Epimedium Extract hmoov

Taw qhia

Epimedium extract hmoovyog lub ntsiab biologically active monomer ntawm flavonoid glycosides muab rho tawm los ntawm Epimedium.Icariin (ICA) yog ib tug ntawm cov tseem ceeb bioactive tebchaw muab rho tawm los ntawm Epimedium, uas kuj yog cov feem ntau lug kawm monomer. ICA feem ntau muaj ntau lub luag haujlwm xws li tswj hwm cov tshuaj hormones poj niam txiv neej, txo atherosclerosis, thiab kev ua haujlwm antioxidant. Nyob rau hauv xyoo tas los no, ntau thiab ntau cov kev tshawb fawb tau pom tias daim ntawv thov ntawm ICA nyob rau hauv autoimmune kab mob xws li mob caj dab rheumatoid, bronchial hawb pob, ntau yam sclerosis thiab systemic lupus erythematosus. Nws cov nyhuv anti-inflammatory. Tsis tas li ntawd, ICA kuj muaj cov tshuaj tiv thaiv kab mob. Ntau lub hom phiaj thiab cov txheej txheem ntawm ICA tau raug tshaj tawm, suav nrog kev tswj hwm ntawm lymphocyte tshuav, tiv thaiv kab mob / inflammatory cytokines, qhia txoj hauv kev xws li NF-kappa thiab Erk-p38-JNK, lymphocyte transcription yam thiab lwm lub hom phiaj xws li TLR , STAT thiab PTEN thiab lwm yam.

Guanjie tsom rau Epimedium hmoov rau 20 xyoo. Txhua kauj ruam ntawm adheres yuav tsum tau nruj tus qauv. Txawv Specifications uas koj xaiv tau (10 feem pua ​​-98 feem pua ​​). Peb siv HPLC txoj kev los kuaj peb cov khoom, nws cov tsos yog xim av hmoov thiab cov ntaub ntawv nthuav dav koj tuaj yeem pom hauv qab COA. Peb muaj ob txoj kab ntau lawm thiab cov chaw ua haujlwm ywj pheej los xyuas kom meej qhov zoo ntawm peb cov khoom. Peb muaj 15 tus kws tshaj lij engineers. Peb cov khoom xa tawm mus rau 50 lub teb chaws thiab tau txais kev qhuas los ntawm peb cov neeg siv khoom.

COA

Muaj nuj nqi

Cov teebmeem ntawmepimedium extract hmoovntawm kev tiv thaiv kab mob thiab nws cov kev siv tau

● Lub luag haujlwm thiab cov txheej txheem ntawm kev tiv thaiv kab mob- lymphocytes

Th1/Th17 hlwb Th17 yog ze ze rau Th1 thaum lub sij hawm kev loj hlob, thiab overexpression ntawm cov hlwb yog paub tias muaj feem xyuam rau ntau yam inflammatory kab mob. ICA tuaj yeem tswj hwm lymphocyte muaj nuj nqi, xws li cuam tshuam rau Th1 / Th17 lossis Th2 tshuav nyiaj li cas. Hauv cov qauv collagen II-induced mob caj dab (CIA), ICA kev kho mob ua rau txo qis ntawm CD4 ntxiv rau IL-17 ntxiv rau cov hlwb thiab txo cov Th17 hlwb. Cov qib ntshav ntawm IgG2a kuj tau txo qis nrog cov qhab-nees mob caj dab tom qab induction los ntawm ICA kev kho mob, thaum ntxiv IL -17 kev tswj hwm tshem tawm cov teebmeem no [16], qhia tias ICA tswj CIA feem ntau los ntawm kev sib kho Th17 hlwb hauv kev sim hauv autoimmune encephalomyelitis (EAE ), cov nas tswj hwm ICA kuj tau pom tias txo qis ntawm Th1 thiab Th17 hlwb hauv tus po thiab lymph nodes. Qhov qis dua ntawm Th17 hlwb kuj pom nyob rau hauv CNS monocytes ntawm ICA-kho nas. Controversially, qee qhov kev tshawb fawb tau qhia tias ICA kuj tseem tuaj yeem txhim kho kev tiv thaiv kab mob. Cov ntaub ntawv los ntawm cov kev sim no qhia tias ICA txhawb kev txhim kho Th1 kab mob hauv cov nas thiab txhawb nqa IgG ntau lawm.

● Inflammatory cytokines

ICA siv ntau yam teebmeem ntawm inflammatory cytokines hauv kev kho mob sib txawv. Hauv kab lis kev cai ntawm bronchoalveolar lavage kua (BALF) hlwb, ICA cuam tshuam interleukin 6 (IL-6), IL-17, tab sis tsis yog IL-10 qib. Hauv cov nas uas muaj LPS-vim lub hlwb tsis ua haujlwm, cov kev tshawb fawb tau pom tias ICA txhim kho qhov kev kawm thiab kev nco thiab txo qis kev qhia ntawm TNF- , IL-1 , thiab COX-2 hauv hippocampus. Rau titanium-stimulated nas, ICA tau pom zoo txo ​​cov qog necrosis factor- (TNF- ) secretion, IL-6 thiab IL-1 hauv calvaria. ICA kev tswj hwm kuj tseem txwv tsis pub cov noob qhia ntawm IL-1 , IL-8, TACR1 thiab ICAM-1 hauv HaCaT hlwb hauv koob tshuaj thiab sijhawm nyob ntawm lub sijhawm. Qhov sib txawv ntawm IFN- -R1 thiab TNF- -R1 kuj tshwm sim tom qab IFN- / TNF- stimulation thiab tau zoo li qub tom qab kho ICA [26]. Txawm li cas los xij, hauv lwm txoj kev tshawb fawb tshuaj hauv vitro ntawm concanavalin A (ConA)-stimulated T lymphocytes, ICA txo qis IL-2, IL-4, thiab IL-10 ntau lawm, tab sis upregulated TNF- thiab IL. -10. IFN- ib. ICA tuaj yeem cuam tshuam rau lub cev tiv thaiv kab mob nyob ntawm qhov microenvironment.

