Nmn tej hmoovTau surged mus rau qhov ua kom muaj kev lag luam kev ua zaub mov thiab kev lag luam tseem ceeb rau kev tsim kho lub zog ntawm cellular lub zog, kho DNA, thiab kev noj qab haus huv me ntsis. Raws li peb NAD + qib poob nrog lub hnub nyoog, ntxiv nrog NMN tej yam zoo los txhawb lub hnub nyoog cov hnub nyoog {}} kev poob qis. Txawm li cas los xij, kev ua tau zoo, kev nyab xeeb, thiab bioavailability ntawm NMN ntxiv yog intrinsically txuas rau nws txoj kev ntau lawm. Yog li, NMN tau ua li cas?
HOw NMN yogMua yeeb yam?
Muaj peb txoj hauv kev tseem ceeb los tsim NMN cov hmoov rau ntawm cov nplai ua lag luam: tshuaj lom neeg, kev sib xyaw ua ke, thiab fermentation. Txhua txoj kev muaj qhov zoo sib xws thiab cov teeb meem hais txog cov txiaj ntsig, kev coj dawb huv, nqi, thiab ib puag ncig cuam tshuam.
Kev Siv Hluav Taws Xob Hluav Taws Xob
Tshuaj lom hluav taws xob hluavtaws sawv cev rau ib qho ntawm cov txheej txheem hauv lub hauv siab rau kev tsim cov nicotinamide mononucleotide nplaus hmoov hauv ib lab. Qhov ntau {-}}}}}}}}}}}}}}}}}}} Cov tshuaj tiv thaiv kab mob nruab nrab ntawm nicotinamide derivative thiab ribose- raws molecule. Txhawm rau tswj cov tshuaj tiv thaiv thiab tiv thaiv cov khoom tsis xav tau sab, pab pawg tiv thaiv feem ntau siv los cuam tshuam txog cov molecules thaum synthesis.
• Ntau Lawm:
Cov txheej txheem feem ntau ua haujlwm hnyav daws, kub siab, thiab cov neeg hlau txuas rau cov pab pawg nicotinamide uas txuas nrog pawg nicotinamide uas txuas rau cov pab pawg nicotinamide uas txuas nrog pawg nicotinamide uas txuas rau cov pab pawg nicotinamide uas txuas nrog pawg nicotinamide uas txuas nrog pab pawg nicotinamide uas txuas nrog pawg nicotinamide uas txuas nrog pawg nicotinamide uas txuas nrog pab pawg nicotinamide uas txuas nrog pab pawg nicotinamide uas txuas nrog pawg nicotinamide uas txuas nrog pawg nicotinamide uas txuas nrog pawg nicotinamide uas txuas rau cov pab pawg nicotinamide uas txuas nrog pawg nicotinamide uas txuas nrog pab pawg niab Thaum cov tshuaj tiv thaiv tiav, kev ua kom tiav kom tshem tawm cov khoom seem, cov kuab tshuaj, thiab lwm yam khoom siv tsis zoo rau kev noj kom zoo.
Cov txiaj ntsig zoo
Ib qho ntsiab lus tseem ceeb ntawm hom qauv no yog tus nqi - ua tau zoo rau me me- nplai, kev tshawb fawb kev tshawb fawb. Nws tseem tso cai rau tsim cov ntawv tshiab cov qauv sib piv ntawm nmn cov hmoov kawm tshwj xeeb rau kev kawm tshwj xeeb.
• tsis pom zoo
Txawm li cas los xij, nws qhov tsis zoo yog qhov tseem ceeb. Cov txheej txheem complex feem ntau ua rau hauv qab kev coj dawb huv, nrog kev pheej hmoo ntawm kev sib kis los ntawm cov kuab tshuaj thiab hlau hnyav. Nws kuj tseem tsim cov khib nyiab ntau ntxiv, nce kev txhawj xeeb ib puag ncig. Tsis tas li ntawd, cov tshuaj lom neeg ua haujlwm tsim cov khoom sib xyaw ntawm ob lub suab paj nruag (alpha thiab cov ntawv beta). Tsuas yog qhov beta - daim ntawv (- nmn) yog biologically nquag nyob rau hauv tib neeg. Cais cov ntshiab, nquag {{{{{- nmn yuav tsum muaj cov kauj ruam ntxiv, sib txawv.
