Bulk Fisetin Powder

TejFisetin hmoovTus neeg muab khoom:

TejFisetin hmoov yog lub teeb daj nyob rau hauv tsos. Nws yog soluble hauv ethanol, acetone thiab acetic acid, tab sis yuav luag insoluble hauv dej. Thiab Guanjie Biotech extractsTejFisetin hmoovlos ntawm lub cev qhuav ntawm Sumac. Peb tau tsom mus rau cov khoom zoo -. Yog tias koj txaus siab rau peb cov khoom, peb tuaj yeem muab cov ntawv tshaj tawm rau koj. Fisetin yog lub ntuj tsim tau los ntawm cov nroj tsuag nrog ntau cov txiaj ntsig thiab yog ib tus tswv cuab ntawm senolytics rau nws lub luag haujlwm hauv kev tshem tawm cov hlwb. Txais tos kom nug nrog peb ntawminfo@gybiotech.com.

COA

Yam khoom	Specification	Kev tshwm sim	Txoj kev
Cov ntaub ntawv tseem ceeb ntawm cov khoom
Genus thiab Hom	Cotinus coggygria Scop.	Ua raws	/
Ib feem ntawm tsob nroj	Ceg	Ua raws	/
Lub Tebchaws Keeb Kwm	Tuam Tshoj	Ua raws	/
Marker Compounds
Cov ntsiab lus	98%	98.12%	HPLC
Kev txheeb xyuas	Tib qhov chaw raws li kev siv	Ua raws	TLC
Cov ntaub ntawv Organoleptic
Qhov tshwm sim	Hmoov	Ua raws	Pom kev
Xim	Daj	Ua raws	GB/T 5492-2008
tsw	Yam ntxwv	Ua raws	GB/T 5492-2008
Saj	Yam ntxwv	Ua raws	GB/T 5492-2008
Cov yam ntxwv ntawm lub cev
Particle Loj	Ntau dua lossis sib npaug rau 95 (%) Hla 80Mesh	99.56	GB/T5507-2008
Poob rau ziab	Tsawg dua lossis sib npaug li 2(%)	1.18	GB5009.3
Total Tshauv	Tsawg dua lossis sib npaug li 2(%)	0.76	PIB 2015
Kev ceev ceev	40-60g / 100ml	53.24	PIB 2015
Cov yam ntxwv tshuaj
Residual Solvent	EP4	Ua raws	Q/GJSW 0002S-2016
Tshuaj tua kab	EP4	Ua raws	PIB 2015
Heavy Metals (raws li Pb)	Tsawg dua los yog sib npaug rau 10 (ppm)	Ua raws	USP<231>, method II
Arsenic (As)	Tsawg dua lossis sib npaug li 2 (ppm)	Ua raws	GB5009.11
Lead (Pb)	Tsawg dua lossis sib npaug li 2 (ppm)	Ua raws	GB5009.12
Cadmium (Cd)	Tsawg dua lossis sib npaug li 0.5 (ppm)	Ua raws	GB5009.15
Mercury (Hg)	Tsawg dua lossis sib npaug li 0.5 (ppm)	Ua raws	GB5009.17
Kev ntsuam xyuas microbiological
Tag Nrho Phaj suav	Tsawg dua lossis sib npaug li 1000 (cfu / g)	Ua raws	GB4789.2
Tag nrho Holothuroidea & Pwm	Tsawg dua lossis sib npaug li 100 (cfu / g)	Ua raws	GB4789.15
E. Coli	Tsis Pom	Tsis Pom	GB4789.3
Salmonella	Tsis Pom	Tsis Pom	GB4789.4
Staphylococcus	Tsis Pom	Tsis Pom	PIB 2015

 

Chromatogram:

 

Fisetin tuaj qhov twg?

