Berberine Bulk Powder

Berberine Bulk Powder Supplier:

Guanjie Biotech tau tsom mus rauberberine tej hmoovkev tshawb nrhiav, tsim, sim, thiab ua lag luam rau ntau tshaj 20 xyoo. Berberine hydrochloride yog hmoov daj. Nws yog soluble nyob rau hauv boiling dej, me ntsis soluble nyob rau hauv dej txias, thiab xyaum insoluble nyob rau hauv txias ethanol, chloroform, thiab ether. Nws yog ib qho organic compound nrog cov tshuaj formula C20H18ClNO4. Txais tos rau kev nug:info@gybiotech.com.

COA

Yam khoom	Specification	Kev tshwm sim	Txoj kev
Cov ntaub ntawv tseem ceeb ntawm cov khoom
Genus thiab Hom	Phellodendron amurense Rupr	Ua raws	/
Ib feem ntawm tsob nroj	Hauv paus	Ua raws	/
Lub Tebchaws Keeb Kwm	Tuam Tshoj	Ua raws	/
Marker Compounds
Berberine hydrochloride	>97.0%	98.12%	Titration
Cov ntaub ntawv Organoleptic
Qhov tshwm sim	Hmoov	Ua raws	/
Xim	Yellow hmoov zoo	Ua raws	/
tsw	Yam ntxwv	Ua raws	/
Saj	Yam ntxwv	Ua raws	/
Cov ntaub ntawv txheej txheem
Txoj kev ua	Kev rho tawm	Ua raws	/
Cov yam ntxwv ntawm lub cev
Particle Loj (80 mesh)	98.0% dhau 80 mesh	Ua raws	GB/T 5507-2008
Poob rau ziab	<5.0%	3.04%	5g / 105℃/ 2 teev
Tshauv Ntsiab Lus	<10.0%	5.12%	2g / 525℃/ 3 teev
Hnyav Hlau
Total Heavy Metals	<10 ppm	Ua raws	USP<231>, method II
Raws li	<1.0 ppm	Ua raws	AOAC 986.15, 18
Pb	<2.0 ppm	Ua raws	AOAC 986.15, 18
Hg	<0.5 ppm	Ua raws	AOAC 971.21, 18
Cd	<0.5 ppm	Ua raws	AOAC 971.21, 18
Tshuaj tua kab
666	<0.2ppm	Ua raws	GB/T5009.19-1996
DDT	<0.2ppm	Ua raws	GB/T5009.19-1996
Microbiology
Tag Nrho Phaj suav	<1,000cfu/g	Ua raws	AOAC 990.12, 18
Total Poov & Pwm	<100cfu/g	Ua raws	FDA (BAM) Tshooj 18, 8th Ed.
E. Coli	Tsis zoo	Tsis zoo	AOAC 997.11, 18
Salmonella	Tsis zoo	Tsis zoo	FDA (BAM) Tshooj 5, 8th Ed.

 

Yuav ua li cas yog Berberine tsim?

Guanjie Biotech siv cov dej alkaline extractionberberine tej hmoov. Alkaline dej extraction yog ib tug classical cog extraction txoj kev, uas siv alkaline tov extract alkaloids los ntawm cov nroj tsuag, thiab ces purifies thiab crystallises lub hom phiaj tshuaj los ntawm ib tug series ntawm tshuaj tiv thaiv thiab lub cev ua hauj lwm. Hauv qab no yog peb cov txheej txheem ntau lawm.

1. Raw khoom npaj

Raw khoom kho

-Kev ziab.

Cov ntaub ntawv nyoos yog ziab hauv tshav ntuj lossis hauv lub tshuab ziab khaub ncaws kom tshem tawm cov dej noo ntau dhau.

- Crushing:

Cov khoom siv qhuav qhuav yog crushed rau cov hmoov zoo los ntawm pulveriser.

Tom qab ziab, cov khoom siv raw yog crushed rau hauvberberine tej hmoovlos ntawm pulveriser.

 

2. Lye Extraction

Kev npaj ntawm aqueous alkali daws

Ib qho aqueous tov ntawm alkali yog npaj ntawm ib tug tej yam concentration. Feem ntau peb siv cov tshuaj alkaline xws li sodium hydroxide (NaOH) lossis potassium hydroxide (KOH). Kev xaiv ntawm concentration yuav tsum tau optimized raws li raw khoom thiab cov txheej txheem extraction.

 

Cov txheej txheem rho tawm

- Sib tov thiab ntub dej.

Lub crushed cog hmoov yog tov nrog ib tug aqueous alkaline tov. Soak ntawm qhov kub thiab txias (feem ntau yog 50-80 degree) rau ob peb teev. Cov tshuaj alkaline tau nkag mus rau hauv cov nroj tsuag hlwb thiab dissolves berberine hauv lawv.

