Ntau Licorice Extract

Licorice Root Extract Powder Supplier:

Guanjie tsom raubulk licorice extract hmoovtsim thiab ua lag luam rau 20 xyoo. Peb muaj cov kab ntau lawm los tsim nws. Cov khoom sib txawv uas koj tuaj yeem xaiv qhov koj xav tau: 10% hmoov dawb, 20% hmoov dawb, 40% hmoov dawb, 40% daj-xim av hmoov thiab 90% tawm-dawb hmoov. Zoo siab thiab tus nqi sib tw, txais tos nug peb:info@gybiotech.com.

 

Vim li cas cov neeg siv khoom nyiam siv Guanjie?

• Guanjie tau tsom mus rau kev txhim kho cov nroj tsuag extract rau 20 xyoo thiab muaj ntau lub teb chaws invention patents.

•International certification system:

ISO9001, ISO22000, halal, Kosher, HACCP thiab lwm yam ntawv pov thawj.

• Cov kws tshaj lij thiab paub txog r&d pab neeg:

Cov xibfwb los ntawm cov tsev kawm ntawv nto moo thiab cov kws tshaj lij nrog ntau xyoo ntawm kev ua haujlwm hauv kev lag luam no.

•Ob lub koom haum ywj pheej thiab peb txoj kab ntau lawm:

Peb muaj ob lub chaw ua haujlwm ywj pheej. Ib lub yog nyob rau hauv Xi'an nroog, lwm qhov yog nyob rau hauv Baoji City.

 

COA:

Peb muaj 5 specifications ntawm cov khoom no.

• 10% hmoov dawb

Cov khoom kuaj		Txuj	Cov qhabnias xeem
Qhov tshwm sim		Off-dawb hmoov	Ua raws li
Poob rau ziab		Tsawg dua lossis sib npaug rau 2.0%	1.77%
Cov ntsiab lus tshauv		Tsawg dua lossis sib npaug rau 0.1%	0.06%
cyclodextrin muaj		85+ -5%	88%
dej-solubility		水溶液2%浓度以下全溶	Ua raws
Hnyav hlau	Pb	Tsawg dua lossis sib npaug rau 1.0ppm	0.50 ppm
	Raws li	Tsawg dua lossis sib npaug rau 0.5 ppm	0.05ppm
	Ni	Tsawg dua lossis sib npaug rau 1.0 ppm	0.10 ppm
	Hg	Tsawg dua lossis sib npaug rau 1.0 ppm	0.01 ppm
	Cd	Tsawg dua lossis sib npaug rau 0.05 ppm	0.005 ppm
Solvent residue	methanol	Tsawg dua lossis sib npaug li 100 ppm	Tsis pom
	formaldehyde	Tsawg dua los yog sib npaug li 10 ppm	Tsis pom
	ethanol	Tsawg dua lossis sib npaug li 330 ppm	87. {1}}ppm
	acetone	Tsawg dua lossis sib npaug li 30 ppm	Tsis pom
	Cov tshuaj dichloromethane	Tsawg dua lossis sib npaug li 30 ppm	Tsis pom
Kab mob	Tag nrho cov kab mob	Tsawg dua lossis sib npaug li 1000cfu / g	Ua raws li
	Cov poov xab thiab pwm	Tsawg dua lossis sib npaug li 100cfu / g	Ua raws li
	Escherichia coli	Tsis txhob raug ntes	Tsis pom
	Salmonella	Tsis txhob raug ntes	Tsis pom
Cov ntsiab lus zoo		Glabridin Ntau dua lossis sib npaug rau 10.0%	10.66%
xaus: Cov khoom raug kuaj raws li tus qauv kev lag luam, thiab cov txiaj ntsig tau ua raws li qhov yuav tsum tau ua.

