NMN hmoov muag

NMnHmoov neeg tsum khoom:

Guanjie Biotech yog ib qhoNMN hmoov muaguas tau ua rau muaj kev sib raug zoo nyob rau hauv kev tsim cov khoom ntau tshaj 20 xyoo. Nicotinamide mononucleAde tau nyiam kev saib xyuas dav dav hauv kev tiv thaiv kev laus. Qhov kev thov rau cov khoom lag luam zoo thiab cov khoom lag luam siab yog loj hlob, thiab cov txheej txheem tsim khoom siv tau zoo thiab muaj txiaj ntsig zoo los ua tus yuam sij rau kev ua lag luam. Tsuas yog los ntawm kev tsim cov txheej txheem siab tuaj yeem muaj ntau cov nmn nrog kev txhim khuities txaus kom tau raws li qhov kev xav tau ntawm cov pab pawg neeg siv thoob ntiaj teb. Thiab Guanjie Biotech tuaj yeem ua tau raws li koj cov kev xav tau.

Kev paub nplua nuj:

Guanjie Biotech tau koom nrog hauv kev tsim cov nmn rau ntau tshaj 20 xyoo. Peb tau txais kev nplua nuj ntau thiab cov kev ua haujlwm zoo. Tau ntau xyoo, lub tuam txhab ib txwm tau cog lus rau kev tshawb fawb thiab ua kom zoo dua ntawm kev tsim kho tshiab los txhim kho cov khoom lag luam zoo thiab ntau lawm. Nrog nws ua kom pom tseeb thiab tsis tu ncua hauv NMN ntau lawm, Guania Biotech tau tsim lub koob npe nrov hauv kev lag luam thiab tau dhau los ua tus thawj coj hauv thaj teb NMN ntau lawm.

 

1. Cov khoom siv tes ua:

• Enzymatic synthesis:

Nyob rau hauv cov nqe lus ntawm enzymatic synthesis, guamanjie biotech yog ib qhoNMN hmoov muagCov. Peb tau ua rau enzyme siab npaj thev naus laus zis thiab cov tshuaj tiv thaiv. Lub tuam txhab tau hloov pauv cov enzyme-ua cov kab mob sib xyaw los ntawm kev paub txog caj ces los txhim kho cov kev qhia thiab kev ua ntawm cov enzymes tseem ceeb. Thaum lub sij hawm cov txheej txheem kev tshuaj tiv thaiv, kev tswj tsis siv neeg siv tau siv cov tshuaj tiv thaiv kom yog li kub, thiab lwm yam. Txhawm rau kom ntseeg tau tias cov tshuaj tiv thaiv zoo, thiab cov tshuaj tiv thaiv kab Nyob rau tib lub sijhawm, lub tuam txhab siv kev sib cais siab thiab ua kom muaj zog ua kom nrawm nrawm thiab ua kom muaj cov ntsiab lus tsis zoo, txo cov khoom tsis zoo.

• Txoj kev fermentation:

Guanjie Biotech Screened thiab ua kom muaj qee cov qauv microbial los tsim nmn los ntawm fermentation. Los ntawm kev ua kom zoo dua cov fermentation nruab nrab, thiab xaiv cov khoom siv cov tsav tsheb, cov khoom noj muaj txiaj ntsig zoo, cov khoom noj muaj txiaj ntsig zoo, cov khoom noj muaj txiaj ntsig zoo, cov khoom noj muaj txiaj ntsig zoo, cov khoom siv hluav taws xob zoo ntawm cov hmoov nmn. Thaum lub sij hawm fermentation cov txheej txheem, qib siab fermentation tank khoom thiab saib xyuas cov kab ke tau siv los saib xyuas cov khoom tsis muaj raws li lub sijhawm. Xws li yaj oxygen, pH nqi, ntsuas kub, thiab peb hloov kho cov kev coj ua kom ntseeg tau tias nmn nyob rau hauv cov xwm txheej zoo tshaj plaws. Tsis tas li ntawd, lub tuam txhab tau tsim kho cov txheej txheem fermentation cov khoom sib cais thiab cov txheej txheem purity nmn nmn hmoov broths kom tau raws li kev xav ua lag luam rau cov khoom lag luam zoo.