● lymphocyte transcription factor

ROR gamma ROR yog ib qho tseem ceeb ntawm kev hloov pauv uas tswj kev ua haujlwm thiab kev loj hlob ntawm CD4 ntxiv rau Th17 thiab CD8 ntxiv rau Tc17 hlwb. ROR txhim kho Th17 cell muaj nuj nqi los ntawm kev ua kom lub zais zis ntawm cytokines lossis chemokines xws li GM-CSF thiab IL-17. Hauv ovalbumin (OVA)-vim tus qauv mob hawb pob, ICA txo cov CD4 ntxiv rau RORgammat ntxiv rau T hlwb thiab nthuav tawm qhov txo qis hauv ROR.

T-thawj koom ruam Qhov T-box yam (T-thawj koom ruam) qhia hauv T hlwb tau txais kev xav tsis yog tsuas yog "tus tswj hwm tus tswv" ntawm Th1 hlwb, tab sis kuj yog ib qho dav, kev tswj hwm ntawm kev tiv thaiv kab mob. GATA-3 mRNA kev qhia thiab T-bet tau txo qis hauv lub ntsws cov ntaub so ntswg ntawm ICA-tswj asthmatic nas thiab alleviated los ntawm regulating Th1/Th2 imbalance.

● Glucocorticoid receptor

Cov glucocorticoid receptor (GR) muaj cov teebmeem tiv thaiv kab mob uas cuam tshuam nrog ntau txoj hauv kev qhia, xws li cov khoom ntawm T-cell receptor (TCR) signaling pathway, PI3K, JNK, thiab pro-inflammatory gene qhia. Hauv cov qauv nas ntawm qhov tsis paub txog kev ntxhov siab me me (CMS) vim muaj kev nyuaj siab, kev tswj hwm qhov ncauj ntawm ICA rau 35 hnub tau pom tias txhawm rau txhim kho tus cwj pwm kev nyuaj siab tshwm sim los ntawm kev raug rau CMS, nrog rau kev nce mRNA qhia ntawm GR. Hauv kev sim autoimmune encephalomyelitis (EAE) nas, ICA induces estrogen-zoo li kev ua si uas modulates HPA muaj nuj nqi thiab ua rau kom dawb teeb meem GR qhia.

Vim li cas thiaj xaiv peb?

● Peb tuaj yeem ua qhov kev xeem thib peb.

● Peb lav qhov zoo ntawm Epimedium extract hmoov yog ua raws li Daim Ntawv Pov Thawj Kev Ntsuam Xyuas muab los ntawm peb, yog tias tsis yog, peb lees txais 100 feem pua ​​​​kev pauv, rov qab thiab rov qab.

● Peb tuaj yeem teb koj li ntawm ib teev rau cov lus nug thiab kev tsis txaus siab.

● Peb tuaj yeem ua OEM / ODM, sachet pob.

● Peb cov khoom muaj ntawv pov thawj ISO 9001-22000, SC, KOSHER, HALAL,

● 20 xyoo dhau los ntawm cov nroj tsuag extract.

Peb lub Hoobkas:

Muaj ob lub chaw tsim khoom hauv Baoji nroog thiab Shangluo City, Guanjie factories npog thaj tsam ntawm 7000㎡, suav nrog GMP tus qauv rhiav ntawm 2000㎡.

Cov khoom tsim nyog

Epimedium nplooj extract hmoov yog tsim nyob rau hauv ib qho chaw ua haujlwm huv si thiab txhua kauj ruam ntawm cov txheej txheem yog ua los ntawm cov kws tshaj lij.

Test Center:

Ob qhov txheej txheem ntawm kev tsim khoom thiab cov khoom nws tus kheej ua tau raws li txhua tus qauv thoob ntiaj teb. Thiab yog tias koj xav tau peb tsab ntawv ceeb toom, peb tuaj yeem muab rau koj.

Daim ntawv pov thawj

Tau 20 xyoo, peb tau tsim kho tshiab thiab txhim kho nws cov qauv tswj tus kheej. Peb tau lees paub los ntawm ISO9001, ISO22000, QS, Halal, Kosher thiab lwm yam.

Pob & Warehouse:

Kev xa khoom xa tuaj:

DHL, hiav txwv freight, FEDEX, koj tuaj yeem xaiv.

Cim npe nrov: Epmedium Extract hmoov, Tuam Tshoj Epmedium Extract hmoov manufacturers, lwm tus neeg, Hoobkas