Senna nplooj Extract hmoov

Senna Leaf Extract Powder Supplier:

Senna nplooj Extract hmoovyog dithane derivative ntawm cov tshuaj suav tshuaj senna. Guanjie Biotech tsom rau cov nroj tsuag extract rau 20 xyoo. Nws yog xim av hmoov thiab peb muaj qhov sib txawv: 3% -20% Sennosides ; 10:1  20:1  30:1. Koj tuaj yeem xaiv qhov kev qhia tshwj xeeb uas koj xav tau. Peb tau tshwj xeeb hauv cov nroj tsuag extract rau ntau tshaj 20 xyoo. Peb muaj kev ywj pheej ob lub chaw tsim khoom, lub chaw soj nstuam thiab pab pawg tshawb fawb. Peb cov neeg muas zaub tuaj ntawm 50 lub teb chaws thoob ntiaj teb. Yog tias koj tseem xav tau peb cov khoom, thov hu rau peb:info@gybiotech.com.

 

 

Vim li cas thiaj xaiv Guanjie?

● Cov chaw ua haujlwm ywj pheej thiab cov chaw sim.

● Muab qhov kev xeem thib peb.

● Tau nyob hauv daim teb no tau 20 xyoo.

● Muaj kev sib koom tes muaj zog: Northwestern University thiab Suav Academy ntawm Sciences chaw tshawb fawb

 

Lus Taw Qhia:

Senna Leaf Extract Powder yog qhov ua tau zoo nrog cov ntsiab lus siab hauv senna. Senna yog muab faib rau hauv cov xeev yav qab teb ntawm Tuam Tshoj thiab tsim nyob rau hauv Guangdong, Guangxi, Yunnan, Hunan thiab lwm qhov chaw. Senna Leaf bulk Extract vim tias lawv cov khoom cathartic tau ib txwm suav tias yog "huv" tshuaj ntsuab. Ntau cov kev tshawb fawb niaj hnub no tau pom tias Folium Sennae extract hauv kev kho cem quav yog qhov zoo heev. Nplooj thiab pods lossis txiv hmab txiv ntoo tuaj yeem siv rau tshuaj.

 

Cov lus piav qhia ntxaws ntxaws

Sennoside A thiab B Cov ntsiab lus
20%	HPLC
10%	HPLC
8%	HPLC
6%	HPLC
Senna nplooj Extract ratio
10:1	TLC
20:1	TLC
Senna nplooj hmoov	TLC

 

COA:

Yam khoom	Specification	Kev tshwm sim	Txoj kev
Cov ntaub ntawv tseem ceeb ntawm cov khoom
Genus thiab Hom	Cassia angustifolia vahl	Ua raws	/
Ib feem ntawm tsob nroj	Nplooj	Ua raws	/
Marker Compound
Sennoside A thiab B cov ntsiab lus	Ntau dua lossis sib npaug li 40%	Sennoside A+B: 41.58% Sennoside A: 18.25% Sennoside B: 23.33%.	HPLC
Cov ntaub ntawv Organoleptic
Qhov tshwm sim	Hmoov zoo	Ua raws	GJ-QCS-1008
Xim	Xim av	Ua raws	GB/T 5492-2008
tsw	Yam ntxwv	Ua raws	GB/T 5492-2008
Saj	Yam ntxwv	Ua raws	GB/T 5492-2008
Cov yam ntxwv ntawm lub cev
Particle Loj (80 mesh)	98.0% dhau 80 mesh	Ua raws	GB/T 5507-2008
Poob rau ziab	<5.0%	3.76%	GB/T 14769-1993
Tshauv Ntsiab Lus	<4.0%	4.47%	AOAC 942.05, 18
Hnyav Hlau
Total Heavy Metals	<10 ppm	Ua raws	USP<231>, method II
Raws li	<2.0ppm	Ua raws	AOAC 986.15, 18
Pb	<2.0 ppm	Ua raws	AOAC 986.15, 18
Hg	<0.5 ppm	Ua raws	AOAC 971.21, 18
Cd	<0.5 ppm	Ua raws	AOAC 971.21, 18
Tshuaj tua kab
666	<0.2ppm	Ua raws	GB/T5009 19-1996
DDT	<0.2ppm	Ua raws	GB/T5009 19-1996
Microbiology
Tag Nrho Phaj suav	<1,000cfu/g	Ua raws	AOAC 990.12, 18
Total Poov & Pwm	<100cfu/g	Ua raws	FDA (BAM) Tshooj 18, 8th Ed.
E. Coli	Tsis zoo	Tsis zoo	AOAC 997.11, 18
Salmonella	Tsis zoo	Tsis zoo	FDA (BAM) Tshooj 5, 8th Ed.