 

• 20% hmoov dawb

Cov khoom kuaj		Txuj	Cov qhabnias xeem
Qhov tshwm sim		Off-dawb hmoov	Ua raws li
Poob rau ziab		Tsawg dua lossis sib npaug rau 2.0%	1.55%
Cov ntsiab lus tshauv		Tsawg dua lossis sib npaug rau 0.1%	0.06%
cyclodextrin muaj		70+ -5%	73%
dej-solubility		水溶液2%浓度以下全溶	Ua raws li
Hnyav hlau	Pb	Tsawg dua lossis sib npaug rau 1.0ppm	0.50 ppm
	Raws li	Tsawg dua lossis sib npaug rau 0.5 ppm	0.05ppm
	Ni	Tsawg dua lossis sib npaug rau 1.0 ppm	0.10 ppm
	Hg	Tsawg dua lossis sib npaug rau 1.0 ppm	0.01 ppm
	Cd	Tsawg dua lossis sib npaug rau 0.05 ppm	0.005 ppm
Solvent residue	methanol	Tsawg dua lossis sib npaug li 100 ppm	Tsis pom
	formaldehyde	Tsawg dua los yog sib npaug li 10 ppm	Tsis pom
	ethanol	Tsawg dua lossis sib npaug li 330 ppm	56. {1}}ppm
	acetone	Tsawg dua lossis sib npaug li 30 ppm	Tsis pom
	Cov tshuaj dichloromethane	Tsawg dua lossis sib npaug li 30 ppm	Tsis pom
Kab mob	Tag nrho cov kab mob	Tsawg dua lossis sib npaug li 1000cfu / g	Ua raws li
	Cov poov xab thiab pwm	Tsawg dua lossis sib npaug li 100cfu / g	Ua raws li
	Escherichia coli	Tsis txhob raug ntes	Tsis pom
	Salmonella	Tsis txhob raug ntes	Tsis pom
Cov ntsiab lus zoo		Glabridin Ntau dua lossis sib npaug rau 20.0%	20.01%
xaus:Cov khoom raug kuaj raws li tus qauv kev lag luam, thiab cov txiaj ntsig tau ua raws li qhov yuav tsum tau ua.

 

• 40% hmoov dawb

Cov khoom kuaj		Txuj	Cov qhabnias xeem
Qhov tshwm sim		Off-dawb hmoov	Ua raws li
Poob rau ziab		Tsawg dua lossis sib npaug rau 2.0%	0.11%
Residue ntawm ignition		Tsawg dua los yog sib npaug rau 0.5%	0.06%
Hnyav hlau	Tag nrho	Tsawg dua los yog sib npaug rau 10.0ppm	Ua raws li
	Pb	Tsawg dua lossis sib npaug rau 5.0 ppm	1. 0 ppm
	Raws li	Tsawg dua lossis sib npaug rau 1.0ppm	0.05 ppm
	Hg	Tsawg dua lossis sib npaug rau 2.0 ppm	0.75 ppm
Solvent residue	methanol	Tsawg dua los yog sib npaug rau 90.0 ppm	13. 0ppm
	formaldehyde	Tsawg dua lossis sib npaug rau 15.0 ppm	Tsis pom
	ethanol	Tsawg dua los yog sib npaug rau 400.0 ppm	1 0.0 ppm
	acetone	Tsawg dua los yog sib npaug rau 10.0 ppm	Tsis pom
	Cov tshuaj dichloromethane	Tsawg dua los yog sib npaug rau 10.0 ppm	Tsis pom
Kab mob	Tag nrho cov kab mob	Tsawg dua lossis sib npaug li 1000cfu / g	Ua raws li
	Cov poov xab thiab pwm	Tsawg dua lossis sib npaug li 100cfu / g	Ua raws li
	Escherichia coli	Tsis txhob raug ntes	Tsis pom
	Salmonella	Tsis txhob raug ntes	Tsis pom
Cov ntsiab lus zoo		Glabridin Ntau dua lossis sib npaug rau 40.0%	40.86%
xaus:Cov khoom raug kuaj raws li tus qauv kev lag luam, thiab cov txiaj ntsig tau ua raws li qhov yuav tsum tau ua.