Lacin muaj nyob rau hauv ntau hom nroj tsuag, thiab cov hauv paus ntsiab lus suav nrog:

• Mullein (Rhus succedanea L):

Qhov no yog ib tsob nroj ntawm tsev neeg Lacertaceae, thiab cov txheej txheem extraction thiab refining yields lacertinic acid. Cov nroj tsuag xws li Sumac, Lacerta, Saltbush, thiab Euphorbia: Cov nroj tsuag no muaj Lacertin, uas tuaj yeem tau txais los ntawm cov txheej txheem rho tawm.

Thiab Guanjie Biotech extractsTejFisetin hmoovlos ntawm lub cev qhuav ntawm Sumac.

 

• Strawberries:

Raws li ib tug txiv hmab txiv ntoo, strawberries muaj laccasein ntawm ib theem ntawm txog 160 ug / g.

Laccasein los ntawm cov nroj tsuag no tuaj yeem tau txais los ntawm ntau txoj kev rho tawm. Nws yog siv rau hauv ntau yam xws li kev lag luam khoom noj, tshuaj thiab tshuaj pleev ib ce. Vim nws muaj ntau yam kev ua ub no xws li antioxidant thiab anti-inflammatory zog, laccasein tau txais qhov tseem ceeb rau nws cov khoom siv hauv kev noj qab haus huv thiab kev zoo nkauj.

 

Fisetin Ua li cas?

•Pretreatment ntawm sumac:

Cov ntaub ntawv raw khoom ntawm sumac tau raug ua raws li cov kauj ruam ua ntej xws li ntxuav, ziab thiab crushing.

•Kev ua kom zoo ntawm cov txheej txheem rho tawm:

Ib qho -txoj kev xeem thiab kev xeem tsim qauv siv los txiav txim siab qhov zoo tshaj plaws ntawm kev rho tawm cov kuab tshuaj, lub sijhawm, pH thiab hnyav npaum li cas.

• Crushing ntawm Sumac raw khoom

Cov qhuav sumac raw cov ntaub ntawv yog crushed rau ib tug tej yam particle loj, nyob rau hauv thiaj li yuav ua rau kom cov cheeb tsam sib cuag ntawm cov kuab tshuaj thiab cov ntaub ntawv raw, thiab txhim kho cov extraction efficiency.

• Xaiv thiab optimization ntawm cov kuab tshuaj

Xaiv ethanol raws li cov kuab tshuaj extraction, txiav txim siab qhov zoo tshaj plaws cov kuab tshuaj concentration los ntawm ib zaug -factor kev tshawb nrhiav.

 

• Optimization ntawm cov txheej txheem rho tawm

Lub sij hawm rho tawm: txiav txim siab lub sij hawm rho tawm zoo tshaj plaws los ntawm ib zaug - qhov kev tshawb nrhiav.

pH tus nqi: kho tus nqi pH ntawm cov kuab tshuaj los txhim kho cov solubility thiab rho tawm tus nqi ntawm laccase.

Qhov hnyav npaum li cas: Txiav txim siab tus nqi tsim nyog ntawm cov kuab tshuaj kom ua tiav qhov zoo tshaj plaws ntawm kev rho tawm efficiency thiab tus nqi.

• Ultrasound- pab rho tawm

Ultrasound- pab extraction yog siv los txhim kho cov extraction efficiency.

• Lim thiab concentration

Cov extract tau lim kom tshem tawm cov khoom impurities thiab tom qab ntawd concentrated nyob rau hauv lub siab txo kom nce concentration ntawmTejFisetin hmoov.

• Resin adsorption thiab elution

Adsorption ntawm fisetin nyob rau hauv cov tshuaj muab rho tawm yog nqa tawm los ntawm kev siv macroporous resin, thiab eluted los ntawm tsim nyog hnyav.

 

• Kev huv thiab kev txheeb xyuas

Lub eluate yog purified los ntawm kem chromatography thiab lwm yam tswv yim kom thaum kawg tau siab purityfisetinhmoov. Cov lacin rho tawm tau txheeb xyuas thiab cov ntsiab lus txiav txim siab los ntawm ultraviolet spectroscopy thiab kev ua haujlwm siab ua kua chromatography (HPLC).

