98% Cycloastragenol hmoov

Kev taw qhia luv luv

98% Cycloastragenol Powder, tsim los ntawm Guanjie, yog muab los ntawm astragalus zus nyob rau hauv peb cog puag. Nws yog muab rho tawm, concentrated siv cov txheej txheem tshwj xeeb, thiab tom qab ntawd ua tiav rau hauv cov hmoov siv tshuaj tsuag kom qhuav tshuab. Cov khoom lag luam nthuav tawm cov dej zoo solubility, instantly dissolving ntawm chav tsev kub, thiab tswj cov khoom ruaj khov. Nws yog nkag tau sai thiab sai absorbed los ntawm tib neeg lub cev, ua rau nws haum rau siv raws li raw cov ntaub ntawv nyob rau hauv kws tshuaj noj thiab veterinary pub ntau lawm.

Raws li ib tug triterpenoid saponin, Cycloastragenol ua hauj lwm ua tus thawj aglycone ntawm Astragaloside thiab yog tsuas yog tau los ntawm hydrolysis ntawm Astragaloside IV. Xyoo 2010, Geron Biotechnology Company ntawm Tebchaws Meskas tau tshawb pom tias cycloastragenol muaj cov nyhuv telomerase tseem ceeb, yog li ncua telomere luv luv thiab thaum kawg nthuav tawm cov khoom tiv thaiv kev laus. Tsis tas li ntawd, cycloastragenol kuj qhia tau tias muaj peev xwm ua haujlwm tshuaj nrog rau cov tshuaj tiv thaiv kab mob, tiv thaiv lub ntsws raug mob, tiv thaiv kev nyuaj siab, thiab tiv thaiv hyperlipidemia.

 

Vim li cas thiaj xaiv Guanjie?

● Cov thev naus laus zis tshiab:

Peb tau mob siab rau txoj kev loj hlob ntawm patented natural khoom nrog 3 patented technologies.

Patent No.	Patent npe
PIB CN105755064A	Lus Nug: Cov khoom tsim muaj cuam tshuam rau ib txoj hauv kev npaj phosphatidylserine los ntawm kev siv kua actinomycete GJ
CN202122662941.X	Lus Cim: Cov khoom tsim tawm nthuav tawm cov cuab yeej tiv thaiv rau cov qauv crushing
CN216261052U	Lus Cim: Cov khoom tsim tawm nthuav tawm cov khoom siv tshuaj ntsuam xyuas kev ua haujlwm siab, uas suav nrog cov khoom noj hopper

● International Certification System:

Peb tau txais ISO9001, ISO22000, IP (tsis yog-GMO), QS, Kosher, Halal, thiab lwm yam.

● Kev tswj xyuas nruj nruj:

Peb ua yuav luag tag nrho cov khoom kuaj hauv tsev, suav nrog kev soj ntsuam, cov ntsiab lus dej, tsw, hnyav hlau, hnyav residue, tshuaj tua kab residue, protein cov ntsiab lus, kuaj microbiological, thiab ntau dua.

● Kev xa khoom xa tuaj:

Peb cov kws tshaj lij shipping neeg ua haujlwm tau koom tes nrog peb rau ntau tshaj 15 xyoo, kom ntseeg tau tias cov khoom tuaj yeem raug xa tawm sai thiab nyab xeeb.

 

COA:

