Nicotinamide Riboside Malate Hmoov

Nicotinamide Riboside Malate Supplier:

Guanjie Biotech yog ibNicotinamide riboside malatetus neeg muag khoom thiab kev tsim khoom. Nicotinamide riboside hydrogen malatehmoov uas tsim los ntawm Guanjie muaj cov ntsiab lus raw khoom siab dua, hloov dua siab tshiab, thiab purity ntau dua 98%. Peb muaj cov chaw ua haujlwm ywj pheej thiab chaw kuaj mob, Thiab peb kuj koom tes nrog Northwestern University thiab Suav Academy ntawm Sciences tshawb fawb chaw. Guanjie Biotech tau txais ntau tshaj 14 patents rau kev tsim cov tshuaj ntsuab rho tawm. Yog tias koj txaus siab rau peb cov khoom, thov hu rau peb:info@gybiotech.com.

Nicotinamide riboside malateyog ib qho ionic compound nrog cov mis molecular C15H20N2O10. Nws muaj 66% Nicotinamide riboside (NR) thiab 34% malate. Malate tau raug xaiv los ua anionic moiety ntawm NR vim tias nws cov khoom lag luam zoo tshaj plaws thiab kev solubility thaum piv rau lwm cov ntaub ntawv. Tsis tas li ntawd, malate tau theorized kom tsis muaj tshuaj lom thiab zam tau zoo vim tias nws cov xwm txheej ua metabolic nruab nrab thiab nws qhov tseem ceeb hauv cov khoom noj (xws li kua). Nicotinamide Riboside Malate yog ib qho khoom noj khoom haus tshiab uas muab cov txiaj ntsig ntawm Nicotinamide Riboside (NR) thiab Malic Acid.

 

Nicotinamide riboside hydrogen malate hmoov yog dab tsi?

1. High purity:

Qhov zoo ntawm cov txheej txheem crystallization yog qhov zoo ntawm kev tshem tawm impurities: Ntau tshaj 98% purity thiab tsawg dua 0.1% Ignition residue.

2. Tsawg impurities:

● Nicotinamide Tsawg dua lossis sib npaug li 0.5%

● Ib qho Impurity Tsawg dua lossis sib npaug li 0.5%

● Tag nrho cov impurities Tsawg dua lossis sib npaug li 2.0%

 

3. High efficiency efficiency:

Peb lub rooj cob qhia ntau lawm efficiency thiab batch loj yog txhim kho kom tau raws li cov neeg xav tau sai.

4. Ua raws li:

PebNicotinamide riboside malatecov kab ntau lawm tau dhau los ntawm ntau qhov kev kuaj xyuas thiab kev tsim khoom tas mus li yog lav.

 

Specification:

Yam khoom	Specification
Qhov tshwm sim	Dawb los yog Tawm -dawb Crystalline lossis Crystalline Hmoov
Kev sib hloov tshwj xeeb	-39 ° ~ -42 ° C
Kev txheeb xyuas	Yuav tsum ua raws li Kev Siv
Dej	Tsawg dua lossis sib npaug li 0.5%
Yam khoom muaj feem	Nicotinamide Tsawg dua lossis sib npaug li 0.5%
	Ib qho Impurity Tsawg dua lossis sib npaug li 0.5%
	Tag nrho impurities Tsawg dua lossis sib npaug li 2.0%
Residue ntawm Ignition	Tsawg dua lossis sib npaug li 0.1%
Hnyav Hlau	Tsawg dua lossis sib npaug li 10ppm
Cov ntsiab lus ntawm L-Malic Acid	33.2%~35.2%
Assay	98.0%~102.0%

 

Flow Chart:

 

Vim li cas thiaj xaiv Guanjie'sNicotinamide riboside malate?

● Ob lub Hoobkas thiab peb cov kab ntau lawm

● Kev tshawb fawb thiab kev muag khoom pab neeg

● ISO, Halal, Kosher tau ntawv pov thawj

● Nicotinamide riboside hydrogen malate ruaj khov zoo yog tswj nruj nruj los ntawm cov ntaub ntawv raw mus rau ib nrab-cov khoom tiav, thiab cov khoom kawg.

● Peb lub tuam txhab koom tes nrog cov koom haum thib peb uas tsim nyog - tog xeem.

● Peb tuaj yeem teb koj li ntawm ib teev rau cov lus nug thiab kev tsis txaus siab.

 

Khoom Taw Qhia:

Nicotinamide riboside (NR) yog ib qho analog ntawm vitamin B3, ib txwm muaj nyob rau hauv cov kab hauv cov khoom noj. Ntau B3 analogs tau paub ua ntej hauv kev sib txuas ntawm nicotinamide adenine dinucleotide, suav nrog nicotinic acid thiab nicotinamide.