 

Yam ntxwv ntawmSenna nplooj Extract:

1. Dej solubility zoo. 500mg ntawm Senna Leaf Extract Powder yog yaj rau hauv 150ml dej ntawm chav tsev kub, xim yog ci thiab tsis muaj impurities.

 

2. Nws tsis yooj yim rau agglomerate (adsorption resin yog siv rau hauv cov txheej txheem tshem tawm polysaccharides, chlorophyll thiab lwm yam khoom uas yooj yim nqus dej).

3. Los ntawm cov txheej txheem adsorption, lub zog saj ntawm cov tshuaj suav tshuaj raug tshem tawm. Thiab tus saj yog haum.

4. Cov nyhuv ntawm cov koob tshuaj tsim nyog yog pom tseeb. Sennoside A hauv senna extract muaj qhov pom tseeb tshaj plaws. Cov neeg uas cem quav yuav muaj lub siab xav mus defecate li ntawm 8-12 teev tom qab noj 150mg Senna Leaf Extract Powder.

 

Kev txiav txim siab ntawm sennoside A thiab sennoside B

1.Chromatographic tej yam kev mob

Chromatographic kem: Zorbax SB-C18 250mm × 4.6mm 5 μ m

Mobile theem: tetrahydrofuran: 0.3% phosphoric acid aqueous tov (15:85, V/V)

Tus nqi ntws: 1mL / min

Ntsuas wavelength: 340nm

rhiab heev: 0.01AUFS

Kem kub: 30 degree

Txhaj ntim: 10 μL

 

2. Kev npaj daws teeb meem

ib. Kev npaj ntawm kev siv tshuaj: raug ntsuas qhov tsim nyog ntawm sennoside A thiab sennoside B siv cov tshuaj, ntxiv methanol rau yaj thiab npaj cov tshuaj siv txog ntawm 0.25mg ib 1mL ntawm sennoside A thiab sennoside B feem.

b. Kev npaj cov qauv tshuaj hnyav hnyav txog 20mg ntawm senna extract qauv, muab tso rau hauv 25mL ntim ntim, ntxiv methanol thiab co nws rau 30min, txias rau hauv chav tsev kub, kho qhov ntim nrog methanol, thiab siv 0.45. μ M microporous membrane pom.

 

3.Sample txiav txim

Nyob rau hauv cov xwm txheej saum toj no chromatographic, tom qab qhov ntsuas tau ruaj khov thiab lub hauv paus ruaj khov, cov qauv raug txhaj rau kev txiav txim siab. Lub sijhawm khaws cia ntawm sennosides A thiab B yog li 18 thiab 50 min feem, thiab cov ntsiab lus suav nrog cov txheej txheem sab nraud.

 

Senna Leaf Extract HPLC Kev Ntsuam Xyuas

1. Kev npaj cov khoom tswj:

Precision hnyav sennoside A, sennoside B (98%) tus nqi tswj cov khoom mus rau 10ml volumetric hwj nrog 0.1% sodium bicarbonate tov nrog ultrasonic yaj nyob rau hauv dilute rau lub cim. Tom qab pom nrog 0.45 m lim membrane, spare.

 

2. Kev npaj ua qauv:

Qhov hnyav hnyavSenna nplooj Extract hmoovyuav tsum tau coj mus rau 25ml muaj peev xwm lub raj mis, diluted nrog 0.1% sodium bicarbonate tov thiab yaj mus rau hauv lub teev tom qab ultrasonic dissolution. Tom qab lim nrog 0.45 m lim membrane, seem.

 

3. Test Kauj Ruam:

Tshawb xyuas raws li cov kev xeem hauv qab no

Instrument: Agilent 1100

Chromatographic kem: Agilent HC-C 18  4.6 * 250mm 5um

Detector: DAB

Qauv loj: 10ul

Tam sim no ceev: 1.0 ml/min

Kub: 30 degree

Kev ntsuas wavelength: 210nm

Mobile theem: acetonitrile /0.1% phosphoric acid aqueous tov (V/V)

 

Gradient elution txheej txheem:

T / min	A (acetonitrile)	B (0.1% phosphoric acid aqueous tov)
0	10	90
20	30	70
23	80	20
30	80	20

 

4. Kev tshuaj xyuas

Cov qauv kev daws teeb meem thiab cov qauv tshuaj tau txhaj rau hauv cov kua chromatograph feem, thiab lub sijhawm khaws cia tau txiav txim siab zoo. Qhov chaw siab tshaj ntawm cov qauv kev daws teeb meem tau muab piv nrog thaj tsam ntawm qhov sib txawv ntawm qhov sib piv.

