Bulk Ergothioneine hmoov

Bulk Ergothioneine Powder yog dab tsi?

Bulk ergothioneine hmoovyog dawb crystal hmoov. Tus txheeb ze molecular loj yog 229.3, nws yog soluble hauv dej, thiab solubility hauv 25 degree dej yog 0.9mol/L. Nws yog soluble hauv methanol thiab ethanol. Hauv lub xeev yaj, muaj ob lub isomers ntawm thiols thiab thione. Raws li lub cev muaj zog, EGT muaj nyob hauv daim ntawv thione.

Bulk ergothioneine muaj kev ruaj ntseg zoo nyob rau hauv ob qho tib si physiological thiab nruab nrab alkaline (pH 8-9) cov xwm txheej. Nws kuj muaj siab thermal stability. Nws qhov decomposition kub tuaj yeem ncav cuag 262 txog 265 degree. Tus qauv redox peev xwm ntawm EGT yog hais txog -0.06 V. Tus qauv redox peev xwm ntawm lwm yam ntuj thiol antioxidant tshuaj (xws li, glutathione, cysteine) feem ntau yog -0.32 rau -0. 2 V. Ergothioneine bulk hmoov muaj tus qauv siab redox peev xwm. Piv nrog rau lwm cov thiols, nws tuaj yeem muab kev ruaj khov thiab kev tiv thaiv ntawm cov hlwb.

 

COA:

Yam khoom	Specification	Txoj kev analytical
Qhov tshwm sim	Tawm-dawb mus rau dawb hmoov zoo	Pom kev
Kev txheeb xyuas	Qhov zoo	IR & 1H NMR
Assay (Rau lub hauv paus qhuav)	Ntau dua lossis sib npaug rau 98.0%	HPLC
Poob rau ziab	Tsawg dua lossis sib npaug rau 1.0%	USP
Residue ntawm ignition	Tsawg dua lossis sib npaug rau 5.0%	USP
Cov hlau hnyav	Tsawg dua los yog sib npaug li 10 ppm	ICP-MS
Arsenic	Tsawg dua lossis sib npaug li 2 ppm	ICP-MS
Coj	Tsawg dua lossis sib npaug li 1ppm	ICP-MS
Mercury	Tsawg dua lossis sib npaug li 2 ppm	ICP-MS
Tag nrho cov kab mob suav	Tsawg dua lossis sib npaug li 10000 CFU / g	AOAC
Pwm thiab Poov xab	Tsawg dua lossis sib npaug li 300 CFU / g	AOAC
Escherichia coli 10 g	Tsis muaj / 10g	AOAC
Staphylococcus aureus 10g	Tsis muaj / 10g	AOAC
Salmonella 25 g	Tsis muaj / 25g	AOAC
Pseudomonas Aeruginosa 25g	Tsis muaj / 25g	AOAC

 

Txoj kev tsim khoom:

Txoj kev npaj ntawmbulk ergothioneine hmoov Feem ntau suav nrog 3 hom kev rho tawm cov khoom lag luam, cov txheej txheem tshuaj lom neeg, thiab cov txheej txheem biosynthesis.

 

• Txoj kev rho tawm cov khoom ntuj tsim

Cov khoom lag luam ntuj xws li cov kab mob noj tau, ergot, cereals, thiab cov ntaub so ntswg tsiaj muaj EGT, ntawm cov kab mob uas noj tau muaj EGT cov ntsiab lus siab dua thiab yog qhov tseem ceeb ntawm EGT. Piv txwv li, cov ntsiab lus ntawm EGT nyob rau hauv porcini nceb yog 1812 ug / g, nyob rau hauv almond nceb yog 542 ug / g, nyob rau hauv shiitake nceb yog 353 ug / g, thiab dub fungus yog 94 ug / g.