- Sib.

Thaum lub sij hawm steeping txheej txheem, tsim nyog stirring yog ua los txhawb kev sib cuag ntawm alkaline aqueous tov thiab cog hmoov los txhim kho cov extraction efficiency.

-Kev lim

Cov sib tov tom qab soaking yog lim los ntawm lim ntaub los yog lim ntawv kom tshem tawm cov khoom seem. Qhov no yields alkaline extract muaj berberine.

 

3. Neutralization thiab nag lossis daus

Neutralization cov tshuaj tiv thaiv

Lub hauv paus extract yog tov nrog ib tug acidic tov (xws li hydrochloric acid) ua ib tug neutralization cov tshuaj tiv thaiv. Nyob rau lub sijhawm no, berberine yuav hloov mus rau berberine hydrochloride thiab precipitate yuav tsim.

Kev sib cais los nag

Lub precipitate yog sib cais los ntawm lub supernatant los ntawm centrifugation los yog static settling thiab cov precipitate yog sau.

4. Purification thiab crystallisation

Recrystallisation

Lub precipitate yog yaj nyob rau hauv ib tug tsim nyog tus nqi ntawm cov dej kub, thiab ces berberine hydrochloride yog recrystallised los ntawm kev txo qhov kub los yog ntxiv ethanol mus ntxiv txhim kho nws purity.

Lim thiab ziab

Lub recrystallised berberine hydrochloride yog cais los ntawm kev pom. Tom qab ntawd nws tau qhuav nyob rau hauv qhov qis - qhov kub ntawm lub tshuab nqus tsev kom qhuav. Thaum kawg, peb yuav tau txaisberberine tej hmoov.

 

5 Kev tswj kom zoo

Kev kuaj xyuas purity

Peb siv High Performance Liquid Chromatography (HPLC) thiab Ultraviolet -Visible Spectrophotometer (UV-Vis) los xyuas qhov purity ntawm Berberine Hydrochloride los xyuas kom meej tias nws ua tau raws li cov qauv zoo.

 

Berberine Ua Dab Tsi?

● Anti-arrhythmic

Arrhythmia feem ntau tshwm sim thaum lub plawv dhia tsis sib xws, lossis lub plawv dhia ceev dhau los yog qeeb dhau. Tsis ntev los no tau pom tias Flavopiridol muaj tshuaj tiv thaiv -arrhythmic teebmeem. Nws tuaj yeem kho ntau hom kev mob plawv thiab tsis muaj teebmeem rau lub plawv dhia, ntshav siab, lub siab thiab lub raum ua haujlwm, lossis cov duab ntshav. Feem ntau cov tshuaj antiarrhythmic muaj qhov tsis zoo ntawm kev ua kom tsis muaj zog ntawm myocardial contractility. Txawm li cas los xij,berberine tej hmoovtuaj yeem ntxiv dag zog rau myocardial contractility. Yog li, nws tuaj yeem kho nrog berberine hydrochloride. Rau ntau hom tachycardia cov neeg mob, txhua zaus qhov ncauj 0.3 ~ 0.6 g, plaub zaug ib hnub . 2 ~ 4 lub lis piam rau kev kho mob. Feem ntau, nws ua haujlwm li ntawm 7 hnub, thiab tag nrho cov txiaj ntsig zoo yog 78%. Nws kuj tseem siv tau rau cov neeg mob pulmonary arrhythmia lossis ventricular arrhythmia cuam tshuam nrog lub plawv tsis ua haujlwm.

 

● Anti-Lub plawv tsis ua hauj lwm

Thaum lub plawv tsis tuaj yeem xa tag nrho cov ntshav rov qab los ntawm cov leeg mus rau hauv cov hlab ntsha vim tsis muaj zog ntawm cov leeg nqaij. Qhov no ua rau stagnation ntawm cov ntshav thiab txo cov ntshav siab, ua rau nws nyuaj rau ua kom tau raws li cov kev xav tau ntawm cov ntaub so ntswg metabolism. Nws tuaj yeem kho tau los ntawm kev noj berberine hmoov ua ntej noj mov, 0.4 mus rau 0.6 grams txhua lub sijhawm, peb zaug ib hnub. Feem ntau, cov nyhuv pom nyob rau hauv 1 mus rau 5 hnub, thiab tag nrho cov txiaj ntsig yog 71%. Txawm li cas los xij, cov neeg mob xwm txheej ceev thiab mob hnyav tseem yuav tsum tau xa mus rau tsev kho mob kom kho.