Thiaj li, thaum cov kws tshawb nrhiav cov tho kev zoo li IMAI kev cia siab rau kev tsim cov qib siab {{}} qib nutraceuticals. Kev lag luam tau hloov pauv ntawm cov tshuaj ntxuav huv, ntau txoj hauv kev los xyuas kom meej txog kev nyab xeeb ntawm tib neeg kev noj haus.
Enzymatic synthesis (biocatalysis)
Qhov no yog tam sim no suav hais tias yog tus qauv kub rau kev tsim cov siab - purity, bioids hmoov nmn hmoov ntau rau cov tshuaj. Nws mimics lub ntuj biosynthetic evam los pom hauv cov cell, siv cais cov enzymes ua catalysts raws li cov xwm txheej me me.
• Txheej txheem:
Feem ntau cov enzymatic pathwering rau enzyme nicotinamide cov tshuaj tiv thaiv ntawm nicoticayl pyrophosporase (prpp) los ua nmn ntau hmoov. Cov chaw tsim khoom tsim cov bioractor muaj cov ua kom muaj cov hmoov av huv thiab substrates, cia lawv tsim cov hmoov ntshiab nmn nrog kev ua haujlwm siab thiab tshwj xeeb.
• Cov txiaj ntsig:
High Purity: Results in exceptionally high purity (often >99%) Nrog tsawg kawg impurities.
Lub serospecificity: enzymes yog ib qho tshwj xeeb, tsim tsuas yog muaj kev ua haujlwm biologically - pain hmoov.
Cov kev siv roj ntsuab: tshwm sim nyob rau hauv cov kua aqueous ntawm kev kub thiab pH, ua rau nws ib puag ncig cov txheej txheem nrog cov khib nyiab ib puag ncig.
Qhov muaj ntawm cov siab siab -}}} Kev tshawb fawb, cia cov kws tshawb fawb kev ntseeg siab rau kev ntseeg siab rau cov txiaj ntsig kev noj qab haus huv.
Guanjie Biotech yog lub siab -}} Tus neeg muag khoom zoo uas siv qhov kev ua tau zoo tshaj plaws ennzymatic sapthesis synthesis. Los ntawm kev ua haujlwm rau cov txheej txheem ncaj qha, lawv ua kom lawv cov khoom muaj kuab lom, thiab yog qhov tseeb ntawm cov suab paj nruag zoo rau tib neeg txoj kev nqus thiab kev ua tau zoo.
Fermentation (microbial biosynthesis)
Cov qauv no muaj kev mob siab rau lub ntuj muaj zog ntawm cov kab mob uas ua kom muaj kab mob me, xws li khib nyiab me me "uas yog ua kom zoo nkauj thiab ua haujlwm NMN ntau hmoov.
Cov microbes muab hluav taws xob zoo dua yog tom qab ntawd faus rau hauv loj- nplai fermentation tso tsheb hlau luam hauv nruab nrab {{}}} kev nplua nuj kev loj hlob nruab nrab. Raws li cov microorganisms haus cov as-ham thiab metabolize, lawv tau hloov lawv mus rau hauv nmn tej hmoov, uas yog tom qab tau zais rau hauv ib puag ncig broth.
• kom zoo dua
Ib qho txiaj ntsig tseem ceeb ntawm fermentation yog nws qhov tshwj xeeb ua kom haum; Nws yog qhov tsis zoo haum rau tus nqi -} Siv tau yooj yim ntau yam tau ua rau thoob ntiaj teb xav tau. Tsis tas li ntawd, raws li nws tau raws li cov txheej txheem roj ntsha, lub txiaj ntsig nmn tej hmoov feem ntau ua rau cov neeg siv khoom nrhiav kom huv si {}}} daim ntawv lo rau cov khoom lag luam.
• Tsis pom zoo:
Txawm li cas los xij, tus qauv tau nthuav tawm cov tsis tau. Thawj qhov kev sib tw yog cov txheej txheem hauv qab. Thaum pib fermentation broth yog ib txoj kab sib xyaw muaj cov microbial, ua kom muaj ntau yam kev sib xyaw ua ke, thiab lwm yam kev ua kom huv thiab huv si ntawm cov tshuaj ntshiab thiab kim kawg. Tsis tas li ntawd, fermentation tuaj yeem raug kev txom nyem los ntawm qis cov txiaj ntsig piv rau lwm txoj kev thiab kev txhim kho cov kev loj hlob thiab txij nkawm txoj kev loj hlob thiab kho kom hloov mus rau hauv cov khoom lag luam.
