Raw Khoom Indole-3-Carbinol

Taw qhia:

Indole-3-carbinol muaj nyob hauv ntau cov nroj tsuag. Xws li broccoli, zaub qhwv, zaub qhwv, zaub qhwv liab, zaub qhwv, thiab lwm yam.Thiab nws yog ib qho tseem ceeb rau tib neeg lub cev. Nrog cov ntsiab lus siab tshaj plaws, cov khoom noj muaj txiaj ntsig zoo, thiab tus nqi tshuaj, hauv kev lag luam kws tshuaj raws li cov tshuaj nruab nrab, cov khoom siv raw Indole-3-Carbinol kuj tuaj yeem siv rau hauv cov khoom noj khoom haus, cov khoom nruab nrab hauv cov khoom kho mob thiab lwm yam.

Guan jie tshwj xeeb hauv kev cog qoob loo rau 17 xyoo, thiab tam sim no tsim cov tshuaj indole, nrog cov khoom muag txaus, lub Hoobkas ncaj muag, tus nqi pheej yig, thiab ntau cov txiaj ntsig thiab cov luv nqi uas tuaj yeem txaus siab los ntawm kev xaj ntau ntau.

COA

Cov khoom	Specifications	Kev tshwm sim	Txoj Kev Xeem
Qhov tshwm sim	Tawm dawb mus rau dawb crystalline hmoov	Ua raws	Pom kev
Nplej, saj	Yam ntxwv	Ua raws	Kev xav
Particle Loj	98% dhau 80 mesh	Ua raws	GB/T 5507-2008
Cov ntsiab lus	Ntau dua lossis sib npaug rau 99.0 feem pua	99.06% ua	HPLC
Residue Ignition	Tsawg dua lossis sib npaug rau 0.1 feem pua	0.06 feem pua	GB/T 9741-2008
Poob rau ziab	Tsawg dua lossis sib npaug rau 1.0 feem pua	0.59 feem pua	GB 5009 3-2016
Melting Point	92 -99 degree	96.5 degree	GB/T 21781-2008
Hnyav Hlau	Tsawg dua lossis sib npaug li 10 ppm	Ua raws	GB 5009 74-2014
Pb	Tsawg dua lossis sib npaug li 2 ppm	Ua raws	GB 5009 12-2017
Raws li	Tsawg dua lossis sib npaug li 2 ppm	Ua raws	GB/T 5009 11-2014
Hg	Tsawg dua lossis sib npaug rau 0.5 ppm	Ua raws	GB/T 5009 17-2014
Cd	Tsawg dua los yog sib npaug rau 0.5ppm	Ua raws	GB 5009 15-2014
Solvent Residue	Tsis muaj toluene lossis benzene	Tsis muaj	GB 5009.262-2016
Tag nrho cov phaj suav	Tsawg dua lossis sib npaug li 1000 cfu / g	Ua raws	GB 4789.2 - 2016
Pwm&Yeast	Tsawg dua lossis sib npaug li 100 cfu / g	Ua raws	GB 4789.15 - 2016
E. Coli	Tsis muaj	Tsis muaj	GB 4789 38-2012
Salmonella	Tsis muaj	Tsis muaj	GB 4789 31-2016
Staphylococcus aureus	Tsis muaj	Tsis muaj	GB 4789 10-2016

Flowchart:

Synthesis Txoj Kev

Raw khoom: indole, phosphorus oxychloride thiab N, N-dimethylformamide

1) Los ntawm Vilsmeier-Haack cov tshuaj tiv thaiv nrog cov txiaj ntsig ntawm 87.1 feem pua.

2) Toluene-dej tshuaj tiv thaiv kab mob.

◆ Tus neeg sawv cev txo qis: potassium borohydride.

◆ Kub: 50-60 degree .

◆ Cov tshuaj tiv thaiv mob me me, thiab cov tshuaj tiv thaiv, kev rho tawm thiab rov ua dua tshiab tau ua tiav ib zaug, thiab cov txiaj ntsig yog 69.0 feem pua ​​.

◆ Ntxiv 8.7kg indole-3-carbaldehyde, 145kg toluene, 6.48kg potassium borohydride, 48kg dej distilled rau 300L enamel tshuaj tiv thaiv kettle, tshav kub, tswj cov tshuaj tiv thaiv kub ntawm 50-60 degree rau 5h, txias rau 15-20 degree, ntxiv 50kg distilled dej rau kev kho mob, centrifugal pom, ntxuav nrog distilled dej, thiab ziab kom tau 6.09 dawb dawb flaky crystals nrog ib tug tawm los ntawm 69.0 feem pua ​​thiab ib tug melting point ntawm 98 mus rau 100 degree (cov ntaub ntawv 99 txog 100 degree [10]).

◆ Elemental tsom xam, sim tus nqi (tus nqi theoretical)/feem pua

C73.58 (73.45), H6.20 (6.16), N9.42 (9.52). IR(KBr), /cm-1:3 380, 3052, 2927, 2865, 1543, 1455, 1420, 1356. 1H-NMR (500MHz, DMSO-d6), δ: 4.67 (d, J=5.3Hz, 2H, CH2), 4.71 (dd, J=6.0, 4.7 Hz, 1H, OH), 6.96-7.63 (m, 5H, ArH ), 10.83 (s, 1H, NH).

Cov ntaub ntawv: [1] Shen Xinan. Synthesis ntawm indole-3-methanol [J]. Modern Chemical Industry, 2008, (06): 43-45.

Cov nyhuv ntawm laryngeal carcinoma:

◆ Kev sim pab pawg thiab tswj pab pawg kho mob

◆ Lub sijhawm sim: 48 teev tom qab.