 

● Antiplatelet aggregation

Ntau tus neeg laus (cov neeg laus noj zaub mov) feem ntau yog vim muaj kab mob thrombosis uas ua rau tuag tes tuag taw, thiab txawm tias lub neej muaj kev hem thawj. Qhov laj thawj tseem ceeb yog qhov siab ntawm platelet aggregation. Lawv tuaj yeem noj berberine hydrochloride kev kho mob, txhua zaus 0.3 gramsbulk berberine hmoov, plaub zaug ib hnub twg . 2 ~ 4 lub lis piam rau kev kho mob, tag nrho cov txiaj ntsig zoo ntawm 95%. Vim tias berberine hydrochloride bulk hmoov tuaj yeem nce cov ntsiab lus ntawm nucleotides hauv platelets, thiaj li ua tiav lub hom phiaj ntawm inhibiting platelet aggregation.

 

● Kev Kho Mob Ntshav Siab Primary

Vim muaj zog sab nraud stimuli rov ua rau lub paj hlwb cortex ntev, tib neeg yuav ntshai thiab kev xav, ua rau lub cev tsis ua haujlwm ntawm cerebral cortex. Yog li ntawd, kev ua haujlwm ntawm subcortical vascular diastolic chaw yog cuam tshuam, kom cov hlab ntsha me me ntawm tag nrho lub cev cog lus. Qhov no yuav ua rau kom ntshav siab. Lub sijhawm no,berberine tej hmoovtuaj yeem coj mus kho. Txhua zaus 0.3 mus rau 0.6 grams ntawm berberine HCL hmoov, peb los yog plaub zaug ib hnub twg, plaub lub lis piam rau kev kho mob, feem ntau 3 mus rau 6 hnub kom pom cov nyhuv, tag nrho cov txiaj ntsig zoo ntawm 81%, zoo dua li cov tshuaj tiv thaiv kab mob siab. Qhov no yuav yog vim cov tshuaj tuaj yeem txhim kho lub luag haujlwm ntawm acetylcholine los ntawm cov tshuaj anticholinesterase, vim yog cov hlab ntsha ntawm cov hlab ntsha.

 

● Kho Mob Ntshav Qab Zib (mob ntshav qab zib zaub mov)

Mob ntshav qab zib mellitus yog ib qho teeb meem ntawm cov piam thaj hauv cov metabolism los ntawm kev tso cov tshuaj insulin tsis txaus hauv lub cev. Cov neeg mob kuj tuaj yeem noj berberine hydrochloride hmoov kho. Txhua zaus 0.3 ~ 0.5 grams, peb zaug ib hnub, ib mus rau peb lub hlis rau ib chav kawm ntawm kev kho mob. Txhawm rau ua cov piam thaj hauv ntshav (cov ntshav qab zib cov zaub mov) kom rov zoo li qub, yuav tsum tau ua haujlwm ntxiv 0.3 grams txhua lub sijhawm. Peb zaug hauv ib hnub, ob lossis peb lub hlis kom tsis txhob noj ib lub lis piam, thiab tom qab ntawd tswj kev kho mob, tag nrho cov txiaj ntsig zoo ntawm 91%. Nws cov txiaj ntsig kho tsis yog tsuas yog cuam tshuam nrog kev tiv thaiv -glucose hormone nyhuv ntawm cov tshuaj tab sis kuj muaj feem xyuam nrog cov tshuaj tuaj yeem txhawb kev ua haujlwm ntawm pancreatic islet hlwb rov qab los.

 

● Rau kev kho mob plawv stenosis

Cov kev sim tsis ntev los no tau pom tiasberberine tej hmoovinhibits vascular endothelial proliferation. Cov kws kho mob tau sim nrog aortic cov leeg nqaij leeg los ntawm cov nas thiab pom tias ntxiv safranin hmoov rau cov hlwb ua rau T21 noob. Qhov no inhibits ob proteins uas muaj cov nyhuv inhibiting vascular du nqaij proliferation. Feem ntau, cov hlab plawv stenosis yog kho nrog lub zais pa dilatation thiab tso cov vascular stents. Txawm li cas los xij, tom qab rau lub hlis txog li 30% mus rau 40% ntawm cov neeg mob muaj vascular du nqaij proliferation, ua rau re-stenosis. Txhawm rau txo qhov rov- cov hlab ntsha, txoj hauv kev tshiab tshaj plaws yog siv cov tshuaj Western rau stent. Cov kws tshaj lij ntseeg tias yav tom ntej, peb tuaj yeem sim siv safranine hmoov es tsis txhob siv tshuaj Western thiab siv rau stent.

 

Factory & Pab Pawg:

 

Daim ntawv pov thawj

 

Ntim & Xa khoom

Cim npe nrov: Tuam Tshoj berberine bulk hmoov manufacturers, lwm tus neeg, Hoobkas