Guanjie Bioch siv cov qauv fermentation no. Lub peev xwm no tso cai rau lawv kom rub tawm nws cov ntsuas rau cov xaj loj. Los ntawm mastering ob qho enzymatic thiab fermentation techniques, guanie biotech cov txheej txheem los tsim cov neeg siv khoom zoo raws tshwj xeeb cov neeg siv khoom, siab- kev tsim khoom zoo.
Kev Tshawb Fawb Tseem Ceeb ntawm NMN Txuj Ci Ntau Lawm
Cov av tshawb fawb uas tau hais tias nmn nmn mus rau hauv lub tsom teeb cia siab dawb, zoo} tus cwj pwm nmn, underscoring qhov tseem ceeb ntawm nws txoj kev ntau lawm.
• David Sinclair cov neeg kawm Harvard (2013):
Kev kawm kev kawm seminal nyob rau hauv cell qhia hais tias ntxiv cov nas laus nrog NMN refendivity, thiab txhim kho cov metabolism uas zoo ib yam li cov neeg hluas. Lub purity ntawm NMN siv tau tseem ceeb los xyuas kom cov teebmeem no tsis yog vim muaj kuab lom lossis impurities.
• Tib neeg sim:
Ntau tib neeg cov kev sim tau pib siv tau cov kev tshawb pom no. Ib qho kev kawm 2020 tau tshaj tawm nyob rau endocrine phau ntawv tshaj tawm pom tias ib qho ntawm qhov ncauj ntawm NMN (100, 250, thiab 500 mg) tau muaj kev nyab xeeb hauv cov txiv neej Japanese tsis muaj ib qho cuam tshuam dab tsi. Txoj kev tshawb no tau sau qhov tseem ceeb ntawm kev siv cov tshuaj ntsuab zoo heev - qib nmn. Lwm qhov 2021 kawm hauv cov ntaub ntawv scientific tau pom tias 250 mg ntawm nmn txhua hnub rau 12 lub lis piam zoo dua cov leeg insulin rhiab nyob rau hauv kev txiav txim siab poj niam. Kev sib xws ntawm cov kev sim siab no yog qhov kev sim siab yog qhov ua tiav los ntawm kev tswj cov txheej txheem ntau lawm xws li enzymatic synthesis.
• Kev Tshawb Fawb Bioavailabus:
Kev tshawb fawb tau pom tias yuav ua li cas nmn yog nqus tau. Kev tshawb fawb hauv kev hais tias NMN yuav nqus ntawm ib qho kev thauj khoom tshwj xeeb hauv kev nkag mus me me (SLC12A8). Kev ntseeg tau ntawm cov kev tshawb fawb nqus tau yog nyob ntawm kev siv daim ntawv ntshiab, tsis tau muaj npe ntawm NMN los yog qhov tseeb lw nws txoj kev hauv lub cev.
Tag
Cov qauv ntawm kev tsim khoom tsis yog ib qho kev tsim khoom tab sis kev txiav txim siab tseem ceeb ntawm kev ua tau zoo, kev nyab xeeb, thiab roj ntsha ua haujlwm ntawm NMN ntxiv. Thaum cov tshuaj lom neeg cov khoom siv hluav taws xob txoj kev rau kev tshawb fawb thaum ntxov, kev lag luam muaj ntau txoj kev nqus tsev ntxhua khaub ncaws, ntau txoj kev siv roj ntsha. Enzymatic synthesis sawv tawm rau nws lub peev xwm los tsim ultra {2} {{}}}}}}}}} nutr sceadorificate. Fermentation muab cov qauv ua kom haum thiab "txoj kev" lwm yam, txawm hais tias muaj nws cov kev cov kev sib tw.
Yog tias koj xav tau NMN cos hmoov, txais tos xaiv Guanjie Biotech. Peb siv ob txoj hauv kev enzymatic thiab fermentation txoj kev, uas sawv cev cov kauj ruam niaj hnub mus rau NMN ntau lawm. Peb siv cov txuj ci siab no ua kom muaj txiaj ntsig zoo, nyab xeeb, thiab muaj kev cia siab rau cov neeg siv khoom thiab kev ntseeg siab rau NMN kom txhawb kev noj qab haus huv thiab ntev. Thov koj xav tiv tauj peb, peb tuaj yeem muab cov tshuaj uas haum. Txais tos rau nug nrog peb ntawminfo@gybiotech.com.
Ntawv Sawv cev
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