 

• 40% daj xim av hmoov

Cov khoom kuaj		Txuj	Cov qhabnias xeem
Qhov tshwm sim		Yellow-xim av hmoov	Ua raws li
Poob rau ziab		Tsawg dua lossis sib npaug rau 2.0%	0.30%
Residue ntawm ignition		Tsawg dua los yog sib npaug rau 0.5%	0.02%
Hnyav hlau	Pb	Tsawg dua lossis sib npaug rau 1.0 ppm	0.50 ppm
	Raws li	Tsawg dua lossis sib npaug rau 0.5ppm	0.10 ppm
	Ni	Tsawg dua lossis sib npaug rau 1.0 ppm	0.10 ppm
	Hg	Tsawg dua lossis sib npaug rau 1.0 ppm	0.01 ppm
	Cd	Tsawg dua lossis sib npaug rau 0.05 ppm	0.005 ppm
Solvent residue	methanol	Tsawg dua los yog sib npaug rau 100.0 ppm	25. 0ppm
	formaldehyde	Tsawg dua los yog sib npaug rau 10.0 ppm	Tsis pom
	ethanol	Tsawg dua los yog sib npaug rau 330.0 ppm	11. 0ppm
	acetone	Tsawg dua los yog sib npaug rau 30.0 ppm	Tsis pom
	Cov tshuaj dichloromethane	Tsawg dua los yog sib npaug rau 30.0 ppm	Tsis pom
Kab mob	Tag nrho cov kab mob	Tsawg dua lossis sib npaug li 1000cfu / g	Ua raws li
	Cov poov xab thiab pwm	Tsawg dua lossis sib npaug li 100cfu / g	Ua raws li
	Escherichia coli	Tsis txhob raug ntes	Tsis pom
	Salmonella	Tsis txhob raug ntes	Tsis pom
Cov ntsiab lus zoo		Glabridin Ntau dua lossis sib npaug rau 40.0%	41.2%
xaus:Cov khoom raug kuaj raws li tus qauv kev lag luam, thiab cov txiaj ntsig tau ua raws li qhov yuav tsum tau ua.

 

• 90% tawm-dawb hmoov

Cov khoom kuaj		Txuj	Cov qhabnias xeem
Qhov tshwm sim		hmoov dawb	Ua raws li
Poob rau ziab		Tsawg dua lossis sib npaug rau 2.0%	0.17%
Residue ntawm ignition		Tsawg dua lossis sib npaug rau 0.1%	0.02%
Hnyav hlau	Pb	Tsawg dua lossis sib npaug rau 1.0ppm	0.5ppm
	Ni	Tsawg dua lossis sib npaug rau 1.0ppm	0.2ppm
	Raws li	Tsawg dua lossis sib npaug rau 1.0ppm	0.1ppm
	Hg	Tsawg dua lossis sib npaug rau 1.0ppm	0.01ppm
	Cd	Tsawg dua lossis sib npaug rau 1.0ppm	0.01ppm
Solvent residue	methanol	Tsawg dua los yog sib npaug rau 100.0 ppm	38. {1}}ppm
	formaldehyde	Tsawg dua los yog sib npaug rau 10.0 ppm	Tsis pom
	ethanol	Tsawg dua los yog sib npaug rau 330.0 ppm	15. 0ppm
	acetone	Tsawg dua los yog sib npaug rau 30.0 ppm	Tsis pom
	Cov tshuaj dichloromethane	Tsawg dua los yog sib npaug rau 30.0 ppm	Tsis pom
Kab mob	Tag nrho cov kab mob	Tsawg dua lossis sib npaug li 1000cfu / g	Ua raws li
	Cov poov xab thiab pwm	Tsawg dua lossis sib npaug li 100cfu / g	Ua raws li
	Escherichia coli	Tsis txhob raug ntes	Tsis pom
	Salmonella	Tsis txhob raug ntes	Tsis pom
Cov ntsiab lus zoo		Glabridin Ntau dua lossis sib npaug rau 90.0%	93.13%
xaus:Cov khoom raug kuaj raws li tus qauv kev lag luam, thiab cov txiaj ntsig tau ua raws li qhov yuav tsum tau ua.