 

5. Cov ntaub ntawv siv

Xa mus rau 2010 tsab ntawm Suav Pharmacopoeia, P.326-327

"Lub tsev muag tshuaj" HPLC txoj kev rau kev txiav txim siab ntawm sennoside A hauv senna thiab sennoside B cov ntsiab lus

 

Main Functions

● Antibacterial nyhuv:

Senna nplooj Extract hmoovNws muaj cov nyhuv inhibitory ntawm Escherichia coli, Proteus, Shigella dysenteriae, Streptococcus A thiab Leucococcus albicans. Qee cov hydroxyanthraquinones hauv senna nplooj muaj qee yam tshuaj tua kab mob. Cov dej cawv extract ntawm senna ovale muaj inhibitory nyhuv ntawm ntau yam kab mob, xws li staphylococcus, diphtheria, typhoid, paratyphoid thiab Escherichia coli, thaum nws cov dej extract tsuas yog tiv thaiv typhoid. Senna nplooj dej extract (1:4) muaj cov nyhuv inhibitory ntawm dermatophytes xws li Tinea aureolata thiab Nocardia stellata hauv vitro.

 

● Hemostatic nyhuv:

Senna hmoov tuaj yeem nce platelet thiab fibrinogen tom qab kev tswj hwm qhov ncauj, txo lub sijhawm coagulation, lub sijhawm calcium rov qab, lub sijhawm thrombin thiab cov ntshav txhaws lub sijhawm, thiab pab kom tsis txhob los ntshav. Cov siv lead ua fiber ntau thiab calcium oxalate pawg siv lead ua hauv senna muaj cov nyhuv hemostatic hauv zos.

 

● Kev cuam tshuam rau lub plab zom mov:

Senna yog ib qho tshuaj laxative. Cov kev tshawb fawb tsis ntev los no tau pom tias cov tshuaj no tuaj yeem tsis tsuas yog txhawb kev tso tawm ntawm PG los ntawm txoj hnyuv mucosa (uas yog suav tias yog ib qho kev ua rau raws plab), tab sis kuj nce qib ntawm PG hauv lub plab lub cev thiab antrum ntawm nas. Senna tuaj yeem tiv thaiv kev puas tsuaj ntawm cov koob tshuaj loj ntawm indomethacin rau hauv lub plab mucosa, uas tej zaum yuav yog vim nws cov antagonism tawm tsam qhov inhibition ntawm tom kawg ntawm cyclooxygenase (PG synthetase) ntawm pais plab mucosa. Txij li thaum cov nyhuv purgative ntawm PG kuj yog ib qho kev tiv thaiv ntawm txoj hnyuv, senna muaj kev tiv thaiv ntawm lub plab mucosa los ntawm stimulating PG synthesis, uas yog raws li nws purgative nyhuv ntawm stimulating PG synthesis.

 

● Cov leeg nqaij so thiab cov nyhuv antispasmodic:

Senna nplooj Extract hmoovmuaj cov nyhuv ntawm xub xub tshuaj lom, uas tuaj yeem thaiv acetylcholine ntawm cov hlab ntsha ntawm lub cev thiab cov leeg pob txha, thiaj li ua kom cov leeg muaj zog. Qee cov hydroxyanthraquinones hauv senna nplooj muaj qee yam tshuaj tua kab mob.

 

● Lwm yam teebmeem:

Cov noob ntawm senna auriculata tuaj yeem txo cov ntshav qab zib sai sai ntawm cov dev, thiab tag nrho cov tshuaj ntsuab kuj muaj plawv glycoside.

 

Kev ua lag luam Prospect

Kev kho mob daim ntawv thov ntawm senna nplooj muaj ib tug dav zeem muag, uas tau tshaj lub Scope ntawm defecation thiab distension. Tshwj xeeb tshaj yog rau kev kho mob ntawm qee qhov xwm txheej ceev. Pharmacological thwmsim tau ua pov thawj tiasSenna nplooj Extract hmoovmuaj tshuaj tua kab mob, raws plab, hemostasis, cov leeg so thiab spasmolysis, nrog rau kev tiv thaiv plab hnyuv thiab lwm yam teebmeem. Ntxiv nrog rau txoj kab uas hla ntawm txoj hnyuv loj, nws tseem yuav tsum suav nrog txoj kab uas hla ntawm daim siab, tus po thiab lub plab. Txawm li cas los xij, cov tshuaj lom thiab ntsim ntawm senna nplooj kuj yog ib qho teeb meem uas tsis tuaj yeem tsis quav ntsej. Cov laj thawj rau nws qhov tshwm sim tsis yog tsuas yog cuam tshuam rau tus kheej qhov sib txawv ntawm cov neeg mob, tab sis kuj tseem cuam tshuam nrog kev siv tshuaj ntau dhau.

Factory & Pab Pawg:

 

Daim ntawv pov thawj

 

Ntim & Xa khoom

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