Cov txheej txheem kev ua kom zoo tshaj plaws tau txiav txim siab los ntawm kev ntsuas orthogonal, suav nrog 65% ethanol concentration, pH 9, thiab 90 min ib qho kev rho tawm rau ob zaug. Piv nrog rau cov txheej txheem extraction ib txwm, cov txheej txheem extraction optimized ho nce tus nqi extraction ntawmTejFisetin hmoovrau 1.03%.

 

Kev tshawb fawbOnTejFisetin hmoov

1. Molecular cov hom phiaj kev tshawb fawb

Lub multi•targeting zog ntawm laccasein pab kom nws muaj feem xyuam rau ntau yam kev taw qhia txoj kev nyob rau hauv thiab sab nraum lub cell. Lub hom phiaj tseem ceeb ntawm molecular muaj xws li:

• NF-κB: Lacertin inhibits transcriptional kev ua ntawm NF-κB los ntawm inhibiting phosphorylation ntawm IκB thiab thaiv kev nkag ntawm NF-κB mus rau hauv lub nucleus.

• Nrf2: Los ntawm kev ua kom Nrf2, Lacertin tuaj yeem txhawb kev qhia ntawm cov noob caj noob ces antioxidant.

• STAT3: Lacosan tuaj yeem cuam tshuam cov phosphorylation ntawm STAT3 thiab thaiv nws cov kev taw qhia hauv qab.

 

2. Metabolism thiab bioavailability

Lacertin yog metabolized hauv lub cev feem ntau los ntawm kev txo qis thiab glucuronidation hauv daim siab. Txawm li cas los xij, qhov tsawg bioavailability ntawmTejFisetin hmoovtxwv nws daim ntawv thov kev kho mob:

• Absorption:

Lacin yog absorbed tsis zoo tom qab kev tswj hwm qhov ncauj thiab feem ntau ntawm nws tawm ntawm lub cev.

• Metabolism:

Nws yog metabolized sai heev nyob rau hauv lub cev mus rau metabolites xws li dihydrolaccasein thiab tetrahydrolaccasein.

Tam sim no, bioavailability ntawm laccasein tau txhim kho los ntawm cov tswv yim hauv qab no:

• Kev hloov kho tshuaj:

Los ntawm cov synthesis ntawm derivatives los txhim kho nws cov dej solubility thiab stability.

 

3. Kev sim tshuaj tiv thaiv - cov teebmeem inflammatory

• Kev tshawb fawb hauv vitro

Cov tshuaj tiv thaiv -inflammatory nyhuv ntawmTejFisetin hmoovtau raug kuaj xyuas tag nrho hauv kev sim hauv vitro. Piv txwv li, nyob rau hauv nas macrophage cell kab RAW 264.7, lacosan txo qis lipopolysaccharide (LPS) -induced NO thiab PGE2 ntau lawm. Nws kuj inhibited qhov kev qhia ntawm COX-2 thiab iNOS. Qhov no qhia tau hais tias laccasein exerts nws anti-inflammatory teebmeem los ntawm inhibiting zus tau tej cov inflammatory mediators.

• Tsiaj cov qauv sim

Hauv cov nas collagen-induced arthritis (CIA) qauv, lacosan txhim kho pob qij txha thiab kev puas tsuaj. Cov txiaj ntsig kev sim qhia tau hais tias nws txo qis kev tso tawm ntawm cov kab mob inflammatory los ntawm inhibiting NF-κB thiab MAPK txoj hauv kev, yog li txo cov lus teb inflammatory.

 

4. Antioxidant nyhuv sim

• Dawb radical scavenging sim

Siv DPPH dawb radical scavenging assay, nws tuaj yeem pom tias laccase muaj qhov tseem ceeb dawb radical scavenging peev xwm. Tus nqi IC50 hauv qhov kev sim qhia tau hais tias cov tshuaj tiv thaiv antioxidant ntawm lacinin txawm ntau dua li ntawm qee cov tshuaj antioxidants.