Nicotinamide adenine dinucleotide (NAD +) yog ib qho tseem ceeb hauv txhua lub hlwb, Nws koom nrog ntau pua cov txheej txheem metabolic xws li lub zog ntawm tes, noj thiab ua haujlwm ntawm lub hlwb. Hmoov tsis zoo, thaum peb muaj hnub nyoog, peb maj mam poob NAD +, ua rau muaj ntau yam teeb meem kev noj qab haus huv. Kev tshawb fawb qhia tau hais tias NAD + qib poob mus rau ib nrab ntawm cov hluas hauv cov hnub nyoog nruab nrab. Los ntawm 80-xyoos, nws poob rau 1%. Txij li thaum peb lub hlwb nqus NAD + ntau, qhov txo qis hauv NAD + yuav cuam tshuam ncaj qha rau lub hlwb ua haujlwm, ua rau muaj teeb meem nco, teeb meem rau lub siab, thiab kev ntxhov siab.

 

Nicotinamide riboside malateyog ib qhov chaw ntawm vitamin B3, uas nce NAD + ntau ntau thiab qhib SIRT1 thiab SIRT3. Nws tuaj yeem ua tau zoo hauv kev txhim kho oxidative metabolism, thiab tiv thaiv siab - noj zaub mov muaj roj- ua rau muaj kev cuam tshuam metabolic.

Nicotinamide riboside (NR) yog ib qho tseem ceeb precursor rau biosynthesis ntawm Nicotinamide adenine dinucleotide (NAD +) thiab lwm yam NAD tsev neeg ntawm molecules. Ntau cov vitamin B3 analogs tau paub ua ntej hauv kev sib txuas ntawm Nicotinamide adenine dinucleotide (NAD), suav nrog nicotinic acid thiab nicotinamide. Vim lub moiety ntawm Nicotinamide, Nicotinamide riboside (NR) yog suav hais tias yog ib daim ntawv ntawm vitamin B3. Lub nicotinamide moiety ntawm Nicotinamide riboside (NR) yog covalently txuas mus rau riboside moiety thiab nqa ib tug zoo nqi ntawm nitrogen atom ntawm lub pyridine nplhaib.

 

NAD plays ntau lub luag haujlwm hauv cov hlwb. Txawm li cas los xij, NAD txoj haujlwm tseem ceeb tshaj plaws yog raws li hydrogen ion txais, pub dawb, thiab lub zog tswj hwm hauv ntau qhov oxidation - txo cov kev cuam tshuam ntawm cellular zog metabolism, suav nrog tricarboxylic acid voj voog, glycolysis, thiab oxidative phosphorylation. NAD ua haujlwm hauv kev degradation ntawm carbohydrates, proteins, rog thiab cawv, uas yog catabolic cov tshuaj tiv thaiv uas tsim lub zog. NAD+ kuj tseem ua haujlwm ua lub substrate rau NAD+-dependent enzymes xws li poly-adenosine, diphosphate ribose polymerase, sirtuin (SIRT), CD38 thiab CD157.

 

NAD muaj ntau txoj hauv kev biosynthetic, suav nrog:

1.Lub de novo biosynthesis txoj kev, uas ntiav cov amino acid thiab tryptophan ua nws precursor.

2.The Preiss-Handler txoj kev, nyob rau hauv uas NAD yog muab los ntawm nicotinic acid.

3.Lub Salvage Pathway, uas siv Nicotinamide riboside (NR) los yog nicotinamide.

Nicotinamide riboside (NR) pom muaj nyob rau hauv nyuj cov mis nyuj thiab kuj muaj nyob rau hauv nutraceutical uas yuav tsum tau supplemented los mus nce NAD.

Malate, ib qho tseem ceeb ntawm Kreb lub voj voog organic acid, txhawb nqa NR lub luag haujlwm hauv cellular zog tsim muaj peev xwm. Nicotinamide riboside (NR) uas yog khi rau hydrogen malate yog cov khoom xyaw uas tshwj xeeb rau Guanjie. Optimizing NR cov txiaj ntsig tuaj yeem ua tiav ntxiv thaum lub cev cov txheej txheem methylation tau nce. Tus kws tshawb fawb tau pom muaj kev sib raug zoo ntawm kev laus ntawm lub cev nqaij daim tawv thiab qhov twg ntawm DNA methylation hu ua "epigenetic moos." Guanjie covNicotinamide riboside malateuas muaj nicotinamide riboside kuj muaj cov as-ham uas paub zoo methyl pub dawb, sib piv rau NR cov khoom lag luam hauv khw uas tsis muaj methyl- pub khoom noj.

 

Nicotinamide riboside hydrogen malate yog dab tsihmoov siv rau?