 

2. Hmoov kom qhuav

• Nqus kom qhuav:

Guania Biotech siv lub tshuab nqus tsev kom qhuav kom qhuav nmn hmoov. Lub tshuab nqus tsev kom qhuav yog cov txheej txheem ntawm kev hloov ua dej nyob hauv cov khoom ntawm qhov kub qis hauv qab lub hom phiaj kom qhuav. Qhov zoo dua ntawm txoj kev ziab no yog tias nws tuaj yeem nqa tawm ntawm qhov kub qis dua. Qhov no zam qhov kev txiav txim siab los yog depomposition lossis denaturation ntawm NMN thaum kub siab, uas yog qhov ua rau kev tswj hwm kev ua haujlwm roj ntsha ntawm NMN. Nyob rau tib lub sijhawm, lub tshuab nqus tsev kom sai sai, txhim kho kom qhuav lub sijhawm, txo lub sijhawm kom qhuav, thiab txo cov nqi kev ziab. Thaum lub tshuab nqus tsev ua kom qhuav, guamanie biotech ua ib qhoNMN hmoov muag, tswj nruj me ntsis xws li lub tshuab nqus tsev, kub thiab sijhawm kom ntseeg tau tias qhov zoo ntawm nmn hmoov.

 

• Ua kom qhuav qhuav:

Ntxiv nrog rau lub tshuab nqus tsev qhuav, guamanie biotech kuj siv khov-kom qhuav thev naus laus zis. Khov kom qhuav yog kom khov cov khoom hauv qab no qhov chaw khov rau hauv dej khov, thiab tom qab ntawd nyob rau hauv ib puag ncig khov, thiab tom qab ntawd nyob rau hauv ib puag ncig khov, thiab tom qab ntawd nyob rau hauv ib puag ncig khov, thiab tom qab ntawd nyob rau hauv ib puag ncig khov, thiab tom qab ntawd nyob rau hauv ib puag ncig khov, sublet cov dej khov ncaj qha rau hauv dej vapor thiab tshem nws. Qhov kev ua kom qhuav no tuaj yeem khaws cov kev ua ub no roj ntsha thiab thawj qauv ntawm nmn mus rau qhov loj tshaj plaws. Vim tias tag nrho cov txheej txheem ziab yog nqa tawm hauv qis qis thiab cov kev puas tsuaj siab, kev puas tsuaj rau nmn los ntawm tshav kub thiab oxygen yog zam. Lub khov-qhuav nmn hmoov muaj cov khoom siv solubility zoo thiab ruaj khov thiab yog ib qho yooj yim rau khw thiab thauj. Guanjie Biotech precisely tswj cov ntsiab lus xws li ua ntej txias txias, sublimation kub, thiab desorption kub thaum lub sij hawm khov-kom qhuav. Qhov no ua kom pom tau ntau lawm cov khoom lag luam zoo khov-qhuav nmn ntau hmoov.

 

Kev qhia tshwj xeeb

● Nicotinamide mononucleotide (nqus-qhuav)

TYogT	METHOD	ANALYTE	SpecIFICATION	ResuLt
Txheeb xyuas	Nmr	Nicotinamide mononaurideide	Conforms rau cov qauv	Conforms rau cov qauv
Kev coj dawb huv	HPLC / UV (WT%)	Nicotinamide mononaurideide	Ntau dua los yog sib npaug rau 99%	99.87%
Dej	Karl Fischer	Ywg dej	Tsawg dua los yog sib npaug rau 5%	0.15%
Sodium Cov Ntsiab Lus			Tsawg dua los yog sib npaug rau 1%	0.02%
Ceev ntom		Qhov hnyav ntom ntom	>0. 55g / ml	{{0 {}}. 54g / ml
PH nqi		Hauv dej ntawm 100mg / ml	2.0-4.0	3.07
Cov hlau hnyav		Hlau Khoom	<5 ppm	0. 01ppm
			<5 ppm	0. 01ppm
Microbial	USP<2021> USP<2022>	Tag Nrho Cov Phaj Suav E. coli	< 750CFU/g < 30MPN/100g	60cfu / g N.D.
Kev tshwm sim	Na	Xim, Daim Ntawv	Dawb rau cov hmoov daj	Cov hmoov dawb

 

 

● Nicotinamide Mononucleotide (khov-qhuav)