 

Tej yam khoom siv extraction txoj kev feem ntau muaj xws li reflux extraction, enzymatic extraction, ultrasonic-microwave ua ke txoj kev thiab hais txog. EGT cov ntsiab lus ntawm cov khoom ntuj feem ntau yog tsawg heev, uas siv ntau cov khoom siv raw thiab tus nqi siab. Nws kuj raug kev txom nyem los ntawm cov teeb meem ntawm raw khoom impurities thiab siab residues. Cov yam tseem ceeb no txwv tsis pub muaj kev thov kev lag luam ntawm cov khoom siv ntuj tsim tawm.

 

• Tshuaj synthesis method

Cov txheej txheem tshuaj synthesis ntawm EGT siv histidine ua cov khoom siv raw. EGT yog synthesized nyob rau hauv aqueous tov los ntawm ntau kauj ruam cov tshuaj xws li mercapto-alkylation, mercapto-tiv thaiv, methylation, deprotection, thiab lwm yam. Nyob rau hauv xyoo tas los no, cov tshuaj tiv thaiv ntawm histidine betaine, cysteine, mercaptopropionic acid, thiab lwm yam. ua EGT. qhov no zam qhov kev taw qhia ntawm mercapto-tiv thaiv pab pawg, uas ua rau luv luv txoj kev hluavtaws thiab txhim kho cov yields.

Cov txheej txheem tshuaj synthesis kuj muaj qee qhov nyuaj. Lub synthesis yog qhov nyuaj thiab qhov kev cia siab tsis tuaj yeem ua tiav vim yog ib nrab lossis tag nrho racemization. Kev nyab xeeb yog qhov nyuaj los xyuas kom meej, cov khoom siv hluavtaws yog kim thiab tus nqi ntawm cov khoom siv hluavtaws yog siab.

 

• Biosynthesis

Txoj kev biosynthesis kom tau EGT muaj qhov zoo ntawm cov ntaub ntawv yooj yim-rau-tau cov ntaub ntawv raw thiab tus nqi qis thiab tau dhau los ua txoj kev npaj tseem ceeb ntawm EGT nyob rau xyoo tas los no. Tam sim no, EGT biosynthesis feem ntau yog ua los ntawm cov kab mob thiab cov kab mob fungal. Piv txwv li, los ntawm kev hloov pauv ntawm histidine rau hauv histidine betaine, thiab tom qab ntawd ua ke nrog cysteine ​​los tsim histidine betaine cysteine ​​sulfoxide, thiab tom qab ntawd catalyzed los ua EGT. nws muaj kev nyab xeeb biotechnological zoo. Ib qho ntawm cov lus qhia tseem ceeb rau kev tsim cov nqi qis. Txawm li cas los xij, fermentation efficiency yog tsawg, purification yog nyuaj thiab tus nqi siab. Guanjie Biotech siv txoj kev no los rho tawm cov hmoov ergothioneine ntau.

 

Muaj nuj nqi:

Ergothioneine yog ib qho tseem ceeb physiological active tshuaj nyob rau hauv lub cev. Nws muaj cov haujlwm ntawm kev tshem tawm cov dawb radicals, detoxification, tswj DNA biosynthesis, kev loj hlob ntawm tes, kev tiv thaiv ntawm tes, tiv thaiv hluav taws xob, ua kom dawb thiab tiv thaiv kev laus. Nws tau lees paub tias nws yog ib qho tshwj xeeb thiab ntau yam kev ua haujlwm ntawm lub cev tiv thaiv kab mob.Bulk ergothioneine hmoov tshwj xeeb tshaj yog ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv kev laus, tiv thaiv glycation, thiab tiv thaiv oxidation.

 

Ergothioneine kev ua haujlwm hauv cov kab mob muaj sia nyob ntawm ib qho kev thauj khoom tshwj xeeb, OCTN1. Organic cation transporter protein N1, ib yam khoom ntawm SLC22A4 gene.OCTN1 muaj nyob rau hauv keratinocytes thiab melanocytes. Qhov no muaj kev sib raug zoo rau ergothioneine. Yog li ntawd cov ntaub so ntswg ntawm daim tawv nqaij thiab cov hlwb tuaj yeem tau txais tau yooj yim heev, nqus, thiab siv tag nrho cov ergothioneine.