Yam khoom	Specification	Kev tshwm sim	Txoj kev
Cov ntaub ntawv tseem ceeb ntawm cov khoom
Genus thiab Hom	Scutellaria baicalensis Georgi.	Ua raws	/
Ib feem ntawm tsob nroj	Hauv paus	Ua raws	/
Lub Tebchaws Keeb Kwm	Tuam Tshoj	Ua raws	/
Marker Compounds
Kev Tshawb Fawb (Baicalin)	Ntau dua lossis sib npaug rau 85.0%	85.98%	HPLC
Cov ntaub ntawv Organoleptic
Qhov tshwm sim	Hmoov zoo	Ua raws	GJ-QCS-1008
Xim	Lub teeb daj mus rau xim av daj	Ua raws	GB/T 5492-2008
tsw	Yam ntxwv	Ua raws	GB/T 5492-2008
Saj	Yam ntxwv	Ua raws	GB/T 5492-2008
Cov yam ntxwv ntawm lub cev
Particle Loj (80 mesh)	100.0% dhau 80 mesh	Ua raws	GB/T 5507-2008
Poob rau ziab	<5.0%	3.22%	GB/T 14769-1993
Tshauv Ntsiab Lus	<5.0%	2.24%	AOAC 942.05, 18
Solvent Residue	Tsis muaj	Ua raws	GJ-QCS-1007
Hnyav Hlau
Total Heavy Metals	<10ppm	Ua raws	USP<231>, method II
Raws li	<2.0ppm	Ua raws	AOAC 986.15, 18
Pb	<2.0ppm	Ua raws	AOAC 986.15, 18
Cd	<0.5ppm	Ua raws	AOAC 986.15, 18
Hg	<0.5ppm	Ua raws	AOAC 971.21, 18
Microbiology
Tag Nrho Phaj suav	<1,000cfu/g	Ua raws	AOAC 990.12, 18
Poov & Pwm	< 100cfu/g	Ua raws	AOAC/Petrifilm
E. Coli	Tsis zoo	Tsis zoo	AOAC 997.11, 18
Salmonella	Tsis zoo	Tsis zoo	FDA (BAM) Tshooj 5, 8th Ed.

 

Txoj Kev Npaj

Raws li aglycone, tus yuam sij rau kev npaj 98% cycloastragenol hmoov yog rhuav tshem cov glycosidic daim ntawv cog lus. Lub cleavage ntawm daim ntawv cog lus aglylate tuaj yeem ua tiav los ntawm homogeneous hydrolysis lossis ob-theem hydrolysis. Txoj kev tom kawg yuav pab kom tsis txhob muaj kev sib cuag ntau dhau ntawm aglylate nrog cov kua qaub thiab cov hauv paus, yog li txhim kho cov txiaj ntsig ntawm aglylate. Raws li cov catalyst siv, cov txheej txheem tuaj yeem koom nrog acid hydrolysis, alkali hydrolysis, acetylation, enzymatic hydrolysis, periodic acid lysis, thiab lwm yam. Cov ntawv ceeb toom tam sim no ntawm kev npaj ntawm cycloastragenol feem ntau tsom rau cov kua qaub hydrolysis, enzymatic hydrolysis, thiab periodic acid lysis.

 

Muaj nuj nqi:

● Anti-aging nyhuv.

Muaj ntau txoj kev xav txog kev laus, tab sis txoj kev xav telomere yog qhov muaj feem cuam tshuam. Nrog rau kev tshawb fawb tob zuj zus ntawm telomerase thiab telomeres, nws pom tau tias kev ua kom telomerase tuaj yeem ua rau cov cell faib thiab ua kom lub neej ntev. Yog li ntawd, nrhiav tau ib qho zoo telomerase activator yog qhov tseem ceeb rau kev tiv thaiv kev laus. Bemanles et al. pom tias cycloastragal cawv tuaj yeem ua kom luv luv telomeres thiab ua kom lub neej noj qab haus huv ntawm cov neeg laus lossis cov neeg laus nas yam tsis muaj qhov tshwm sim ntawm cov kab mob.

Cao Yanling et al. tau kawm txog kev tiv thaiv kev laus ntawm cycloastragalus cawv ntawm d-galactose-induced aging nas, thiab cov txiaj ntsig tau pom muaj txiaj ntsig zoo los tiv thaiv kev laus. Qhov no tej zaum yuav yog vim muaj kev nce ntxiv ntawm tag nrho superoxide dismutase (T-SOD) thiab tag nrho cov peev xwm antioxidant (T-AOC), thiab txo qis ntawm malondialdehyde (MDA) thiab hydroxytrophin (HYP).

 

● Antiviral nyhuv.