 

High Quality Raw Khoom:

 

Cov teebmeem ntawm glycyrrhiza glabra cag extract ntawm daim tawv nqaij:

Hauv vitro cytotoxicity ntawm photoglycyrrhizidine ntawm B16 melanoma hlwb

• Lub cytotoxicity ntawmntau licorice extractntawm B16 melanoma hlwb tau pom. Photoglycyrrhizidine tsis yog cytotoxic rau B16 hlwb ntawm qhov concentration tsis siab tshaj 30 μmol / L. Yog li ntawd, qhov concentration ntawm 5 μmol / L thiab 30 μmol / L ntawm photoglycopyrrolidine tau raug xaiv los ua cov kev sim tom ntej ntawm B16 hlwb.

 

Qhov kev pab cuam molecular docking AutoDock (4.2.6) tau siv los simulate qhov kev nthuav qhia ntawm kev cuam tshuam ntawm photoglycoside thiab tyrosinase, microphthalmia-associated transcription factor (MITF).

• Cov paub inhibitors ntawm tyrosinase kev ua si, -arbutin thiab tol phenolone, raug xaiv los ua cov khoom siv rau kev sib tham no. Cov txiaj ntsig tau pom nyob rau hauv daim duab. Trophenone txoj kev khi rau tyrosinase los ntawm kev tsim ib daim ntawv cog lus hydrogen nrog Asn260 residue thiab ob daim ntawv cog lus uas tsis yog hydrogen nrog ob lub tooj liab ions hauv qhov chaw nquag (daim duab a).

• -Arbutin khi rau tyrosinase los ntawm kev tsim cov hydrogen bonds nrog Asn260 thiab Met280 residues thiab tsis-hydrogen bond nrog ib tug tooj liab ion nyob rau hauv lub active site (Daim duab b).

• Photoglycyrrhizidine khi rau qhov chaw nquag ntawm tyrosinase los ntawm kev tsim hydrogen bonds nrog Met319 thiab Glu322 residues (Daim duab c).

• glycyrrhiza glabra cag extract kuj khi rau MITF los ntawm kev tsim hydrogen bonds nrog Arg216 thiab Asn219 residues nyob rau hauv DNA binding site ntawm MITF. qhia tias nws tuaj yeem cuam tshuam ncaj qha rau MITF transcriptional kev ua haujlwm (Daim duab d).

 

Hauv kev sim molecular docking simulation, docking zog yog qhov ntsuas ntsuas qhov sib cuam tshuam ntawm ligand thiab nws cov receptor. Lub zog docking ntawm photoglycyrrhizidine nrog tyrosinase thiab MITF yog -7.16 thiab -6.67 kcal/mol, feem, piv rau -4.37 thiab -4.89 kcal/ mol rau -arbutin thiab tol phenolone, ntsig txog, qhia tias photoglycyrrhizidine khi rau ob qho tib si tyrosinase thiab MITF thiab tsim cov complexes ruaj khov. Photoglycyrrhizidine yuav siab dua tyrosinase binding affinity tshaj -arbutin thiab trophenone.

 

Hauv vitro kawm txog inhibition ntawm tyrosinase kev ua haujlwm thiab melanogenesis los ntawm photoglycodine

Peb tau ua hauv vitro tyrosinase monophenolase kev sim tshuaj ntsuam xyuas kev sim, hauv vitro tyrosinase diphenolase kev sim tshuaj ntsuam xyuas, thiab B16 intracellular tyrosinase kev ua ub no. Cov txiaj ntsig kev sim tau pom tias photoglycoside nthuav tawm cov kev ua haujlwm tyrosinase zoo dua li -arbutin (Fig. a, b).

 

Tyrosinase paub tias yog ib qho tseem ceeb ntawm cov neeg koom nrog hauv cov txheej txheem melanogenesis. Los ntawm kev tsim cov qauv hauv vitro cellular ntawm -MSH-induced melanin ntau lawm hauv B16 melanoma hlwb. Cov nyhuv ntawmntau licorice extractntawm melanin biosynthesis hauv B16 hlwb tuaj yeem txiav txim siab ntxiv. Cov txiaj ntsig tau tshwm sim hauv daim duab c, d. Photoglycoside inhibited melanogenesis hauv B16 hlwb ntau dua li -arbutin.