TYogT	METHOD	ANALYTE	SpecIFICATION	ResuLt
Txheeb xyuas	Nmr	Nicotinamide mononaurideide	Conforms rau cov qauv	Conforms rau cov qauv
Kev coj dawb huv	HPLC / UV (WT%)	Nicotinamide mononaurideide	Ntau dua los yog sib npaug rau 99%	99.94%
Dej	Karl Fischer	Ywg dej	Tsawg dua los yog sib npaug rau 5%	0.16%
Sodium Cov Ntsiab Lus			Tsawg dua los yog sib npaug rau 1%	0.01%
Ceev ntom		Qhov hnyav ntom ntom	<0.20g/ml	{{0 {}. 16g / ml
PH nqi		Hauv dej ntawm 100mg / ml	2.0-4.0	3.10
Cov hlau hnyav		Hlau Khoom	Tsawg dua los yog sib npaug rau 1. 0 ppm	0. 01ppm
			Tsawg dua los yog sib npaug rau 1. 0 ppm	0. 01ppm
Microbial	USP<2021> USP<2022>	Tag Nrho Cov Phaj Suav E. coli	Tsawg dua li lossis sib npaug rau 750cfu / g Tsawg dua los yog sib npaug rau 30mpn / 100g	50cfu / g N.D.
Kev tshwm sim	Na	Xim, Daim Ntawv	Dawb rau cov hmoov daj	Cov hmoov dawb

 

Flow chart:

Kev Tswj Xyuas Zoo

1. Cov Khoom Siv Raw Khoom Zoo

• Cov Khoom Siv Roos Khoom:

Qhov zoo ntawm cov ntaub ntawv raw siv hauv NMN kev tsim khoom ncaj qha cuam tshuam rau qhov zoo ntawm cov khoom. Seb nws yog enzymatic synthesis los yog fermentation, nws yog qhov tseem ceeb los xaiv cov ntaub ntawv raw zoo. Piv txwv li, hauv Enzymatic synthesis, lub ntsiab lus purityes thiab impurity cov ntaub ntawv ntawm raw cov ntaub ntawv xws li nicotinamide thiab bibose yuav tsum ua raws li cov qauv nruj. Rau txoj kev fermentation, qhov zoo ntawm cov ntaub ntawv raw xws li cov pa roj carbon thiab nitrogen qhov tseem ceeb ntawm cov txheej txheem fermentation thiab nmn ntau lawm. Raws li ib tugNMN hmoov muag, cov qauv nruj me ntsis tau tsim los ntawm cov khoom siv raw, thiab tsuas yog xaiv cov khoom siv nruj thiab muaj kev txhim khu kev ua kom zoo nkauj, kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb thiab kev nyab xeeb ntawm cov khoom siv raw.

 

• Cov khoom siv tshuaj ntsuam cov qauv:

Txhawm rau kom muaj qhov zoo ntawm cov khoom siv raw, Guamanjie Biotech siv ntau txoj kev ntsuas siab. Rau cov ntaub ntawv tso cai tshuaj lom neeg, cov khoom siv chromatography (HPLC) Rau cov ntaub ntawv muaj roj ntsha, lawv qhov zoo yog kev ntsuas los ntawm cov hau kev xws li kev xeem microbial thiab cov ntsiab lus protein. Ua ntej cov ntaub ntawv raw sau cov txuas ntau lawm, lawv yuav tsum yauv tshuaj xyuas nruj, thiab tsuas yog cov khoom siv nyoos uas ua tau raws li cov qauv zoo tuaj yeem muab tso rau hauv kev siv.

 

2. Ntau Txheej Txheej Txheem xyuas

• Cov Ntsiab Lus Tseem Ceeb:

Hauv cov txheej txheem ntau lawm ntawm NMN, Kev tshuaj xyuas lub sijhawm tiag tiag ntawm cov tsis tseem ceeb yog tus yuam sij kom ntseeg tau cov khoom muaj zog zoo. Hauv kev ua si sib luag, cov tsis sib xws xws li cov tshuaj tiv thaiv kub, pH nqi, enzyme kev ua si ncaj qha cuam tshuam rau cov tshuaj tiv thaiv tus nqi thiab cov tshuaj purity. Nyob rau hauv cov txheej txheem fermentation, tsis muaj xws li fermentation oxygen kub, yaj tus nqi, thiab microbial kev loj hlob yog qhov tseem ceeb rau kev sib txuas ntawm NMN. Guanjie Biotech inctrial sensors thiab siv hluav taws xob tswj cov ntsiab lus ntawm lub sijhawm tam sim no kom ntseeg tau tias cov txheej txheem ntau lawm ib txwm nyob hauv lub xeev zoo tshaj plaws.

