 μL ntawm cov txheej txheem kev daws teeb meem (0.5 mg / mL), feem, ua cov tshuaj ntsuam xyuas chromatographic raws li A.4.4 thiab A.4.5, thiab coj thaj chaw ncov - qhov ntim ntawm cov txheej txheem kev daws teeb meem raws li tus qauv nkhaus thiab recorrelation, kos duab. coefficient R yuav tsum siab tshaj 0.999 0

A.4.8 Kev txiav txim siab

Nqa cov qauv npaj thiab ntsuas nws raws li A.4.4. Sau lub sijhawm khaws cia thiab thaj chaw ncov ntawm lub ncov chromatographic, thiab lub sijhawm los ntawm kev ua kom zoo ntawm cov qauv thiab cov qauv kev daws teeb meem rau kev txhaj tshuaj yuav tsum zoo ib yam. Raws li thaj chaw ncov ntawm chromatographic ncov, qhov sib thooj ntawm gamma -aminobutyric acid raug xam los ntawm cov txheej txheem sab nraud. Cov lus teb tus nqi ntawm cov tshuaj ntsuam xyuas hauv cov qauv kev daws teeb meem yuav tsum yog nyob rau hauv cov kab uas txiav txim siab los ntawm cov instrumen

 

Muaj nuj nqi

● Gamma{0}}aminobutyric acid hmoovtuaj yeem txhawb kev tso tawm ntawm kev loj hlob hormone los ntawm lub caj pas pituitary; tib lub sijhawm, gamma-aminobutyric acid tuaj yeem txo qhov tshwm sim ntawm insomnia, ua kom lub sijhawm pw tsaug zog ntev, thiab txhim kho kev pw tsaug zog zoo. Lub sij hawm pw tsaug zog txaus kuj tseem ceeb rau cov menyuam yaus kom loj hlob, vim tib neeg lub cev Lub pulsatile secretion ntawm kev loj hlob hormone peaks thaum hmo ntuj, yog li tsim nyog gamma -aminobutyric acid supplementation muaj qee yam txiaj ntsig rau kev loj hlob thiab qhov siab ntawm cov menyuam yaus.

 

● Nws tuaj yeem nkag mus rau lub voj voog tricarboxylic acid nyob rau hauv lub hlwb, txhawb lub hlwb cell metabolism, thiab nyob rau tib lub sij hawm nce cov kev ua ntawm qabzib phosphatase thaum lub sij hawm qabzib metabolism, ua rau kom cov acetylcholine ntau lawm, dilate cov hlab ntsha kom cov ntshav khiav, txo cov ntshav ammonia, txhawb lub hlwb metabolism, thiab restore hlwb hlwb muaj nuj nqi.

 

● GABA hmoov tuaj yeem inhibit decarboxylation ntawm glutamic acid thiab txo cov ntshav ammonia. Ntau glutamic acid ua ke nrog ammonia los tsim urea thiab tso tawm kom txo tau ammonia toxicity, yog li txhim kho daim siab ua haujlwm.

 

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