● Nws tuaj yeem txo qhov acetylation ntawm Ndufa9 thiab SOD2.

● Nws tuaj yeem nce intracellular thiab mitochondrial NAD + ntau ntau hauv qhov concentration-raws li nyob rau hauv C2C12, Hepa1.6 thiab HEK293 hlwb nyob rau hauv ib tug concentration ntawm 1-1000 μM.

● Nws tuaj yeem txhim kho NAD, rov kho cov tshuaj tiv thaiv kab mob poly (ADP-ribose) polymerase (PARP) muaj nuj nqi, thiab txhawb kev tiv thaiv kab mob hauv lub cev rau tus mob coronavirus (CoVs). (CoVs is one of the cause of COVID-19)

 

Kev ua haujlwm tshwj xeeb:

Kev laus: Raws li peb muaj hnub nyoog, NAD + qib maj mam txo qis, uas tuaj yeem ua kom cov txheej txheem kev laus ntawm tib neeg lub cev.Nicotinamide riboside hydrogen malate tuaj yeem pab tswj lub cev NAD + qib, pab ncua kev laus thiab ncua kev ua neej.

● Kev muaj peev xwm kis las:

NAD + koom nrog hauv lub zog metabolism thiab cov leeg ua haujlwm, thiab ntxiv nrog cov malate no tuaj yeem txhawb cov txheej txheem no, yog li txhim kho kev ua haujlwm ntawm kev tawm dag zog.

● Mob plawv:

Ntxiv nrog rau kev txhim kho cov txheej txheem rho tawm lub zog ntawm txhua lub hlwb, NAD + tuaj yeem tiv thaiv mitochondria los ntawm kev tuag ntxov ntxov thiab txo cov cellular aging.Nicotinamide riboside malatetuaj yeem pab txo qis kev pheej hmoo ntawm kab mob plawv thiab kab mob hlwb.

● Mob hlwb:

Qib NAD + txaus yog qhov tseem ceeb rau kev tswj xyuas lub hlwb kev noj qab haus huv, kev paub txog kev ua haujlwm, thiab tiv thaiv kev puas hlwb hlwb.

 

Lub tuam txhab zoo:

● Peb pab pawg kws tshaj lij yeej ib txwm muaj los teb cov lus nug lossis kev txhawj xeeb los ntawm peb cov neeg siv khoom.

● Peb lub tuam txhab tau tshaj tawm rau txhua tus tswv cuab nws txoj kev txhim kho lub tswv yim ntawm kev nce qib nrog lub sijhawm, nrhiav kev ua tau zoo thiab lub siab tawv ntawm kev sib koom siab thiab kev ua haujlwm hnyav. Nyob rau tib lub sijhawm, nrog kev txhim kho sai ntawm lub tuam txhab, txhua tus tswvcuab qhia nws txoj kev mob siab rau, kev txawj ntse, kev mob siab, kev muaj peev xwm thiab kev ua raws.

● Peb yog ib tug siab -zoo cog extract tsum thiab txhim khu kev qha chaw tsim tshuaj paus

● Peb muaj cov ntaub ntawv muag khoom zoo tshaj plaws.

● Peb muab peb tus kheej kev tshawb fawb thiab kev tswj hwm tib neeg kom peb muaj pab pawg ua lag luam dynamic.

● Peb cov khoom yog 100% ntuj yam tsis muaj tshuaj phem los yog additives.

● Peb cog lus tias peb yuav muab cov neeg siv khoom zoo tshaj plawsNicotinamide riboside malatethiab cov kev pabcuam zoo tshaj plaws kom ua tiav kev txhim kho thiab noj qab nyob zoo.

● Peb cov khoom tsim los ua kom tau raws li cov qauv kev lag luam siab tshaj plaws, kom ntseeg tau tias txhua yam muaj kev nyab xeeb thiab siv tau zoo.

● Peb ib txwm coj cov neeg siv khoom xav tau ntawm qhov chaw thiab muab cov neeg- taw qhia lub tswv yim rau hauv txhua qhov kev nthuav dav ntawm cov khoom tsim.

● Peb tau cog lus los muab cov kev pabcuam siab tshaj plaws thiab kev txhawb nqa rau peb cov neeg siv khoom.

● Peb nyiam qhov chaw zoo heev ntawm peb cov neeg siv khoom vim tias muaj kev pabcuam zoo, siab -cov khoom zoo, tus nqi hnyav thiab xa khoom zoo.

 

Factory & Pab Pawg:

 

Daim ntawv pov thawj

 

Ntim & Xa khoom

Cim npe nrov: Nicotinamide Riboside Malate Powder, Tuam Tshoj Nicotinamide Riboside Malate Powder manufacturers, lwm tus neeg, Hoobkas