Cov hlwb ntawm lub cev tiv thaiv kab mob tau txais kev faib ntau los ua lawv txoj haujlwm, ua rau muaj kev ua haujlwm telomerase qis. Cov kev tshawb fawb tau pom tias thaum lub zog tiv thaiv kab mob T hlwb raug txhawb, kev ua haujlwm telomerase tuaj yeem hloov kho, thiab nws qhov kev siv zog tuaj yeem zoo ib yam li cov qog hlwb. Lwm cov kev tshawb fawb tau pom tias txo qis kev ua haujlwm telomerase ua rau poob ntxov ntxov hauv lub cev tsis muaj zog. Yog li ntawd, ua kom telomerase kev ua haujlwm hauv T hlwb tau dhau los ua qhov tseem ceeb ntawm kev tshawb fawb tshuaj tiv thaiv kab mob. Molgora piv cov teebmeem ntawm ob lub astragalus rho tawm, TA-65 thiab HTA, ntawm kev loj hlob thiab telomerase kev ua ntawm tib neeg CD4 T hlwb thiab CD8 T hlwb. Cov txiaj ntsig tau pom tias TA-65, uas yog cov cawv extract ntawm astragalus membranaceus, nthuav tawm pom tseeb telomerase ua kom. Faus et al. tau pom tias kev txhim kho telomerase yog txuam nrog kev txhim kho T cell thiab txo cov kab mob HIV. Yog li, TA-65 muaj peev xwm kho tau lwm yam kab mob uas yuav tsum tau txhim kho telomerase kev ua haujlwm hauv T hlwb.

 

● Kev tiv thaiv ntawm lub ntsws raug mob.

Idiopathic pulmonary fibrosis (IPF) yog ib tus kab mob tuag taus uas muaj qhov ua rau tsis paub meej, qhov pib tsis zoo, thiab ua rau hnyav dua, feem ntau cuam tshuam rau cov neeg muaj hnub nyoog nruab nrab. Nyob rau hauv xyoo tas los no, qee cov kws tshawb fawb tau pom tias IPF tiam yuav cuam tshuam nrog luv telomeres, vim tias qhov ntev ntawm telomere hauv cov neeg mob cov qe ntshav dawb luv dua li qub. Le Saux et al. kawm txog cov nyhuv ntawm cycloastragal cawv ntawm bleomycin-induced fibrosis hauv mTERT heterozygous nas raws li tus qauv nas ntawm idiopathic fibrosis. Hauv txoj kev tshawb no, cov pab pawg kho mob nrog cycloastragalus cawv cuam tshuam qhov kev loj hlob ntawm pulmonary fibrosis los ntawm kev ua kom telomerase thiab txo cov pob txha ntawm cov hlwb hauv lub ntsws. Kev tshawb fawb txog kev kho mob ntawm cycloastragalus cawv ntawm cov hlab ntsws me me hauv cov hlab ntsha me me los yog pulmonary fibrosis hauv vitro tau pom tias kev ua kom telomerase thiab rov ua lub neej txuas ntxiv tau ua tiav tsuas yog hauv cov hlwb epithelial, qhia tias kev tiv thaiv kev tiv thaiv ntawm cycloastragalus cawv tiv thaiv kev raug mob ntawm lub ntsws cuam tshuam nrog qee hom mob ntsws. . Yog li, telomerase activators muaj peev xwm kho idiopathic pulmonary fibrosis.

 

● Antidepressant nyhuv.

Nyob rau hauv xyoo tas los no, qee cov kws tshawb fawb tau hais tias kev ntxhov siab ntev, kev nyuaj siab, schizophrenia, thiab lwm yam kab mob tuaj yeem raug txiav txim los ntawm kev soj ntsuam qhov ntev ntawm telomere ntawm peripheral ntshav lymphocytes. Yog li, ncua sijhawm telomere luv lossis txawm tias ncua sijhawm telomeres tuaj yeem ua lub luag haujlwm hauv kev tiv thaiv lossis kev kho mob ntawm cov kab mob saum toj no. Ip et al. qhia tau hais tias cycloastragalus cawv tuaj yeem ua kom muaj kev ua haujlwm telomerase thiab txhawb kev loj hlob ntawm neonatal keratinocytes, tshwj xeeb tshaj yog hauv kev kho cov kab mob keratinocyte hauv vitro. Lub caij no, cycloastragalus cawv tuaj yeem ua rau muaj kev ua haujlwm ntawm telomerase kev ua haujlwm thiab cAMP cov lus teb cov ntsiab lus-binding protein (CREB) hauv PC12 hlwb thiab thawj cov neurons. Tom qab kev tswj hwm qhov ncauj ntawm cycloastragal cawv rau 7 hnub, cov txiaj ntsig tau pom tias nws tuaj yeem txo tus cwj pwm kev nyuaj siab hauv cov nas sim, qhia tias cycloastragal cawv muaj peev xwm loj hauv kev txhim kho kev nyuaj siab.

 

● Anti~hyperlipidemia nyhuv.