 

Los ntawm OCTN1, uas muaj nyob rau hauv lub cell thiab mitochondrial daim nyias nyias, ergothioneine yog thauj mus rau mitochondria, lub ntsiab 'foci' ntawm dawb radical ntau lawm nyob rau hauv lub cell. Ntshiab Ergothioneine yog thauj mus rau mitochondria, lub ntsiab 'foci' ntawm dawb radical ntau lawm nyob rau hauv lub cell. Nws tiv thaiv mitochondria los ntawm oxidative puas thiab scavenges reactive oxygen radicals ncaj qha. Raws li qhov tshwm sim, nws tuaj yeem ua tau zoo khaws cia thiab nws cov tshuaj tiv thaiv redox tshwm sim ntawm oxidized thiab txo cov ntaub ntawv ntawm leej faj daim ntawv cog lus. Cov khoom no xyuas kom meej tias ergothioneine zoo tiv thaiv cov hlwb los ntawm kev puas tsuaj oxidative kev nyuaj siab kom ua tiav lub hom phiaj ntawm kev ncua kev laus ntawm tib neeg cellular.

• Cov neeg tiv thaiv lub cev

EGT ergothioneine hmoov yog koom tes hauv kev tiv thaiv mitochondrial DNA los ntawm superoxide tsim thaum lub sij hawm thauj electron.EGT nyiam tiv thaiv cov dej-soluble proteins los ntawm oxidative puas tsuaj thiab tseem tiv thaiv cov hlwb los ntawm kev puas tsuaj induced los ntawm reactive oxygen hom thiab UV hluav taws xob. Lub xub ntiag ntawm ergothioneine transporter (ETT) yog lub luag haujlwm rau cov ntaub so ntswg EGT siab. Qhov siab ceev ntawm ETT hauv mitochondria ua lub luag haujlwm tshwj xeeb hauv kev tiv thaiv cov kab mob no los ntawm cov pa oxygen reactive uas sib sau ua ke txawm tias nyob rau hauv ib txwm oxidative metabolism.

 

• Oxidation

Ergothioneine yog lub ntuj antioxidant. Nws cov khoom tshwj xeeb physicochemical thiab kev faib tshwj xeeb ua rau nws ruaj khov zoo dua li cov tshuaj antioxidants. Nws cov khoom antioxidant yog piv rau cov glutathione (GSH), ascorbic acid, thiab lwm yam kev lees paub cov tshuaj antioxidants.

Lub zog antioxidant zog ntawmbulk ergothioneine hmoovtuaj yeem siv los ntawm nws cov muaj peev xwm dawb radical scavenging muaj peev xwm los ntawm ntau yam txheej txheem. Hauv vitro antioxidant zog kuj tau pom los ntawm cov hluav taws xob dawb khi rau hydroxyl radicals (-OH), hypochlorite, singlet oxygen, thiab peroxynitrite. Nws lub peev xwm redox siab yog scavenging los ntawm quenching single-linear state oxygen thiab scavenging. Ntshiab ergothioneine kuj activates antioxidant enzymes uas scavenge reactive oxygen radicals (ROS). Xws li Glutathione Peroxidase (GSH-Px) thiab Superoxide Dismutase (SOD), uas ua rau cov teebmeem antioxidant.

 

• Anti-inflammatory nyhuv

Lub inflammatory teb nyob rau hauv lub cev yog ib qho kev tiv thaiv tej yam ntuj tso cov tshuaj tiv thaiv generated nyob rau hauv cov lus teb rau ib tug stimulus thiab ib tug tshwm sim ntawm lub cev tiv thaiv kev puas tsuaj yam. Ergothioneine tau pom tias muaj kev cuam tshuam tseem ceeb ntawm kev ua kom muaj zog ntawm nuclear factor-κB (NF-κB) thiab tso tawm ntawm interleukin -8 (IL-8) hauv tib neeg alveolar epithelial hlwb. Cov noob no tau kawm kom nkag siab txog lub luag haujlwm ntawm ergothioneine hauv qhov no. Qhov no yog qhov tseem ceeb los tshawb txog qhov ua tau zoo ntawm ergothioneine hauv kev kho cov kab mob inflammatory.