 

• Txheem cov txheej txheem kom pom kev zoo:

Ntxiv rau kev soj ntsuam cov ntsiab lus tseem ceeb, Guamanoj Biotech kuj tseem ua kev soj ntsuam zoo thaum lub sijhawm tsim khoom. Piv txwv, thaum cov txheej txheem fermerming, kev coj ua ib txwm tau ua los xyuas cov ntsiab lus ntawm cov khoom lag luam thiab cov ntsiab lus nmn ntawm cov khoom lag luam nruab nrab, peb ntsuas qhov kev nce qib thiab Cov nyhuv ntawm cov tshuaj tiv thaiv thaum lub sij hawm enzymatic synthesis cov tshuaj tiv thaiv. Los ntawm cov txheej txheem no zoo kuaj, teeb meem uas tej zaum yuav tshwm sim hauv cov txheej txheem ntau lawm, thiab sib tw ntsuas tau los kho lawv kom tsis txhob muaj cov khoom lag luam uas tsis muaj peev xwm.

 

3. Cov khoom tiav zoo tshuaj xyuas

• Soj ntsuam purection:

Lub purity ntawm nmn tiav cov khoom yog ib qho ntawm cov ntsuas tseem ceeb los ntsuas cov khoom lag luam zoo. Guanjie Biotech siv siab thev naus laus zis xws li HPLC thiab Mass Spectrometry (MS) kom pom tseeb txog cov khoom lag luam nmn tiav. Cov thev naus laus zis tuaj yeem cais thiab txheeb xyuas NMN thiab nws cov impurities los xyuas kom meej tias kev coj dawb huv ntawm cov khoom ua tau raws cov qauv siab. Feem ntau hais lus, lub purity ntawm nmn cov khoom lag luam tsim los ntawm Guaanjie Biotech tuaj yeem ncav cuag ntau dua 99%, ntsib kev ua lag luam thov kom muaj txiaj ntsig zoo.

 

• Nrhiav cov khoom ua si:

Ntxiv nrog rau kev paub huv si tau pom, kev ua haujlwm roj ntsha ntawm NMN tseem yog cov ntsiab lus tseem ceeb ntawm kev tshuaj xyuas zoo. Guanjie Biotech ntsuas kev ua haujlwm roj ntsha ntawm NMN hmoov ntau los ntawm kev sim ntawm tes, cov kev sim tsiaj thiab lwm txoj hauv kev. Piv txwv li, NMN ntxiv rau lub cell kab lis kev cai nruab nrab los soj ntsuam cov kev hloov pauv ntawm cov ntsuas ntawm tes thiab cov metabolism los ntsuas cov nyhuv nmn ntawm kev muaj mob cellility; Hauv kev sim tsiaj, NMN tau sim rau cov txiaj ntsig ntawm kev txhim kho NAD + qib hauv tsiaj thiab kev txhim kho ntawm cov haujlwm ntawm lub cev. Los ntawm cov kev xeem ua haujlwm no, nws yog kom ntseeg tau tias NMN cov khoom siv siv los ntawm cov neeg siv khoom muaj kev ua haujlwm zoo thiab kev ua tau zoo.

 

 

 

Peb Lub Hoobkas:

 

Cov Khoom Tsim Kho

 

Kuaj Chaw:

Kev tsim khoom lag luam ntawm NMN yog tas li kev txhim kho thiab txhim kho cov tshuaj synthesis, thiab enzymatic synthesis los fermentation, txhua txoj kev muaj txiaj ntsig zoo thiab qhov tsis zoo. Guanjie Biotech yog ib qhoNMN hmoov muagCov. Peb yog lub Hoobkas NMN hmoov zoo. Los ntawm ntau tshaj 20 xyoo ntawm kev mob siab rau kev muaj kev paub nplua nuj nyob hauv kev tsim cov nmn los ntawm enzymatic synthesis thiab fermentation. Thiab peb siv cov tshuab nqus tsev kom qhuav thiab khov-kom qhuav thev naus laus zis los ua cov khoom lag luam. Nyob rau tib lub sijhawm, kev tswj hwm nruj zoo ua kom muaj txiaj ntsig zoo ntawm NMN cov khoom lag luam.

 

Daim ntawv muaj cai

 

 

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Cim npe nrov: NMN hmoov cov khoom siv, Tuam Tshoj Nmn Hmoov Cov Khoom Siv Khoom Siv, cov chaw muag khoom, Hoobkas