◆ Cov txiaj ntsig kev sim: Cov kab mob apoptosis ntawm Hep{{0}} cov hlwb yog (3.95±{19}}.68) feem pua ​​, (8.54±1.35) feem pua ​​, (21.28±2.32) feem pua ​​, (38.65± 4.85) feem pua ​​thiab (4.26 ± 0.58) feem pua.

◆ Kev sim tau pom

1) Indole-3-carbinol inhibited kev loj hlob ntawm Hep-2 nyob rau hauv ib tug concentration-dependent yam, induced apoptosis thiab kev qhia ntawm Livin protein.

2) Indole-3-carbinol tuaj yeem cuam tshuam kev loj hlob ntawm Hep-2 hlwb, thiab nws induction ntawm apoptosis tej zaum yuav cuam tshuam rau inhibition ntawm Livin protein qhia.

3) Nrog rau qhov nce ntawm indole-3-carbinol concentration, Livin qhia ntawm Tshuaj Phau Ntawv maj mam txo qis, qhia tias Livin protein qhia tau cuam tshuam tsis zoo nrog tus nqi apoptosis ntawm tib neeg laryngeal carcinoma cell kab Hep-2 tom qab indole{{ 3}}kev kho carbinol.

◆ Xaus: Livin protein tuaj yeem ua lub luag haujlwm hauv apoptosis ntawm tib neeg laryngeal carcinoma hlwb raug ntxias los ntawmRaw Khoom Indole-3-Carbinol. Indole-3-carbinol tsuas tuaj yeem ua rau apoptosis ntawm cov qog nqaij hlav cancer, muaj kev nyab xeeb rau cov qog nqaij hlav, thiab tsis muaj cytotoxicity.

Vim tias nws cov txiaj ntsig zoo, tsis muaj tshuaj lom thiab tiv thaiv qog noj ntshav, indole-3-carbinol tuaj yeem yog ib tus neeg sib tw rau kev tiv thaiv thiab kho mob qog noj ntshav. Lub tshuab molecular ntawm indole-3-carbinol inhibiting laryngeal qog nqaij hlav cancer tseem xav tau kev kawm ntxiv txhawm rau muab lub hauv paus theoretical rau kev tshawb fawb tshuaj kho mob yav tom ntej.

Cov ntaub ntawv:[2] Suav Journal of Clinical Pharmacology, 2015, (11): 932-934 ntxiv rau 959.

Kev siv ntawm Indole Trimethanol

Raw Khoom Indole-3-Carbinoltau siv los encapsulate poly-lactic-co-glycolic acid (PLGA) los kawm txog nws cov nyhuv ntawm lub mis adenocarcinoma epithelial cells (MCF7), colon adenocarcinoma epithelial cells (Caco2), prostate cancer epithelial cells (PC3) in vitro anticancer effect. Nws kuj tau siv los ua cytochrome P4501A (CYP1A) inducer.

Feem ntau siv raws li qib zaub mov, qib pub thiab qib tshuaj.

Biochemical / Physiological teebmeem

Txhawb nqa carcinogenesis ntawm thawj theem. Nws tau pom tias inhibit carcinogenesis nyob rau hauv ntau yam tsiaj, tab sis nws ua rau mob qog nqaij hlav yog tias siv nyob rau hauv cov theem tom qab pib. Pom nyob rau hauv cov zaub cruciferous. Indole-3-carbinol Powder activates aryl hydrocarbon receptor (AhR) induce G1 cell voj voog ntes thiab apoptosis. Yog li ntawd, nws yog ib tug muaj peev xwm anticancer neeg sawv cev. Tsis tas li ntawd, nws induces estradiol metabolism los ntawm stimulating cytochrome P450 enzymes. Yog li ntawd, I3C raug suav hais tias yog tus kws khomob zoo rau ntau hom mob qog noj ntshav, suav nrog lub mis, prostate, txoj hnyuv thiab leukemia.

Cov ntaub ntawv molecular

◆ Molar Refractive Index: 44.97

Molar ntim (m3/mol): 115.6

◆ Isometric tshwj xeeb ntim (90.2K): 324.2

◆ Nto nro (dyne/cm): 61.7

◆ Dielectric tsis tu ncua

◆ Dipole nrug (10-24cm3)

◆ Polarizability: 17.83

Computational chemical cov ntaub ntawv ntawm Raw Material Indole-3-Carbinol

◆ Hydrophobic parameter xam tus nqi siv (XlogP): 1.1

◆ Tus naj npawb ntawm cov neeg pub nyiaj hydrogen: 2

◆ Tus naj npawb ntawm hydrogen daim ntawv lees txais: 1

◆ Number of rotatable chemical bonds: 1

◆ Topological molecular polar nto cheeb tsam (TPSA): 36

◆ Tus naj npawb ntawm cov atom hnyav: 11

◆ Nto nqi: 0

◆ complexity: 138

◆ Tus naj npawb ntawm isotope atoms: 0

◆ Txiav txim seb tus naj npawb ntawm atomic stereocenters: 0

◆ Muaj pes tsawg tus atomic stereocenters: 0

◆ Txiav txim seb tus naj npawb ntawm cov chaw tso tshuaj stereo chemical: 0

◆ Tsis paub tseeb tus naj npawb ntawm cov tshuaj stereocenters: 0

◆ Tus lej ntawm covalent daim ntawv cog lus: 1

Peb lub Hoobkas:

Chaw Tshawb Fawb:

Daim ntawv pov thawj

Pob:

1kg / Al.foil hnab nrog pob tshab hnab yas sab hauv

25kg / ntawv nruas nrog lub hnab yas dub sab hauv

Kev xa khoom xa tuaj:

Cim npe nrov: raw khoom indole-3-carbinol, Tuam Tshoj raw khoom indole-3-carbinol manufacturers, lwm tus neeg, Hoobkas