 

• Tiv thaiv ultraviolet thiab gamma rays

Tshaj dhau ultraviolet (UV) hluav taws xob tuaj yeem ua rau ntau dhau ntawm ROS hauv daim tawv nqaij. Tus nqi ntawm epidermal cell division thiab proliferation yog ceev, nrog rau degradation ntawm extracellular matrix thiab txo nyob rau hauv collagen fiber synthesis. Qhov no ua rau daim tawv nqaij ntxhib thiab xoob, txhim kho hyperpigmentation, thiab ua rau oxidative thiab inflammatory ntawm daim tawv nqaij puas. Ergothioneine inhibited qhov kev ua ntawm myeloperoxidase (MPO) secreted los ntawm activated leukocytes.MPO plays lub luag haujlwm tseem ceeb hauv kev tiv thaiv tus tswv ntawm qhov chaw mob. Nws yog ze ze rau qhov pib thiab kev loj hlob ntawm ntau tus tib neeg cov kab mob.

 

Ergothioneine bulk hmoov ntawm physiological concentrations tsis tsuas yog ua raws li ib tug anti-ultraviolet kev puas tsuaj tus neeg saib xyuas tab sis kuj raws li ib tug anti-inflammatory tus neeg saib xyuas nyob rau hauv cov kab mob inflammatory. Yog li ntawd,bulk ergothioneine hmoov tuaj yeem ua raws li ib qho ntawm cov tshuaj tiv thaiv zoo ntawm lub cev tiv thaiv UVB irradiation-induced inflammatory kev puas tsuaj.

Yog li, ergothioneine muaj peev xwm tshem tawm lossis txo cov pa oxygen reactive uas tshwm sim los ntawm UVB hluav taws xob, tiv thaiv cov hlwb los ntawm kev puas tsuaj lossis kev tuag. Nws tiv thaiv lossis txo cov tawv nqaij puas tsuaj thiab muab kev tiv thaiv zoo tiv thaiv UV thiab gamma rays.

 

• Whitening nyhuv

Bulk L-ergothioneine hmoov kuj muaj qee yam cuam tshuam rau kev ua haujlwm tyrosinase. Nws yog ib qho tsis sib tw tyrosinase inhibitor. Qhov kev tiv thaiv no cuam tshuam tsis muaj zog nrog nws cov haujlwm antioxidant. Tej zaum qhov no muaj feem xyuam rau lub xub ntiag ntawm lub nplhaib imidazole hauv nws cov qauv. Qhov no kuj txhais tau tias EGT muaj qee lub peev xwm los siv rau hauv cov tshuaj pleev ib ce.

 

Lub tuam txhab zoo:

Guanjie Biotech lub Hoobkas tau tsim nyog. Peb muaj ntau hom SC extract ntau lawm daim ntawv tso cai, nqa tawm cov ntaub ntawv zus tau tej cov tsoos suav tshuaj extracts, thiab yog cov ntaub ntawv chaw tsim tshuaj paus ntawm export zaub mov ntau lawm. Peb muaj ntau yam zoo, HALAL, thiab KOSHER daim ntawv pov thawj. Cov chaw thiab cov khoom siv yog tus qauv, thiab kev tswj hwm kev tsim khoom tiav.

Peb muaj lub peev xwm kuaj xyuas ua tiav, thev naus laus zis, kev tsim khoom, thiab pab pawg zoo. Peb tuaj yeem muab cov khoom lag luam customized nrog ntau yam khoom xyaw rau cov neeg siv khoom 'bulk ergothioneine hmoov tshwj xeebkev lag luam thiab kev siv xav tau. Nyob rau tib lub sijhawm kom ua tau raws li cov neeg siv khoom siab tshaj plaws hauv lub Hoobkas tshuaj xyuas, kev tshuaj xyuas txuas ntxiv, thiab ua ntaub ntawv xav tau.

 

Ntim & Xa khoom

Cim npe nrov: Tuam Tshoj bulk ergothioneine hmoov manufacturers, lwm tus neeg, Hoobkas