• Kev sim ntawm tes

Hauv HepG2 hepatocellular carcinoma cells, siv cov qauv kev ntxhov siab oxidative, cov txiaj ntsig tau pom tias lacin tuaj yeem txhim kho qhov kev qhia ntawm intracellular antioxidant enzymes (piv txwv li, SOD thiab GPx) los ntawm kev nce - tswj cov Nrf2 signaling pathway, yog li txo cov tiam ntawm ROS, thiab tiv thaiv hlwb los ntawm oxidative puas tsuaj.

 

Fisetin Market Trend yog dab tsi?

Lub ntiaj teb noTejFisetin hmoovkev ua lag luam tau qhia txog kev loj hlob zoo hauv xyoo tas los no. Qhov no feem ntau yog vim nws txoj kev siv ntau yam hauv ntau yam xws li tshuaj, khoom noj khoom haus additives, tshuaj pleev ib ce, thiab nutraceuticals. Cov hauv qab no yog ib qho kev soj ntsuam ntawm lub ntiaj teb laccasein kev ua lag luam txheej txheem cej luam:

• Txoj Kev Loj Hlob:

Kev lag luam thoob ntiaj teb cov pa luam yeeb tsob ntoo extract yuav tsum loj hlob mus rau USD 490 lab los ntawm 2029. Qhov no qhia tau hais tias qhov kev loj hlob tsis tu ncua txhua xyoo (CAGR) ntawm 6.4% (2023-2029). Ntxiv mus, kev loj hlob sai ntawm lub ntiaj teb no los tiv thaiv- kev lag luam kev laus yuav tsum tau nthuav dav ntxiv ntawm kev lag luam wholesale fisetin. Qhov no yog vim muaj zog tiv thaiv kev laus ntawm Fisetin Bulk.

 

• Kev Lag Luam Hauv cheeb tsam:

Asia Pacific, tshwj xeeb tshaj yog Tuam Tshoj ua lag luam. Nws cia siab tias yuav txuas ntxiv raws li qhov tseem ceeb ntawm kev loj hlob rau lub ntiaj teb enkephalin kev ua lag luam.

• Kev Tsim Kho Tshuab:

Ntuj nonsterones (laccasein) raug kev txom nyem los ntawm qis tawm los thiab tus nqi siab. Nrog rau kev loj hlob ntawm kev lag luam xav tau, cov txheej txheem hluavtaws xws li biosynthesis thiab tshuaj synthesis tau txais kev saib xyuas ntau hauv kev ua lag luam, uas yuav tsum tau tsav kev loj hlob ntxiv, ntawm kev ua lag luam.

 

• Kev sib tw toj roob hauv pes:

Kev sib tw toj roob hauv pes ntawm lub ntiaj teb laccasein kev ua lag luam yog maj mam hloov, thiab kev sib tw ntawm cov tuam txhab loj thoob ntiaj teb thiab cov hom lag luam hauv cheeb tsam tau dhau los ua khaus. Ntau yam ntawm cov khoom uas muaj cov khoom xyaw laccasein twb muaj nyob rau hauv kev ua lag luam.

Lub ntiaj teb noTejFisetin hmoovkev ua lag luam tab tom muaj kev loj hlob zoo, tau tsav los ntawm kev txhim kho thev naus laus zis, kev xav tau ntawm kev lag luam nce ntxiv, thiab cov chaw thov tshiab. Kev ua lag luam no xav tias yuav txuas ntxiv nws txoj kev loj hlob nyob rau xyoo tom ntej.

 

Factory & Pab Pawg:

 

Ntim & Xa khoom

Cim npe nrov: Tuam Tshoj bulk fisetin hmoov manufacturers, lwm tus neeg, Hoobkas