Nrog rau kev tshawb fawb tob zuj zus ntawm kev sib raug zoo ntawm hyperlipidemia thiab kab mob plawv, kev tshawb fawb thiab kev tsim cov tshuaj lipid-txo qis tau dhau los ua qhov tseem ceeb ntawm kev sib tw ntawm cov tuam txhab loj. 3T3-L1 pre-adipocytes feem ntau yog siv los tshuaj xyuas cov khoom xyaw nquag los txo cov rog rog. Wang et al., siv cov kab xov tooj ntawm tes no raws li kev tshawb fawb platform, pom tias cycloastragal cawv txhawb cov calcium nkag mus rau hauv 3T3-L1 pre-adipocytes nyob rau hauv cov koob tshuaj-dependent qauv, nrog ib nrab-zoo concentration mus txog 21.9 μmol·L. . Cov ntawv nyeem tau pom tias muaj calcium ntau ntxiv ua lub luag haujlwm tseem ceeb hauv inhibiting adipocytes sib txawv, yog li cycloastragal cawv tuaj yeem cuam tshuam cov cytoplasmic lipid droplets hauv 3T3-L1 adipocytes, qhia txog nws cov txiaj ntsig kho mob hauv kev txo cov rog rog thiab hyperlipidemia.

Tsis tas li ntawd, Yung et al. Kawm txog cov txheej txheem ntawm kev ua ntawm astragaloside IV thiab cycloastragal cawv ntawm kev loj hlob ntawm CD thiab T lymphocytes, thiab cov txiaj ntsig tau pom tias ob lub tebchaw kuj tuaj yeem txhawb nqa cov phosphorylation ntawm extracellular teeb liab tswj kinases hauv lwm cov kab ntawm tes, xws li ntsws, hlwb, cov qog mammary, cov hlwb endothelial, thiab cov kab mob hematopoietic, yog li cuam tshuam cov cell proliferation thiab sib txawv.

 

Txoj Kev Xeem

Chromatographic tej yam kev mob: Chromatographic kem: ZORBAX RX-C18 (4.6mm × 150mm), 5μm; Mobile theem: acetonitrile-dej (30:70); Tus nqi ntws: 1.0mL / min; Kem kub: 35 degree; ELSD tsis muaj: Drift tube kub: 105 degree, Nitrogen txaus tus nqi: 2.70mL / min.

 

Kev cia siab

Txawm hais tias 98% cycloastragenol hmoov muaj keeb kwm ntev ntawm kev siv, muaj tsawg heev qhia txog aglycones - cycloastragalus cawv ntawm feem ntau astragalus saponins. Nws tuaj yeem pom los ntawm kev tshuaj xyuas cov ntaub ntawv saum toj no tias txoj hauv kev zoo tshaj plaws rau kev npaj ntawm cycloastragalus cawv yog Smith degradation txoj kev tam sim no. Txawm li cas los xij, txoj kev no muaj ntau cov kauj ruam, tsis tshua muaj txiaj ntsig, thiab tus nqi nyiaj txiag siab, yog li nws tseem xav tau kev txhim kho ntxiv. Tshwj xeeb, cycloastragal cawv tau yooj yim hloov mus rau hauv astragalus cawv hauv qhov chaw acidic, uas ua rau muaj kev nyuaj siab ntawm kev npaj.

Ntxiv nrog rau cov lus tshaj tawm los tiv thaiv kev laus, tshuaj tiv thaiv kab mob, tiv thaiv kev raug mob ntsws, tshuaj tiv thaiv kev ntxhov siab, tshuaj tiv thaiv hyperlipidemia, thiab lwm yam dej num, xav tau kev tshawb fawb ntxiv los npaj cov tshuaj thiab siv rau hauv kev xyaum. Tsis tas li ntawd, cov qauv analogues ntawm cycloastragalus cawv tau los ntawm hydrolysis thiab biocatalysis kuj tseem muaj qee yam kev ua haujlwm lom neeg, uas kuj yog ib qho kev taw qhia rau kev tshawb fawb yav tom ntej. Nws tuaj yeem pom tau tias cycloastragalus cawv muaj qhov chaw tshawb fawb dav thiab kev lag luam zoo kev lag luam.

Factory & Pab Pawg:

 

Daim ntawv pov thawj

 

Ntim & Xa khoom

Cim npe nrov: 98% cycloastragenol hmoov, Tuam Tshoj 98% cycloastragenol hmoov manufacturers, lwm tus neeg, Hoobkas