 

4. Inhibit melanogenesis hauv B16 hlwb los ntawm kev tswj cov tshuaj melanogenesis

Melanogenesis-associated factors muaj xws li melanocortin receptor (MC1R), microphthalmia-associated transcription factor (MITF), tyrosinase (TYR), TYR-related protein-1 (TRP-1), thiab TYR-related protein{{ 7}} (TRP-2). Tom qab kev cuam tshuam photoglycoside nyob rau hauv vitro cell qauv ntawm -MSH-induced melanin ntau lawm hauv B16 melanoma hlwb, transcription thiab qhia txog melanogenesis-txog yam hauv -MSH-induced B16 hlwb raug kuaj los ntawm Q-PCR thiab Western-blot.

 

Cov txiaj ntsig tau pom tias photoglycoside tuaj yeem cuam tshuam melanogenesis los ntawm kev txo qis ntawm kev hloov pauv thiab kev qhia ntawm cov yam ntxwv ntawm melanogenesis.

 

5. Inhibit melanogenesis hauv B16 hlwb los ntawm kev tswj PKA thiab MAPK txoj kev taw qhia

-MSH tuaj yeem ua kom muaj kev ua haujlwm tyrosinase hauv melanocytes los ntawm -MSH/cAMP teeb liab txoj hauv kev. Thaum PKA tau qhib los ntawm cAMP, phosphorylated PKA (p-pPKA) ua raws li kev hloov kho phosphorylation ntawm CREB (p-CREB) txhawb nqa melanogenesis tom qab ua kom MITF. Hauv kev sib piv, hauv MAPK txoj hauv kev, phosphorylated ERK (p-ERK) ua rau ubiquitination thiab degradation ntawm MITF, ua rau txo melanogenesis. Phosphorylated p38 (p-p38) los yog phosphorylated JNK (p-JNK) activates MITF, uas up-regulates protein synthesis ntawm melanogenesis-txog yam xws li tyrosinase, TRP-1, thiab TRP{12}}, thiab thaum kawg stimulates melanocytes los tsim melanin. Ib qho qauv hauv vitro cellular ntawm -MSH-induced melanin ntau lawm hauv B16 melanoma hlwb tau cuam tshuam siv photoglycoside.

 

Cov txiaj ntsig tau pom tias licorice cag extract hmoov txo qis-tswj cov lus qhia ntawm cAMP hauv B16 hlwb tom qab -MSH induction (Daim duab a). Nws inhibited phosphorylation txheej txheem ntawm downstream PKA / CREB, P38, thiab JNK signaling txoj kev, thaum txhawb nqa cov txheej txheem phosphorylation ntawm ERK signaling pathway (Daim duab 5b, c). Yog li, lub teeb liab uas txhawb nqa melanogenesis yog inhibited rau qee yam, uas thaum kawg txo cov melanogenesis.

 

6. Photoglycopyrrolidine ameliorates UVA hluav taws xob-induced tawv nqaij hyperpigmentation hauv nas.

UVA hluav taws xob ua rau ntau tshaj melanin synthesis thiab deposition nyob rau hauv daim tawv nqaij, yog li ib tug UVA hluav taws xob-induced hyperpigmentation qauv nyob rau hauv cov nas tau tsim los ntsuam xyuas lub vivo antimelanogenic kev ua ntawmntau licorice extract.

Cov ntaub ntawv sim qhia tau hais tias kev tswj hwm kev cuam tshuam ntawm glycyrrhiza glabra extract txo UVA-induced tawv nqaij o, melanin ntau lawm thiab tsub zuj zuj hauv epidermis.

 

Factory & Pab Pawg:

 

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Cim npe nrov: Tuam Tshoj bulk licorice extract manufacturers, lwm tus neeg, Hoobkas